Search Results - "AZZAM, Edouard I"

Ionizing radiation-induced metabolic oxidative stress and prolonged cell injury by Azzam, Edouard I, Jay-Gerin, Jean-Paul, Pain, Debkumar

“…Abstract Cellular exposure to ionizing radiation leads to oxidizing events that alter atomic structure through direct interactions of radiation with target…”
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The Importance and Clinical Implications of FLASH Ultra-High Dose-Rate Studies for Proton and Heavy Ion Radiotherapy by Colangelo, Nicholas W., Azzam, Edouard I.

“…The goal of radiation therapy is to provide the highest probability of tumor control while minimizing normal tissue toxicity. Recently, it has been discovered…”
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Extracellular vesicles originating from glioblastoma cells increase metalloproteinase release by astrocytes: the role of CD147 (EMMPRIN) and ionizing radiation by Colangelo, Nicholas W, Azzam, Edouard I

“…Glioblastoma multiforme is an aggressive primary brain tumor that is characterized by local invasive growth and resistance to therapy. The role of the…”
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Acquired radioresistance in cancer associated fibroblasts is concomitant with enhanced antioxidant potential and DNA repair capacity by Domogauer, Jason D, de Toledo, Sonia M, Howell, Roger W, Azzam, Edouard I

“…Cancer-associated fibroblasts (CAFs) are a major component of the cancer stroma, and their response to therapeutic treatments likely impacts the outcome. We…”
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Identification of Novel Regulators of Radiosensitivity Using High-Throughput Genetic Screening by Tamaddondoust, Rosette N, Wong, Alicia, Chandrashekhar, Megha, Azzam, Edouard I, Alain, Tommy, Wang, Yi

“…The biological impact of ionizing radiation (IR) on humans depends not only on the physical properties and absorbed dose of radiation but also on the unique…”
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Adverse outcome pathways, key events, and radiation risk assessment by Preston, R. Julian, Rühm, Werner, Azzam, Edouard I., Boice, John D., Bouffler, Simon, Held, Kathryn D., Little, Mark P., Shore, Roy E., Shuryak, Igor, Weil, Michael M.

“…The overall aim of this contribution to the 'Second Bill Morgan Memorial Special Issue' is to provide a high-level review of a recent report developed by a…”
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Gap Junction Communication and the Propagation of Bystander Effects Induced by Microbeam Irradiation in Human Fibroblast Cultures: The Impact of Radiation Quality by Autsavapromporn, Narongchai, Suzuki, Masao, Funayama, Tomoo, Usami, Noriko, Plante, Ianik, Yokota, Yuichiro, Mutou, Yasuko, Ikeda, Hiroko, Kobayashi, Katsumi, Kobayashi, Yasuhiko, Uchihori, Yukio, Hei, Tom K., Azzam, Edouard I., Murakami, Takeshi

“…Understanding the mechanisms underlying the bystander effects of low doses/low fluences of low- or high-linear energy transfer (LET) radiation is relevant to…”
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Metabolic oxidation/reduction reactions and cellular responses to ionizing radiation: a unifying concept in stress response biology by Spitz, Douglas R, Azzam, Edouard I, Li, Jian Jian, Gius, David

“…Exposure of eukaryotic cells to ionizing radiation (IR) results in the immediate formation of free radicals that last a matter of milliseconds. It has been…”
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Role of the translationally controlled tumor protein in DNA damage sensing and repair by Zhang, Jie, de Toledo, Sonia M, Pandey, Badri N, Guo, Guozheng, Pain, Debkumar, Li, Hong, Azzam, Edouard I

“…The translationally controlled tumor protein (TCTP) is essential for survival by mechanisms that as yet are incompletely defined. Here we describe an important…”
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Considerations for application of benchmark dose modeling in radiation research: workshop highlights by Chauhan, Vinita, Yu, Jihang, Vuong, Ngoc, Haber, Lynne T., Williams, Andrew, Auerbach, Scott S., Beaton, Danielle, Wang, Yi, Stainforth, Robert, Wilkins, Ruth C., Azzam, Edouard I., Richardson, Richard B., Khan, Md Gulam Musawwir, Jadhav, Ashok, Burtt, Julie J., Leblanc, Julie, Randhawa, Kristi, Tollefsen, Knut Erik, Yauk, Carole L.

“…Exposure to different forms of ionizing radiation occurs in diverse occupational, medical, and environmental settings. Improving the accuracy of the estimated…”
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Increased frequency of spontaneous neoplastic transformation in progeny of bystander cells from cultures exposed to densely ionizing radiation by Buonanno, Manuela, de Toledo, Sonia M, Azzam, Edouard I

“…An increased risk of carcinogenesis caused by exposure to space radiation during prolonged space travel is a limiting factor for human space exploration…”
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Crosstalk between telomere maintenance and radiation effects: A key player in the process of radiation-induced carcinogenesis by Shim, Grace, Ricoul, Michelle, Hempel, William M., Azzam, Edouard I., Sabatier, Laure

“…•Telomere dysfunction can cause genomic instability, leading to carcinogenesis.•Inherent telomere length heterogeneity may be an important factor in cancer…”
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Genetic changes in progeny of bystander human fibroblasts after microbeam irradiation with X-rays, protons or carbon ions: The relevance to cancer risk by Autsavapromporn, Narongchai, Plante, Ianik, Liu, Cuihua, Konishi, Teruaki, Usami, Noriko, Funayama, Tomoo, Azzam, Edouard I., Murakami, Takeshi, Suzuki, Masao

“…Abstract Purpose: Radiation-induced bystander effects have important implications in radiotherapy. Their persistence in normal cells may contribute to risk of…”
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Health risks of space exploration: targeted and nontargeted oxidative injury by high-charge and high-energy particles by Li, Min, Gonon, Géraldine, Buonanno, Manuela, Autsavapromporn, Narongchai, de Toledo, Sonia M, Pain, Debkumar, Azzam, Edouard I

“…During deep space travel, astronauts are often exposed to high atomic number (Z) and high-energy (E) (high charge and high energy [HZE]) particles. On…”
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Low-dose energetic protons induce adaptive and bystander effects that protect human cells against DNA damage caused by a subsequent exposure to energetic iron ions by Buonanno, Manuela, De Toledo, Sonia M., Howell, Roger W., Azzam, Edouard I.

“…During interplanetary missions, astronauts are exposed to mixed types of ionizing radiation. The low ‘flux’ of the high atomic number and high energy (HZE)…”
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The NF90/NF45 Complex Participates in DNA Break Repair via Nonhomologous End Joining by Shamanna, Raghavendra A., Hoque, Mainul, Lewis-Antes, Anita, Azzam, Edouard I., Lagunoff, David, Pe'ery, Tsafi, Mathews, Michael B.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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COVID-19: The Disease, the Immunological Challenges, the Treatment with Pharmaceuticals and Low-Dose Ionizing Radiation by Yu, Jihang, Azzam, Edouard I., Jadhav, Ashok B., Wang, Yi

“…The year 2020 will be carved in the history books—with the proliferation of COVID-19 over the globe and with frontline health workers and basic scientists…”
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Oxidative metabolism, gap junctions and the ionizing radiation-induced bystander effect by Azzam, Edouard I, de Toledo, Sonia M, Little, John B

“…Evidence accumulated over the past two decades has indicated that exposure of cell populations to ionizing radiation results in significant biological effects…”
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Radiation Type- and Dose-Specific Transcriptional Responses across Healthy and Diseased Mammalian Tissues by Sagkrioti, Eftychia, Biz, Gökay Mehmet, Takan, Işıl, Asfa, Seyedehsadaf, Nikitaki, Zacharenia, Zanni, Vassiliki, Kars, Rumeysa Hanife, Hellweg, Christine E, Azzam, Edouard I, Logotheti, Stella, Pavlopoulou, Athanasia, Georgakilas, Alexandros G

“…Ionizing radiation (IR) is a genuine genotoxic agent and a major modality in cancer treatment. IR disrupts DNA sequences and exerts mutagenic and/or cytotoxic…”
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Micro RNA responses to chronic or acute exposures to low dose ionizing radiation by Chaudhry, M. Ahmad, Omaruddin, Romaica A., Kreger, Bridget, de Toledo, Sonia M., Azzam, Edouard I.

“…Human health risks of exposure to low dose ionizing radiation remain ambiguous and are the subject of intense debate. A wide variety of biological effects are…”
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