Search Results - "AYLOR, KEVIN W."

Long-term high-fat diet induces hippocampal microvascular insulin resistance and cognitive dysfunction by Fu, Zhuo, Wu, Jing, Nesil, Tanseli, Li, Ming D, Aylor, Kevin W, Liu, Zhenqi

“…Insulin action on hippocampus improves cognitive function, and obesity and type 2 diabetes are associated with decreased cognitive function. Cerebral…”
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Inflammation-induced microvascular insulin resistance is an early event in diet-induced obesity by Zhao, Lina, Fu, Zhuo, Wu, Jing, Aylor, Kevin W, Barrett, Eugene J, Cao, Wenhong, Liu, Zhenqi

“…Endothelial dysfunction and vascular insulin resistance usually coexist and chronic inflammation engenders both. In the present study, we investigate the…”
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Pathways for insulin access to the brain: the role of the microvascular endothelial cell by Meijer, Rick I, Gray, Sarah M, Aylor, Kevin W, Barrett, Eugene J

“…Insulin affects multiple important central nervous system (CNS) functions including memory and appetite, yet the pathway(s) by which insulin reaches brain…”
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GLP-1 at physiological concentrations recruits skeletal and cardiac muscle microvasculature in healthy humans by Subaran, Sharmila C, Sauder, Matthew A, Chai, Weidong, Jahn, Linda A, Fowler, Dale E, Aylor, Kevin W, Basu, Ananda, Liu, Zhenqi

“…Muscle microvascular surface area determines substrate and hormonal exchanges between plasma and muscle interstitium. GLP-1 (glucagon-like peptide-1) regulates…”
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Brain Endothelial Cells Regulate Glucagon-Like Peptide 1 Entry Into the Brain via a Receptor-Mediated Process by Fu, Zhuo, Gong, Liying, Liu, Jia, Wu, Jing, Barrett, Eugene J, Aylor, Kevin W, Liu, Zhenqi

“…Glucagon-like peptide 1 (GLP-1) in addition to regulating glucose-dependent insulin and glucagon secretion exerts anorexic and neuroprotective effects. While…”
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Adaptive thermogenesis in brown adipose tissue involves activation of pannexin-1 channels by Senthivinayagam, Subramanian, Serbulea, Vlad, Upchurch, Clint M., Polanowska-Grabowska, Renata, Mendu, Suresh K., Sahu, Srabani, Jayaguru, Prathiba, Aylor, Kevin W., Chordia, Mahendra D., Steinberg, Limor, Oberholtzer, Nathaniel, Uchiyama, Seichii, Inada, Noriko, Lorenz, Ulrike M., Harris, Thurl E., Keller, Susanna R., Meher, Akshaya K., Kadl, Alexandra, Desai, Bimal N., Kundu, Bijoy K., Leitinger, Norbert

“…Brown adipose tissue (BAT) is specialized in thermogenesis. The conversion of energy into heat in brown adipocytes proceeds via stimulation of β-adrenergic…”
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Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-Induced Obesity by Liu, Jia, Aylor, Kevin W, Liu, Zhenqi

“…Inflammation-induced vascular insulin resistance is an early event in diet-induced obesity and contributes to metabolic insulin resistance. To examine whether…”
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Erratum. Liraglutide and Exercise Synergistically Attenuate Vascular Inflammation and Enhance Metabolic Insulin Action in Early Diet-Induced Obesity. Diabetes 2023;72:918-931 by Liu, Jia, Aylor, Kevin W, Liu, Zhenqi

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Regulation of Intracellular Signaling Cascades by GNRH Pulse Frequency in the Rat Pituitary: Roles for CaMK II, ERK, and JNK Activation by Burger, Laura L, Haisenleder, Daniel J, Aylor, Kevin W, Marshall, John C

“…Pulsatile GnRH (GNRH) differentially regulates LH and FSH subunit genes, with faster frequencies favoring Lhb transcription and slower favoring FSHB: Various…”
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Regulation of Lhb and Egr1 Gene Expression by GNRH Pulses in Rat Pituitaries Is Both c-Jun N-Terminal Kinase (JNK)- and Extracellular Signal-Regulated Kinase (ERK)-Dependent by Burger, Laura L, Haisenleder, Daniel J, Aylor, Kevin W, Marshall, John C

“…Pulsatile GNRH regulates the gonadotropin subunit genes in a differential manner, with faster frequencies favoring Lhb gene expression and slower frequencies…”
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Unravelling the regulation of insulin transport across the brain endothelial cell by Gray, Sarah M., Aylor, Kevin W., Barrett, Eugene J.

“…Aims/hypothesis For circulating insulin to act on the brain it must cross the blood–brain barrier (BBB). Remarkably little is known about how circulating…”
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1784-PUB: Empagliflozin (EMPA) Enhances Vascular Insulin Sensitivity and Lowers Plasma ICAM in Subjects with Type 2 Diabetes (T2D) by NGUYEN, THI, JAHN, LINDA, HARTLINE, LEE, AYLOR, KEVIN W., BARRETT, EUGENE

“…Background: The mechanism(s) by which sodium-glucose cotransporter 2 inhibitor (SGLT2i) use improves cardiovascular and renal outcomes in T2D are not…”
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1889-P: Light Exercise and Liraglutide Synergistically Improve Muscle Insulin Action in Diet-Induced Obesity by LIU, JIA, AYLOR, KEVIN W., LIU, ZHENQI

“…Insulin recruits muscle microvasculature which contributes to insulin’s metabolic action but is blunted in humans with obesity. Both exercise and glucagon-like…”
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Metformin prevents endothelial oxidative stress and microvascular insulin resistance during obesity development in male rats by Liu, Jia, Aylor, Kevin W, Chai, Weidong, Barrett, Eugene J, Liu, Zhenqi

“…Insulin increases muscle microvascular perfusion, which contributes to its metabolic action in muscle, but this action is impaired in obesity. Metformin…”
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868-P: Empagliflozin (EMPA) Improves Vascular Insulin Sensitivity and Enhances Skeletal and Cardiac Muscle Microvascular Perfusion in Persons with Type 2 Diabetes by JAHN, LINDA, HARTLINE, LEE, AYLOR, KEVIN W., HORTON, WILLIAM B., BARRETT, EUGENE

“…Sodium-glucose cotransporter 2 inhibitors (SGLT2i) decreased cardiac events in large clinical trials; however, an understanding of the physiology driving this…”
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Impact of Free Fatty Acids on Vascular Insulin Responses Across the Arterial Tree: A Randomized Crossover Study by Love, Kaitlin M, Jahn, Linda A, Hartline, Lee M, Aylor, Kevin W, Liu, Zhenqi

“…Abstract Context Vascular insulin resistance is commonly observed in obesity and diabetes; yet, insulin action across the vascular tree and the relationship…”
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Liraglutide prevents microvascular insulin resistance and preserves muscle capillary density in high-fat diet-fed rats by Chai, Weidong, Fu, Zhuo, Aylor, Kevin W, Barrett, Eugene J, Liu, Zhenqi

“…Muscle microvasculature critically regulates endothelial exchange surface area to facilitate transendothelial delivery of insulin, nutrients, and oxygen to…”
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GnRH Pulse Frequency Modulation of Gonadotropin Subunit Gene Transcription in Normal Gonadotropes—Assessment by Primary Transcript Assay Provides Evidence for Roles of GnRH and Follistatin by Burger, Laura L, Dalkin, Alan C, Aylor, Kevin W, Haisenleder, Daniel J, Marshall, John C

“…We examined the time course of action of GnRH pulse frequency on gonadotropin subunit gene transcription and assessed the roles of GnRH, follistatin (FS), and…”
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Acute hyperglycaemia enhances both vascular endothelial function and cardiac and skeletal muscle microvascular function in healthy humans by Horton, William B., Jahn, Linda A., Hartline, Lee M., Aylor, Kevin W., Patrie, James T., Barrett, Eugene J.

“…Key points Multiple clinical studies report that acute hyperglycaemia (induced by mixed meal or oral glucose) decreases arterial vascular function in healthy…”
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Vasodilatory Actions of Glucagon-Like Peptide 1 Are Preserved in Skeletal and Cardiac Muscle Microvasculature but Not in Conduit Artery in Obese Humans With Vascular Insulin Resistance by Wang, Nasui, Tan, Alvin W K, Jahn, Linda A, Hartline, Lee, Patrie, James T, Lin, Shaoda, Barrett, Eugene J, Aylor, Kevin W, Liu, Zhenqi

“…Obesity is associated with microvascular insulin resistance, which is characterized by impaired insulin-mediated microvascular recruitment. Glucagon-like…”
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