Search Results - "Aa, Jiye"

Silybin ameliorates hepatic lipid accumulation and modulates global metabolism in an NAFLD mouse model by Sun, Runbin, Xu, Dan, Wei, Qingli, Zhang, Bangling, Aa, Jiye, Wang, Guangji, Xie, Yuan

“…[Display omitted] Silybin shows good effects against obesity and metabolic syndrome, but the systemic modulation effect of silybin has not been fully revealed…”
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Orally Administered Berberine Modulates Hepatic Lipid Metabolism by Altering Microbial Bile Acid Metabolism and the Intestinal FXR Signaling Pathway by Sun, Runbin, Yang, Na, Kong, Bo, Cao, Bei, Feng, Dong, Yu, Xiaoyi, Ge, Chun, Huang, Jingqiu, Shen, Jianliang, Wang, Pei, Feng, Siqi, Fei, Fei, Guo, Jiahua, He, Jun, Aa, Nan, Chen, Qiang, Pan, Yang, Schumacher, Justin D, Yang, Chung S, Guo, Grace L, Aa, Jiye, Wang, Guangji

“…Previous studies suggest that the lipid-lowering effect of berberine (BBR) involves actions on the low-density lipoprotein receptor and the AMP-activated…”
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Reduced Neuronal cAMP in the Nucleus Accumbens Damages Blood-Brain Barrier Integrity and Promotes Stress Vulnerability by Zhang, Yue, Lu, Wuhuan, Wang, Zibin, Zhang, Ran, Xie, Yuan, Guo, Suhan, Jiao, Li, Hong, Yu, Di, Zizhen, Wang, Guangji, Aa, Jiye

“…Studies have suggested that chronic social stress specifically downregulates endothelial tight junction protein expression in the nucleus accumbens (NAc), thus…”
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Effects of 'Healthy' Fecal Microbiota Transplantation against the Deterioration of Depression in Fawn-Hooded Rats by Hu, Bing, Das, Promi, Lv, Xianglin, Shi, Meng, Aa, Jiye, Wang, Kun, Duan, Liping, Gilbert, Jack A, Nie, Yong, Wu, Xiao-Lei

“…Depression is a recurrent, heterogeneous mood disorder occurring in more than 260 million people worldwide. Gut microbiome dysbiosis is associated with the…”
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Metabolomics analysis identifies lysine and taurine as candidate prognostic biomarkers for AML-M2 patients by Zhou, Xuan, Zheng, Meihong, Wang, Qien, Aa, Jiye, Cao, Bei, Li, Juan

“…There is an ongoing search for potential biomarkers for acute myeloid leukemia (AML) patients using metabolic analysis. However, only few studies to date have…”
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Intestinal Metabolism of Crocin and a Pharmacokinetics and Pharmacodynamics Study in the Chronic Social Defeat Stress Mouse Model by Xiao, Fan, Song, Yulong, Wang, Guangji, Aa, Jiye

“…Orally administered crocin rapidly and efficiently rescues depressive-like behaviors in depression models; however, crocin levels in the circulatory and…”
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The down-regulation of SLC7A11 enhances ROS induced P-gp over-expression and drug resistance in MCF-7 breast cancer cells by Ge, Chun, Cao, Bei, Feng, Dong, Zhou, Fang, Zhang, Jingwei, Yang, Na, Feng, Siqi, Wang, Guangji, Aa, Jiye

“…Adriamycin (ADR) induces the over-expression of P-glycoprotein (P-gp) and multiple drug resistance in breast cancer cells. However, the biochemical process and…”
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Modulation of Perturbed Cardiac Metabolism in Rats Under High-Altitude Hypoxia by Combination Treatment With L-carnitine and Trimetazidine by Xie, Hebing, Xu, Gang, Aa, Jiye, Gu, Shuhua, Gao, Yuqi

“…High-altitude hypoxia has long been recognized as a vital etiology for high-altitude illnesses. High-altitude myocardial injury (HAMI) usually occurs in people…”
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Apatinib induces 3‐hydroxybutyric acid production in the liver of mice by peroxisome proliferator‐activated receptor α activation to aid its antitumor effect by Feng, Siqi, Wang, Huan, Wang, Ying, Sun, Runbin, Xie, Yuan, Zhou, Zhu, Wang, Hong, Aa, Jiye, Zhou, Fang, Wang, Guangji

“…Apatinib, an antiangiogenic agent, shows efficient antitumor activity in a broad range of malignancies. Considering tumor is a type of metabolic disease, we…”
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Desorption Electrospray Ionization Mass Spectrometry Imaging Techniques Depict a Reprogramming of Energy and Purine Metabolism in the Core Brain Regions of Chronic Social Defeat Stress Mice by Song, Yulong, Xiao, Fan, Aa, Jiye, Wang, Guangji

“…Depression is associated with pathological changes and metabolic abnormalities in multiple brain regions. The simultaneous comprehensive and in situ detection…”
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Plasma Metabolomics Reveals Diagnostic Biomarkers and Risk Factors for Esophageal Squamous Cell Carcinoma by Yu, Mengjie, Wen, Wei, Yi, Xin, Zhu, Wei, Aa, Jiye, Wang, Guangji

“…Esophageal squamous carcinoma (ESCC) has a high morbidity and mortality rate. Identifying risk metabolites associated with its progression is essential for the…”
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GC/TOFMS analysis of metabolites in serum and urine reveals metabolic perturbation of TCA cycle in db/db mice involved in diabetic nephropathy by Li, Mengjie, Wang, Xufang, Aa, Jiye, Qin, Weisong, Zha, Weibin, Ge, Yongchun, Liu, Linsheng, Zheng, Tian, Cao, Bei, Shi, Jian, Zhao, Chunyan, Wang, Xinwen, Yu, Xiaoyi, Wang, Guangji, Liu, Zhihong

“…Early diagnosis of diabetic nephropathy (DN) is difficult although it is of crucial importance to prevent its development. To probe potential markers and the…”
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Plasma metabolomics reveals risk factors for lung adenocarcinoma by Yu, Mengjie, Wen, Wei, Wang, Yue, Shan, Xia, Yi, Xin, Zhu, Wei, Aa, Jiye, Wang, Guangji

“…Metabolic reprogramming plays a significant role in the advancement of lung adenocarcinoma (LUAD), yet the precise metabolic changes remain incompletely…”
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Emerging Mechanisms and Disease Implications of Ferroptosis: Potential Applications of Natural Products by Ge, Chun, Zhang, Sujie, Mu, Huiwen, Zheng, Shaojun, Tan, Zhaoyi, Huang, Xintong, Xu, Chen, Zou, Jianjun, Zhu, Yubing, Feng, Dong, Aa, Jiye

“…Ferroptosis, a newly discovered form of regulatory cell death (RCD), has been demonstrated to be distinct from other types of RCD, such as apoptosis,…”
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Orally Administered Crocin Protects Against Cerebral Ischemia/Reperfusion Injury Through the Metabolic Transformation of Crocetin by Gut Microbiota by Zhang, Yue, Geng, Jianliang, Hong, Yu, Jiao, Li, Li, Shuning, Sun, Runbin, Xie, Yuan, Yan, Caixia, Aa, Jiye, Wang, Guangji

“…Our pilot study suggested that orally administered crocin was hardly absorbed into circulatory system, but it was effective against cerebral…”
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Prediction of Liver Weight Recovery by an Integrated Metabolomics and Machine Learning Approach After 2/3 Partial Hepatectomy by Sun, Runbin, Zhao, Haokai, Huang, Shuzhen, Zhang, Ran, Lu, Zhenyao, Li, Sijia, Wang, Guangji, Aa, Jiye, Xie, Yuan

“…Liver has an ability to regenerate itself in mammals, whereas the mechanism has not been fully explained. Here we used a GC/MS-based metabolomic method to…”
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AI Machine Learning Technique Characterizes Potential Markers of Depression in Two Animal Models of Depression by Zhang, Jing, Zhang, Ran, Peng, Ying, Aa, Jiye, Wang, Guangji

“…(1) Background: there is an urgent clinical need for rapid and effective antidepressants. (2) Methods: We employed proteomics to profile proteins in two animal…”
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In vitro co-culture systems of hepatic and intestinal cells for cellular pharmacokinetic and pharmacodynamic studies of capecitabine against colorectal cancer by Ge, Chun, Huang, Xintong, Zhang, Sujie, Yuan, Man, Tan, Zhaoyi, Xu, Chen, Jie, Qiong, Zhang, Jingjing, Zou, Jianjun, Zhu, Yubing, Feng, Dong, Zhang, Yue, Aa, Jiye

“…As a prodrug of 5-fluorouracil (5-FU), orally administrated capecitabine (CAP) undergoes preliminary conversion into active metabolites in the liver and then…”
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Quantitative determination of D4-cystine in mice using LC-MS/MS and its application to the assessment of pharmacokinetics and bioavailability by Li, Shuning, Lu, Zhenyao, Jiao, Li, Zhang, Ran, Hong, Yu, Aa, Jiye, Wang, Guangji

“…Cystine is the primary source material for the synthesis of glutathione. However, the pharmacokinetics and tissue distribution of cystine are largely unknown…”
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Erratum for Hu et al., "Effects of 'Healthy' Fecal Microbiota Transplantation against the Deterioration of Depression in Fawn-Hooded Rats" by Hu, Bing, Das, Promi, Lv, Xianglin, Shi, Meng, Aa, Jiye, Wang, Kun, Duan, Liping, Gilbert, Jack A, Nie, Yong, Wu, Xiao-Lei

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