Thioredoxin-binding protein-2 (TBP-2): Its potential roles in the aging process

Thioredoxin (TRX) binding protein‐2 (TBP‐2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP‐2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP‐2 suppresses cellular proliferation along wit...

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Bibliographic Details
Published in:	BioFactors (Oxford) Vol. 27; no. 1-4; pp. 47 - 51
Main Authors:	Yoshida, Toru, Kondo, Norihiko, Oka, Shin-Ichi, Ahsan, Md Kaimul, Hara, Tomijiro, Masutani, Hiroshi, Nakamura, Hajime, Ab, Junji Yodoi
Format:	Journal Article
Language:	English
Published:	Amsterdam IOS Press 2006
Subjects:	aging Animals Apoptosis - physiology Carrier Proteins - physiology Cell Cycle - physiology Cellular Senescence - physiology energy metabolism Energy Metabolism - physiology Humans lipid Models, Biological Oxidation-Reduction redox Thioredoxin Thioredoxins
Online Access:	Get full text
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Summary:	Thioredoxin (TRX) binding protein‐2 (TBP‐2), a negative regulator of TRX, is involved in intracellular redox regulation and cellular growth. The expression of TBP‐2 is frequently lost in tumor cell lines and tissues, whereas the ectopic expression of TBP‐2 suppresses cellular proliferation along with cell cycle arrest at the G1 phase. TBP‐2 was also reported to be a cellular senescence‐associated gene. Besides the retardation of cellular growth, the reduction of white adipose, and alteration of the energy pathway are involved in several features of the aging process. We have generated TBP‐2 genetically modified mice and found that TBP‐2 is closely linked to lipid metabolism. Indeed, TBP‐2 has been suggesting to be related to familial combined hyperlipidemia analyzed by a spontaneous mutant mouse strain. As lipid metabolism is one of the most primitive sources of energy production, we discussed the possible roles of TBP‐2 in the regulation of energy utilization connected to the aging process.
Bibliography:	ark:/67375/WNG-7JTF93LH-M istex:431155CA8EF8621D09860990481C64F60CAD70EB Bio-oriented Technology Research Advancement Institution (BRAIN) ArticleID:BIOF5520270105 Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1
ISSN:	0951-6433 1872-8081
DOI:	10.1002/biof.5520270105