Search Results - "ATARASHI, SHOHGO"

(Fluorocyclopropyl)quinolones. 2. Synthesis and Stereochemical Structure-Activity Relationships of Chiral 7-(7-Amino-5-azaspiro[2.4]heptan-5-yl)-1-(2-fluorocyclopropyl)quinolone Antibacterial Agents by Kimura, Youichi, Atarashi, Shohgo, Kawakami, Katsuhiro, Sato, Kenichi, Hayakawa, Isao

“…A series of novel chiral 7-(7-amino-5-azaspiro[2.4]heptan-4-yl)-8-chloro-1-(2-fluo rocyclopropyl)- quinolones were synthesized as a continuation of a research…”
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Fluorocyclopropyl quinolones. 1. Synthesis and structure-activity relationships of 1-(2-fluorocyclopropyl)-3-pyridonecarboxylic acid antibacterial agents by Atarashi, Shohgo, Imamura, Masazumi, Kimura, Youichi, Yoshida, Atomi, Hayakawa, Isao

“…A series of 1-(2-fluorocyclopropyl)-3-pyridonecarboxylic acids has been prepared. These derivatives are characterized by having a fluorine atom at the…”
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Synthesis and Antibacterial Activity of Novel Pyridobenzoxazine Analogues by KAWAKAMI, Katsuhiro, ATARASHI, Shohgo, KIMURA, Youichi, TAKEUMURA, Makoto, HAYAKAWA, Isao

“…A series of novel LVFX (7) analogues bearing 4, 4-dialkyl-3-aminopyrrolidines at the C-10 position of pyridobenzoxazine was synthesized and their antibacterial…”
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Synthesis and Antibacterial Activities of Optically Active Ofloxacin and Its Fluoromethyl Derivative by ATARASHI, SHOHGO, YOKOHAMA, SHUICHI, YAMAZAKI, KEN-ICHI, SAKANO, KATSU-ICHI, IMAMURA, MASAZUMI, HAYAKAWA, ISAO

“…Two optically active (100% enantiomeric excess) isomers (13a and 13b) of ofloxacin (1) [(±) -ofloxacin; DL-8280; (±) -9-fluoro-2, 3-dihydro-3-methyl-10-…”
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Synthesis and Structure-Activity Relationships of 7-(3-(1-Aminoalkyl)pyrrolidinyl)- and 7-(3-1-aminocycloalkyl)pyrrolidinyl)quinolone Antibacterials by KIMURA, Youichi, ATARASHI, Shohgo, TAKAHASHI, Masanobu, HAYAKAWA, Isao

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Regio- and Stereoselective Synthesis of Carbocyclic 2', 3'-Dideoxy-3'-fluoro Nucleosides as Potential Antiviral Agents by NAKAYAMA, Toshiaki, MATSUMURA, Yasushi, MORIZAWA, Yoshitomi, YASUDA, Arata, UCHIDA, Keiichi, TAKASE, Hiroyuki, MURAKAMI, Yoichi, ATARASHI, Shohgo, IKEUCHI, Tohru, OSADA, Yasuaki

“…The synthesis and antiviral activity of racemic carbocyclic 2', 3'-dideoxy-3'-fluoro nucleosides are reported. Carbocyclic 2', 3'-dideoxy-3'-fluoro nucleosides…”
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Bicyclo [3. 3. 1] nonanes as Synthetic Intermediates. V. The Baeyer-Villiger Oxidation of Bicyclo [3. 3. 1] nonane-3, 7-dione and Its Congeners by MOMOSE, TAKEFUMI, ATARASHI, SHOHGO

“…The Baeyer-Villiger oxidation, which is known to be unsuccessful with the bicyclo [3. 3. 1] nonan-3-one system, was shown to proceed smoothyl with the 3,…”
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Modification of the cysteamine side chain of thienamycin. II by Sato, M, Takemura, M, Atarashi, S, Higashi, K, Fujiwara, H, Nagahara, T, Furukawa, M, Ikeuchi, T, Ozawa, S, Nishizawa, N

“…A new type of thienamycin derivatives (3a-3j, 4a, 4b), having a monothioacetal or a thioacetal side chain at the C-2 position was prepared, and the…”
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Modification of the cysteamine side chain of thienamycin. III by Sato, M, Takemura, M, Atarashi, S, Higashi, K, Nagahara, T, Furukawa, M, Ikeuchi, T, Osada, Y

“…Thienamycin derivatives (4) having a cyclic amidine moiety at the C-2 position were prepared. The susceptibility to renal dehydropeptidase-1 and the…”
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Bicyclo [3. 3. 1]nonanes as Synthetic Intermediates. IV. Behavior of Bicyclo [3. n. 1] alkan-3-ones toward the Baeyer-Villiger Oxidation by MOMOSE, TAKEFUMI, MURAOKA, OSAMU, ATARASHI, SHOHGO, HORITA, TAMIKO

“…The Baeyer-Villiger oxidation of bicyclo [3. n. 1] alkan-3-ones and related systems is described. Bicyclo [3. 3. 1] nonan-2-one (8) was oxidized into the…”
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Asymmetric reduction of 7,8-difluoro-3-methyl-2H-1,4-benzoxazine. Synthesis of a key intermediate of (S)-(-)-ofloxacin (DR-3355) by Atarashi, Shohgo, Tsurumi, Hideaki, Fujiwara, Toshihiro, Hayakawa, Isao

“…An efficient, highly enantioselective synthesis of (S)‐(‐)‐7,8‐difluoro‐2,3‐dihydro‐3‐methyl‐4H‐1,4‐benzoxazine, a key intermediate of (S)‐(‐)‐ofloxacin, using…”
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Synthesis and Structure-Activity Relationships of 7-[3-(1-Aminoalkyl)pyrrolidinyl]-and 7-[3-1-aminocycloalkyl)pyrrolidinyl]-quinolone Antibacterials by KIMURA, Youichi, ATARASHI, Shohgo, TAKAHASHI, Masanobu, HAYAKAWA, Isao

“…A series of 7-[3-(1-aminoalkyl and 1-aminocycloalkyl)-1-pyrrolidinyl]quinolones have been prepared and their biological properties evaluated. Among them,…”
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Asymmetric reduction of 7,8‐difluoro‐3‐methyl‐2 H ‐1,4‐benzoxazine. Synthesis of a key intermediate of ( S )‐(‐)‐ofloxacin (DR‐3355) by Atarashi, Shohgo, Tsurumi, Hideaki, Fujiwara, Toshihiro, Hayakawa, Isao

“…An efficient, highly enantioselective synthesis of ( S )‐(‐)‐7,8‐difluoro‐2,3‐dihydro‐3‐methyl‐4 H ‐1,4‐benzoxazine, a key intermediate of ( S )‐(‐)‐ofloxacin,…”
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1H-NMR Spectral Evidences from the Double-chair Comformation of the 9-Azabicyclo[3.3.1]nonane-3,7-dione System by Momose, Takefumi, Atarashi, Shohgo

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Reaction of N-Benzenesulfonyl-9-azabicyclo[3.3.1]nona-2,6-diene with Diborane: Failure of Cyclic Hydroboration in the Intramolecularly Faces Diene System by Momose, Takefumi, Atarashi, Shohgo

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Site-specificity in the Baeyer-Villiger Oxidation of 2-Alkyl-9-azabicyclo[3.3.1]nonane-3,7-diones: Exclusive Cleavage of the Alkylated Half of the Twin-piperidinone System by Momose, Takefumi, Atarashi, Shohgo, Hans Eugster, Conrad

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Bicyclo[3.3.1]nonanes as Synthetic Intermediates VI. An Oxaadamantanol Intermediate which Functions in the Highly Chemoselective Ring-enlargement of Bicyclo[3.3.1]nonane-3,7-dione by Diazomethane by Momose, Takefumi, Muraoka, Osamu, Atarashi, Shohgo

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