Search Results - "ATKINSON, Jeffrey J"

PARP9-DTX3L ubiquitin ligase targets host histone H2BJ and viral 3C protease to enhance interferon signaling and control viral infection by Zhang, Yong, Mao, Dailing, Roswit, William T, Jin, Xiaohua, Patel, Anand C, Patel, Dhara A, Agapov, Eugene, Wang, Zhepeng, Tidwell, Rose M, Atkinson, Jeffrey J, Huang, Guangming, McCarthy, Ronald, Yu, Jinsheng, Yun, Nadezhda E, Paessler, Slobodan, Lawson, T Glen, Omattage, Natalie S, Brett, Tom J, Holtzman, Michael J

“…Holtzman and colleagues identify PARP9-DTX3L as an E3 ubiquitin ligase complex that interacts with STAT1 to modify chromatin accessibility for expression in…”
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Matrix Metalloproteinase-9 in Lung Remodeling by Atkinson, Jeffrey J, Senior, Robert M

“…Matrix metalloproteinase (MMP)-9 (Gelatinase B, 92-kD type IV collagenase, EC 3.4.24.35) is an MMP that is present in low quantities in the healthy adult lung,…”
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Standardizing nasal nitric oxide measurement as a test for primary ciliary dyskinesia by Leigh, Margaret W, Hazucha, Milan J, Chawla, Kunal K, Baker, Brock R, Shapiro, Adam J, Brown, David E, Lavange, Lisa M, Horton, Bethany J, Qaqish, Bahjat, Carson, Johnny L, Davis, Stephanie D, Dell, Sharon D, Ferkol, Thomas W, Atkinson, Jeffrey J, Olivier, Kenneth N, Sagel, Scott D, Rosenfeld, Margaret, Milla, Carlos, Lee, Hye-Seung, Krischer, Jeffrey, Zariwala, Maimoona A, Knowles, Michael R

“…Several studies suggest that nasal nitric oxide (nNO) measurement could be a test for primary ciliary dyskinesia (PCD), but the procedure and interpretation…”
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Identification of kidney injury released circulating osteopontin as causal agent of respiratory failure by Khamissi, Fatima Zohra, Ning, Liang, Kefaloyianni, Eirini, Dun, Hao, Arthanarisami, Akshayakeerthi, Keller, Amy, Atkinson, Jeffrey J, Li, Wenjun, Wong, Brian, Dietmann, Sabine, Lavine, Kory, Kreisel, Daniel, Herrlich, Andreas

“…Tissue injury can drive secondary organ injury; however, mechanisms and mediators are not well understood. To identify interorgan cross-talk mediators, we used…”
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PET-based Imaging of Chemokine Receptor 2 in Experimental and Disease-related Lung Inflammation by Liu, Yongjian, Gunsten, Sean P, Sultan, Deborah H, Luehmann, Hannah P, Zhao, Yongfeng, Blackwell, T Scott, Bollermann-Nowlis, Zachary, Pan, Jie-Hong, Byers, Derek E, Atkinson, Jeffrey J, Kreisel, Daniel, Holtzman, Michael J, Gropler, Robert J, Combadiere, Christophe, Brody, Steven L

“…Purpose To characterize a chemokine receptor type 2 (CCR2)-binding peptide adapted for use as a positron emission tomography (PET) radiotracer for noninvasive…”
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Mechanisms Underlying HIV-Associated Noninfectious Lung Disease by Presti, Rachel M., Flores, Sonia C., Palmer, Brent E., Atkinson, Jeffrey J., Lesko, Catherine R., Lau, Bryan, Fontenot, Andrew P., Roman, Jesse, McDyer, John F., Twigg, Homer L.

“…Pulmonary disease remains a primary source of morbidity and mortality in persons living with HIV (PLWH), although the advent of potent combination…”
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The Role of Matrix Metalloproteinase-9 in Cigarette Smoke-induced Emphysema by ATKINSON, Jeffrey J, LUTEY, Barbara A, CONRADI, Susan H, GIERADA, David S, PIERCE, Richard A, BETSUYAKU, Tomoko, SENIOR, Robert M, SUZUKI, Yoko, TOENNIES, Holly M, KELLEY, Diane G, KOBAYASHI, Dale K, IJEM, Whitney G, DESLEE, Gaetan, MOORE, Carla H, EILEEN JACOBS, M

“…Matrix metalloprotease (MMP)-9 is an elastolytic endopeptidase produced by activated macrophages that may be involved in the development of human pulmonary…”
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Microfibril-associated Glycoprotein 2 (MAGP2) Loss of Function Has Pleiotropic Effects in Vivo by Combs, Michelle D., Knutsen, Russell H., Broekelmann, Thomas J., Toennies, Holly M., Brett, Thomas J., Miller, Chantel A., Kober, Daniel L., Craft, Clarissa S., Atkinson, Jeffrey J., Shipley, J. Michael, Trask, Barbara C., Mecham, Robert P.

“…The function of MAGP2 was studied by inactivating its gene (Mfap5−/−) in mice. Results: Mfap5−/− mice have a neutrophil deficiency and other phenotypes that…”
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Accurate Measurement of Small Airways on Low-Dose Thoracic CT Scans in Smokers by Lutey, Barbara A., MD, Conradi, Susan H., PhD, Atkinson, Jeffrey J., MD, Zheng, Jie, PhD, Schechtman, Kenneth B., PhD, Senior, Robert M., MD, Gierada, David S., MD

“…Background Partial volume averaging and tilt relative to the scan plane on transverse images limit the accuracy of airway wall thickness measurements on CT…”
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Oxidative damage to nucleic acids in severe emphysema by Deslee, Gaetan, Woods, Jason C, Moore, Carla, Conradi, Susan H, Gierada, David S, Atkinson, Jeffrey J, Battaile, John T, Liu, Lucy, Patterson, G Alexander, Adair-Kirk, Tracy L, Holtzman, Michael J, Pierce, Richard A

“…Oxidative stress is a key element in the pathogenesis of emphysema, but oxidation of nucleic acids has been largely overlooked. The aim of this study was to…”
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Macrophage chitinase 1 stratifies chronic obstructive lung disease by Agapov, Eugene, Battaile, John T, Tidwell, Rose, Hachem, Ramsey, Patterson, G Alexander, Pierce, Richard A, Atkinson, Jeffrey J, Holtzman, Michael J

“…Diagnosis and therapy of chronic inflammatory lung disease is limited by the need for individualized biomarkers that provide insight into pathogenesis. Herein…”
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Panton-Valentine Leukocidin-positive methicillin-resistant Staphylococcus aureus lung infection in patients with cystic fibrosis by Elizur, Arnon, Orscheln, Rachel C, Ferkol, Thomas W, Atkinson, Jeffrey J, Dunne, Jr, W Michael, Buller, Richard S, Armstrong, Jon R, Mardis, Elaine R, Storch, Gregory A, Cannon, Carolyn L

“…Panton-Valentine Leukocidin-expressing (PVL+) methicillin-resistant Staphylococcus aureus (MRSA) is an emerging pathogen worldwide causing fatal necrotizing…”
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FDG PET Imaging in Cystic Fibrosis by Chen, Delphine L., MD, Atkinson, Jeffrey J., MD, Ferkol, Thomas W., MD

“…Cystic fibrosis (CF) is characterized by persistent neutrophilic lung inflammation that begins early in life and leads to an inexorable progressive loss of…”
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TNF or EGFR inhibition equally block AKI-to-CKD transition: opportunities for etanercept treatment by Abdelmageed, Mai M, Kefaloyianni, Eirini, Arthanarisami, Akshayakeerthi, Komaru, Yohei, Atkinson, Jeffrey J, Herrlich, Andreas

“…ABSTRACT Background Inflammation is a key driver of the transition of acute kidney injury to progressive fibrosis and chronic kidney disease (AKI-to-CKD…”
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Single-Nucleus RNA-Sequencing Profiling of Mouse Lung. Reduced Dissociation Bias and Improved Rare Cell-Type Detection Compared with Single-Cell RNA Sequencing by Koenitzer, Jeffrey R, Wu, Haojia, Atkinson, Jeffrey J, Brody, Steven L, Humphreys, Benjamin D

“…Single-cell RNA sequencing (scRNASeq) has advanced our understanding of lung biology, but its utility is limited by the need for fresh samples, loss of cell…”
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Membrane‐type 1 matrix metalloproteinase is required for normal alveolar development by Atkinson, Jeffrey J., Holmbeck, Kenn, Yamada, Susan, Birkedal‐Hansen, Henning, Parks, William C., Senior, Robert M.

“…Matrix metalloproteinases (MMPs) are expressed during lung development, but their role may be limited, as mice deficient in MMP‐3, 7, 9, or 12 develop a normal…”
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Clara cell adhesion and migration to extracellular matrix by Atkinson, Jeffrey J, Adair-Kirk, Tracy L, Kelley, Diane G, Demello, Daphne, Senior, Robert M

“…Clara cells are the epithelial progenitor cell of the small airways, a location known to be important in many lung disorders. Although migration of alveolar…”
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Matrix metalloproteinase-9 activates TGF-β and stimulates fibroblast contraction of collagen gels by Kobayashi, Tetsu, Kim, HuiJung, Liu, Xiangde, Sugiura, Hisatoshi, Kohyama, Tadashi, Fang, Qiuhong, Wen, Fu-Qiang, Abe, Shinji, Wang, Xingqi, Atkinson, Jeffrey J, Shipley, James M, Senior, Robert M, Rennard, Stephen I

“…Matrix metalloproteinase-9 (MMP-9) is a matrix-degrading enzyme implicated in many biological processes, including inflammation. It is produced by many cells,…”
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Chemokine Receptor 2-targeted Molecular Imaging in Pulmonary Fibrosis. A Clinical Trial by Brody, Steven L, Gunsten, Sean P, Luehmann, Hannah P, Sultan, Debbie H, Hoelscher, Michelle, Heo, Gyu Seong, Pan, Jiehong, Koenitzer, Jeffrey R, Lee, Ethan C, Huang, Tao, Mpoy, Cedric, Guo, Shuchi, Laforest, Richard, Salter, Amber, Russell, Tonya D, Shifren, Adrian, Combadiere, Christophe, Lavine, Kory J, Kreisel, Daniel, Humphreys, Benjamin D, Rogers, Buck E, Gierada, David S, Byers, Derek E, Gropler, Robert J, Chen, Delphine L, Atkinson, Jeffrey J, Liu, Yongjian

“…Idiopathic pulmonary fibrosis (IPF) is a progressive inflammatory lung disease without effective molecular markers of disease activity or treatment responses…”
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Macrophage NOX2 NADPH oxidase maintains alveolar homeostasis in mice by Bhattacharya, Sourav, Idol, Rachel A., Yang, Wei, Rojas Márquez, Jorge David, Li, Yanan, Huang, Guangming, Beatty, Wandy L., Atkinson, Jeffrey J., Brumell, John H., Bagaitkar, Juhi, Magee, Jeffrey A., Dinauer, Mary C.

“…The leukocyte NADPH oxidase 2 (NOX2) plays a key role in pathogen killing and immunoregulation. Genetic defects in NOX2 result in chronic granulomatous disease…”
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