Search Results - "AUGUSTIN, THOMAS"

Conditional variable importance for random forests by Strobl, Carolin, Boulesteix, Anne-Laure, Kneib, Thomas, Augustin, Thomas, Zeileis, Achim

“…Random forests are becoming increasingly popular in many scientific fields because they can cope with "small n large p" problems, complex interactions and even…”
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Generating survival times to simulate Cox proportional hazards models by Bender, Ralf, Augustin, Thomas, Blettner, Maria

“…Simulation studies present an important statistical tool to investigate the performance, properties and adequacy of statistical models in pre‐specified…”
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Open Flow Microperfusion as a Dermal Pharmacokinetic Approach to Evaluate Topical Bioequivalence by Bodenlenz, Manfred, Tiffner, Katrin I., Raml, Reingard, Augustin, Thomas, Dragatin, Christian, Birngruber, Thomas, Schimek, Denise, Schwagerle, Gerd, Pieber, Thomas R., Raney, Sam G., Kanfer, Isadore, Sinner, Frank

“…Background The availability of generic topical dermatological drug products is constrained by the limited methods established to assess topical bioequivalence…”
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Unbiased split selection for classification trees based on the Gini Index by Strobl, Carolin, Boulesteix, Anne-Laure, Augustin, Thomas

“…Classification trees are a popular tool in applied statistics because their heuristic search approach based on impurity reduction is easy to understand and the…”
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Variability of Skin Pharmacokinetic Data: Insights from a Topical Bioequivalence Study Using Dermal Open Flow Microperfusion by Bodenlenz, Manfred, Augustin, Thomas, Birngruber, Thomas, Tiffner, Katrin I., Boulgaropoulos, Beate, Schwingenschuh, Simon, Raney, Sam G., Rantou, Elena, Sinner, Frank

“…Purpose Dermal open flow microperfusion (dOFM) has previously demonstrated its utility to assess the bioequivalence (BE) of topical drug products in a clinical…”
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The parameters in the near-miss-to-Weber's law by Augustin, Thomas

“…Many empirical data support the hypothesis that the sensitivity function grows as a power function of the stimulus intensity. This is usually referred to as…”
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Compare and Contrast Meta Analysis (CCMA): A Method for Identification of Pleiotropic Loci in Genome-Wide Association Studies by Baurecht, Hansjörg, Hotze, Melanie, Rodríguez, Elke, Manz, Judith, Weidinger, Stephan, Cordell, Heather J, Augustin, Thomas, Strauch, Konstantin

“…In recent years, genome-wide association studies (GWAS) have identified many loci that are shared among common disorders and this has raised interest in…”
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Imprecise Bayesian optimization by Rodemann, Julian, Augustin, Thomas

“…Bayesian optimization (BO) with Gaussian processes (GPs) surrogate models is widely used to optimize analytically unknown and expensive-to-evaluate functions…”
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Comment: On Focusing, Soft and Strong Revision of Choquet Capacities and Their Role in Statistics by Augustin, Thomas, Schollmeyer, Georg

“…We congratulate Ruobin Gong and Xiao-Li Meng on their thought-provoking paper demonstrating the power of imprecise probabilities in statistics. In particular,…”
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Learning de-biased regression trees and forests from complex samples by Nalenz, Malte, Rodemann, Julian, Augustin, Thomas

“…Regression trees and forests are widely used due to their flexibility and predictive accuracy. Whereas typical tree induction assumes independently identically…”
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Isomeric stability of indaziflam and major degradation products in the environment by Eckelmann, Dennis, Augustin, Thomas, Leake, Christopher

“…Understanding the isomeric behavior of active ingredients in the soil and water environment is the first and a major part of deriving an exposure assessment…”
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Statistical modeling under partial identification: Distinguishing three types of identification regions in regression analysis with interval data by Schollmeyer, Georg, Augustin, Thomas

“…One of the most promising applications of the methodology of imprecise probabilities in statistics is the reliable analysis of interval data (or more generally…”
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A comprehensive approach to qualify and validate the essential parameters of an in vitro release test (IVRT) method for acyclovir cream, 5 by Tiffner, Katrin I., Kanfer, Isadore, Augustin, Thomas, Raml, Reingard, Raney, Sam G., Sinner, Frank

“…[Display omitted] The rate of release of an active pharmaceutical ingredient (API) from a topical semisolid dosage form can be influenced by its physical and…”
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On the impact of robust statistics on imprecise probability models: A review by Augustin, Thomas, Hable, Robert

“…Robust statistics is concerned with statistical methods that still lead to reliable conclusions if an ideal model is only approximately true. More recently,…”
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Stevens’ power law and the problem of meaningfulness by Augustin, Thomas

“…Frequently, it is postulated that the results of a ratio production (resp., ratio estimation) experiment can be summarized by Stevens’ power law ψ=αϕβ. In the…”
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Comparative in vitro release testing (IVRT) of acyclovir products by Tiffner, Katrin I., Kanfer, Isadore, Augustin, Thomas, Raml, Reingard, Raney, Sam G., Sinner, Frank

“…[Display omitted] The aim was to evaluate whether an in vitro release test (IVRT) could differentiate the release rates from five pharmaceutically equivalent…”
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Gender Measurement Invariance of the Minnesota Multiphasic Personality Inventory - Adolescent - Restructured Form (MMPI-A-RF) Internalizing and Externalizing Specific Problem Scales by Augustin, Thomas Jay

“…Due to social, psychological, biological, and cultural differences in adolescent development, it is important to evaluate measurement invariance in…”
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Effect of LiraglutideTreatment on Whole-body Glucose Fluxes in C-peptide-Positive Type 1 Diabetes During Hypoglycemia by Zenz, Sabine, Regittnig, Werner, Boulgaropoulos, Beate, Augustin, Thomas, Brunner, Ma, Korsatko, Stefan, Munzker, Julia, Narath, Sophie H, Raml, Reingard, Magnes, Christoph, Pieber, Thomas R

“…Context: The effect of liraglutide in C-peptide-positive (C-pos) type 1 diabetes (T1 D) patients during hypoglycemia remains unclear. Objective: To investigate…”
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Pharmacokinetics and Pharmacodynamics of Three Different Formulations of Insulin Aspart: A Randomized, Double-Blind, Crossover Study in Men With Type 1 Diabetes by Svehlikova, Eva, Mursic, Ines, Augustin, Thomas, Magnes, Christoph, Gerring, David, Jezek, Jan, Schwarzenbacher, Daniela, Ratzer, Maria, Wolf, Michael, Howell, Sarah, Zakrzewski, Leon, Urschitz, Martina, Tschapeller, Bernd, Gatschelhofer, Christina, Feichtner, Franz, Lawrence, Fiona, Pieber, Thomas R

“…To investigate the pharmacokinetic and pharmacodynamic properties and safety of a novel formulation of insulin aspart (AT247) versus two currently marketed…”
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Effect of Liraglutide Treatment on Whole-body Glucose Fluxes in C-peptide–Positive Type 1 Diabetes During Hypoglycemia by Zenz, Sabine, Regittnig, Werner, Boulgaropoulos, Beate, Augustin, Thomas, Brunner, Martina, Korsatko, Stefan, Münzker, Julia, Narath, Sophie H, Raml, Reingard, Magnes, Christoph, Pieber, Thomas R

“…Context: The effect of liraglutide in C-peptide--positive (C-pos) type 1 diabetes (T1D) patients during hypoglycemia remains unclear. Objective: To investigate…”
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