Search Results - "Aarts, Tineke"

Cellular immunotherapy on primary multiple myeloma expanded in a 3D bone marrow niche model by Braham, Maaike V. J., Minnema, Monique C., Aarts, Tineke, Sebestyen, Zsolt, Straetemans, Trudy, Vyborova, Anna, Kuball, Jurgen, Öner, F. Cumhur, Robin, Catherine, Alblas, Jacqueline

“…Bone marrow niches support multiple myeloma, providing signals and cell-cell interactions essential for disease progression. A 3D bone marrow niche model was…”
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Evaluating in vivo efficacy: toxicity profile of TEG001 in humanized mice xenografts against primary human AML disease and healthy hematopoietic cells by Johanna, Inez, Straetemans, Trudy, Heijhuurs, Sabine, Aarts-Riemens, Tineke, Norell, Haakan, Bongiovanni, Laura, de Bruin, Alain, Sebestyen, Zsolt, Kuball, Jürgen

“…© The Author(s). 2019 Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0 International License…”
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Sepantronium bromide (YM155) improves daratumumab-mediated cellular lysis of multiple myeloma cells by abrogation of bone marrow stromal cell-induced resistance by de Haart, Sanne J, Holthof, Lisa, Noort, Willy A, Minnema, Monique C, Emmelot, Maarten E, Aarts-Riemens, Tineke, Doshi, Parul, Sasser, Kate, Yuan, Huipin, de Bruijn, Joost, Martens, Anton C M, van de Donk, Niels W C J, Lokhorst, Henk M, Groen, Richard W J, Mutis, Tuna

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Characterization and modulation of anti-αβTCR antibodies and their respective binding sites at the βTCR chain to enrich engineered T cells by Kierkels, Guido J.J., van Diest, Eline, Hernández-López, Patricia, Scheper, Wouter, de Bruin, Anja C.M., Frijlink, Elselien, Aarts-Riemens, Tineke, van Dooremalen, Sanne F.J., Beringer, Dennis X., Oostvogels, Rimke, Kramer, Lovro, Straetemans, Trudy, Uckert, Wolfgang, Sebestyén, Zsolt, Kuball, Jürgen

“…T cell engineering strategies offer cures to patients and have entered clinical practice with chimeric antibody-based receptors; αβT cell receptor…”
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Human Regulatory T Cells Control Xenogeneic Graft-versus-Host Disease Induced by Autologous T Cells in RAG2−/−γc−/− Immunodeficient Mice by Mutis, Tuna, van Rijn, Rozemarijn S., Simonetti, Elles R., Aarts-Riemens, Tineke, Emmelot, Maarten E., van Bloois, Louis, Martens, Anton, Verdonck, Leo F., Ebeling, Saskia B.

“…Purpose: Effective prevention of graft-versus-host disease (GvHD) is a major challenge to improve the safety of allogeneic stem cell transplantation for…”
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Identification of a 40S Ribosomal Protein S4–Derived H-Y Epitope Able to Elicit a Lymphoblast-Specific Cytotoxic T Lymphocyte Response by IVANOV, Roman, AARTS, Tineke, HOL, Samantha, DOORNENBAL, Angeline, HAGENBEEK, Anton, PETERSEN, Eefke, EBELING, Saskia

“…Purpose: The superior graft-versus-leukemia (GVL) effect of the female-to-male stem cell transplantation is partially independent from the concomitant…”
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Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4⁺CD25⁻ cells by Aarts-Riemens, Tineke, Emmelot, Maarten E, Verdonck, Leo F, Mutis, Tuna

“…The forkhead/winged helix transcription factor (Foxp3) is expressed as two different isoforms in humans: the full-length isoform (Foxp3FL) and an…”
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HLA‐DRB116‐restricted recognition of myeloid cells, including CD34+ CML progenitor cells by Ebeling, Saskia B., Ivanov, Roman, Hol, Samantha, Aarts, Tineke I., Hagenbeek, Anton, Verdonck, Leo F., Petersen, Eefke J.

“…The therapeutic effect of a human leucocyte antigen (HLA)‐identical allogeneic stem cell transplantation (allo‐SCT) for the treatment of haematological…”
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TEG001 Insert Integrity from Vector Producer Cells until Medicinal Product by Straetemans, Trudy, Janssen, Anke, Jansen, Koen, Doorn, Ruud, Aarts, Tineke, van Muyden, Anna D.D., Simonis, Marieke, Bergboer, Judith, de Witte, Moniek, Sebestyen, Zsolt, Kuball, Jurgen

“…Despite extensive usage of gene therapy medicinal products (GTMPs) in clinical studies and recent approval of chimeric antigen receptor (CAR) T cell therapy,…”
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Towards the Next Generation CAR T Cells with TEGs: In Vivo Efficacy — Toxicity Profile in Xenografts of Primary Human AML Disease and Healthy Bone Marrow by Straetemans, Trudy, Gan, Inez Johanna, Heijhuurs, Sabine, Kierkels, Guido, Jansen, Koen, Doorn, Ruud, Aarts, Tineke, Norrel, Haakan, Sebestyen, Zsolt, Kuball, Jurgen

“…T.S. and I.J.G. contributed equally</span Background γδT cells mediate essential cancer immune surveillance by sensing transformation-dependent metabolic…”
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Host Dendritic Cell Vaccinations Combined with Donor Lymphocyte Infusions Induce Host and KLH Specific Immunity in Multiple Myeloma Patients by Kneppers, Evelien, Minnema, Monique C., Aarts, Tineke, Emmelot, Maarten E., Slaper-Cortenbach, Ineke, Westinga, Kasper, Mutis, Tuna, Lokhorst, Henk M.

“…Abstract 2875 Poster Board II-851 Allogeneic stem cell transplantation followed by donor lymphocyte infusions (DLI) induces a clinical significant graft versus…”
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Lenalidomide Is Highly Effective in Patients with Relapsed Multiple Myeloma Following Allogeneic Stem Cell Transplantation and Increases the Frequency of CD4+FOXP3+ T Cells by Minnema, Monique C., van der Veer, Michael, Aarts, Tineke, Emmelot, Maarten, Mutis, Tuna, Lokhorst, Henk M.

“…Lenalidomide has demonstrated significant clinical activity in patients with newly diagnosed and relapsed multiple myeloma (MM). Its actions are partly…”
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Induction of Potent Anti-Tumor Effects by Original and TCR-Redirected CD4 + Cytotoxic T Cells by Spaapen, Robbert M, van den Oudenalder, Kelly, van Elk, Maureen, Aarts, Tineke, Guichelaar, Teun, Groen, Richard WJ, Bloem, Andries C, Storm, Gert, Martens, Anton C, Lokhorst, Henk M, Mutis, Tuna

“…Abstract 1333 Poster Board I-355 The curative Graft versus Tumor (GvT) effect of allogeneic stem cell transplantation and donor lymphocyte infusions is mainly…”
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Generation of Graft-Versus-Leukemia (GVL)-Effector T Cells through Targeting of Leukemia-Associated HY Antigens Via TCR Transfer by Ivanov, Roman, Hol, Samantha, Aarts, Tineke, Hagenbeek, Anton, Ebeling, Saskia

“…In this study we present two novel leukemia-associated antigens and their specific targeting through TCR-transfer. First, two CD8+ CTL clones were…”
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UTY‐specific TCR‐transfer generates potential graft‐versus‐leukaemia effector T cells by Ivanov, Roman, Hol, Samantha, Aarts, Tineke, Hagenbeek, Anton, Slager, Elisabeth H., Ebeling, Saskia

“…Summary Immunotherapeutic approaches that target antigens that are differentially recognized on haematopoietic and non‐haematopoietic cells may specifically…”
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Human CD4+ CD25+ Regulatory T Cells Effectively Control Xenogeneic-GvHD Induced by Autologous T Cells in Rag2−/− γc−/− Immune-Deficient Mice by Mutis, Tuna, van Rijn, Rozemarijn S., Simonetti, Elles R., Aarts, Tineke, Emmelot, Maarten, Ebeling, Saskia B.

“…The curative Graft-versus-Leukemia (GvL) effect of allogeneic stem cell transplantation (SCT) and Donor Lymphocyte Infusions (DLI) is frequently complicated by…”
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HLA-DRB116-restricted recognition of myeloid cells, including CD34^sup +^ CML progenitor cells by Ebeling, Saskia B, Ivanov, Roman, Hol, Samantha, Aarts, Tineke I

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Accessory Cells of the Microenvironment Protect Multiple Myeloma from T-Cell Cytotoxicity through Cell Adhesion-Mediated Immune Resistance by DE HAART, Sanne J, VAN DE DONK, Niels W. C. J, LOKHORST, Henk M, MARTENS, Anton C, MITSIADES, Constantine S, MUTIS, Tuna, MINNEMA, Monique C, HUANG, Julie H, AARTS-RIEMENS, Tineke, BOVENSCHEN, Niels, HUIPIN YUAN, GROEN, Richard W. J, MCMILLIN, Douglas W, JAKUBIKOVA, Jana

“…Cellular immunotherapy frequently fails to induce sustained remissions in patients with multiple myeloma, indicating the ability of multiple myeloma cells to…”
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The Survivin Suppressant YM155 Overcomes Microenvironment-Mediated Immune Resistance In a Humanized Multiple Myeloma Mouse Model by de Haart, Sanne J., Minnema, Monique C., Huang, Julie H., Aarts-Riemens, Tineke, Lokhorst, Henk, Martens, Anton, Mitsiades, Constantine S., Mutis, Tuna

“…Durable tumor regression can be achieved in Multiple Myeloma (MM) patients by immunotherapeutic approaches, such as allogeneic stem cell transplantation and…”
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Microenvironment Shields Myeloma From Adoptive Immunotherapy by Cell Adhesion Mediated Immune Resistance (CAM-IR) by de Haart, Sanne J, Minnema, Monique C., Aarts-Riemens, Tineke, Bovenschen, Niels, Lokhorst, Henk M., Mutis, Tuna

“…Abstract 4039 Cellular immunotherapy can induce long term remissions in multiple myeloma (MM) patients. Despite reported successes in a limited number of…”
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