Search Results - "AVILÉS, FRANCESC X."

AGGRESCAN: a server for the prediction and evaluation of "hot spots" of aggregation in polypeptides by Conchillo-Solé, Oscar, de Groot, Natalia S, Avilés, Francesc X, Vendrell, Josep, Daura, Xavier, Ventura, Salvador

“…Protein aggregation correlates with the development of several debilitating human disorders of growing incidence, such as Alzheimer's and Parkinson's diseases…”
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Use of artichoke (Cynara scolymus) flower extract as a substitute for bovine rennet in the manufacture of Gouda-type cheese: Characterization of aspartic proteases by Llorente, Berta E., Obregón, Walter David, Avilés, Francesc X., Caffini, Néstor O., Vairo-Cavalli, Sandra

“…•Gouda cheeses were manufactured by using artichoke extracts as coagulants.•Five milk-clotting activity fractions were isolated from artichoke extracts.•Three…”
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New Palladium(II) and Platinum(II) Complexes with 9-Aminoacridine: Structures, Luminiscence, Theoretical Calculations, and Antitumor Activity by Ruiz, José, Lorenzo, Julia, Vicente, Consuelo, López, Gregorio, Monge, Miguel, Avilés, Francesc X, Bautista, Delia, Moreno, Virtudes, Laguna, Antonio

“…The new complexes [Pd(dmba)(N10-9AA)(PPh3)]ClO4 (1), [Pt(dmba)(N9-9AA)(PPh3)]ClO4 (2), [Pd(dmba)(N10-9AA)Cl] (3), and [Pd(C6F5)(N10-9AA)(PPh3)Cl] (4) (9-AA =…”
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Inclusion bodies: Specificity in their aggregation process and amyloid-like structure by Morell, Montse, Bravo, Ramona, Espargaró, Alba, Sisquella, Xavier, Avilés, Francesc X., Fernàndez-Busquets, Xavier, Ventura, Salvador

“…The accumulation of aggregated protein in the cell is associated with the pathology of many diseases and constitutes a major concern in protein production…”
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Protein complementation assays: Approaches for the in vivo analysis of protein interactions by Morell, Montse, Ventura, Salvador, Avilés, Francesc X.

“…The in vivo identification and characterization of protein–protein interactions (PPIs) are essential to understand cellular events in living organisms. In this…”
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A novel vanadyl complex with a polypyridyl DNA intercalator as ligand: A potential anti-protozoa and anti-tumor agent by Benítez, Julio, Guggeri, Lucía, Tomaz, Isabel, Pessoa, João Costa, Moreno, Virtudes, Lorenzo, Julia, Avilés, Francesc X., Garat, Beatriz, Gambino, Dinorah

“…In the search for new metal-based drugs for the treatment of tumoral and parasitic diseases a vanadyl complex, [V IVO(SO 4)(H 2O) 2(dppz)]·2H 2O, that includes…”
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DNA interaction and cytotoxicity studies of new ruthenium(II) cyclopentadienyl derivative complexes containing heteroaromatic ligands by Moreno, Virtudes, Font-Bardia, Mercè, Calvet, Teresa, Lorenzo, Julia, Avilés, Francesc X., Garcia, M. Helena, Morais, Tânia S., Valente, Andreia, Robalo, M. Paula

“…Four ruthenium(II) complexes with the formula [Ru(η5-C5H5)(PP)L][CF3SO3], being (PP=two triphenylphosphine molecules), L=1-benzylimidazole, 1; (PP=two…”
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Detection of transient protein-protein interactions by bimolecular fluorescence complementation: The Abl-SH3 case by Morell, Montse, Espargaró, Alba, Avilés, Francesc X., Ventura, Salvador

“…Protein–protein interactions are essential in most biological processes. Many proteomic approaches have succeeded in the identification of strong and…”
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Progress in metallocarboxypeptidases and their small molecular weight inhibitors by Fernández, Daniel, Pallarès, Irantzu, Vendrell, Josep, Avilés, Francesc X.

“…In what corresponds to a life span, metallocarboxypeptidases (MCPs) have jumped from being mere contaminants in animal pancreas powders (in depression year…”
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A Noncanonical Mechanism of Carboxypeptidase Inhibition Revealed by the Crystal Structure of the Tri-Kunitz SmCI in Complex with Human CPA4 by Alonso del Rivero, Maday, Reytor, Mey L., Trejo, Sebastian A., Chávez, María A., Avilés, Francesc X., Reverter, David

“…The crystal structure of SmCI (Sabellastarte magnifica carboxypeptidase inhibitor) has been determined in complex with human carboxypeptidase A4 (hCPA4). SmCI…”
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The novel structure of a cytosolic M14 metallocarboxypeptidase (CCP) from Pseudomonas aeruginosa: a model for mammalian CCPs by Otero, Anabel, Vega, Mónica Rodríguez, Tanco, Sebastian, Lorenzo, Julia, Avilés, Francesc X., Reverter, David

“…PaCCP is a metallocarboxypeptidase (MCP) of the M14 family from Pseudomonas aeruginosa, which belongs to a bacterial clade of carboxypeptidases that are…”
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Cyclobutane-containing peptides: Evaluation as novel metallocarboxypeptidase inhibitors and modelling of their mode of action by Fernández, Daniel, Torres, Elisabeth, Avilés, Francesc X., Ortuño, Rosa M., Vendrell, Josep

“…Among other peptides evaluated, these compounds were active and selective. Aromatic stacking plays an important role in the binding to the active sited of the…”
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Internalization of cystatin C in human cell lines by Ekström, Ulf, Wallin, Hanna, Lorenzo, Julia, Holmqvist, Bo, Abrahamson, Magnus, Avilés, Francesc X.

“…Altered protease activity is considered important for tumour invasion and metastasis, processes in which the cysteine proteases cathepsin B and L are involved…”
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Discovery of Mechanism-Based Inactivators for Human Pancreatic Carboxypeptidase A from a Focused Synthetic Library by Testero, Sebastián A, Granados, Carla, Fernández, Daniel, Gallego, Pablo, Covaleda, Giovanni, Reverter, David, Vendrell, Josep, Avilés, Francesc X, Pallarès, Irantzu, Mobashery, Shahriar

“…Metallocarboxypeptidases (MCPs) are involved in many biological processes such as fibrinolysis or inflammation, development, Alzheimer’s disease, and various…”
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Functional segregation and emerging role of cilia‐related cytosolic carboxypeptidases (CCPs) by Otazo, Mónica Rodríguez de la Vega, Lorenzo, Julia, Tort, Olivia, Avilés, Francesc X., Bautista, José M.

“…Recent experimental data indicating axonal regeneration, axogenesis, dendritogenesis, and ciliary axoneme assembly and wellness have linked the role of…”
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Crystal Structure of Novel Metallocarboxypeptidase Inhibitor from Marine Mollusk Nerita versicolor in Complex with Human Carboxypeptidase A4 by Covaleda, Giovanni, Alonso del Rivero, Maday, Chávez, María A., Avilés, Francesc X., Reverter, David

“…NvCI is a novel exogenous proteinaceous inhibitor of metallocarboxypeptidases from the marine snail Nerita versicolor. The complex between human…”
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Linking amyloid protein aggregation and yeast survival by Morell, Montse, de Groot, Natalia S, Vendrell, Josep, Avilés, Francesc X, Ventura, Salvador

“…Protein aggregation and amyloid formation lie behind an increasing number of human diseases. Here we describe the application of an "aggregation reporter", in…”
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Monitoring the interference of protein-protein interactions in vivo by bimolecular fluorescence complementation: the DnaK case by Morell, Montse, Czihal, Patricia, Hoffmann, Ralf, Otvos, Laszlo, Avilés, Francesc X, Ventura, Salvador

“…Many cellular processes depend on protein-protein interactions. The identification of molecules able to modulate protein contacts is of significant interest…”
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Uncovered p1 and p2 waves preceding the N3 vestibular evoked neurogenic potential in profound sensorineural hearing loss by Pascual‐Rubio, Vicenç, Domènech‐Vadillo, Esther, Cárdenas‐Escalante, Paulina, Avilés‐Jurado, Francesc X., Pellisé‐Guinjoan, Anna, Figuerola‐Massana, Enric

“…Background The N3 wave is a vestibular evoked neurogenic potential detected in some patients with profound sensorineural hearing loss (PSNHL) during brainstem…”
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Structure of Human Carboxypeptidase A4 with Its Endogenous Protein Inhibitor, Latexin by Pallarès, Irantzu, Bonet, Roman, García-Castellanos, Raquel, Ventura, Salvador, Avilés, Francesc X., Vendrell, Josep, Gomis-Rüth, F. Xavier, Huber, Robert

“…The only endogenous protein inhibitor known for metallocarboxypeptidases (MCPs) is latexin, a 25-kDa protein discovered in the rat brain. Latexin, alias…”
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