Search Results - "AVRAHAM, Roi"

Immunometabolic crosstalk during bacterial infection by Rosenberg, Gili, Riquelme, Sebastian, Prince, Alice, Avraham, Roi

“…Following detection of bacteria, macrophages switch their metabolism from oxidative respiration through the tricarboxylic acid cycle to high-rate aerobic…”
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Bacterial lifestyle switch in response to algal metabolites by Barak-Gavish, Noa, Dassa, Bareket, Kuhlisch, Constanze, Nussbaum, Inbal, Brandis, Alexander, Rosenberg, Gili, Avraham, Roi, Vardi, Assaf

“…Unicellular algae, termed phytoplankton, greatly impact the marine environment by serving as the basis of marine food webs and by playing central roles in the…”
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scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing by Avital, Gal, Avraham, Roi, Fan, Amy, Hashimshony, Tamar, Hung, Deborah T, Yanai, Itai

“…The interaction between a pathogen and a host is a highly dynamic process in which both agents activate complex programs. Here, we introduce a single-cell…”
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Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses by Avraham, Roi, Haseley, Nathan, Brown, Douglas, Penaranda, Cristina, Jijon, Humberto B., Trombetta, John J., Satija, Rahul, Shalek, Alex K., Xavier, Ramnik J., Regev, Aviv, Hung, Deborah T.

“…Encounters between immune cells and invading bacteria ultimately determine the course of infection. These interactions are usually measured in populations of…”
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Predicting bacterial infection outcomes using single cell RNA-sequencing analysis of human immune cells by Bossel Ben-Moshe, Noa, Hen-Avivi, Shelly, Levitin, Natalia, Yehezkel, Dror, Oosting, Marije, Joosten, Leo A. B., Netea, Mihai G., Avraham, Roi

“…Complex interactions between different host immune cell types can determine the outcome of pathogen infections. Advances in single cell RNA-sequencing…”
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Silencing of a large microRNA cluster on human chromosome 14q32 in melanoma: biological effects of mir-376a and mir-376c on insulin growth factor 1 receptor by Zehavi, Liron, Avraham, Roi, Barzilai, Aviv, Bar-Ilan, Dalia, Navon, Roy, Sidi, Yechezkel, Avni, Dror, Leibowitz-Amit, Raya

“…Metastatic melanoma is a devastating disease with limited therapeutic options. MicroRNAs (miRNAs) are small non coding RNA molecules with important roles in…”
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Generation of specialized blood vessels via lymphatic transdifferentiation by Das, Rudra N., Tevet, Yaara, Safriel, Stav, Han, Yanchao, Moshe, Noga, Lambiase, Giuseppina, Bassi, Ivan, Nicenboim, Julian, Brückner, Matthias, Hirsch, Dana, Eilam-Altstadter, Raya, Herzog, Wiebke, Avraham, Roi, Poss, Kenneth D., Yaniv, Karina

“…The lineage and developmental trajectory of a cell are key determinants of cellular identity. In the vascular system, endothelial cells (ECs) of blood and…”
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Protocol for comparing ribosomal levels in single bacterial cells at different growth stages using rRNA-FISH by Ciolli Mattioli, Camilla, Avraham, Roi

“…Ribosome quantification in single cells is typically achieved through fluorescence tagging of ribosomal proteins. Here, we present a protocol for comparing…”
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Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence by Barczak, Amy K, Avraham, Roi, Singh, Shantanu, Luo, Samantha S, Zhang, Wei Ran, Bray, Mark-Anthony, Hinman, Amelia E, Thompson, Matthew, Nietupski, Raymond M, Golas, Aaron, Montgomery, Paul, Fitzgerald, Michael, Smith, Roger S, White, Dylan W, Tischler, Anna D, Carpenter, Anne E, Hung, Deborah T

“…A key to the pathogenic success of Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis, is the capacity to survive within host macrophages…”
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Hybridization-based capture of pathogen mRNA enables paired host-pathogen transcriptional analysis by Betin, Viktoria, Penaranda, Cristina, Bandyopadhyay, Nirmalya, Yang, Rui, Abitua, Angela, Bhattacharyya, Roby P., Fan, Amy, Avraham, Roi, Livny, Jonathan, Shoresh, Noam, Hung, Deborah T.

“…Dual transcriptional profiling of host and bacteria during infection is challenging due to the low abundance of bacterial mRNA. We report Pathogen Hybrid…”
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Blood Transfusion Promotes Cancer Progression : A Critical Role for Aged Erythrocytes by ATZIL, Shir, ARAD, Michal, GLASNER, Ariella, ABIRI, Noa, AVRAHAM, Roi, GREENFELD, Keren, ROSENNE, Ella, BEILIN, Benzion, BEN-ELIYAHU, Shamgar

“…In cancer patients, allogeneic blood transfusion is associated with poorer prognosis, but the independent effect of the transfusion is controversial. Moreover,…”
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EGR1 and the ERK‐ERF axis drive mammary cell migration in response to EGF by Tarcic, Gabi, Avraham, Roi, Pines, Gur, Amit, Ido, Shay, Tal, Lu, Yiling, Zwang, Yaara, Katz, Menachem, Ben‐Chetrit, Nir, Jacob‐Hirsch, Jasmine, Virgilio, Laura, Rechavi, Gideon, Mavrothalassitis, George, Mills, Gordon B., Domany, Eytan, Yarden, Yosef

“…The signaling pathways that commit cells to migration are incompletely understood. We employed human mammary cells and two stimuli: epidermal growth factor…”
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Pharyngeal mesoderm regulatory network controls cardiac and head muscle morphogenesis by Harel, Itamar, Maezawa, Yoshiro, Avraham, Roi, Rinon, Ariel, Ma, Hsiao-Yen, Cross, Joe W., Leviatan, Noam, Hegesh, Julius, Roy, Achira, Jacob-Hirsch, Jasmine, Rechavi, Gideon, Carvajal, Jaime, Tole, Shubha, Kioussi, Chrissa, Quaggin, Susan, Tzahor, Eldad

“…The search for developmental mechanisms driving vertebrate organogénesis has paved the way toward a deeper understanding of birth defects. During…”
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Two Phases of Mitogenic Signaling Unveil Roles for p53 and EGR1 in Elimination of Inconsistent Growth Signals by Zwang, Yaara, Sas-Chen, Aldema, Drier, Yotam, Shay, Tal, Avraham, Roi, Lauriola, Mattia, Shema, Efrat, Lidor-Nili, Efrat, Jacob-Hirsch, Jasmine, Amariglio, Ninette, Lu, Yiling, Mills, Gordon B., Rechavi, Gideon, Oren, Moshe, Domany, Eytan, Yarden, Yosef

“…Normal cells require continuous exposure to growth factors in order to cross a restriction point and commit to cell-cycle progression. This can be replaced by…”
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miR‐10b, a master inhibitor of the cell cycle, is down‐regulated in human breast tumours by Biagioni, Francesca, Bossel Ben‐Moshe, Noa, Fontemaggi, Giulia, Canu, Valeria, Mori, Federica, Antoniani, Barbara, Di Benedetto, Anna, Santoro, Raffaela, Germoni, Sabrina, De Angelis, Fernanda, Cambria, Anna, Avraham, Roi, Grasso, Giuseppe, Strano, Sabrina, Muti, Paola, Mottolese, Marcella, Yarden, Yosef, Domany, Eytan, Blandino, Giovanni

“…Deregulated proliferation is a hallmark of cancer cells. Here, we show that microRNA‐10b* is a master regulator of breast cancer cell proliferation and is…”
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Untangling Cellular Host-Pathogen Encounters at Infection Bottlenecks by Avraham, Roi

“…Bacterial pathogens can invade the tissue and establish a protected intracellular niche at the site of invasion that can spread locally (e.g., microcolonies)…”
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Do stress responses promote leukemia progression? An animal study suggesting a role for epinephrine and prostaglandin-E2 through reduced NK activity by Inbar, Shelly, Neeman, Elad, Avraham, Roi, Benish, Marganit, Rosenne, Ella, Ben-Eliyahu, Shamgar

“…In leukemia patients, stress and anxiety were suggested to predict poorer prognosis. Oncological patients experience ample physiological and psychological…”
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Synergism between immunostimulation and prevention of surgery-induced immune suppression: An approach to reduce post-operative tumor progression by Avraham, Roi, Benish, Marganit, Inbar, Shelly, Bartal, Inbal, Rosenne, Ella, Ben-Eliyahu, Shamgar

“…Abstract Background: A unique opportunity to eradicate cancer is presented immediately after the excision of the primary tumor, but surgical procedures often…”
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Feedback regulation of EGFR signalling: decision making by early and delayed loops by Yarden, Yosef, Avraham, Roi

“…Key Points The epidermal growth factor receptor (EGFR)/ERBB family has evolved from a primordial, simple pathway of a single ligand receptor pair to a complex…”
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Tissue-specific macrophage immunometabolism by Ben-Arosh, Hadar, Avraham, Roi

“…Macrophages are phagocytic cells distributed across tissues that sustain homeostasis by constantly probing their local environment. Upon perturbations,…”
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