Search Results - "AUDETTE, Charlene A"

The effect of different linkers on target cell catabolism and pharmacokinetics/pharmacodynamics of trastuzumab maytansinoid conjugates by Erickson, Hans K, Lewis Phillips, Gail D, Leipold, Douglas D, Provenzano, Carmela A, Mai, Elaine, Johnson, Holly A, Gunter, Bert, Audette, Charlene A, Gupta, Manish, Pinkas, Jan, Tibbitts, Jay

“…Trastuzumab emtansine (T-DM1) is an antibody-drug conjugate consisting of the anti-HER2 antibody trastuzumab linked via a nonreducible thioether linker to the…”
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A CD123-targeting antibody-drug conjugate, IMGN632, designed to eradicate AML while sparing normal bone marrow cells by Kovtun, Yelena, Jones, Gregory E., Adams, Sharlene, Harvey, Lauren, Audette, Charlene A., Wilhelm, Alan, Bai, Chen, Rui, Lingyun, Laleau, Rassol, Liu, Fenghua, Ab, Olga, Setiady, Yulius, Yoder, Nicholas C., Goldmacher, Victor S., Chari, Ravi V.J., Pinkas, Jan, Chittenden, Thomas

“…The outlook for patients with refractory/relapsed acute myeloid leukemia (AML) remains poor, with conventional chemotherapeutic treatments often associated…”
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Antibody-Maytansinoid Conjugates Designed to Bypass Multidrug Resistance by KOVTUN, Yelena V, AUDETTE, Charlene A, LAI, Katharine C, WIDDISON, Wayne C, KELLOGG, Brenda, JOHNSON, Holly, PINKAS, Jan, LUTZ, Robert J, SINGH, Rajeeva, GOLDMACHER, Victor S, CHARI, Ravi V. J, MAYO, Michele F, JONES, Gregory E, DOHERTY, Heather, MALONEY, Erin K, ERICKSON, Hans K, XIUXIA SUN, WILHELM, Sharon, AB, Olga

“…Conjugation of cytotoxic compounds to antibodies that bind to cancer-specific antigens makes these drugs selective in killing cancer cells. However, many of…”
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High-affinity accumulation of a maytansinoid in cells via weak tubulin interaction by Goldmacher, Victor S, Audette, Charlene A, Guan, Yinghua, Sidhom, Eriene-Heidi, Shah, Jagesh V, Whiteman, Kathleen R, Kovtun, Yelena V

“…The microtubule-targeting maytansinoids accumulate in cells and induce mitotic arrest at 250- to 1000-fold lower concentrations than those required for their…”
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A New Class of Antibody-Drug Conjugates with Potent DNA Alkylating Activity by Miller, Michael L, Fishkin, Nathan E, Li, Wei, Whiteman, Kathleen R, Kovtun, Yelena, Reid, Emily E, Archer, Katie E, Maloney, Erin K, Audette, Charlene A, Mayo, Michele F, Wilhelm, Alan, Modafferi, Holly A, Singh, Rajeeva, Pinkas, Jan, Goldmacher, Victor, Lambert, John M, Chari, Ravi V J

“…The promise of tumor-selective delivery of cytotoxic agents in the form of antibody-drug conjugates (ADC) has now been realized, evidenced by the approval of…”
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Antibody-drug conjugates designed to eradicate tumors with homogeneous and heterogeneous expression of the target antigen by KOVTUN, Yelena V, AUDETTE, Charlene A, YUMEI YE, HONGSHENG XIE, RUBERTI, Mary F, PHINNEY, Sara J, LEECE, Barbara A, CHITTENDEN, Thomas, BLÄTTLER, Walter A, GOLDMACHER, Victor S

“…Conjugates of the anti-CanAg humanized monoclonal antibody huC242 with the microtubule-formation inhibitor DM1 (a maytansinoid), or with the DNA alkylator DC1…”
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Development of Anilino-Maytansinoid ADCs that Efficiently Release Cytotoxic Metabolites in Cancer Cells and Induce High Levels of Bystander Killing by Widdison, Wayne C, Ponte, Jose F, Coccia, Jennifer A, Lanieri, Leanne, Setiady, Yulius, Dong, Ling, Skaletskaya, Anna, Hong, E. Erica, Wu, Rui, Qiu, Qifeng, Singh, Rajeeva, Salomon, Paulin, Fishkin, Nathan, Harris, Luke, Maloney, Erin K, Kovtun, Yelena, Veale, Karen, Wilhelm, Sharon D, Audette, Charlene A, Costoplus, Juliet A, Chari, Ravi V. J

“…Antibody anilino maytansinoid conjugates (AaMCs) have been prepared in which a maytansinoid bearing an aniline group was linked through the aniline amine to a…”
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Lorvotuzumab mertansine, a CD56-targeting antibody-drug conjugate with potent antitumor activity against small cell lung cancer in human xenograft models by Whiteman, Kathleen R, Johnson, Holly A, Mayo, Michele F, Audette, Charlene A, Carrigan, Christina N, LaBelle, Alyssa, Zukerberg, Lawrence, Lambert, John M, Lutz, Robert J

“…Lorvotuzumab mertansine (LM) is an antibody-drug conjugate composed of a humanized anti-CD56 antibody, lorvotuzumab, linked via a cleavable disulfide linker to…”
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Synthetic nonpsychotropic cannabinoids with potent antiinflammatory, analgesic, and leukocyte antiadhesion activities by Burstein, Sumner H, Audette, Charlene A, Breuer, Aviva, Devane, William A, Colodner, Sharona, Doyle, Sharon A, Mechoulam, Raphael

“…Two strategies for the design of therapeutically useful cannabinoids have been combined to produce compounds with greatly increased antiinflammatory activity…”
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Inhibition of leukocyte adhesion by the in vivo and in vitro administration of cannabinoids by Audette, C A, Burstein, S

“…Cannabinoids have been shown to affect various aspects of arachidonic acid metabolism both in vivo and in vitro. Eicosanoid metabolites of arachidonate and…”
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Detection of cannabinoid receptors by photoaffinity labelling by Burstein, S H, Audette, C A, Charalambous, A, Doyle, S A, Guo, Y, Hunter, S A, Makriyannis, A

“…A novel [125I]-labelled photoaffinity ligand designed to detect cannabinoid binding sites has been used in mouse brain preparations and in cultured S49 mouse…”
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G-protein mediation of cannabinoid-induced phospholipase activation by Audette, C A, Burstein, S H, Doyle, S A, Hunter, S A

“…The release of arachidonic acid from mouse peritoneal and S49 cells induced by delta 1-tetrahydrocannabinol was found to be altered by prior exposure of the…”
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