Search Results - "Aapola, Ulla"
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Integrative proteomics in prostate cancer uncovers robustness against genomic and transcriptomic aberrations during disease progression
Published in Nature communications (21-03-2018)“…To understand functional consequences of genetic and transcriptional aberrations in prostate cancer, the proteomic changes during disease formation and…”
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Clinical Tear Fluid Proteomics—A Novel Tool in Glaucoma Research
Published in International journal of molecular sciences (23-07-2022)“…Tear fluid forms the outermost layer of the ocular surface and its characteristics and composition have been connected to various ocular surface diseases. As…”
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Antibacterial and Oxidative Stress-Protective Effects of Five Monoterpenes from Softwood
Published in Molecules (Basel, Switzerland) (17-06-2022)“…Volatile organic compounds (VOC) affect the quality of indoor air. Terpenes and especially monoterpenes are the main molecules emitted from softwood material…”
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Proteomics Analysis of R-Ras Deficiency in Oxygen Induced Retinopathy
Published in International journal of molecular sciences (26-04-2023)“…Small GTPase R-Ras regulates vascular permeability in angiogenesis. In the eye, abnormal angiogenesis and hyperpermeability are the leading causes of vision…”
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Age-associated changes in human tear proteome
Published in Clinical proteomics (30-03-2019)“…Prevalence of many eye and ocular surface diseases increases with age. While the clinical characteristics and pathophysiologic mechanisms of these conditions…”
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Comparison of iTRAQ and SWATH in a clinical study with multiple time points
Published in Clinical proteomics (30-07-2018)“…Advances in mass spectrometry have accelerated biomarker discovery in many areas of medicine. The purpose of this study was to compare two mass spectrometry…”
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Comparative proteomic analysis of human embryonic stem cell-derived and primary human retinal pigment epithelium
Published in Scientific reports (20-07-2017)“…Human embryonic stem cell-derived retinal pigment epithelial cells (hESC-RPE) provide an unlimited cell source for retinal cell replacement therapies. Clinical…”
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Proteomics of Deep Cervical Lymph Nodes After Experimental Traumatic Brain Injury
Published in Neurotrauma reports (01-05-2023)“…Traumatic brain injury (TBI) damages the glymphatic-lymphatic system. We hypothesized that brain injury associated with trauma results in the enrichment of…”
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Meiotic and Epigenetic Defects in Dnmt3L-Knockout Mouse Spermatogenesis
Published in Proceedings of the National Academy of Sciences - PNAS (15-03-2005)“…The production of mature germ cells capable of generating totipotent zygotes is a highly specialized and sexually dimorphic process. The transition from…”
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Isolation and Initial Characterization of a Novel Zinc Finger Gene, DNMT3L, on 21q22.3, Related to the Cytosine-5- Methyltransferase 3 Gene Family
Published in Genomics (San Diego, Calif.) (01-05-2000)“…We have isolated the DNMT3L gene that is related to the cytosine-5-methyltransferase 3 (DNMT3) family. The gene is located on chromosome 21q22.3 between the…”
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Looking deeper into ocular surface health: an introduction to clinical tear proteomics analysis
Published in Acta ophthalmologica (Oxford, England) (01-08-2022)“…Ocular surface diseases are becoming more prevalent worldwide. Reasons for this include the ongoing population ageing and increasing use of digital displays,…”
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Intraluminal deposits: A rare cause of glaucoma drainage implant total obstruction
Published in European journal of ophthalmology (01-01-2023)“…Purpose To report the unforeseen complication of total obstruction of a glaucoma drainage implant (GDI) tube lumen by white deposit material and to present a…”
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Comparison of early changes in tear film protein profiles after small incision lenticule extraction surgery
Published in Clinical proteomics (17-02-2024)“…Background Small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (LASIK) are widely used surgical methods to…”
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ocular surface health affects the quality of life of the elderly
Published in Acta ophthalmologica (Oxford, England) (01-12-2022)“…Purpose: To examine the association of ocular surface health with the quality of life (QoL) in a population‐based cohort of older people. Methods: This…”
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Biological processes and clinical variables affecting trabeculectomy surgery outcome
Published in Acta ophthalmologica (Oxford, England) (01-12-2022)“…Purpose: To establish what preoperative clinical factors and tear protein levels influence the trabeculectomy outcome. Methods: In this prospective study, we…”
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The effect of successful trabeculectomy on the ocular surface and tear proteomics—a prospective cohort study with 1‐year follow‐up
Published in Acta ophthalmologica (Oxford, England) (01-03-2021)“…Purpose To report changes in the ocular surface and tear proteomics after discontinuation of chronic glaucoma medication. Methods Patients requiring…”
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Comparison of Capillary and Schirmer Strip Tear Fluid Sampling Methods Using SWATH-MS Proteomics Approach
Published in Translational vision science & technology (13-02-2020)“…The purpose of this study was to examine the protein profile differences between capillary and Schirmer strip tear fluid samples. Both capillary and Schirmer…”
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Comparison of early changes in tear film protein profiles after small incision lenticule extraction (SMILE) and femtosecond LASIK (FS-LASIK) surgery
Published in Clinical proteomics (17-02-2024)“…Small incision lenticule extraction (SMILE) and femtosecond laser-assisted in situ keratomileusis (LASIK) are widely used surgical methods to correct myopia…”
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Long noncoding RNA EPCART regulates translation through PI3K/AKT/mTOR pathway and PDCD4 in prostate cancer
Published in Cancer gene therapy (01-10-2024)“…While hundreds of cancer-associated long noncoding RNAs (lncRNAs) have been discovered, their functional role in cancer cells is still largely a mystery. An…”
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Ocular surface health of the Finnish elderly population
Published in Acta ophthalmologica (Oxford, England) (01-12-2022)“…Purpose The aim of this study was to describe the clinical ocular surface characteristics in a population‐based sample of Finnish elderly people. Methods This…”
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