Search Results - "AVILA, Matias A"

Messenger RNA therapy for rare genetic metabolic diseases by Berraondo, Pedro, Martini, Paolo G V, Avila, Matias A, Fontanellas, Antonio

“…Decades of intense research in molecular biology and biochemistry are fructifying in the emergence of therapeutic messenger RNAs (mRNA) as a new class of…”
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Recent advances in alcohol-related liver disease (ALD): summary of a Gut round table meeting by Avila, Matias A, Dufour, Jean-François, Gerbes, Alexander L, Zoulim, Fabien, Bataller, Ramon, Burra, Patrizia, Cortez-Pinto, Helena, Gao, Bin, Gilmore, Ian, Mathurin, Philippe, Moreno, Christophe, Poznyak, Vladimir, Schnabl, Bernd, Szabo, Gyongyi, Thiele, Maja, Thursz, Mark R

“…Alcohol-related liver disease (ALD), which includes a range of disorders of different severity and is one of the most prevalent types of liver disease…”
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Gut roundtable meeting paper: selected recent advances in hepatocellular carcinoma by Gerbes, Alexander, Zoulim, Fabien, Tilg, Herbert, Dufour, Jean-François, Bruix, Jordi, Paradis, Valérie, Salem, Riad, Peck-Radosavljevic, Markus, Galle, Peter R, Greten, Tim F, Nault, Jean-Charles, Avila, Matias A

“…Hepatocellular carcinoma (HCC) ranks number three among the most frequent causes of death from solid tumors worldwide. With obesity and fatty liver diseases as…”
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Fibroblast growth factor 15/19 (FGF15/19) protects from diet-induced hepatic steatosis: development of an FGF19-based chimeric molecule to promote fatty liver regeneration by Alvarez-Sola, Gloria, Uriarte, Iker, Latasa, M Ujue, Fernandez-Barrena, Maite G, Urtasun, Raquel, Elizalde, Maria, Barcena-Varela, Marina, Jiménez, Maddalen, Chang, Haisul C, Barbero, Roberto, Catalán, Victoria, Rodríguez, Amaia, Frühbeck, Gema, Gallego-Escuredo, José M, Gavaldà-Navarro, Aleix, Villarroya, Francesc, Rodriguez-Ortigosa, Carlos M, Corrales, Fernando J, Prieto, Jesus, Berraondo, Pedro, Berasain, Carmen, Avila, Matias A

“…Fibroblast growth factor 15/19 (FGF15/19), an enterokine that regulates synthesis of hepatic bile acids (BA), has been proposed to influence fat metabolism…”
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The search for novel diagnostic and prognostic biomarkers in cholangiocarcinoma by Macias, Rocio I.R., Banales, Jesus M., Sangro, Bruno, Muntané, Jordi, Avila, Matias A., Lozano, Elisa, Perugorria, Maria J., Padillo, Francisco J., Bujanda, Luis, Marin, Jose J.G.

“…The poor prognosis of cholangiocarcinoma (CCA) is in part due to late diagnosis, which is currently achieved by a combination of clinical, radiological and…”
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Epigenetic remodelling in human hepatocellular carcinoma by Braghini, Maria Rita, Lo Re, Oriana, Romito, Ilaria, Fernandez-Barrena, Maite G, Barbaro, Barbara, Pomella, Silvia, Rota, Rossella, Vinciguerra, Manlio, Avila, Matias A, Alisi, Anna

“…Hepatocellular carcinoma (HCC) is the most frequent primary liver cancer, being the sixth most commonly diagnosed cancer and the fourth leading cause of…”
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Causes of hOCT1‐Dependent Cholangiocarcinoma Resistance to Sorafenib and Sensitization by Tumor‐Selective Gene Therapy by Lozano, Elisa, Macias, Rocio I.R., Monte, Maria J., Asensio, Maitane, Carmen, Sofia, Sanchez‐Vicente, Laura, Alonso‐Peña, Marta, Al‐Abdulla, Ruba, Munoz‐Garrido, Patricia, Satriano, Letizia, O'Rourke, Colm J., Banales, Jesus M., Avila, Matias A., Martinez‐Chantar, Maria L., Andersen, Jesper B., Briz, Oscar, Marin, Jose J.G.

“…Although the multi‐tyrosine kinase inhibitor sorafenib is useful in the treatment of several cancers, cholangiocarcinoma (CCA) is refractory to this drug…”
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Amphiregulin Aggravates Glomerulonephritis via Recruitment and Activation of Myeloid Cells by Melderis, Simon, Hagenstein, Julia, Warkotsch, Matthias Tobias, Dang, Julien, Herrnstadt, Georg Rudolf, Niehus, Christoph Benjamin, Neumann, Katrin, Panzer, Ulf, Berasain, Carmen, Avila, Matias A, Tharaux, Pierre-Louis, Tiegs, Gisa, Steinmetz, Oliver M

“…Recent studies have identified the EGF receptor (EGFR) ligand amphiregulin (AREG) as an important mediator of inflammatory diseases. Both pro- and…”
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Ileal FGF15 contributes to fibrosis‐associated hepatocellular carcinoma development by Uriarte, Iker, Latasa, M. Ujue, Carotti, Simone, Fernandez‐Barrena, Maite G., Garcia‐Irigoyen, Oihane, Elizalde, Maria, Urtasun, Raquel, Vespasiani‐Gentilucci, Umberto, Morini, Sergio, Mingo, Alvaro, Mari, Montserrat, Corrales, Fernando J., Prieto, Jesus, Berasain, Carmen, Avila, Matias A.

“…Fibroblast growth factor 15 (FGF15), FGF19 in humans, is a gut‐derived hormone and a key regulator of bile acids and carbohydrate metabolism. FGF15 also…”
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Splicing regulator SLU7 is essential for maintaining liver homeostasis by Elizalde, María, Urtasun, Raquel, Azkona, María, Latasa, María U, Goñi, Saioa, García-Irigoyen, Oihane, Uriarte, Iker, Segura, Victor, Collantes, María, Di Scala, Mariana, Lujambio, Amaia, Prieto, Jesús, Ávila, Matías A, Berasain, Carmen

“…A precise equilibrium between cellular differentiation and proliferation is fundamental for tissue homeostasis. Maintaining this balance is particularly…”
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Sensitizing cholangiocarcinoma to chemotherapy by inhibition of the drug-export pump MRP3 by Asensio, Maitane, Briz, Oscar, Herraez, Elisa, Perez-Silva, Laura, Espinosa-Escudero, Ricardo, Bueno-Sacristan, Diego, Peleteiro-Vigil, Ana, Hammer, Helen, Pötz, Oliver, Kadioglu, Onat, Banales, Jesus M., Martinez-Chantar, Maria L., Avila, Matias A., Macias, Rocio I.R., Efferth, Thomas, Marin, Jose J.G., Lozano, Elisa

“…Drug export through ABC proteins hinders cancer response to chemotherapy. Here, we have evaluated the relevance of MRP3 (ABCC3) in cholangiocarcinoma (CCA) as…”
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Fragile X mental retardation protein in intrahepatic cholangiocarcinoma: regulating the cancer cell behavior plasticity at the leading edge by Carotti, Simone, Zingariello, Maria, Francesconi, Maria, D’Andrea, Laura, Latasa, M. Ujue, Colyn, Leticia, Fernandez-Barrena, Maite G., Flammia, Rocco Simone, Falchi, Mario, Righi, Daniela, Pedini, Giorgia, Pantano, Francesco, Bagni, Claudia, Perrone, Giuseppe, Rana, Rosa Alba, Avila, Matias A., Morini, Sergio, Zalfa, Francesca

“…Intrahepatic cholangiocarcinoma (iCCA) is a rare malignancy of the intrahepatic biliary tract with a very poor prognosis. Although some clinicopathological…”
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Connective tissue growth factor autocriny in human hepatocellular carcinoma: Oncogenic role and regulation by epidermal growth factor receptor/yes‐associated protein–mediated activation by Urtasun, Raquel, Latasa, Maria U., Demartis, Maria I., Balzani, Stella, Goñi, Saioa, Garcia‐Irigoyen, Oihane, Elizalde, Maria, Azcona, Maria, Pascale, Rosa M., Feo, Francesco, Bioulac‐Sage, Paulette, Balabaud, Charles, Muntané, Jordi, Prieto, Jesus, Berasain, Carmen, Avila, Matias A.

“…The identification of molecular mechanisms involved in the maintenance of the transformed phenotype of hepatocellular carcinoma (HCC) cells is essential for…”
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Vitamin A in Nonalcoholic Fatty Liver Disease: A Key Player in an Offside Position? by Berasain, Carmen, Avila, Matias A.

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Application of Graph Models to the Identification of Transcriptomic Oncometabolic Pathways in Human Hepatocellular Carcinoma by Barace, Sergio, Santamaría, Eva, Infante, Stefany, Arcelus, Sara, De La Fuente, Jesus, Goñi, Enrique, Tamayo, Ibon, Ochoa, Idoia, Sogbe, Miguel, Sangro, Bruno, Hernaez, Mikel, Avila, Matias A, Argemi, Josepmaria

“…Whole-tissue transcriptomic analyses have been helpful to characterize molecular subtypes of hepatocellular carcinoma (HCC). Metabolic subtypes of human HCC…”
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Epigenetics in Liver Fibrosis: Could HDACs be a Therapeutic Target? by Claveria-Cabello, Alex, Colyn, Leticia, Arechederra, Maria, Urman, Jesus M, Berasain, Carmen, Avila, Matias A, Fernandez-Barrena, Maite G

“…Chronic liver diseases (CLD) represent a worldwide health problem. While CLDs may have diverse etiologies, a common pathogenic denominator is the presence of…”
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The epidermal growth factor receptor ligand amphiregulin participates in the development of mouse liver fibrosis by Perugorria, Maria J., Latasa, M. Ujue, Nicou, Alexandra, Cartagena‐Lirola, Hugo, Castillo, Josefa, Goñi, Saioa, Vespasiani‐Gentilucci, Umberto, Zagami, Maria G., Lotersztajn, Sophie, Prieto, Jesús, Berasain, Carmen, Avila, Matias A.

“…The hepatic wound‐healing response to chronic noxious stimuli may lead to liver fibrosis, a condition characterized by excessive deposition of extracellular…”
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A GAPDH-Mediated Trans-Nitrosylation Pathway Is Required for Feedback Inhibition of Bile Salt Synthesis in Rat Liver by Rodríguez-Ortigosa, Carlos M, Celay, Jon, Olivas, Israel, Juanarena, Nerea, Arcelus, Sara, Uriarte, Iker, Marín, José Juan G, Avila, Matias A, Medina, Juan F, Prieto, Jesus

“…Background & Aims Bile salts inhibit their own production by inducing the nuclear receptor small heterodimer partner (SHP) (encoded by NR0B2 ), which…”
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Gene supplementation of CYP27A1 in the liver restores bile acid metabolism in a mouse model of cerebrotendinous xanthomatosis by Lumbreras, Sara, Ricobaraza, Ana, Baila-Rueda, Lucia, Gonzalez-Aparicio, Manuela, Mora-Jimenez, Lucia, Uriarte, Iker, Bunuales, Maria, Avila, Matias A., Monte, Maria J., Marin, Jose J.G., Cenarro, Ana, Gonzalez-Aseguinolaza, Gloria, Hernandez-Alcoceba, Ruben

“…Cerebrotendinous xanthomatosis (CTX) is an autosomal recessive disease caused by mutations in the CYP27A1 gene, encoding the sterol 27-hydroxylase. Disruption…”
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Immunogenomic classification of hepatocellular carcinoma patients for immune check-point inhibitors therapy: cui bono ? by Hernaez, Ruben, Avila, Matias A

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