Search Results - "Aaron Van Hooser"

Construction of a computable cell proliferation network focused on non-diseased lung cells by Westra, Jurjen W, Schlage, Walter K, Frushour, Brian P, Gebel, Stephan, Catlett, Natalie L, Han, Wanjiang, Eddy, Sean F, Hengstermann, Arnd, Matthews, Andrea L, Mathis, Carole, Lichtner, Rosemarie B, Poussin, Carine, Talikka, Marja, Veljkovic, Emilija, Van Hooser, Aaron A, Wong, Benjamin, Maria, Michael J, Peitsch, Manuel C, Deehan, Renee, Hoeng, Julia

“…Critical to advancing the systems-level evaluation of complex biological processes is the development of comprehensive networks and computational methods to…”
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Specification of kinetochore-forming chromatin by the histone H3 variant CENP-A by Van Hooser, A A, Ouspenski, I I, Gregson, H C, Starr, D A, Yen, T J, Goldberg, M L, Yokomori, K, Earnshaw, W C, Sullivan, K F, Brinkley, B R

“…The mechanisms that specify precisely where mammalian kinetochores form within arrays of centromeric heterochromatin remain largely unknown. Localization of…”
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perichromosomal layer by Van Hooser, Aaron A, Yuh, Patrick, Heald, Rebecca

“…In addition to genetic information, mitotic chromosomes transmit essential components for nuclear assembly and function in a new cell cycle. A specialized…”
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Histone H3 phosphorylation is required for the initiation, but not maintenance, of mammalian chromosome condensation by Van Hooser, A, Goodrich, D W, Allis, C D, Brinkley, B R, Mancini, M A

“…The temporal and spatial patterns of histone H3 phosphorylation implicate a specific role for this modification in mammalian chromosome condensation. Cells…”
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Early patient stratification and predictive biomarkers in drug discovery and development: a case study of ulcerative colitis anti-TNF therapy by Laifenfeld, Daphna, Drubin, David A, Catlett, Natalie L, Park, Jennifer S, Van Hooser, Aaron A, Frushour, Brian P, de Graaf, David, Fryburg, David A, Deehan, Renée

“…The current drug discovery paradigm is long, costly, and prone to failure. For projects in early development, lack of efficacy in Phase II is a major…”
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Localization of human SMC1 protein at kinetochores by Gregson, Heather C, Van Hooser, Aaron A, Ball, Jr, Alexander R, Brinkley, B R, Yokomori, Kyoko

“…Proper cohesion of sister chromatids is prerequisite for correct segregation of chromosomes during cell division. The cohesin multiprotein complex, conserved…”
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The mammalian centromere: structural domains and the attenuation of chromatin modeling by Van Hooser, Aaron A., Mancini, Michael A., Allis, C. David, Sullivan, Kevin F., Brinkley, B. R.

“…ABSTRACTThe centromere‐kinetochore complex can be divided into distinct domains based on structure and function. Previous work has used CREST auto‐antibodies…”
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Kinetochore function: The complications of becoming attached by Van Hooser, Aaron A, Heald, Rebecca

“…Kinetochores are specialized protein complexes assembled on centromeric DNA that connect to spindle microtubules and mediate proper chromosome segregation…”
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Relevance of histone acetylation and replication timing for deposition of centromeric histone CENP-A by Ouspenski, Ilia I, Van Hooser, Aaron A, Brinkley, B.R

“…A centromere-specific variant of histone H3, centromere protein A (CENP-A), is a critical determinant of centromeric chromatin, and its location on the…”
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Blood-based identification of non-responders to anti-TNF therapy in rheumatoid arthritis by Thomson, Ty M, Lescarbeau, Reynald M, Drubin, David A, Laifenfeld, Daphna, de Graaf, David, Fryburg, David A, Littman, Bruce, Deehan, Renée, Van Hooser, Aaron

“…Faced with an increasing number of choices for biologic therapies, rheumatologists have a critical need for better tools to inform rheumatoid arthritis (RA)…”
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A computable cellular stress network model for non-diseased pulmonary and cardiovascular tissue by Schlage, Walter K, Westra, Jurjen W, Gebel, Stephan, Catlett, Natalie L, Mathis, Carole, Frushour, Brian P, Hengstermann, Arnd, Van Hooser, Aaron, Poussin, Carine, Wong, Ben, Lietz, Michael, Park, Jennifer, Drubin, David, Veljkovic, Emilija, Peitsch, Manuel C, Hoeng, Julia, Deehan, Renee

“…Humans and other organisms are equipped with a set of responses that can prevent damage from exposure to a multitude of endogenous and environmental stressors…”
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Mitosis-specific phosphorylation of histone H3 initiates primarily within pericentromeric heterochromatin during G2 and spreads in an ordered fashion coincident with mitotic chromosome condensation by Hendzel, M J, Wei, Y, Mancini, M A, Van Hooser, A, Ranalli, T, Brinkley, B R, Bazett-Jones, D P, Allis, C D

“…We have generated and characterized a novel site-specific antibody highly specific for the phosphorylated form of the amino-terminus of histone H3 (Ser10). In…”
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Abstract 4132: Predictive classifiers for response to c-Met targeted therapies in lung and colon cancer by Drubin, David, Catlett, Natalie L., Park, Jennifer, Van Hooser, Aaron A., Frushour, Brian P., Kenney, Renee Deehan

“…Abstract A fundamental challenge in the development of cancer therapies is the co-development of companion biomarkers to select patients most likely to respond…”
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Protein Phosphatase 4 Is Involved in Tumor Necrosis Factor-α-induced Activation of c-Jun N-terminal Kinase by Zhou, Guisheng, Mihindukulasuriya, Kathie A., MacCorkle-Chosnek, Rebecca A., Van Hooser, Aaron, Hu, Mickey C.-T., Brinkley, B.R., Tan, Tse-Hua

“…Protein phosphatase 4 (PP4, previously named protein phosphatase X (PPX)), a PP2A-related serine/threonine phosphatase, has been shown to be involved in…”
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Protein Phosphatase 4 Is Involved in Tumor Necrosis Factor-α-induced Activation of c-Jun N-terminal Kinase by Guisheng Zhou, Kathie A. Mihindukulasuriya, Rebecca A. MacCorkle-Chosnek, Aaron Van Hooser, Mickey C.-T. Hu, B. R. Brinkley, Tse-Hua Tan

“…Protein phosphatase 4 (PP4, previously named protein phosphatase X (PPX)), a PP2A-related serine/threonine phosphatase, has been shown to be involved in…”
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