Search Results - "AWASTHI, Shanjana"

Toll-like receptor-4 modulation for cancer immunotherapy by Awasthi, Shanjana

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TLR4-interacting SPA4 peptide improves host defense and alleviates tissue injury in a mouse model of Pseudomonas aeruginosa lung infection by Awasthi, Shanjana, Singh, Bhupinder, Ramani, Vijay, Xie, Jun, Kosanke, Stanley

“…Interaction between surfactant protein-A (SP-A) and toll-like receptor (TLR)4 plays a critical role in host defense. In this work, we studied the host defense…”
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Lung and general health effects of Toll-like receptor-4 (TLR4)-interacting SPA4 peptide by Awasthi, Shanjana, Rahman, Negar, Rui, Bin, Kumar, Gaurav, Awasthi, Vibhudutta, Breshears, Melanie, Kosanke, Stanley

“…A surfactant protein-A-derived peptide, which we call SPA4 peptide (amino acids: GDFRYSDGTPVNYTNWYRGE), alleviates lung infection and inflammation. This study…”
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EF24 suppresses maturation and inflammatory response in dendritic cells by Vilekar, Prachi, Awasthi, Shanjana, Natarajan, Aravindan, Anant, Shrikant, Awasthi, Vibhudutta

“…Synthetic curcuminoid EF24 was studied for its effect on the maturation and inflammatory response in murine bone marrow derived immortalized JAWS II dendritic…”
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A TLR4-interacting SPA4 peptide inhibits LPS-induced lung inflammation by Ramani, Vijay, Madhusoodhanan, Rakhesh, Kosanke, Stanley, Awasthi, Shanjana

“…The interaction between surfactant protein-A (SP-A) and TLR4 is important for host defense. We have recently identified an SPA4 peptide region from the…”
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A TLR4-interacting peptide inhibits lipopolysaccharide-stimulated inflammatory responses, migration and invasion of colon cancer SW480 cells by Rakhesh, Madhusoodhanan, Cate, Moriasi, Vijay, Ramani, Shrikant, Anant, Shanjana, Awasthi

“…Inflammation is a major risk factor for carcinogenesis in patients affected by chronic colitis, yet the molecular mechanisms underlying the progression from…”
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Prevention of colitis-associated cancer: natural compounds that target the IL-6 soluble receptor by Moriasi, Cate, Subramaniam, Dharmalingam, Awasthi, Shanjana, Ramalingam, Satish, Anant, Shrikant

“…The risk of developing colorectal cancer increases in patients with inflammatory bowel disease (IBD) and a growing body of evidence shows the critical role of…”
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Diphenyldifluoroketone EF24 Suppresses Pro-inflammatory Interleukin-1 receptor 1 and Toll-like Receptor 4 in lipopolysaccharide-stimulated dendritic cells by Vilekar, Prachi, Rao, Geeta, Awasthi, Shanjana, Awasthi, Vibhudutta

“…Unresolved and prolonged inflammation is a pathological basis of many disorders such as cancer and multiple organ failure in shock. Interleukin-1 receptor…”
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Distinct Compartmentalization of NF-κB Activity in Crypt and Crypt-Denuded Lamina Propria Precedes and Accompanies Hyperplasia and/or Colitis following Bacterial Infection by CHANDRAKESAN, Parthasarathy, AHMED, Ishfaq, CHINTHALAPALLY, Anisha, SINGH, Pomila, AWASTHI, Shanjana, ANANT, Shrikant, UMAR, Shahid

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Effects of SPA4 peptide on lipopolysaccharide‐disrupted lung epithelial barrier, injury, and function in a human cell system and mouse model of lung injury by Chowdhury, Asif Alam, Godbole, Nachiket M., Chataut, Neha, Kosanke, Stanley, Rodgers, Karla, Awasthi, Shanjana

“…Disrupted epithelial barrier, fluid accumulation, inflammation, and compromised physiology are hallmarks of lung injury. Here we investigated the structural…”
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Effect of liposome-encapsulated hemoglobin resuscitation on proteostasis in small intestinal epithelium after hemorrhagic shock by Rao, Geeta, Yadav, Vivek R, Awasthi, Shanjana, Roberts, Pamela R, Awasthi, Vibhudutta

“…Gut barrier dysfunction is the major trigger for multiorgan failure associated with hemorrhagic shock (HS). Although the molecular mediators responsible for…”
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Surfactant protein-A and toll-like receptor-4 modulate immune functions of preterm baboon lung dendritic cell precursor cells by Awasthi, Shanjana, Madhusoodhanan, Rakhesh, Wolf, Roman

“…Lung infections are important risk factors for an increased morbidity and mortality in prematurely-delivered babies. Immaturity of the innate immune components…”
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Hemorrhage-Induced Interleukin-1 Receptor Pathway in Lung Is Suppressed by 3,5-Bis(2-Fluorobenzylidene)-4-Piperidone in a Rat Model of Hypovolemic Shock by Yadav, Vivek R., Vilekar, Prachi, Awasthi, Shanjana, Awasthi, Vibhudutta

“…Severe blood loss in victims of trauma creates an exaggerated inflammatory background that contributes to the development of intravascular coagulopathy and…”
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Bacillus anthracis Lethal Toxin Reduces Human Alveolar Epithelial Barrier Function by LANGER, Marybeth, DUGGAN, Elizabeth Stewart, WILLIAMS, Daniel M, COGGESHALL, Kenneth Mark, AWASTHI, Shanjana, LUPU, Florea, BURIAN, Dennis, DALE BALLARD, Jimmy, BRAUN, Armin, METCALF, Jordan Patrick, BOOTH, John Leland, INDRAJIT PATEL, Vineet, ZANDER, Ryan A, SILASI-MANSAT, Robert, RAMANI, Vijay, ZOLTAN VERES, Tibor, PRENZLER, Frauke, SEWALD, Katherina

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In vivo trafficking and immunostimulatory potential of an intranasally-administered primary dendritic cell-based vaccine by Vilekar, Prachi, Awasthi, Vibhudutta, Lagisetty, Pallavi, King, Catherine, Shankar, Nathan, Awasthi, Shanjana

“…Coccidioidomycosis or Valley fever is caused by a highly virulent fungal pathogen: Coccidioides posadasii or immitis. Vaccine development against Coccidioides…”
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SPA4 peptide suppresses the lipopolysaccharide (LPS)-stimulated lactate secretion in lung epithelial cells through modulation of Toll-like receptor-4 (TLR4) by Godbole, Nachiket Madan, Awasthi, Shanjana

“…Lung infection and inflammation can cause severe injury leading to acute respiratory distress syndrome. An increased expression and activity of the TLR4 is…”
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Intranasal Antifungal Vaccination Using DNA-Transfected Dendritic Cells by Awasthi, Shanjana

“…Dendritic cells are the most potent antigen-presenting cells, and are critical for the generation of an antigen-specific immune response and protective…”
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Efficacy of Antigen 2/Proline-Rich Antigen cDNA-Transfected Dendritic Cells in Immunization of Mice against Coccidioides posadasii by Awasthi, Shanjana, Awasthi, Vibhudutta, Magee, D. Mitchell, Coalson, Jacqueline J

“…Coccidioides posadasii causes coccidioidomycosis, or Valley fever, in the endemic regions of the Southwestern United States. The susceptibility to C. posadasii…”
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Role of CD14 in Responses to Clinical Isolates of Escherichia coli: Effects of K1 Capsule Expression by Metkar, Shalaka, Awasthi, Shanjana, Denamur, Erick, Kim, Kwang Sik, Gangloff, Sophie C, Teichberg, Saul, Haziot, Alain, Silver, Jack, Goyert, Sanna M

“…Severe bacterial infections leading to sepsis or septic shock can be induced by bacteria that utilize different factors to drive pathogenicity and/or…”
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Transfection of murine dendritic cell line (JAWS II) by a nonviral transfection reagent by Awasthi, Shanjana, Cox, Rebecca A

“…Dendritic cells are the most potent antigen-presenting cells that initiate and modulate the host immune system. Based on their immunostimulatory activity, a…”
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