Search Results - "Aardema, Marilyn J"

A weight of evidence review of the genotoxicity of titanium dioxide (TiO2) by Kirkland, David, Aardema, Marilyn J., Battersby, Rüdiger V., Beevers, Carol, Burnett, Karin, Burzlaff, Arne, Czich, Andreas, Donner, E. Maria, Fowler, Paul, Johnston, Helinor J., Krug, Harald F., Pfuhler, Stefan, Stankowski, Leon F.

“…Titanium dioxide is a ubiquitous white material found in a diverse range of products from foods to sunscreens, as a pigment and thickener, amongst other uses…”
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A comparison of transgenic rodent mutation and in vivo comet assay responses for 91 chemicals by Kirkland, David, Levy, Dan D., LeBaron, Matthew J., Aardema, Marilyn J., Beevers, Carol, Bhalli, Javed, Douglas, George R., Escobar, Patricia A., Farabaugh, Christopher S., Guerard, Melanie, Johnson, George E., Kulkarni, Rohan, Le Curieux, Frank, Long, Alexandra S., Lott, Jasmin, Lovell, David P., Luijten, Mirjam, Marchetti, Francesco, Nicolette, John J., Pfuhler, Stefan, Roberts, Daniel J., Stankowski, Leon F., Thybaud, Veronique, Weiner, Sandy K., Williams, Andrew, Witt, Kristine L., Young, Robert

“…•In vivo comet assay compared with transgenic rodent assay for 91 chemicals.•Comparison focussed on evaluation of in vivo genotoxicity per se.•Fair to good…”
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The reconstructed skin micronucleus assay (RSMN) in EpiDerm™: Detailed protocol and harmonized scoring atlas by Dahl, Erica L., Curren, Rodger, Barnett, Brenda C., Khambatta, Zubin, Reisinger, Kerstin, Ouedraogo, Gladys, Faquet, Brigitte, Ginestet, Anne-Claire, Mun, Greg, Hewitt, Nicola J., Carr, Greg, Pfuhler, Stefan, Aardema, Marilyn J.

“…The European Cosmetic Toiletry and Perfumery Association (COLIPA), along with contributions from the European Centre for the Validation of Alternative Methods…”
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Dermal penetration and metabolism of p-aminophenol and p-phenylenediamine: Application of the EpiDerm™ human reconstructed epidermis model by Hu, Ting, Bailey, Ruth E., Morrall, Stephen W., Aardema, Marilyn J., Stanley, Lesley A., Skare, Julie A.

“…To address the provision of the 7th Amendment to the EU Cosmetics Directive banning the use of in vivo genotoxicity assays for testing cosmetic ingredients in…”
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Genotoxicity Assessment of Nanomaterials: Recommendations on Best Practices, Assays, and Methods by Elespuru, Rosalie, Pfuhler, Stefan, Aardema, Marilyn J, Chen, Tao, Doak, Shareen H, Doherty, Ann, Farabaugh, Christopher S, Kenny, Julia, Manjanatha, Mugimane, Mahadevan, Brinda, Moore, Martha M, Ouédraogo, Gladys, Stankowski, Leon F, Tanir, Jennifer Y

“…Abstract Nanomaterials (NMs) present unique challenges in safety evaluation. An international working group, the Genetic Toxicology Technical Committee of the…”
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Validation of the 3D reconstructed human skin micronucleus (RSMN) assay: an animal-free alternative for following-up positive results from standard in vitro genotoxicity assays by Pfuhler, Stefan, Downs, Thomas R, Hewitt, Nicola J, Hoffmann, Sebastian, Mun, Greg C, Ouedraogo, Gladys, Roy, Shambhu, Curren, Rodger D, Aardema, Marilyn J

“…Abstract In vitro test batteries have become the standard approach to determine the genotoxic potential of substances of interest across industry sectors…”
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The EpiDerm™ 3D human reconstructed skin micronucleus (RSMN) assay: Historical control data and proof of principle studies for mechanistic assay adaptations by Roy, Shambhu, Kulkarni, Rohan, Hewitt, Nicola J., Aardema, Marilyn J.

“…•We report historical control data from the reconstructed skin micronucleus (RSMN) assay.•True/false positive and negative chemicals were correctly…”
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A review of mammalian in vivo genotoxicity of hexavalent chromium: implications for oral carcinogenicity risk assessment by Thompson, Chad M., Aardema, Marilyn J., Heintz, Melissa M., MacGregor, James T., Young, Robert R.

“…Assessment of genotoxicity is a critical component of mode of action (MOA) analysis and carcinogen risk assessment due to its influence on quantitative risk…”
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A weight of evidence assessment of the genotoxic potential of 4-methylimidazole as a possible mode of action for the formation of lung tumors in exposed mice by Brusick, David, Aardema, Marilyn J., Allaben, William T., Kirkland, David J., Williams, Gary, Llewellyn, G. Craig, Parker, Julia M., Rihner, Marisa O.

“…4-Methylimidazole (4-MeI) is a byproduct formed during the cooking of foods containing carbohydrates and amino acids, including the production of flavors and…”
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The holy grail in genetic toxicology: Follow-up approaches for positive results in the Ames assay by Aardema, Marilyn J.

“…Positive results in the Ames/E. coli bacterial mutagenicity assay create a significant hurdle for the development of new products/drugs and as a result, most…”
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Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell gene mutation assays) and integration with somatic cell testing by Marchetti, Francesco, Aardema, Marilyn J., Beevers, Carol, van Benthem, Jan, Godschalk, Roger, Williams, Andrew, Yauk, Carole L., Young, Robert, Douglas, George R.

“…• Current designs within OECD Test Guideline 488 have limitations for germ cell testing. • The standard design for somatic tissues is not useful for mutation…”
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ECVAM prevalidation study on in vitro cell transformation assays: General outline and conclusions of the study by Corvi, Raffaella, Aardema, Marilyn J., Gribaldo, Laura, Hayashi, Makoto, Hoffmann, Sebastian, Schechtman, Leonard, Vanparys, Philippe

“…► ECVAM prevalidated SHE and BALB/c 3T3 cell transformation assays (CTAs). ► Standardised protocols for CTAs are now available. ► Further testing should…”
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In vitro genotoxicity testing using the micronucleus assay in cell lines, human lymphocytes and 3D human skin models by Kirsch-Volders, Micheline, Decordier, Ilse, Elhajouji, Azeddine, Plas, Gina, Aardema, Marilyn J, Fenech, Michael

“…The toxicological relevance of the micronucleus (MN) test is well defined: it is a multi-target genotoxic endpoint, assessing not only clastogenic and…”
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Application of in vitro cell transformation assays in regulatory toxicology for pharmaceuticals, chemicals, food products and cosmetics by Vanparys, Philippe, Corvi, Raffaella, Aardema, Marilyn J., Gribaldo, Laura, Hayashi, Makoto, Hoffmann, Sebastian, Schechtman, Leonard

“…► Alternative ways for carcinogenicity testing are urgently required. ► Transformation, a key event of carcinogenesis, can be assessed by cell transformation…”
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Corrigendum to “Simulation of mouse and rat spermatogenesis to inform genotoxicity testing using OECD test guideline 488” [Mutat. Res. 832–833 (2018) 19–28] by Marchetti, Francesco, Aardema, Marilyn J., Beevers, Carol, van Benthem, Jan, Douglas, George R., Godschalk, Roger, Yauk, Carole L., Young, Robert, Williams, Andrew

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Corrigendum to “Identifying germ cell mutagens using OECD test guideline 488 (transgenic rodent somatic and germ cell Gene mutation assays) and integration with somatic cell testing.” [Mutat. Res. 832–833 (2018) 7–18] by Marchetti, Francesco, Aardema, Marilyn J., Beevers, Carol, van Benthem, Jan, Godschalk, Roger, Williams, Andrew, Yauk, Carole L., Young, Robert, Douglas, George R.

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Improvement of in vivo genotoxicity assessment: Combination of acute tests and integration into standard toxicity testing by Rothfuss, Andreas, Honma, Masamitu, Czich, Andreas, Aardema, Marilyn J., Burlinson, Brian, Galloway, Sheila, Hamada, Shuichi, Kirkland, David, Heflich, Robert H., Howe, Jonathan, Nakajima, Madoka, O’Donovan, Mike, Plappert-Helbig, Ulla, Priestley, Catherine, Recio, Leslie, Schuler, Maik, Uno, Yoshifumi, Martus, Hans-Jörg

“…A working group convened at the 2009 5th IWGT to discuss possibilities for improving in vivo genotoxicity assessment by investigating possible links to…”
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Integration of Pig-a, micronucleus, chromosome aberration and comet assay endpoints in a 28-day rodent toxicity study with urethane by Stankowski, Jr, Leon F, Aardema, Marilyn J, Lawlor, Timothy E, Pant, Kamala, Roy, Shambhu, Xu, Yong, Elbekai, Reem

“…As part of the international Pig-a validation trials, we examined the induction of Pig-a mutant reticulocytes and red blood cells (RET(CD59-) and RBC(CD59-),…”
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Emerging approaches in predictive toxicology by Zhang, Luoping, McHale, Cliona M., Greene, Nigel, Snyder, Ronald D., Rich, Ivan N., Aardema, Marilyn J., Roy, Shambhu, Pfuhler, Stefan, Venkatactahalam, Sundaresan

“…Predictive toxicology plays an important role in the assessment of toxicity of chemicals and the drug development process. While there are several…”
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Genotoxicity of nanomaterials: Refining strategies and tests for hazard identification by Pfuhler, Stefan, Elespuru, Rosalie, Aardema, Marilyn J., Doak, Shareen H., Maria Donner, E., Honma, Masamitsu, Kirsch-Volders, Micheline, Landsiedel, Robert, Manjanatha, Mugimane, Singer, Tim, Kim, James H.

“…A workshop addressing strategies for the genotoxicity assessment of nanomaterials (NMs) was held on October 23, 2010 in Fort Worth Texas, USA. The workshop was…”
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