Search Results - "ASKOXYLAKIS, Vasileios"

Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival by Kloepper, Jonas, Riedemann, Lars, Amoozgar, Zohreh, Seano, Giorgio, Susek, Katharina, Yu, Veronica, Dalvie, Nisha, Amelung, Robin L., Datta, Meenal, Song, Jonathan W., Askoxylakis, Vasileios, Taylor, Jennie W., Lu-Emerson, Christine, Batista, Ana, Kirkpatrick, Nathaniel D., Jung, Keehoon, Snuderl, Matija, Muzikansky, Alona, Stubenrauch, Kay G., Krieter, Oliver, Wakimoto, Hiroaki, Xu, Lei, Munn, Lance L., Duda, Dan G., Fukumura, Dai, Batchelor, Tracy T., Jain, Rakesh K.

“…Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve overall survival of patients with glioblastoma (GBM). We previously…”
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Emerging Strategies for Treating Brain Metastases from Breast Cancer by Kodack, David P., Askoxylakis, Vasileios, Ferraro, Gino B., Fukumura, Dai, Jain, Rakesh K.

“…Brain metastasis is an end stage in breast cancer progression. Traditional treatment options have minimal efficacy, and overall survival is on the order of…”
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Long-term survival of cancer patients compared to heart failure and stroke: a systematic review by Askoxylakis, Vasileios, Thieke, Christian, Pleger, Sven T, Most, Patrick, Tanner, Judith, Lindel, Katja, Katus, Hugo A, Debus, Jürgen, Bischof, Marc

“…Cancer, heart failure and stroke are among the most common causes of death worldwide. Investigation of the prognostic impact of each disease is important,…”
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Blockade of MMP14 activity in murine breast carcinomas: implications for macrophages, vessels, and radiotherapy by Ager, Eleanor I, Kozin, Sergey V, Kirkpatrick, Nathaniel D, Seano, Giorgio, Kodack, David P, Askoxylakis, Vasileios, Huang, Yuhui, Goel, Shom, Snuderl, Matija, Muzikansky, Alona, Finkelstein, Dianne M, Dransfield, Daniel T, Devy, Laetitia, Boucher, Yves, Fukumura, Dai, Jain, Rakesh K

“…Matrix metalloproteinase (MMP) 14 may mediate tumor progression through vascular and immune-modulatory effects. Orthotopic murine breast tumors (4T1 and E0771…”
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Dual Inhibition of IGF-1R and ErbB3 Enhances the Activity of Gemcitabine and Nab-Paclitaxel in Preclinical Models of Pancreatic Cancer by Camblin, Adam J, Pace, Emily A, Adams, Sharlene, Curley, Michael D, Rimkunas, Victoria, Nie, Lin, Tan, Gege, Bloom, Troy, Iadevaia, Sergio, Baum, Jason, Minx, Charlene, Czibere, Akos, Louis, Chrystal U, Drummond, Daryl C, Nielsen, Ulrik B, Schoeberl, Birgit, Pipas, J Marc, Straubinger, Robert M, Askoxylakis, Vasileios, Lugovskoy, Alexey A

“…Insulin-like growth factor receptor 1 (IGF-1R) is critically involved in pancreatic cancer pathophysiology, promoting cancer cell survival and therapeutic…”
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Solid stress in brain tumours causes neuronal loss and neurological dysfunction and can be reversed by lithium by Seano, Giorgio, Nia, Hadi T., Emblem, Kyrre E., Datta, Meenal, Ren, Jun, Krishnan, Shanmugarajan, Kloepper, Jonas, Pinho, Marco C., Ho, William W., Ghosh, Mitrajit, Askoxylakis, Vasileios, Ferraro, Gino B., Riedemann, Lars, Gerstner, Elizabeth R., Batchelor, Tracy T., Wen, Patrick Y., Lin, Nancy U., Grodzinsky, Alan J., Fukumura, Dai, Huang, Peigen, Baish, James W., Padera, Timothy P., Munn, Lance L., Jain, Rakesh K.

“…The compression of brain tissue by a tumour mass is believed to be a major cause of the clinical symptoms seen in patients with brain cancer. However, the…”
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Synergy between EphA2-ILs-DTXp, a Novel EphA2-Targeted Nanoliposomal Taxane, and PD-1 Inhibitors in Preclinical Tumor Models by Kamoun, Walid S, Dugast, Anne-Sophie, Suchy, James J, Grabow, Stephanie, Fulton, Ross B, Sampson, James F, Luus, Lia, Santiago, Michael, Koshkaryev, Alexander, Sun, Gang, Askoxylakis, Vasileios, Tam, Eric, Huang, Zhaohua Richard, Drummond, Daryl C, Sawyer, Andrew J

“…Combinations of chemotherapy with immunotherapy have seen recent clinical success, including two approvals of anti-PD-1/L1 agents in combination with…”
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Intensity modulated radiation therapy (IMRT) for sinonasal tumors: a single center long-term clinical analysis by Askoxylakis, Vasileios, Hegenbarth, Pia, Timke, Carmen, Saleh-Ebrahimi, Ladan, Debus, Juergen, Röder, Falk, Huber, Peter E

“…Radiotherapy has a central role in the treatment of sinonasal malignancies, either as postoperative or as primary therapy. To study the efficacy and safety of…”
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Combination of Phage Display and Molecular Grafting Generates Highly Specific Tumor-Targeting Miniproteins by Zoller, Frederic, Markert, Annette, Barthe, Philippe, Zhao, Wenye, Weichert, Wilko, Askoxylakis, Vasileios, Altmann, Annette, Mier, Walter, Haberkorn, Uwe

“…Frankenstein′s peptide: The grafting of the binding domain from miniprotein Min‐23 into the sunflower trypsin inhibitor (SFTI‐I) peptide scaffold (see scheme)…”
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Closing the gap： astrocytes and brain metastasis by Ferraro, Gino B, Kodack, David P, Askoxylakis, Vasileios, Jain, Rakesh K

“…Astrocytes are emerging as essential regulators of brain metastasis progression. In a current issue of Nature, Chen et al. identify a novel mechanism of…”
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The stability of osseous metastases of the spine in lung cancer--a retrospective analysis of 338 cases by Rief, Harald, Bischof, Marc, Bruckner, Thomas, Welzel, Thomas, Askoxylakis, Vasileios, Rieken, Stefan, Lindel, Katja, Combs, Stephanie, Debus, Jürgen

“…The objective of this retrospective analysis is to systematically assess osseous lesions on the basis of a validated scoring system in terms of stability and…”
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Peptide-Based Targeting of the Platelet-Derived Growth Factor Receptor Beta by Askoxylakis, Vasileios, Marr, Annabell, Altmann, Annette, Markert, Annette, Mier, Walter, Debus, Jürgen, Huber, Peter E., Haberkorn, Uwe

“…Purpose The aim of this work is to identify new ligands targeting the platelet-derived growth factor receptor beta (PDGFRβ). Procedures Biopanning was carried…”
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Targeting EphA2 in Bladder Cancer Using a Novel Antibody-Directed Nanotherapeutic by Kamoun, Walid, Swindell, Elden, Pien, Christine, Luus, Lia, Cain, Jason, Pham, Minh, Kandela, Irawati, Huang, Zhaohua Richard, Tipparaju, Suresh K., Koshkaryev, Alexander, Askoxylakis, Vasileios, Kirpotin, Dmitri B., Bloom, Troy, Mino-Kenudson, Mari, Marks, James D., Zalutskaya, Alena, Bshara, Wiam, Morrison, Carl, Drummond, Daryl C.

“…Ephrin receptor A2 (EphA2) is a member of the Ephrin/Eph receptor cell-to-cell signaling family of molecules, and it plays a key role in cell proliferation,…”
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Optimization of a novel peptide ligand targeting human carbonic anhydrase IX by Rana, Shoaib, Nissen, Felix, Marr, Annabell, Markert, Annette, Altmann, Annette, Mier, Walter, Debus, Juergen, Haberkorn, Uwe, Askoxylakis, Vasileios

“…Carbonic anhydrase IX (CA IX) is a hypoxia-regulated transmembrane protein over-expressed in various types of human cancer. Recently, a new peptide with…”
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A new peptide ligand for targeting human carbonic anhydrase IX, identified through the phage display technology by Askoxylakis, Vasileios, Garcia-Boy, Regine, Rana, Shoaib, Krämer, Susanne, Hebling, Ulrike, Mier, Walter, Altmann, Annette, Markert, Annette, Debus, Jürgen, Haberkorn, Uwe

“…Carbonic anhydrase IX (CAIX) is a transmembrane enzyme found to be overexpressed in various tumors and associated with tumor hypoxia. Ligands binding this…”
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Dual endothelin receptor inhibition enhances T-DM1 efficacy in brain metastases from HER2-positive breast cancer by Askoxylakis, Vasileios, Ferraro, Gino B., Badeaux, Mark, Kodack, David P., Kirst, Isabelle, Shankaraiah, Ram C., Wong, Christina S. F., Duda, Dan G., Fukumura, Dai, Jain, Rakesh K.

“…The effective treatment of cerebral metastases from HER2-positive breast cancer remains an unmet need. Recent studies indicate that activated astrocytes and…”
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Screening of a Novel Peptide Targeting the Proteoglycan-Like Region of Human Carbonic Anhydrase IX by Rana, Shoaib, Nissen, Felix, Lindner, Thomas, Altmann, Annette, Mier, Walter, Debus, Juergen, Haberkorn, Uwe, Askoxylakis, Vasileios

“…The extracellular domain of human carbonic anhydrase IX (CA IX) is extended by a proteoglycan-like region (PGLR). The aim of the present study was the…”
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A New Prostate Carcinoma Binding Peptide (DUP-1) for Tumor Imaging and Therapy by ZITZMANN, Sabine, MIER, Walter, SCHAD, Arno, KINSCHERF, Ralf, ASKOXYLAKIS, Vasileios, KRÄMER, Susanne, ALTMANN, Annette, EISENHUT, Michael, HABERKORN, Uwe

“…Purpose: Prostate carcinomas belong to the most widespread tumors, and their number is increasing. Imaging modalities used for diagnosis, such as ultrasound,…”
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Simultaneous integrated boost for adjuvant treatment of breast cancer--intensity modulated vs. conventional radiotherapy: the IMRT-MC2 trial by Askoxylakis, Vasileios, Jensen, Alexandra D, Häfner, Matthias F, Fetzner, Leonie, Sterzing, Florian, Heil, Joerg, Sohn, Christof, Hüsing, Johannes, Tiefenbacher, Uta, Wenz, Frederik, Debus, Jürgen, Hof, Holger

“…Radiation therapy is an essential modality in the treatment of breast cancer. Addition of radiotherapy to surgery has significantly increased local control and…”
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Multimodal hypoxia imaging and intensity modulated radiation therapy for unresectable non-small-cell lung cancer: the HIL trial by Askoxylakis, Vasileios, Dinkel, Julien, Eichinger, Monika, Stieltjes, Bram, Sommer, Gregor, Strauss, Ludwig G, Dimitrakopoulou-Strauss, Antonia, Kopp-Schneider, Annette, Haberkorn, Uwe, Huber, Peter E, Bischof, Marc, Debus, Jürgen, Thieke, Christian

“…Radiotherapy, preferably combined with chemotherapy, is the treatment standard for locally advanced, unresectable non-small cell lung cancer (NSCLC). The tumor…”
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