Search Results - "ASPLEY, S"

Oleamide is a selective endogenous agonist of rat and human CB 1 cannabinoid receptors by Leggett, James D, Aspley, S, Beckett, S R G, D'Antona, A M, Kendall, D A

“…The ability of the endogenous fatty acid amide, cis ‐oleamide (ODA), to bind to and activate cannabinoid CB 1 and CB 2 receptors was investigated. ODA…”
Get full text

Randomised, double-blind, placebo-controlled studies on flurbiprofen 8.75 mg lozenges in patients with/without group A or C streptococcal throat infection, with an assessment of clinicians' prediction of 'strep throat' by Shephard, A, Smith, G, Aspley, S, Schachtel, B P

“…Diagnosing group A streptococcus (Strep A) throat infection by clinical examination is difficult, and misdiagnosis may lead to inappropriate antibiotic use…”
Get more information

Differential diagnosis of strep A and C by Shephard, A, Smith, G, Aspley, S, Schachtel, B

Get full text

The qualities of sore throat index (QUASTI): first use in a clinical trial testing the effects of Flurbiprofen 8.75 Mg lozenge on patient-reported qualities of throat pain by Schachtel, B, Aspley, S, Shephard, A, Smith, G, Sanner, K, Savino, L, Schachtel, E, Lorton, M, Shea, T

“…At baseline and hourly for 3 hours post dose, patients used Likert scales to rate throat soreness and 10 other qualities of throat pain: sensory symptoms…”
Get full text

Scintigraphy can be used to compare delivery of sore throat formulations by Limb, M, Connor, A, Pickford, M, Church, A, Mamman, R, Reader, S, Shephard, A, Aspley, S, Goulder, M A

“…Sore throat (pharyngitis) is commonly treated with over-the-counter lozenges, tablets, sprays and gargles. While the efficacy of the active ingredients has…”
Get more information

Effects of lesioning noradrenergic neurones in the locus coeruleus on conditioned and unconditioned aversive behaviour in the rat by Neophytou, Savvas Ioannou, Aspley, Sue, Butler, Sarah, Beckett, Simon, Marsden, Charles Alexander

“…1. The brain noradrenergic system may have a role in anxiety disorder. This study has examined the effect of bilateral 6-hydroxydopamine lesions of the…”
Get full text

Central C-Fos expression following 20kHz/ultrasound induced defence behaviour in the rat by BECKETT, S. R. G, DUXON, M. S, ASPLEY, S, MARSDEN, C. A

“…Exposure of rats to aversive stimuli produces specific defence behaviour including the emission of 20-27kHz ultrasonic calls. Recent studies in this laboratory…”
Get full text

Comparison of the effects of sibutramine and other weight-modifying drugs on extracellular dopamine in the nucleus accumbens of freely moving rats by Rowley, H.L., Butler, S.A., Prow, M.R., Dykes, S.G., Aspley, S., Kilpatrick, I.C., Heal, D.J.

“…The acute effects of systemic administration of the anti‐obesity agent sibutramine on extracellular dopamine (DA) in the nucleus accumbens of freely moving…”
Get full text

Pharmacological manipulation of ultrasound induced defence behaviour in the rat by BECKETT, S. R. G, ASPLEY, S, GRAHAM, M, MARSDEN, C. A

“…Rats exposed to aversive stimuli display species specific defence behaviour as part of their natural survival strategy. one component of this behaviour is the…”
Get full text

A randomised controlled trial of ibuprofen, paracetamol or a combination tablet of ibuprofen/paracetamol in community-derived people with knee pain by Doherty, Michael, Hawkey, Chris, Goulder, Michael, Gibb, Iain, Hill, Nicola, Aspley, Sue, Reader, Sandie

“…To compare the efficacy and safety of single versus combination non-prescription oral analgesics in community-derived people aged 40 years and older with…”
Get more information

Additive effects on rat brain 5HT release of combining phentermine with dexfenfluramine by PROW, M. R, LANCASHIRE, B, ASPLEY, S, HEAL, D. J, KILPATRICK, I. C

“…This study examined the effects of the anti-obesity agents, phentermine and dexfenfluramine given alone or in combination, on in vitro and in vivo 5HT release…”
Get full text

purification and properties of myo-inositol monophosphatase from bovine brain by Gee, N.S, Ragan, C.I, Watling, K.J, Aspley, S, Jackson, R.G, Reid, G.G, Gani, D, Shute, J.K

“…1. An inositol monophosphatase was purified to homogeneity from bovine brain. 2. The enzyme is a dimer of subunit Mr 29,000. 3. The enzyme hydrolyses both…”
Get full text

A randomised, five-parallel-group, placebo-controlled trial comparing the efficacy and tolerability of analgesic combinations including a novel single-tablet combination of ibuprofen/paracetamol for postoperative dental pain by Daniels, Stephen E., Goulder, Michael A., Aspley, Sue, Reader, Sandie

“…Combination analgesia is often recommended for the relief of severe pain. This was a double-blind, 5-arm, parallel-group, placebo-controlled, randomised,…”
Get full text

Chronic, but not acute, dosing of antipsychotic drugs alters neurotensin binding in rat brain regions by Holtom, P E, Needham, P L, Bennett, G W, Aspley, S

“…The present study compared high affinity neurotensin (NT) binding in rat brain following acute or chronic treatment with the classical antipsychotic,…”
Get full text

Implementation of ISO 9002 in cancer care by Aspley, S.J

“…Implementation and maintenance of a quality system in radiotherapy organization is discussed in the context of the Wessex Radiotherapy Centre, Southampton…”
Get full text

Comparison of the analgesic efficacy of concurrent ibuprofen and paracetamol with ibuprofen or paracetamol alone in the management of moderate to severe acute postoperative dental pain in adolescents and adults: A randomized, double-blind, placebo-controlled, parallel-group, single-dose, two-center, modified factorial study by Mehlisch, Donald R., MD, DDS, Aspley, Sue, PhD, Daniels, Stephen E., DO, Bandy, Donald P., DDS

“…Abstract Background: Combination analgesics may offer improved analgesic efficacy, particularly for moderate to severe pain. Objective: This study evaluated…”
Get full text

Oleamide is a selective endogenous agonist of rat and human CB1 cannabinoid receptors by Leggett, James D, Aspley, S, Beckett, S R G, D'Antona, A M, Kendall, D A, Kendall, D A

“…The ability of the endogenous fatty acid amide, cis‐oleamide (ODA), to bind to and activate cannabinoid CB1 and CB2 receptors was investigated. ODA…”
Get full text

The dephosphorylation of inositol 1,4-bisphosphate to inositol in liver and brain involves two distinct Li+-sensitive enzymes and proceeds via inositol 4-phosphate by Ragan, C I, Watling, K J, Gee, N S, Aspley, S, Jackson, R G, Reid, G G, Baker, R, Billington, D C, Barnaby, R J, Leeson, P D

“…1. Hydrolysis of both enantiomers of inositol 1-phosphate and both enantiomers of inositol 4-phosphate to inositol is inhibited by LiCl in liver and brain. 2…”
Get full text

Sibutramine: a novel anti-obesity drug. A review of the pharmacological evidence to differentiate it from d-amphetamine and d-fenfluramine by Heal, D J, Aspley, S, Prow, M R, Jackson, H C, Martin, K F, Cheetham, S C

“…Sibutramine (BTS 54 524; N-[1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl]-N,N-dimethylamine hydrochloride monohydrate) is a novel 5-HT (serotonin) and…”
Get more information

Effects on serotonin in rat hypothalamus of d-fenfluramine, aminorex, phentermine and fluoxetine by Tao, Rui, Fray, Anne, Aspley, Sue, Brammer, Richard, Heal, David, Auerbach, Sidney

“…Hypothalamic 5-HT (serotonin) regulates food intake, energy expenditure and bodyweight. Using in vivo microdialysis, we determined the effects of various…”
Get full text