Search Results - "Aaraj, Yassmin Al"

Distinct plasma gradients of microRNA-204 in the pulmonary circulation of patients suffering from WHO Groups I and II pulmonary hypertension by Estephan, Leonard E., Genuardi, Michael V., Kosanovich, Chad M., Risbano, Michael G., Zhang, Yingze, Petro, Nancy, Watson, Annie, Al Aaraj, Yassmin, Sembrat, John C., Rojas, Mauricio, Goncharov, Dmitry A., Simon, Marc A., Goncharova, Elena A., Vaidya, Anjali, Smith, Akaya, Mazurek, Jeremy, Han, Yuchi, Chan, Stephen Y.

“…Pulmonary hypertension (PH), a heterogeneous vascular disease, consists of subtypes with overlapping clinical phenotypes. MicroRNAs, small non-coding RNAs that…”
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Frataxin deficiency promotes endothelial senescence in pulmonary hypertension by Culley, Miranda K, Zhao, Jingsi, Tai, Yi Yin, Tang, Ying, Perk, Dror, Negi, Vinny, Yu, Qiujun, Woodcock, Chen-Shan C, Handen, Adam, Speyer, Gil, Kim, Seungchan, Lai, Yen-Chun, Satoh, Taijyu, Watson, Annie Mm, Aaraj, Yassmin Al, Sembrat, John, Rojas, Mauricio, Goncharov, Dmitry, Goncharova, Elena A, Khan, Omar F, Anderson, Daniel G, Dahlman, James E, Gurkar, Aditi U, Lafyatis, Robert, Fayyaz, Ahmed U, Redfield, Margaret M, Gladwin, Mark T, Rabinovitch, Marlene, Gu, Mingxia, Bertero, Thomas, Chan, Stephen Y

“…The dynamic regulation of endothelial pathophenotypes in pulmonary hypertension (PH) remains undefined. Cellular senescence is linked to PH with intracardiac…”
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Profiling of repetitive RNA sequences in the blood plasma of patients with cancer by Reggiardo, Roman E., Maroli, Sreelakshmi Velandi, Peddu, Vikas, Davidson, Andrew E., Hill, Alexander, LaMontagne, Erin, Aaraj, Yassmin Al, Jain, Miten, Chan, Stephen Y., Kim, Daniel H.

“…Liquid biopsies provide a means for the profiling of cell-free RNAs secreted by cells throughout the body. Although well-annotated coding and non-coding…”
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Single Nucleotide Polymorphism rs9277336 Controls the Nuclear Alpha Actinin 4-Human Leukocyte Antigen-DPA1 Axis and Pulmonary Endothelial Pathophenotypes in Pulmonary Arterial Hypertension by Hafeez, Neha, Kirillova, Anna, Yue, Yunshan, Rao, Rashmi J, Kelly, Neil J, El Khoury, Wadih, Al Aaraj, Yassmin, Tai, Yi-Yin, Handen, Adam, Tang, Ying, Jiang, Danli, Wu, Ting, Zhang, Yingze, McNamara, Dennis, Kudryashova, Tatiana V, Goncharova, Elena A, Goncharov, Dmitry, Bertero, Thomas, Nouraie, Mehdi, Li, Gang, Sun, Wei, Chan, Stephen Y

“…Background Pulmonary arterial hypertension (PAH) is a complex, fatal disease where disease severity has been associated with the single nucleotide polymorphism…”
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Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension by Negi, Vinny, Yang, Jimin, Speyer, Gil, Pulgarin, Andres, Handen, Adam, Zhao, Jingsi, Tai, Yi Yin, Tang, Ying, Culley, Miranda K, Yu, Qiujun, Forsythe, Patricia, Gorelova, Anastasia, Watson, Annie M, Al Aaraj, Yassmin, Satoh, Taijyu, Sharifi-Sanjani, Maryam, Rajaratnam, Arun, Sembrat, John, Provencher, Steeve, Yin, Xianglin, Vargas, Sara O, Rojas, Mauricio, Bonnet, Sébastien, Torrino, Stephanie, Wagner, Bridget K, Schreiber, Stuart L, Dai, Mingji, Bertero, Thomas, Al Ghouleh, Imad, Kim, Seungchan, Chan, Stephen Y

“…Cancer therapies are being considered for treating rare noncancerous diseases like pulmonary hypertension (PH), but effective computational screening is…”
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Long-term Outcomes for Teen Mothers Who Participated in a Mentoring Program to Prevent Repeat Teen Pregnancy by Lin, Chyongchiou Jeng, Nowalk, Mary Patricia, Ncube, Collette N., Aaraj, Yassmin AL, Warshel, McKenzie, South-Paul, Jeannette E.

“…Each year in the United States (US), one million adolescents are pregnant, of which approximately 20% are repeat pregnancies. Adolescent motherhood is…”
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Abstract 15579: Stem Cell Modeling of a Candidate Genetic Variant in a Family With Complex Inherited Cardiomyopathy by Kirillova, Anna, Jiang, Siyi, Al Aaraj, Yassmin, Reuter, Chloe, Yue, Yunshan, Rao, Rashmi, Creager, Michael, Barndt, Robert, Wu, Haodi, Scott, Stuart, Okawa, Satoshi, Parikh, Victoria N, Chan, Stephen Y

“…Abstract only Introduction: Inherited cardiomyopathies, such as arrhythmogenic right (or left) ventricular cardiomyopathy (ARVC; ALVC) and dilated…”
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Abstract 10137: Functional Brain Imaging Reveals Decreased Cerebellar Volume and Altered Brain Connectivity in Pulmonary Arterial Hypertension by Kim, Timothy S, Huppert, Theodore, Fatukasi, Omolara, Al Aaraj, Yassmin, Girard, Timothy, Mettenburg, Joseph, Becker, James, Nouraie, Seyed, Chan, Stephen Y

“…IntroductionPsychiatric and cognitive deficiencies are increasingly appreciated in pulmonary arterial hypertension (PAH). Brain abnormalities potentially…”
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Abstract 17196: Genetic and Acquired DHCR7 Deficiency Upregulates 7β-hydroxycholesterol to Drive Endothelial Apoptosis and Pulmonary Hypertension by Rao, Rashmi J, Kim, Hee-Jung, Jiang, Siyi, Tai, Yi-Yin, Wang, Bing, Tang, Ying, El Khoury, Wadih, Kirillova, Anna, Al Aaraj, Yassmin, Watson, Annie, Sharma, Ankit X, McDonald, Jeffrey, Francis, Kevin, Ramachandra Rao, Sriganesh, Fliesler, Steven J, Bertero, Thomas, Sun, Wei, Harvey, Lloyd D, Chan, Stephen Y

“…Abstract only Introduction: Pulmonary hypertension (PH) is a fatal disease without a cure, in which endothelial dysfunction drives pathologic remodeling of the…”
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Abstract 9770: Endothelial Loss of Amphiregulin Drives Inflammation and Endothelial Apoptosis in Pulmonary Hypertension by Florentin, Jonathan, Zhao, Jingsi, Tai, Yi-Yin, Sun, Wei, Ohayon, Lee, O'Neil, Scott, arunkumar, anagha, zhang, xinyi, Al Aaraj, Yassmin, Watson, Annie, Sembrat, John C, rojas, mauricio, Chan, Stephen Y, Dutta, Partha

“…Pulmonary hypertension (PH) is a vascular disease characterized by elevated pulmonary arterial pressure (PAP), leading to right ventricular failure and death…”
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Abstract 10096: Genetic Control of Lysosomal Dysfunction Reprograms Sterol Metabolism in Pulmonary Arterial Hypertension by Harvey, Lloyd D, Kim, Hee-Jung J, Alotaibi, Mona, Tai, Yi-Yin, Tang, Ying, Arshad, Sanya, Sun, Wei, Wu, Haodi, Zhao, Jingsi, Kirillova, Anna, Woodcock, Chen-shan J, Handen, Adam, Al Aaraj, Yassmin, Culley, Miranda K, Hafeez, Neha, Watson, Annie, Wallace, Callen, Sullivan, Mara G, St. Croix, Claudette M, Stolz, Donna, Li, Gang, Corley, Chase, McDonald, Jeffrey G, Nouraie, Mehdi, Schwantes-An, Tae-Hwi, Desai, Ankit A, Pauciulo, Michael, Nichols, Bill, Lafyatis, Robert, Benza, Raymond L, Bertero, Thomas, Jain, Mohit, Chan, Stephen Y

“…Background Vascular inflammation critically regulates endothelial pathophenotypes, yet causative mechanisms remain incompletely defined, particularly in…”
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Dietary intake and glutamine-serine metabolism control pathologic vascular stiffness by Rachedi, Nesrine S, Tang, Ying, Tai, Yi-Yin, Zhao, Jingsi, Chauvet, Caroline, Grynblat, Julien, Akoumia, Kouamé Kan Firmin, Estephan, Leonard, Torrino, Stéphanie, Sbai, Chaima, Ait-Mouffok, Amel, Latoche, Joseph D, Al Aaraj, Yassmin, Brau, Frederic, Abélanet, Sophie, Clavel, Stephan, Zhang, Yingze, Guillermier, Christelle, Kumar, Naveen V G, Tavakoli, Sina, Mercier, Olaf, Risbano, Michael G, Yao, Zhong-Ke, Yang, Guangli, Ouerfelli, Ouathek, Lewis, Jason S, Montani, David, Humbert, Marc, Steinhauser, Matthew L, Anderson, Carolyn J, Oldham, William M, Perros, Frédéric, Bertero, Thomas, Chan, Stephen Y

“…Perivascular collagen deposition by activated fibroblasts promotes vascular stiffening and drives cardiovascular diseases such as pulmonary hypertension (PH)…”
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Abstract 15826: SCUBE1 Controls BMPR2-relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension by Sun, Wei, Tang, Ying, Tai, Yi-Yin, Handen, Adam, Zhao, Jingsi, Speyer, Gil, Al Aaraj, Yassmin, Watson, Annie, Romanelli, Makenna, Sembrat, John C, Rojas, Mauricio, Simon, Marc A, Zhang, Yingze, Lee, Janet S, Xiong, Zeyu, Dutta, Partha, Vasamsetti, Sathish, McNamara, Dennis M, McVerry, Bryan, MCTIERNAN, Charles F, Sciurba, Frank, Kim, Seungchan, Smith, Akaya, Mazurek, Jeremy A, Han, Yuchi, Vaidya, Anjali, Nouraie, Mehdi, Kelly, Neil, Chan, Stephen Y

“…IntroductionPulmonary arterial hypertension (PAH) is a morbid vascular disease where mutations of bone morphogenetic protein receptor 2 (BMPR2) control…”
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Allele-specific control of rodent and human lncRNA KMT2E-AS1 promotes hypoxic endothelial pathology in pulmonary hypertension by Tai, Yi-Yin, Yu, Qiujun, Tang, Ying, Sun, Wei, Kelly, Neil J, Okawa, Satoshi, Zhao, Jingsi, Schwantes-An, Tae-Hwi, Lacoux, Caroline, Torrino, Stephanie, Al Aaraj, Yassmin, El Khoury, Wadih, Negi, Vinny, Liu, Mingjun, Corey, Catherine G, Belmonte, Frances, Vargas, Sara O, Schwartz, Brian, Bhat, Bal, Chau, B Nelson, Karnes, Jason H, Satoh, Taijyu, Barndt, Robert J, Wu, Haodi, Parikh, Victoria N, Wang, Jianrong, Zhang, Yingze, McNamara, Dennis, Li, Gang, Speyer, Gil, Wang, Bing, Shiva, Sruti, Kaufman, Brett, Kim, Seungchan, Gomez, Delphine, Mari, Bernard, Cho, Michael H, Boueiz, Adel, Pauciulo, Michael W, Southgate, Laura, Trembath, Richard C, Sitbon, Olivier, Humbert, Marc, Graf, Stefan, Morrell, Nicholas W, Rhodes, Christopher J, Wilkins, Martin R, Nouraie, Mehdi, Nichols, William C, Desai, Ankit A, Bertero, Thomas, Chan, Stephen Y

“…Hypoxic reprogramming of vasculature relies on genetic, epigenetic, and metabolic circuitry, but the control points are unknown. In pulmonary arterial…”
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Reversal of inflammatory reprogramming by vasodilator agents in pulmonary hypertension by Kirillova, Anna, Sethuraman, Meena, Dong, Xishuang, Kirdar, Almina, Speyer, Gil, Al Aaraj, Yassmin, Watson, Annie, Schneider, Lily K., Creager, Michael D., Lafyatis, Robert, Okawa, Satoshi, Kim, Seungchan, Chan, Stephen Y.

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Loss of Amphiregulin drives inflammation and endothelial apoptosis in pulmonary hypertension by Florentin, Jonathan, Zhao, Jingsi, Tai, Yi-Yin, Sun, Wei, Ohayon, Lee L, O'Neil, Scott P, Arunkumar, Anagha, Zhang, Xinyi, Zhu, Jianhui, Al Aaraj, Yassmin, Watson, Annie, Sembrat, John, Rojas, Mauricio, Chan, Stephen Y, Dutta, Partha

“…Pulmonary hypertension (PH) is a vascular disease characterized by elevated pulmonary arterial pressure, leading to right ventricular failure and death…”
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SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function: Implications for Diagnostic Marker Development in Pulmonary Arterial Hypertension by Sun, Wei, Tang, Ying, Tai, Yi-Yin, Handen, Adam, Zhao, Jingsi, Speyer, Gil, Al Aaraj, Yassmin, Watson, Annie, Romanelli, Makenna E, Sembrat, John, Rojas, Mauricio, Simon, Marc A, Zhang, Yingze, Lee, Janet, Xiong, Zeyu, Dutta, Partha, Vasamsetti, Sathish Badu, McNamara, Dennis, McVerry, Bryan, McTiernan, Charles F, Sciurba, Frank C, Kim, Seungchan, Smith, Kerri Akaya, Mazurek, Jeremy A, Han, Yuchi, Vaidya, Anjali, Nouraie, Seyed Mehdi, Kelly, Neil J, Chan, Stephen Y

“…Utilizing publicly available ribonucleic acid sequencing data, we identified as a BMPR2-related gene differentially expressed between induced pluripotent stem…”
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Computational repurposing of therapeutic small molecules from cancer to pulmonary hypertension by Negi, Vinny, Yang, Jimin, Speyer, Gil, Pulgarin, Andres, Handen, Adam, Zhao, Jingsi, Tai, Yi Yin, Tang, Ying, Culley, Miranda K, Yu, Qiujun, Forsythe, Patricia, Gorelova, Anastasia, Watson, Annie M, Al Aaraj, Yassmin, Satoh, Taijyu, Sharifi-Sanjani, Maryam, Rajaratnam, Arun, Sembrat, John, Provencher, Steeve, Yin, Xianglin, Vargas, Sara O, Rojas, Mauricio, Bonnet, Sébastien, Torrino, Stephanie, Wagner, Bridget K, Schreiber, Stuart L, Dai, Mingji, Bertero, Thomas, Al Ghouleh, Imad, Kim, Seungchan, Chan, Stephen Y

“…Cancer therapies are being considered for treating rare noncancerous diseases like pulmonary hypertension (PH), but effective computational screening is…”
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SCUBE1 Controls BMPR2-Relevant Pulmonary Endothelial Function by Sun, Wei, Tang, Ying, Tai, Yi-Yin, Handen, Adam, Zhao, Jingsi, Speyer, Gil, Al Aaraj, Yassmin, Watson, Annie, Romanelli, Makenna E., Sembrat, John, Rojas, Mauricio, Simon, Marc A., Zhang, Yingze, Lee, Janet, Xiong, Zeyu, Dutta, Partha, Vasamsetti, Sathish Badu, McNamara, Dennis, McVerry, Bryan, McTiernan, Charles F., Sciurba, Frank C., Kim, Seungchan, Smith, Kerri Akaya, Mazurek, Jeremy A., Han, Yuchi, Vaidya, Anjali, Nouraie, Seyed Mehdi, Kelly, Neil J., Chan, Stephen Y.

“…[Display omitted] •Guided by public sequencing data of iPSC-derived BMPR2-mutant ECs derived from patients with PAH and related family members, SCUBE1 was…”
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ENDOTHELIAL FRATAXIN DEFICIENCY DRIVES NUCLEAR REPLICATION STRESS-INDUCED SENESCENCE AND MITOCHONDRIAL DYSFUNCTION ACROSS MULTIPLE SUBTYPES OF PULMONARY HYPERTENSION by Culley, Miranda K., Zhao, Jingsi, Tang, Ying, Tai, Yi Yin, Perk, Dror, Negi, Vinny, Lai, Yen-Chun, Yu, Qiujun, Handen, Adam, Speyer, Gil, Kim, Seungchan, Satoh, Taijyu, Reynolds, Michael, Shiva, Sruti, Watson, Annie, Al Aaraj, Yassmin, Sembrat, John, Rojas, Mauricio, Norris, Karen, Gurkar, Aditi, Gu, Mingxia, Rabinovitch, Marlene, Bertero, Thomas, Chan, Stephen

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