Search Results - "ATWOOD, CRAIG S"

Effects of Hormone Therapy on Cognition and Mood in Recently Postmenopausal Women: Findings from the Randomized, Controlled KEEPS-Cognitive and Affective Study by Gleason, Carey E, Dowling, N Maritza, Wharton, Whitney, Manson, JoAnn E, Miller, Virginia M, Atwood, Craig S, Brinton, Eliot A, Cedars, Marcelle I, Lobo, Rogerio A, Merriam, George R, Neal-Perry, Genevieve, Santoro, Nanette F, Taylor, Hugh S, Black, Dennis M, Budoff, Matthew J, Hodis, Howard N, Naftolin, Frederick, Harman, S Mitchell, Asthana, Sanjay

“…Menopausal hormone therapy (MHT) reportedly increases the risk of cognitive decline in women over age 65 y. It is unknown whether similar risks exist for…”
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Positron Emission Tomography reveals age-associated hypothalamic microglial activation in women by Butler, Tracy, Glodzik, Lidia, Wang, Xiuyuan Hugh, Xi, Ke, Li, Yi, Pan, Hong, Zhou, Liangdong, Chiang, Gloria Chia-Yi, Morim, Simon, Wickramasuriya, Nimmi, Tanzi, Emily, Maloney, Thomas, Harvey, Patrick, Mao, Xiangling, Razlighi, Qolamreza Ray, Rusinek, Henry, Shungu, Dikoma C., de Leon, Mony, Atwood, Craig S., Mozley, P. David

“…In rodents, hypothalamic inflammation plays a critical role in aging and age-related diseases. Hypothalamic inflammation has not previously been assessed in…”
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Estropause, Sex Hormones and Metal Homeostasis in the Mouse Brain by Liu, Tianbing, Bowen, Richard L, Wilson, Andrea C, Atwood, Craig S

“…Alterations in brain metal ion homeostasis have been reported with aging and are implicated in the pathogenesis of neurodegenerative diseases. To assess…”
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Oxidative Damage Is the Earliest Event in Alzheimer Disease by NUNOMURA, AKIHIKO, PERRY, GEORGE, ALIEV, GJUMRAKCH, HIRAI, KEISUKE, TAKEDA, ATSUSHI, BALRAJ, ELIZABETH K, JONES, PAUL K, GHANBARI, HOSSEIN, WATAYA, TAKAFUMI, SHIMOHAMA, SHUN, CHIBA, SHIGERU, ATWOOD, CRAIG S, PETERSEN, ROBERT B, SMITH, MARK A

“…Recently, we demonstrated a significant increase of an oxidized nucleoside derived from RNA, 8-hydroxyguanosine (8OHG), and an oxidized amino acid,…”
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Playing Russian Roulette with Alzheimer's Disease Patients: Do the Cognitive Benefits of Lecanemab Outweigh the Risk of Edema, Stroke and Encephalitis? by Atwood, Craig S, Perry, George

“…The questionable approval of aducanumab and the recent approval of lecanemab (Leqembi; Eisai and Biogen) by the FDA has raised the issue of safety (stroke,…”
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Mitochondrial Abnormalities in Alzheimer's Disease by Hirai, Keisuke, Aliev, Gjumrakch, Nunomura, Akihiko, Fujioka, Hisashi, Russell, Robert L, Atwood, Craig S, Johnson, Anne B, Kress, Yvonne, Vinters, Harry V, Tabaton, Massimo, Shimohama, Shun, Cash, Adam D, Siedlak, Sandra L, Harris, Peggy L. R, Jones, Paul K, Petersen, Robert B, Perry, George, Smith, Mark A

“…The finding that oxidative damage, including that to nucleic acids, in Alzheimer's disease is primarily limited to the cytoplasm of susceptible neuronal…”
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Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury by Geddes, Rastafa I, Hayashi, Kentaro, Bongers, Quinn, Wehber, Marlyse, Anderson, Icelle M, Jansen, Alex D, Nier, Chase, Fares, Emily, Farquhar, Gabrielle, Kapoor, Amita, Ziegler, Toni E, VadakkadathMeethal, Sivan, Bird, Ian M, Atwood, Craig S

“…Long-chain polyunsaturated fatty acids like conjugated linoleic acids (CLA) are required for normal neural development and cognitive function and have been…”
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Correction: Conjugated Linoleic Acid Administration Induces Amnesia in Male Sprague Dawley Rats and Exacerbates Recovery from Functional Deficits Induced by a Controlled Cortical Impact Injury by Geddes, Rastafa I, Hayashi, Kentaro, Bongers, Quinn, Wehber, Marlyse, Anderson, Icelle M, Jansen, Alex D, Nier, Chase, Fares, Emily, Farquhar, Gabrielle, Kapoor, Amita, Ziegler, Toni E, Vadakkadath Meethal, Sivan, Bird, Ian M, Atwood, Craig S

“…[This corrects the article DOI: 10.1371/journal.pone.0169494.]…”
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Chronic antioxidant therapy reduces oxidative stress in a mouse model of Alzheimer's disease by Siedlak, Sandra L, Casadesus, Gemma, Webber, Kate M, Pappolla, Miguel A, Atwood, Craig S, Smith, Mark A, Perry, George

“…Oxidative modifications are a hallmark of oxidative imbalance in the brains of individuals with Alzheimer's, Parkinson's and prion diseases and their…”
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Differential activation of neuronal ERK, JNK/SAPK and p38 in Alzheimer disease: the ‘two hit’ hypothesis by Zhu, Xiongwei, Castellani, Rudolph J, Takeda, Atsushi, Nunomura, Akihiko, Atwood, Craig S, Perry, George, Smith, Mark A

“…There are multiple lines of evidence showing that oxidative stress and aberrant mitogenic signaling play an important role in the pathogenesis of Alzheimer…”
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Hypogonadism induced by surgical stress and brain trauma is reversed by human chorionic gonadotropin in male rats: A potential therapy for surgical and TBI‐induced hypogonadism? by Geddes, Rastafa I., Kapoor, Amita, Hayashi, Kentaro, Rauh, Ryan, Wehber, Marlyse, Bongers, Quinn, Jansen, Alex D., Anderson, Icelle M., Farquhar, Gabrielle, Vadakkadath‐Meethal, Sivan, Ziegler, Toni E., Atwood, Craig S.

“…Introduction Hypogonadotropic hypogonadism (HH) is an almost universal, yet underappreciated, endocrinological complication of traumatic brain injury (TBI)…”
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Luteinizing hormone receptor mediates neuronal pregnenolone production via up‐regulation of steroidogenic acute regulatory protein expression by Liu, Tianbing, Wimalasena, Jay, Bowen, Richard L., Atwood, Craig S.

“…The functional consequences of luteinizing hormone/human chorionic gonadotropin signaling via neuronal luteinizing hormone/human chorionic gonadotropin…”
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Identification of a regulatory loop for the synthesis of neurosteroids: a steroidogenic acute regulatory protein-dependent mechanism involving hypothalamic-pituitary-gonadal axis receptors by Meethal, Sivan Vadakkadath, Liu, Tianbing, Chan, Hsien W, Ginsburg, Erika, Wilson, Andrea C, Gray, Danielle N, Bowen, Richard L, Vonderhaar, Barbara K, Atwood, Craig S

“…Brain sex steroids are derived from both peripheral (primarily gonadal) and local (neurosteroids) sources and are crucial for neurogenesis, neural…”
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Effects of simvastatin on cerebrospinal fluid biomarkers and cognition in middle-aged adults at risk for Alzheimer's disease by Carlsson, Cynthia M, Gleason, Carey E, Hess, Timothy M, Moreland, Kimberly A, Blazel, Hanna M, Koscik, Rebecca L, Schreiber, Nathan T N, Johnson, Sterling C, Atwood, Craig S, Puglielli, Luigi, Hermann, Bruce P, McBride, Patrick E, Stein, James H, Sager, Mark A, Asthana, Sanjay

“…Statins reduce amyloid-beta (Abeta) levels in the brain and cerebrospinal fluid (CSF) in animals and may thereby favorably alter the pathobiology of AD. It is…”
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fMRI activation during episodic encoding and metacognitive appraisal across the lifespan: Risk factors for Alzheimer's disease by Trivedi, Mehul A., Schmitz, Taylor W., Ries, Michele L., Hess, Timothy M., Fitzgerald, Michele E., Atwood, Craig S., Rowley, Howard A., Asthana, Sanjay, Sager, Mark A., Johnson, Sterling C.

“…In the present study, we used fMRI to examine the influence of age on two other known risk factors for Alzheimer's disease (AD), APOE genotype and parental…”
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Redox active iron accumulation in aceruloplasminemia by Gonzalez-Cuyar, Luis F., Perry, George, Miyajima, Hiroaki, Atwood, Craig S., Riveros-Angel, Marcela, Lyons, Patrick F., Siedlak, Sandra L., Smith, Mark A., Castellani, Rudy J.

“…Aceruloplasminemia is an autosomal recessive disorder characterized by a ceruloplasmin gene mutation and defective or absent ceruloplasmin function. Because…”
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Human neurons express type I GnRH receptor and respond to GnRH I by increasing luteinizing hormone expression by Wilson, Andrea C, Salamat, M Shahriar, Haasl, Ryan J, Roche, Kelly M, Karande, Anjali, Meethal, Sivan Vadakkadath, Terasawa, Ei, Bowen, Richard L, Atwood, Craig S

“…Gonadotropin-releasing hormone receptor I (GnRHR I) has been localized to the limbic system of the rat brain, although the functional consequences of GnRH…”
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The spatiotemporal hormonal orchestration of human folliculogenesis, early embryogenesis and blastocyst implantation by Atwood, Craig S., Vadakkadath Meethal, Sivan

“…The early reproductive events starting with folliculogenesis and ending with blastocyst implantation into the uterine endometrium are regulated by a complex…”
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A Unified Hypothesis of Early- and Late-Onset Alzheimer's Disease Pathogenesis by Atwood, Craig S, Bowen, Richard L

“…Early-onset familial Alzheimer's disease (EOFAD) and late-onset sporadic AD (LOSAD) both follow a similar pathological and biochemical course that includes:…”
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Human versus non-human sex steroid use in hormone replacement therapies part 1: Preclinical data by Atwood, Craig S., Ekstein, Samuel F.

“…Prior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of…”
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