Search Results - "AWADALLAH, Fadi M"

Design and synthesis of some new benzoylthioureido benzenesulfonamide derivatives and their analogues as carbonic anhydrase inhibitors by Oudah, Khulood H., Mahmoud, Walaa R., Awadallah, Fadi M., Taher, Azza T., Abbas, Safinaz E.-S, Allam, Heba Abdelrasheed, Vullo, Daniela, Supuran, Claudiu T.

“…The present investigation reports the design and synthesis of three series of benzoylthioureido derivatives bearing either benzenesulfonamide 7a-f, benzoic…”
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Synthesis and anticancer activity of some 8-substituted-7-methoxy-2H-chromen-2-one derivatives toward hepatocellular carcinoma HepG2 cells by Amin, Kamilia M., Abou-Seri, Sahar M., Awadallah, Fadi M., Eissa, Amal A.M., Hassan, Ghaneya S., Abdulla, Mohamed M.

“…Based on the reported anticancer activity of coumarin and pyrazoline derivatives, the present investigation dealt with the design and synthesis of coumarin…”
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Inhibition studies on a panel of human carbonic anhydrases with N1-substituted secondary sulfonamides incorporating thiazolinone or imidazolone-indole tails by Awadallah, Fadi M., Bua, Silvia, Mahmoud, Walaa R., Nada, Hossam H., Nocentini, Alessio, Supuran, Claudiu T.

“…Being the primary sulfonamide among the most efficient zinc binding group (ZBG) to design inhibitors for the metallo-enzymes carbonic anhydrases (CA, EC…”
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Design and synthesis of some new benzoylthioureido phenyl derivatives targeting carbonic anhydrase enzymes by Najm, Mazin A. A., Mahmoud, Walaa R., Taher, Azza T., Abbas, Safinaz E-S., Awadallah, Fadi M., Allam, Heba Abdelrasheed, Vullo, Daniela, Supuran, Claudiu T.

“…The present study aimed to develop potent carbonic anhydrase inhibitors (CAIs). The design of the target compounds was based on modifying the structure of the…”
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Design, synthesis and molecular docking of novel diarylcyclohexenone and diarylindazole derivatives as tubulin polymerization inhibitors by Ahmed, Riham I., Osman, Essam Eldin A., Awadallah, Fadi M., El-Moghazy, Samir M.

“…New target compounds were designed as inhibitors of tubulin polymerization relying on using two types of ring B models (cyclohexenone and indazole) to replace…”
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Identification of new potent phthalazine derivatives with VEGFR-2 and EGFR kinase inhibitory activity by Amin, Kamilia M., Barsoum, Flora F., Awadallah, Fadi M., Mohamed, Nehal E.

“…Efforts to develop new antitumor agents are now directed towards multitarget therapies that are believed to have high potency and low tendency to resistance…”
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Sulfonamides as anticancer agents: A brief review on sulfonamide derivatives as inhibitors of various proteins overexpressed in cancer by Elsayad, Khaled A., Elmasry, Ghada F., Mahmoud, Sally T., Awadallah, Fadi M.

“…[Display omitted] Sulfonamides have gained prominence as versatile agents in cancer therapy, effectively targeting a spectrum of cancer-associated enzymes…”
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Corrigendum to “Sulfonamides as anticancer agents: A brief review on sulfonamide derivatives as inhibitors of various proteins overexpressed in cancer” [Bioorg. Chem. 147 (2024) 107409] by Elsayad, Khaled A., Elmasry, Ghada F., Mahmoud, Sally T., Awadallah, Fadi M.

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Synthesis and biological evaluation of novel coumarin–pyrazoline hybrids endowed with phenylsulfonyl moiety as antitumor agents by Amin, Kamilia M., Eissa, Amal A.M., Abou-Seri, Sahar M., Awadallah, Fadi M., Hassan, Ghaneya S.

“…Two groups of coumarin–pyrazoline hybrids were synthesized. The target compounds were obtained by cyclization of the coumarin chalcones with various…”
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Synthesis of some N-aroyl-2-oxindole benzenesulfonamide conjugates with carbonic anhydrase inhibitory activity by George, Riham F., Bua, Silvia, Supuran, Claudiu T., Awadallah, Fadi M.

“…[Display omitted] •Three series of benzenesulfonamide based compounds were prepared.•All compounds were screened for CA inhibition against CA I, II, IX and XII…”
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Design and synthesis of novel PARP-1 inhibitors based on pyridopyridazinone scaffold by Elmasry, Ghada F., Aly, Enayat E., Awadallah, Fadi M., El-Moghazy, Samir M.

“…[Display omitted] •Twenty pyridopyridazinone were synthesized.•Target compounds were evaluated as PARP-1 enzyme inhibitors.•The best PARP-1 inhibition results…”
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Synthesis, carbonic anhydrase inhibition and cytotoxic activity of novel chromone-based sulfonamide derivatives by Awadallah, Fadi M., El-Waei, Tamer A., Hanna, Mona M., Abbas, Safinaz E., Ceruso, Mariangela, Oz, Beyza Ecem, Guler, Ozen Ozensoy, Supuran, Claudiu T.

“…Four series of sulfonamides incorporating chromone moieties were synthesized and assessed for their cytotoxic activity against MCF-7 and A-549 cell lines,…”
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New quinazolinone–pyrimidine hybrids: Synthesis, anti-inflammatory, and ulcerogenicity studies by Abbas, Safinaz E., Awadallah, Fadi M., Ibrahin, Nashwa A., Said, Eman G., Kamel, Gihan M.

“…Two groups of hybrid compounds: the quinazolinone–dihydropyrimidines and quinazolinone–pyrimidines, were synthesized. The starting derivative 3 was reacted…”
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Molecular docking simulation, synthesis and 3D pharmacophore studies of novel 2-substituted-5-nitro-benzimidazole derivatives as anticancer agents targeting VEGFR-2 and c-Met by Ibrahim, Heba A., Awadallah, Fadi M., Refaat, Hanan M., Amin, Kamilia M.

“…3D QSAR based pharmacophore models of 12e in Fig. (a) non-small lung cancer and Fig.(b) colorectal cancer cell lines. IC50 = 2.19 ± 0.09 and 10.97 ± 0.09 µM,…”
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Synthesis of some dihydropyrimidine-based compounds bearing pyrazoline moiety and evaluation of their antiproliferative activity by Awadallah, Fadi M., Piazza, Gary A., Gary, Bernard D., Keeton, Adam B., Canzoneri, Joshua C.

“…Two series of 2-(3,5-diaryl-4,5-dihydropyrazol-1-yl)-1-methyl-6-oxo-4-phenyl-1,6-dihydropyrimidine-5-carbonitriles 5a–h and…”
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Synthesis, vasorelaxant activity, and molecular modeling study of some new phthalazine derivatives by Awadallah, Fadi M., El-Eraky, Wafaa I., Saleh, Dalia O.

“…New phthalazine-based vasodilators were synthesized through the chloroacylation of the starting compound 1-hydrazinophthalazine 4 to give the two key…”
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Design, synthesis and molecular modeling study for some new 2-substituted benzimidazoles as dual inhibitors for VEGFR-2 and c-Met by Ibrahim, Heba A, Awadallah, Fadi M, Refaat, Hanan M, Amin, Kamilia M

“…Computer-aided drug design techniques were adopted to design three series of 2-substituted-5-nitrobenzimidazole derivatives hybridized with piperzine ,…”
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Design and synthesis of potent 1,2,4-trisubstituted imidazolinone derivatives with dual p38αMAPK and ERK1/2 inhibitory activity by Awadallah, Fadi M., Abou-Seri, Sahar M., Abdulla, Mohamed M., Georgey, Hanan H.

“…The synthesis of new 1,2,4-trisubstituted imidazolinone derivatives was described. The new compounds were designed as dual p38αMAPK and ERK1/2 inhibitors…”
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4-Substituted-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine Derivatives: Design, Synthesis, Antitumor and EGFR Tyrosine Kinase Inhibitory Activity by Abbas, Safinaz E.-S., Aly, Enayat I., Awadallah, Fadi M., Mahmoud, Walaa R.

“…Four series of some 4‐substituted‐1‐phenyl‐1H‐pyrazolo[3,4‐d]pyrimidine derivatives 5a–f, 6a–f, 8a–f, and 9a–f were designed to be screened for their antitumor…”
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Novel substituted and fused pyrrolizine derivatives: Synthesis, anti-inflammatory and ulcerogenecity studies by ABBAS, Safinaz E, AWADALLAH, Fadi M, IBRAHIM, Nashwa A, GOUDA, Ahmed M

“…Synthesis of several substituted pyrrolizines 10a-f, 11a-f, 13a-c, pyrimidopyrrolizines 14a-c, 15a-c, and pyrrolizinopyrimidoisoindoles 12a-c was discussed…”
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