Search Results - "ASSAID, Christopher"

A phase IIb randomized, double-blind, placebo-controlled trial of ubrogepant for the acute treatment of migraine by Voss, Tiffini, Lipton, Richard B, Dodick, David W, Dupre, Nicole, Ge, Joy Yang, Bachman, Robert, Assaid, Christopher, Aurora, Sheena K, Michelson, David

“…The aim of this trial was to evaluate the efficacy and tolerability of ubrogepant (MK-1602), a calcitonin gene-related peptide receptor antagonist (CGRP-RA),…”
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Randomized controlled trial of the CGRP receptor antagonist MK-3207 in the acute treatment of migraine by Hewitt, David J, Aurora, Sheena K, Dodick, David W, Goadsby, Peter J, Ge, Yang Joy, Bachman, Robert, Taraborelli, Donna, Fan, Xiaoyin, Assaid, Christopher, Lines, Christopher, Ho, Tony W

“…This study evaluated the CGRP receptor antagonist MK-3207 for acute treatment of migraine. Multicenter, double-blind, randomized, placebo-controlled,…”
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Efficacy and tolerability of MK-0974 (telcagepant), a new oral antagonist of calcitonin gene-related peptide receptor, compared with zolmitriptan for acute migraine: a randomised, placebo-controlled, parallel-treatment trial by Ho, Tony W, Dr, Ferrari, Michel D, Prof, Dodick, David W, Prof, Galet, Vince, PhD, Kost, James, PhD, Fan, Xiaoyin, PhD, Leibensperger, Heather, BS, Froman, Samar, BS, Assaid, Christopher, PhD, Lines, Christopher, PhD, Koppen, Hille, MD, Winner, Paul K, DO

“…Summary Background Calcitonin gene-related peptide (CGRP) probably has a role in migraine pathophysiology, and antagonism of its receptors might provide…”
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Deep Neuromuscular Blockade Improves Laparoscopic Surgical Conditions: A Randomized, Controlled Study by Rosenberg, Jacob, Herring, W. Joseph, Blobner, Manfred, Mulier, Jan P., Rahe-Meyer, Niels, Woo, Tiffany, Li, Michael K., Grobara, Peter, Assaid, Christopher A., Fennema, Hein, Szegedi, Armin

“…Introduction Sustained deep neuromuscular blockade (NMB) during laparoscopic surgery may facilitate optimal surgical conditions. This exploratory study…”
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Sugammadex efficacy for reversal of rocuronium- and vecuronium-induced neuromuscular blockade: A pooled analysis of 26 studies by Herring, William Joseph, Woo, Tiffany, Assaid, Christopher A., Lupinacci, Robert J., Lemmens, Hendrikus J., Blobner, Manfred, Khuenl-Brady, Karin S.

“…To summarize and compare efficacy of sugammadex with neostigmine or placebo for reversal of rocuronium- or vecuronium-induced neuromuscular blockade (NMB), and…”
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Design and rationale of two phase 3 randomised controlled trials (COUGH-1 and COUGH-2) of gefapixant, a P2X3 receptor antagonist, in refractory or unexplained chronic cough by Muccino, David R, Morice, Alyn H, Birring, Surinder S, Dicpinigaitis, Peter V, Pavord, Ian D, Assaid, Christopher, Kleijn, Huub Jan, Hussain, Azher, La Rosa, Carmen, McGarvey, Lorcan, Smith, Jaclyn A

“…We present study designs, dose selection and preliminary patient characteristics from two phase 3 clinical trials of gefapixant, a P2X3 receptor antagonist, in…”
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Phase 2/3 Trial of Molnupiravir for Treatment of Covid-19 in Nonhospitalized Adults by Caraco, Yoseph, Crofoot, Gordon E, Moncada, Pablo Andres, Galustyan, Anna Nikolaevna, Musungaie, Dany Badibanga, Payne, Brendan, Kovalchuk, Evgeniy, Gonzalez, Antonio, Brown, Michelle L, Williams-Diaz, Angela, Gao, Wei, Strizki, Julie M, Grobler, Jay, Du, Jiejun, Assaid, Christopher A, Paschke, Amanda, Butterton, Joan R, Johnson, Matthew G, De Anda, Carisa

“…BACKGROUND: Safe and effective oral treatments are needed to improve clinical outcomes for nonhospitalized patients with Covid-19. Molnupiravir is an orally…”
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Dosing in heavy-weight/obese patients with the LMWH, tinzaparin: a pharmacodynamic study by Hainer, James W, Barrett, Jeffrey S, Assaid, Christopher A, Fossler, Michael J, Cox, Donna S, Leathers, Todd, Leese, Philip T

“…This pharmacodynamic study examined weight-based dosing of the low molecular weight heparin (LMWH), tinzaparin, in heavyweight/obese subjects. Single doses…”
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Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients by Jayk Bernal, Angélica, Gomes da Silva, Monica M., Musungaie, Dany B., Kovalchuk, Evgeniy, Gonzalez, Antonio, Delos Reyes, Virginia, Martín-Quirós, Alejandro, Caraco, Yoseph, Williams-Diaz, Angela, Brown, Michelle L., Du, Jiejun, Pedley, Alison, Assaid, Christopher, Strizki, Julie, Grobler, Jay A., Shamsuddin, Hala H., Tipping, Robert, Wan, Hong, Paschke, Amanda, Butterton, Joan R., Johnson, Matthew G., De Anda, Carisa

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Rofecoxib in patients with mild cognitive impairment: further analyses of data from a randomized, double-blind, trial by Aisen, Paul S, Thal, Leon J, Ferris, Steven H, Assaid, Christopher, Nessly, Michael L, Giuliani, Michael J, Lines, Christopher R, Norman, Barbara A, Potter, William Z

“…A recent clinical trial in patients with Mild Cognitive Impairment (MCI) found an increased rate of possible or probable Alzheimer's disease (AD) diagnoses in…”
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Molnupiravir for Oral Treatment of Covid-19 in Nonhospitalized Patients by Jayk Bernal, Angélica, Gomes da Silva, Monica M, Musungaie, Dany B, Kovalchuk, Evgeniy, Gonzalez, Antonio, Delos Reyes, Virginia, Martín-Quirós, Alejandro, Caraco, Yoseph, Williams-Diaz, Angela, Brown, Michelle L, Du, Jiejun, Pedley, Alison, Assaid, Christopher, Strizki, Julie, Grobler, Jay A, Shamsuddin, Hala H, Tipping, Robert, Wan, Hong, Paschke, Amanda, Butterton, Joan R, Johnson, Matthew G, De Anda, Carisa

“…Oral outpatient treatment for Covid-19 is needed. In this phase 3, double-blind, randomized, controlled trial, molnupiravir, a small-molecule antiviral, was…”
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Intravenous and subcutaneous weight-based dosing of the low molecular weight heparin tinzaparin (Innohep) in end-stage renal disease patients undergoing chronic hemodialysis by Hainer, James W., Sherrard, Donald J., Swan, Suzanne K., Barrett, Jeffrey S., Assaid, Christopher A., Fossler, Michael J., Cox, Donna S., Williams, Robert M., Pittenger, Amy L., Stephenson, Carol A., Hua, Tsushung A.

“…Background: Patients with end-stage renal disease are subject to a broad range of thrombotic complications. Low molecular weight heparins (LMWHs) are effective…”
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Randomized controlled trial of the CGRP receptor antagonist telcagepant for prevention of headache in women with perimenstrual migraine by Ho, Tony W, Ho, Andrew P, Ge, Yang Joy, Assaid, Christopher, Gottwald, Regina, MacGregor, E Anne, Mannix, Lisa K, van Oosterhout, Willebrordus P J, Koppenhaver, Janelle, Lines, Christopher, Ferrari, Michel D, Michelson, David

“…The aim of this article is to evaluate the safety and efficacy of perimenstrual telcagepant, a CGRP receptor antagonist, for headache prophylaxis. We conducted…”
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A Phase Ib Randomized Controlled Study to Evaluate the Effectiveness of a Single-Dose of the NR2B Selective N-Methyl-D-Aspartate Antagonist MK-0657 on Levodopa-Induced Dyskinesias and Motor Symptoms in Patients With Parkinson Disease by Herring, W Joseph, Assaid, Christopher, Budd, Kerry, Vargo, Ryan, Mazenko, Ralph S, Lines, Christopher, Ellenbogen, Aaron, Verhagen Metman, Leo

“…Blockade of N-methyl-D-aspartate receptors containing the NR2B subunit has been shown to be therapeutic in animal models of Parkinson disease (PD). However,…”
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Automatic bandwidth selection in robust nonparametric regression by Christopher, Assaid A., Jeffrey, Birch B.

“…Nonparametric regression techniques have been studied extensively in the literature in recent years due to their flexibility.In addition robust versions of…”
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Incidence of hypersensitivity and anaphylaxis with sugammadex by Min, K. Chris, Woo, Tiffany, Assaid, Christopher, McCrea, Jacqueline, Gurner, Deborah M., Sisk, Christine McCrary, Adkinson, Franklin, Herring, W. Joseph

“…To evaluate the incidence of hypersensitivity and anaphylaxis after administration of sugammadex. Retrospective analysis. Sugammadex clinical development…”
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Orexin Receptor Antagonism in Painful Diabetic Neuropathy: A Phase 2 Trial With Filorexant by Joseph Herring, W, Ge, Joy Y, Jackson, Saheeda, Assaid, Christopher, Connor, Kathryn M, Michelson, David

“…OBJECTIVES:To evaluate whether orexin receptor antagonism with filorexant provides pain relief in patients with painful diabetic neuropathy (PDN). METHODS:In…”
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Randomized, controlled, proof-of-concept trial of MK-7622 in Alzheimer's disease by Voss, Tiffini, Li, Jerry, Cummings, Jeffrey, Farlow, Martin, Assaid, Christopher, Froman, Samar, Leibensperger, Heather, Snow-Adami, Linda, McMahon, Kerry Budd, Egan, Michael, Michelson, David

“…We evaluated the selective M1 muscarinic positive allosteric modulator, MK-7622, as adjunctive cognitive enhancing therapy in individuals with Alzheimer's…”
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Efficacy and tolerability of rizatriptan in pediatric migraineurs: results from a randomized, double-blind, placebo-controlled trial using a novel adaptive enrichment design by Ho, Tony W, Pearlman, Eric, Lewis, Donald, Hämäläinen, Mirja, Connor, Kathryn, Michelson, David, Zhang, Ying, Assaid, Christopher, Mozley, Lyn Harper, Strickler, Nancy, Bachman, Robert, Mahoney, Erin, Lines, Christopher, Hewitt, David J

“…Treatment options for children and adolescents with migraine are limited. This study evaluated rizatriptan for the acute treatment of migraine in children and…”
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A Randomized, Double-Blind, Study of Rofecoxib in Patients with Mild Cognitive Impairment by THAL, Leon J, FERRIS, Steven H, REINES, Scott A, KIRBY, Louis, BLOCK, Gilbert A, LINES, Christopher R, YUEN, Eric, ASSAID, Christopher, NESSLY, Michael L, NORMAN, Barbara A, BARANAK, Christine C

“…Inflammatory mechanisms have been implicated in Alzheimer's disease (AD) and might be mediated via the COX-2 enzyme. Previous studies with the selective COX-2…”
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