Search Results - "ASPINALL, RICHARD"

Transjugular intrahepatic portosystemic stent-shunt in the management of portal hypertension by Tripathi, Dhiraj, Stanley, Adrian J, Hayes, Peter C, Travis, Simon, Armstrong, Matthew J, Tsochatzis, Emmanuel A, Rowe, Ian A, Roslund, Nicholas, Ireland, Hamish, Lomax, Mandy, Leithead, Joanne A, Mehrzad, Homoyon, Aspinall, Richard J, McDonagh, Joanne, Patch, David

“…These guidelines on transjugular intrahepatic portosystemic stent-shunt (TIPSS) in the management of portal hypertension have been commissioned by the Clinical…”
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Addressing liver disease in the UK: a blueprint for attaining excellence in health care and reducing premature mortality from lifestyle issues of excess consumption of alcohol, obesity, and viral hepatitis by Williams, Roger, Prof, Aspinall, Richard, MBChB, Bellis, Mark, Prof, Camps-Walsh, Ginette, DMS, Cramp, Matthew, Prof, Dhawan, Anil, Prof, Ferguson, James, MD, Forton, Dan, PhD, Foster, Graham, Prof, Gilmore, Sir Ian, Prof, Hickman, Matthew, Prof, Hudson, Mark, FRCP, Kelly, Deirdre, Prof, Langford, Andrew, PhD, Lombard, Martin, Prof, Longworth, Louise, PhD, Martin, Natasha, DPhil, Moriarty, Kieran, FRCP, Newsome, Philip, Prof, O'Grady, John, Prof, Pryke, Rachel, MRCGP, Rutter, Harry, MB BChir, Ryder, Stephen, FRcP, Sheron, Nick, Prof, Smith, Tom, PhD

“…Liver disease in the UK stands out as the one glaring exception to the vast improvements made during the past 30 years in health and life expectancy for…”
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A randomised placebo controlled trial of VSL#3 ® probiotic on biomarkers of cardiovascular risk and liver injury in non-alcoholic fatty liver disease by Chong, Pui Lin, Laight, David, Aspinall, Richard J, Higginson, Antony, Cummings, Michael H

“…Non-alcoholic fatty liver disease (NAFLD) is associated with increased cardiovascular risk irrespective of conventional risk factors. The role of gut-liver…”
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Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated by Atallah, Edmond, Grove, Jane I., Crooks, Colin, Burden-Teh, Esther, Abhishek, Abhishek, Moreea, Sulleman, Jordan, Kelsey M., Ala, Aftab, Hutchinson, David, Aspinall, Richard J., Murphy, Ruth, Aithal, Guruprasad P.

“…The risk of significant liver fibrosis from prolonged methotrexate (MTX) exposure has been estimated at around 5%, prompting intensive monitoring strategies…”
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Vitamin D Status and the Host Resistance to Infections: What It Is Currently (Not) Understood by Lang, Pierre Olivier, MD, MPH, PhD, Aspinall, Richard, DSc, FRCP (Edin), FRCPath

“…Abstract Purpose Vitamin D is increasingly thought to play a role in regulating immunity. This comprehensive review updates the current understanding regarding…”
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Interventions to restore appropriate immune function in the elderly by Aspinall, Richard, Lang, Pierre Olivier

“…Advanced age is one indicator of likely immune dysfunction. As worldwide, the global population contains progressively more and more older individuals there is…”
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Universal screening for alcohol misuse in acute medical admissions is feasible and identifies patients at high risk of liver disease by Westwood, Greta, Meredith, Paul, Atkins, Susan, Greengross, Peter, Schmidt, Paul E., Aspinall, Richard J.

“…[Display omitted] •There is an unmet need to identify patients with alcohol related liver disease at an earlier stage.•Our analysis of over 50,000 medical…”
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Primary biliary cholangitis: advances in understanding and management by Smith, Alex, Giles, Benjamin, Aspinall, Richard J

“…Recent years have seen major advances in our understanding of primary biliary cholangitis, with the condition now renamed to reflect the majority of patients…”
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Efficacy and Safety of Sofosbuvir/Velpatasvir in Patients With Chronic Hepatitis C Virus Infection Receiving Opioid Substitution Therapy: Analysis of Phase 3 ASTRAL Trials by Grebely, Jason, Dore, Gregory J., Zeuzem, Stefan, Aspinall, Richard J., Fox, Raymond, Han, Lingling, McNally, John, Osinusi, Anu, Brainard, Diana M., Subramanian, G. Mani, Natha, Macky, Foster, Graham R., Mangia, Alessandra, Sulkowski, Mark, Feld, Jordan J.

“…In this analysis of the ASTRAL trials (non-opioid substitution therapy [OST], n = 984; OST, n = 51) evaluating the once-daily, pan-genotypic regimen of…”
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Implementation of the Lancet Standing Commission on Liver Disease in the UK by Williams, Roger, Prof, Ashton, Kathryn, MSc, Aspinall, Richard, MBChB, Bellis, Mark A, Prof, Bosanquet, Joanne, MSc, Cramp, Matthew E, Prof, Day, Natalie, MA, Dhawan, Anil, Prof, Dillon, John, Prof, Dyson, Jessica, MBBS, Ferguson, James, MD, Foster, Graham, Prof, Gilmore, Sir Ian, Prof, Glynn, Michael, FRCP, Guthrie, J Ashley, FRCR, Hudson, Mark, FRCP, Kelly, Deirdre, Prof, Langford, Andrew, PhD, Newsome, Philip, Prof, O'Grady, John, Prof, Pryke, Rachel, MRCGP, Ryder, Stephen, FRcP, Samyn, Marianne, MD, Sheron, Nick, Prof, Verne, Julia, Prof

“…Obesity-related liver disease and prevalence of primary hepatocellular carcinoma (HCC) are both increasing, with ever increasing costs to the National Health…”
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A phase II, randomized, open-label, 52-week study of seladelpar in patients with primary biliary cholangitis by Bowlus, Christopher L, Galambos, Michael R, Aspinall, Richard J, Hirschfield, Gideon M, Jones, David E J, Dörffel, Yvonne, Gordon, Stuart C, Harrison, Stephen A, Kremer, Andreas E, Mayo, Marlyn J, Thuluvath, Paul J, Levy, Cynthia, Swain, Mark G, Neff, Guy W, Sheridan, David A, Stanca, Carmen M, Berg, Christoph P, Goel, Aparna, Shiffman, Mitchell L, Vierling, John M, Boudes, Pol, Steinberg, Alexandra, Choi, Yun-Jung, McWherter, Charles A

“…We examined the efficacy and safety of seladelpar, a selective peroxisome proliferator-activated receptor-delta agonist, in adults with primary biliary…”
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Vaccination choices for older people, looking beyond age specific approaches by Aspinall, Richard, Lang, Pierre Olivier

“…To improve the ability of vaccines to protect older individuals we can no longer consider those over 65 years of age to be an homogenous population termed the…”
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Incorporating spatial dependence in predictive vegetation models by Miller, Jennifer, Franklin, Janet, Aspinall, Richard

“…Predictive vegetation modeling (PVM), is defined as predicting the distribution of vegetation across a landscape based on the relationship between the spatial…”
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Liver fibrosis for the dermatologist: a review by Raahimi, Mina M, Livesey, Amy, Hamilton, Jessica, Shipman, Alexa R, Aspinall, Richard J

“…Methotrexate-induced liver fibrosis is not a well-defined pathology, and many of the reported cases can instead be classified as nonalcoholic fatty liver…”
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Reducing recurrent hospital admissions in patients with decompensated cirrhosis by Aspinall, Richard J

“…Recurrent admissions to hospital are a major issue for people living with decompensated cirrhosis, particularly those who develop chronic hepatic…”
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A Conceptual Model for Land System Dynamics as a Coupled Human–Environment System by Aspinall, Richard, Staiano, Michele

“…This paper presents a conceptual model of land as a coupled human–environment system. Land use and land cover are incorporated as elements of the human and…”
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Can we translate vitamin D immunomodulating effect on innate and adaptive immunity to vaccine response? by Lang, Pierre Olivier, Aspinall, Richard

“…Vitamin D (VitD), which is well known for its classic role in the maintenance of bone mineral density, has now become increasingly studied for its…”
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Functional characteristics of macrophages in patients with acute liver failure by Aspinall, Richard J.

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Open‐label, clinical trial extension: Two‐year safety and efficacy results of seladelpar in patients with primary biliary cholangitis by Mayo, Marlyn J., Vierling, John M., Bowlus, Christopher L., Levy, Cynthia, Hirschfield, Gideon M., Neff, Guy W., Galambos, Michael R., Gordon, Stuart C., Borg, Brian B., Harrison, Stephen A., Thuluvath, Paul J., Goel, Aparna, Shiffman, Mitchell L., Swain, Mark G., Jones, David E. J., Trivedi, Palak, Kremer, Andreas E., Aspinall, Richard J., Sheridan, David A., Dörffel, Yvonne, Yang, Ke, Choi, Yun‐Jung, McWherter, Charles A.

“…Summary Background Seladelpar is a potent and selective peroxisome proliferator‐activated receptor‐δ agonist that targets multiple cell types involved in…”
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Prevalence and clinical significance of relative adrenal insufficiency in decompensated cirrhosis by Levick, Christina, Aspinall, Richard J

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