Search Results - "Abad, Leslie"

Immunogenicity of biologically-derived therapeutics: Assessment and interpretation of nonclinical safety studies by Ponce, Rafael, Abad, Leslie, Amaravadi, Lakshmi, Gelzleichter, Thomas, Gore, Elizabeth, Green, James, Gupta, Shalini, Herzyk, Danuta, Hurst, Christopher, Ivens, Inge A., Kawabata, Thomas, Maier, Curtis, Mounho, Barbara, Rup, Bonita, Shankar, Gopi, Smith, Holly, Thomas, Peter, Wierda, Dan

“…An evaluation of potential antibody formation to biologic therapeutics during the course of nonclinical safety studies and its impact on the toxicity profile…”
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Cytokines, insulin-like growth factor 1, sarcopenia, and mortality in very old community-dwelling men and women: the Framingham Heart Study by Roubenoff, Ronenn, Parise, Helen, Payette, Hélène A, Abad, Leslie W, D'Agostino, Ralph, Jacques, Paul F, Wilson, Peter W F, Dinarello, Charles A, Harris, Tamara B

“…Aging is associated with increased production of catabolic cytokines, reduced circulating levels of insulin-like growth factor 1 (IGF-1), and acceleration of…”
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Insulin-Like Growth Factor-1 and Interleukin 6 Predict Sarcopenia in Very Old Community-Living Men and Women: The Framingham Heart Study by Payette, Hélène, Roubenoff, Ronenn, Jacques, Paul F., Dinarello, Charles A., Wilson, Peter W. F., Abad, Leslie W., Harris, Tamara

“…Objectives: To assess the prognostic role of the inflammatory cytokine, interleukin 6 (IL‐6), and insulin‐like growth factor‐1 (IGF‐1) in predicting 2‐year…”
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Tumor necrosis factor-alpha production is associated with less body cell mass in women with rheumatoid arthritis by WALSMITH, Joseph, ABAD, Leslie, KEHAYIAS, Joseph, ROUBENOFF, Ronenn

“…OBJECTIVE: To examine the relationship between inflammatory cytokine production and body cell mass (BCM) in women with stable, medically well-controlled…”
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Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation by Roubenoff, Ronenn, Harris, Tamara B., Abad, Leslie W., Wilson, Peter W. F., Dallal, Gerard E., Dinarello, Charles A.

“…Objective. To determine the association among aging, inflammation, and cytokine production by peripheral blood mononuclear cells. Population and Methods. We…”
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Eccentric exercise markedly increases c-Jun NH2-terminal kinase activity in human skeletal muscle by Boppart, Marni D, Aronson, Doron, Gibson, Lindsay, Roubenoff, Ronenn, Abad, Leslie W, Bean, Jonathan, Goodyear, Laurie J, Fielding, Roger A

“…1  Research Division, Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and 2  Department of Health…”
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Development of a biosensor-based method for detection and isotyping of antibody responses to adenoviral-based gene therapy vectors by Abad, Leslie W, Neumann, Meredith, Tobias, Lori, Obenauer-Kutner, Linda, Jacobs, Sheila, Cullen, Constance

“…A biosensor-based assay, using a surface plasmon resonance detection system, was developed to detect and isotype anti-adenoviral antibodies in patients dosed…”
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CYTOKINE RESPONSES DIFFER BY COMPARTMENT AND WASTING STATUS IN PATIENTS WITH HIV INFECTION AND HEALTHY CONTROLS by Abad, Leslie W., Schmitz, Heather R., Parker, Russell, Roubenoff, Ronenn

“…Inflammatory cytokines are implicated in the loss of lean tissue that occurs in patients with inflammatory and infectious diseases, including HIV infection…”
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Acute phase responses and cytokine secretion in chronic fatigue syndrome by CANNON, J. G, ANGEL, J. B, BALL, R. W, ABAD, L. W, FAGIOLI, L, KOMAROFF, A. L

“…This study addresses the hypothesis that clinical manifestations of chronic fatigue syndrome (CFS) are due in part to abnormal production of or sensitivity to…”
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Effect of acquired immune deficiency syndrome wasting on the protein metabolic response to acute exercise by Roubenoff, Ronenn, Abad, Leslie W., Lundgren, Nancy

“…Wasting is a major complication of human immunodeficiency virus (HIV) infection, which remains prevalent even in the era of highly-active antiretroviral…”
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Effects of progressive resistance training on immune response in aging and chronic inflammation by RALL, L. C, ROUBENOFF, R, CANNON, J. G, ABAD, L. W, DINARELLO, C. A, MEYDANI, S. N

“…The effects of 12 wk of progressive resistance strength training on in vivo and in vitro immune parameters were evaluated in a controlled study of eight…”
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A phase II study of cixutumumab (IMC-A12, NSC742460) in advanced hepatocellular carcinoma by Abou-Alfa, Ghassan K, Capanu, Marinela, O’Reilly, Eileen M, Ma, Jennifer, Chou, Joanne F, Gansukh, Bolorsukh, Shia, Jinru, Kalin, Marcia, Katz, Seth, Abad, Leslie, Reidy-Lagunes, Diane L, Kelsen, David P, Chen, Helen X, Saltz, Leonard B

“…Background & Aims IGF-IR is implicated in hepatic carcinogenesis. This and preliminary evidence of biological activity of anti-IGF-1R monoclonal antibody…”
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Hormonal influences on stress-induced neutrophil mobilization in health and chronic fatigue syndrome by CANNON, J. G, ANGEL, J. B, ABAD, L. W, O'GRADY, J, LUNDGREN, N, FAGIOLI, L, KOMAROFF, A. L

“…This investigation tested the hypotheses that women diagnosed with chronic fatigue syndrome (CFS) would exhibit significantly greater systemic indices of…”
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Abstract 986: A BioPharma best practices framework to enable successful morphology guided spatial biology studies using NanoString GeoMx® Digital Spatial Profiler by Abad, Leslie, McClain, Maxine, Bonnevie, Edward, Chen, Benjamin, Church, Sarah, Demirkan, Gokhan, Haynes, Premi, Hunter, Kelly, Kersarwani, Anil, Krull, David, Liang, Yan, Pal, Prithwish, Ramos, Corinne, Rodriguez, Deniliz, Runyon, Jessica, Tessier, Julien, Anguiano, Esperanza

“…Abstract The interest and utility of high-plex spatial profiling of RNA and protein biomarkers has increased over the last few years. The implementation of…”
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Menstrual- and gender-dependent variations in circulating IL-1 agonists, antagonists, and binding proteins by Cannon, Joseph G., Abad, Leslie W., Vannier, Edouard, Lynch, Elizabeth A.

“…This study tested the hypotheses that sex‐related differences in circulating binding proteins for interleukin‐1 β (IL‐1 β) exist and that these binding…”
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Abstract P4-01-02: Prospective characterization of HER2-positive circulating tumor cells in patients with HER2-negative metastatic breast cancer by Krop, Ian E, Macrae, Erin, Galler, Sarah R, Bischoff, Farideh, Fauni, Romeo, Sales, Edgar, Huynh, Lan, Mitchell, Christine, Clarin-Tamayo, Trisky, Anderson, Mark, Abad, Leslie, Winer, Eric

“…Abstract Background: We have previously shown feasibility by CLIA validation of HER2 FISH on circulating tumor cells (CTCs). Several small retrospective…”
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Randomized phase II study of docetaxel with or without ramucirumab (IMC-1121B) or icrucumab (IMC-18F1) in patients with urothelial transitional cell carcinoma (TCC) following progression on first-line platinum-based therapy by Petrylak, Daniel Peter, Chi, Kim N., Vogelzang, Nicholas J., Sonpavde, Guru, Rutstein, Mark D., Schwartz, Jonathan D., Fox, Floyd E., Wang, Weigang, Abad, Leslie W, Cosaert, Jan, Grebennik, Dmitri O.

“…Abstract only TPS4675^ Background: The vascular endothelial growth factor (VEGF) pathway may play an important role in the pathogenesis of bladder cancer. Two…”
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Role of cytokines and testosterone in regulating lean body mass and resting energy expenditure in HIV-infected men by Roubenoff, Ronenn, Grinspoon, Steven, Skolnik, Paul R, Tchetgen, Eric, Abad, Leslie, Spiegelman, Donna, Knox, Tamsin, Gorbach, Sherwood

“…Although catastrophic weight loss is no longer common in HIV-infected men, we hypothesized that a more gradual process of cachexia [loss of lean body mass…”
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Cachexia in rheumatoid arthritis is not explained by decreased growth hormone secretion by Rall, Laura C., Walsmith, Joseph M., Snydman, Laura, Reichlin, Seymour, Veldhuis, Johannes D., Kehayias, Joseph J., Abad, Leslie W., Lundgren, Nancy T., Roubenoff, Ronenn

“…Objective Patients with rheumatoid arthritis (RA) lose body cell mass (BCM) by unknown mechanisms. Since the loss of BCM in normal aging individuals parallels…”
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Abnormal homocysteine metabolism in rheumatoid arthritis by Roubenoff, R, Dellaripa, P, Nadeau, M R, Abad, L W, Muldoon, B A, Selhub, J, Rosenberg, I H

“…To assess total homocysteine (tHcy) metabolism in patients with rheumatoid arthritis (RA). Assessments were performed to determine the fasting levels of tHcy…”
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