Search Results - "ASTER, Jon"

What is in a Name? Consequences of the Classification Schism in Hematopathology by Aster, Jon C

Get full text

The Varied Roles of Notch in Cancer by Aster, Jon C, Pear, Warren S, Blacklow, Stephen C

“…Notch receptors influence cellular behavior by participating in a seemingly simple signaling pathway, but outcomes produced by Notch signaling are remarkably…”
Get full text

Notch signaling in cancer: Complexity and challenges on the path to clinical translation by Ferreira, Antonio, Aster, Jon C.

“…Notch receptors participate in a conserved pathway in which ligands expressed on neighboring cells trigger a series of proteolytic cleavages that allow the…”
Get full text

Mechanical Allostery: Evidence for a Force Requirement in the Proteolytic Activation of Notch by Gordon, Wendy R., Zimmerman, Brandon, He, Li, Miles, Laura J., Huang, Jiuhong, Tiyanont, Kittichoat, McArthur, Debbie G., Aster, Jon C., Perrimon, Norbert, Loparo, Joseph J., Blacklow, Stephen C.

“…Ligands stimulate Notch receptors by inducing regulated intramembrane proteolysis (RIP) to produce a transcriptional effector. Notch activation requires…”
Get full text

Comprehensive analyses of tumor immunity: implications for cancer immunotherapy by Li, Bo, Severson, Eric, Pignon, Jean-Christophe, Zhao, Haoquan, Li, Taiwen, Novak, Jesse, Jiang, Peng, Shen, Hui, Aster, Jon C, Rodig, Scott, Signoretti, Sabina, Liu, Jun S, Liu, X Shirley

“…Understanding the interactions between tumor and the host immune system is critical to finding prognostic biomarkers, reducing drug resistance, and developing…”
Get full text

In Brief: Notch signalling in health and disease by Aster, Jon C

“…The Notch pathway controls many aspects of development and is mutated in various human cancers. Remarkably, Notch function changes during the development of…”
Get full text

The Role of Notch Receptors in Transcriptional Regulation by Wang, Hongfang, Zang, Chongzhi, Liu, X. Shirley, Aster, Jon C.

“…Notch signaling has pleiotropic context‐specific functions that have essential roles in many processes, including embryonic development and maintenance and…”
Get full text

Qualifying antibodies for image-based immune profiling and multiplexed tissue imaging by Du, Ziming, Lin, Jia-Ren, Rashid, Rumana, Maliga, Zoltan, Wang, Shu, Aster, Jon C., Izar, Benjamin, Sorger, Peter K., Santagata, Sandro

“…Multiplexed tissue imaging enables precise, spatially resolved enumeration and characterization of cell types and states in human resection specimens. A…”
Get full text

Activity of the PI3K-δ,γ inhibitor duvelisib in a phase 1 trial and preclinical models of T-cell lymphoma by Horwitz, Steven M., Koch, Raphael, Porcu, Pierluigi, Oki, Yasuhiro, Moskowitz, Alison, Perez, Megan, Myskowski, Patricia, Officer, Adam, Jaffe, Jacob D., Morrow, Sara N., Allen, Kerstin, Douglas, Mark, Stern, Howard, Sweeney, Jennifer, Kelly, Patrick, Kelly, Virginia, Aster, Jon C., Weaver, David, Foss, Francine M., Weinstock, David M.

“…Duvelisib (IPI-145) is an oral inhibitor of phosphatidylinositol 3-kinase (PI3K)–δ/γ isoforms currently in clinical development. PI3K-δ/γ inhibition may…”
Get full text

Loss of atrx cooperates with p53-deficiency to promote the development of sarcomas and other malignancies by Oppel, Felix, Tao, Ting, Shi, Hui, Ross, Kenneth N, Zimmerman, Mark W, He, Shuning, Tong, Guangxiang, Aster, Jon C, Look, A Thomas

“…The SWI/SNF-family chromatin remodeling protein ATRX is a tumor suppressor in sarcomas, gliomas and other malignancies. Its loss of function facilitates the…”
Get full text

Ibrutinib in Previously Treated Waldenström’s Macroglobulinemia by Treon, Steven P, Tripsas, Christina K, Meid, Kirsten, Warren, Diane, Varma, Gaurav, Green, Rebecca, Argyropoulos, Kimon V, Yang, Guang, Cao, Yang, Xu, Lian, Patterson, Christopher J, Rodig, Scott, Zehnder, James L, Aster, Jon C, Harris, Nancy Lee, Kanan, Sandra, Ghobrial, Irene, Castillo, Jorge J, Laubach, Jacob P, Hunter, Zachary R, Salman, Zeena, Li, Jianling, Cheng, Mei, Clow, Fong, Graef, Thorsten, Palomba, M. Lia, Advani, Ranjana H

“…In a study conducted at three institutions, ibrutinib was associated with major responses in 73% of patients with Waldenström's macroglobulinemia who had…”
Get full text

An immunogenic personal neoantigen vaccine for patients with melanoma by Ott, Patrick A., Hu, Zhuting, Keskin, Derin B., Shukla, Sachet A., Sun, Jing, Bozym, David J., Zhang, Wandi, Luoma, Adrienne, Giobbie-Hurder, Anita, Peter, Lauren, Chen, Christina, Olive, Oriol, Carter, Todd A., Li, Shuqiang, Lieb, David J., Eisenhaure, Thomas, Gjini, Evisa, Stevens, Jonathan, Lane, William J., Javeri, Indu, Nellaiappan, Kaliappanadar, Salazar, Andres M., Daley, Heather, Seaman, Michael, Buchbinder, Elizabeth I., Yoon, Charles H., Harden, Maegan, Lennon, Niall, Gabriel, Stacey, Rodig, Scott J., Barouch, Dan H., Aster, Jon C., Getz, Gad, Wucherpfennig, Kai, Neuberg, Donna, Ritz, Jerome, Lander, Eric S., Fritsch, Edward F., Hacohen, Nir, Wu, Catherine J.

“…The results of a phase I trial assessing a personal neoantigen multi-peptide vaccine in patients with melanoma, showing feasibility, safety, and…”
Get full text

Generation of mouse models of myeloid malignancy with combinatorial genetic lesions using CRISPR-Cas9 genome editing by Heckl, Dirk, Kowalczyk, Monika S, Yudovich, David, Belizaire, Roger, Puram, Rishi V, McConkey, Marie E, Thielke, Anne, Aster, Jon C, Regev, Aviv, Ebert, Benjamin L

“…The genetic complexity of human leukemia is modeled using the CRISPR-Cas9 system in mice. Genome sequencing studies have shown that human malignancies often…”
Get full text

NOTCH1–RBPJ complexes drive target gene expression through dynamic interactions with superenhancers by Wang, Hongfang, Zang, Chongzhi, Taing, Len, Arnett, Kelly L., Wong, Yinling Joey, Pear, Warren S., Blacklow, Stephen C., Liu, Shirley, Aster, Jon C.

“…The main oncogenic driver in T-lymphoblastic leukemia is NOTCH1, which activates genes by forming chromatin-associated Notch transcription complexes…”
Get full text

Shortwave-infrared meso-patterned imaging enables label-free mapping of tissue water and lipid content by Zhao, Yanyu, Pilvar, Anahita, Tank, Anup, Peterson, Hannah, Jiang, John, Aster, Jon C., Dumas, John Paul, Pierce, Mark C., Roblyer, Darren

“…Water and lipids are key participants in many biological processes, but there are few non-invasive methods that provide quantification of these components in…”
Get full text

RhoA G17V is sufficient to induce autoimmunity and promotes T-cell lymphomagenesis in mice by Ng, Samuel Y., Brown, Leon, Stevenson, Kristen, deSouza, Tiffany, Aster, Jon C., Louissaint, Abner, Weinstock, David M.

“…Patients with angioimmunoblastic T-cell lymphoma (AITL) and other peripheral T-cell lymphomas that harbor features of follicular helper T (TFH) cells have a…”
Get full text

FcγR engagement reprograms neutrophils into antigen cross-presenting cells that elicit acquired anti-tumor immunity by Mysore, Vijayashree, Cullere, Xavier, Mears, Joseph, Rosetti, Florencia, Okubo, Koshu, Liew, Pei X., Zhang, Fan, Madera-Salcedo, Iris, Rosenbauer, Frank, Stone, Richard M., Aster, Jon C., von Andrian, Ulrich H., Lichtman, Andrew H., Raychaudhuri, Soumya, Mayadas, Tanya N.

“…Classical dendritic cells (cDC) are professional antigen-presenting cells (APC) that regulate immunity and tolerance. Neutrophil-derived cells with properties…”
Get full text

Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance by Liau, Brian B., Sievers, Cem, Donohue, Laura K., Gillespie, Shawn M., Flavahan, William A., Miller, Tyler E., Venteicher, Andrew S., Hebert, Christine H., Carey, Christopher D., Rodig, Scott J., Shareef, Sarah J., Najm, Fadi J., van Galen, Peter, Wakimoto, Hiroaki, Cahill, Daniel P., Rich, Jeremy N., Aster, Jon C., Suvà, Mario L., Patel, Anoop P., Bernstein, Bradley E.

“…Glioblastoma, the most common and aggressive malignant brain tumor, is propagated by stem-like cancer cells refractory to existing therapies. Understanding the…”
Get full text

Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets by Ferrarotto, Renata, Mitani, Yoshitsugu, McGrail, Daniel J, Li, Kaiyi, Karpinets, Tatiana V, Bell, Diana, Frank, Steven J, Song, Xingzhi, Kupferman, Michael E, Liu, Bin, Lee, J Jack, Glisson, Bonnie S, Zhang, Jianhua, Aster, Jon C, Lin, Shiaw-Yih, Futreal, P Andrew, Heymach, John V, El-Naggar, Adel K

“…Salivary gland adenoid cystic carcinoma (ACC) has heterogeneous clinical behavior. Currently, all patients are treated uniformly, and no standard-of-care…”
Get full text

Pharmacological disruption of the Notch transcription factor complex by Lehal, Rajwinder, Zaric, Jelena, Vigolo, Michele, Urech, Charlotte, Frismantas, Viktoras, Zangger, Nadine, Cao, Linlin, Berger, Adeline, Chicote, Irene, Loubéry, Sylvain, Choi, Sung Hee, Koch, Ute, Blacklow, Stephen C., Palmer, Hector G., Bornhauser, Beat, González-Gaitán, Marcos, Arsenijevic, Yvan, Zoete, Vincent, Aster, Jon C., Bourquin, Jean-Pierre, Radtke, Freddy

“…Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation,…”
Get full text