Search Results - "Aardema, M.J."

Standardized cell sources and recommendations for good cell culture practices in genotoxicity testing by Lorge, E., Moore, M.M., Clements, J., O’Donovan, M., Fellows, M.D., Honma, M., Kohara, A., Galloway, S., Armstrong, M.J., Thybaud, V., Gollapudi, B., Aardema, M.J., Tanir, J.Y.

“…•Good cell culture practice is critical in in vitro genotoxicity testing.•This initiative made stocks of mammalian cell lines available worldwide.•Cell lines…”
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Vehicle and positive control values from the in vivo rodent comet assay and biomonitoring studies using human lymphocytes: Historical database and influence of technical aspects by Pant, Kamala, Springer, S., Bruce, S., Lawlor, T., Hewitt, N., Aardema, M.J.

“…There is increased interest in the in vivo comet assay in rodents as a follow‐up approach for determining the biological relevance of chemicals that are…”
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Xenobiotic metabolism gene expression in the EpiDerm™ in vitro 3D human epidermis model compared to human skin by Hu, T., Khambatta, Z.S., Hayden, P.J., Bolmarcich, J., Binder, R.L., Robinson, M.K., Carr, G.J., Tiesman, J.P., Jarrold, B.B., Osborne, R., Reichling, T.D., Nemeth, S.T., Aardema, M.J.

“…There is an urgent need to validate in vitro human skin models for use in safety testing. An important component of validation is characterizing the…”
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Genetic toxicology of acrylic acid by McCarthy, K L, Thomas, W C, Aardema, M J, Seymour, J L, Putman, D L, Yang, L L, Curren, R D, Valencia, R

“…Acrylic acid was tested for gene mutations in the in vitro CHO/HGPRT assay, for chromosome aberrations in CHO cells in culture, and for potential to induce…”
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The pH 6.7 Syrian hamster embryo cell transformation assay for assessing the carcinogenic potential of chemicals by LeBoeuf, R A, Kerckaert, G A, Aardema, M J, Gibson, D P, Brauninger, R, Isfort, R J

“…Cell transformation models have been established for studying the cellular and molecular basis of the neoplastic process. Transformation models have also been…”
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A comprehensive protocol for conducting the Syrian hamster embryo cell transformation assay at pH 6.70 by Kerckaert, G A, Isfort, R J, Carr, G J, Aardema, M J, LeBoeuf, R A

“…Studies from our laboratory have demonstrated several advantages of conducting the Syrian hamster embryo (SHE) cell transformation assay at pH 6.70 compared to…”
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Aneuploidy: a report of an ECETOC task force by Aardema, M.J, Albertini, S, Arni, P, Henderson, L.M, Kirsch-Volders, M, Mackay, J.M, Sarrif, A.M, Stringer, D.A, Taalman, R.D.F

“…Aneuploidy plays a significant role in adverse human health conditions including birth defects, pregnancy wastage and cancer. Although there is clear evidence…”
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A refined protocol for conducting the low pH 6.7 Syrian hamster embryo (SHE) cell transformation assay by Custer, L, Gibson, D P, Aardema, M J, LeBoeuf, R A

“…The Syrian hamster embryo (SHE) cell transformation assay evaluates the potential of chemicals to induce morphological transformation in karyotypically normal…”
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Genotoxicity and subchronic toxicity studies with heated olestra by Williams, G.M., Aardema, M.J., Long, P.H., Thompson, E.D., Allgood, G.S.

“…Olestra is a class of sucrose-fatty acid polyesters intended for use as a non-caloric replacement of edible oil. Genotoxicity and subchronic toxicity studies…”
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Cytogenetic analysis of mouse oocytes and one-cell zygotes as a potential assay for heritable germ cell aneuploidy by Mailhes, J B, Yuan, Z P, Aardema, M J

“…Assays are needed for detecting chemically-induced aneuploidy, for investigating the mechanisms of aneuploidy production, and for obtaining heritable germ cell…”
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