Search Results - "ASHOT KOZAK, J"

Use of tetraethylammonium (TEA) and Tris loading for blocking TRPM7 channels in intact cells by Holderby, Katherine G, Kozak, J Ashot

“…Tetraethylammonium (TEA), a quaternary ammonium compound, is a well-known blocker of potassium channels belonging to various subfamilies, such as K 1-3, K 1, 2…”
Get full text

Phagocytic activity of splenic macrophages is enhanced and accompanied by cytosolic alkalinization in TRPM7 kinase‐dead mice by Beesetty, Pavani, Rockwood, Jananie, Kaitsuka, Taku, Zhelay, Tetyana, Hourani, Siham, Matsushita, Masayuki, Kozak, J. Ashot

“…Transient receptor potential melastatin 7 (TRPM7) is a unique protein functioning as a cation channel as well as a serine/threonine kinase and is highly…”
Get full text

STIM1 is a Ca2+ sensor that activates CRAC channels and migrates from the Ca2+ store to the plasma membrane by ZHANG, Shenyuan L, YING YU, ROOS, Jack, ASHOT KOZAK, J, DEERINCK, Thomas J, ELLISMAN, Mark H, STAUDERMAN, Kenneth A, CAHALAN, Michael D

“…As the sole Ca2+ entry mechanism in a variety of non-excitable cells, store-operated calcium (SOC) influx is important in Ca2+ signalling and many other…”
Get full text

Depletion of plasma membrane–associated phosphoinositides mimics inhibition of TRPM7 channels by cytosolic Mg2+, spermine, and pH by Zhelay, Tetyana, Wieczerzak, Krystyna B., Beesetty, Pavani, Alter, Gerald M., Matsushita, Masayuki, Kozak, J. Ashot

“…Transient receptor potential cation channel subfamily M member 7 (TRPM7) is an ion channel/protein kinase belonging to the TRP melastatin and eEF2 kinase…”
Get full text

NSAIDs Naproxen, Ibuprofen, Salicylate, and Aspirin Inhibit TRPM7 Channels by Cytosolic Acidification by Chokshi, Rikki, Bennett, Orville, Zhelay, Tetyana, Kozak, J Ashot

“…Non-steroidal anti-inflammatory drugs (NSAIDs) are used for relieving pain and inflammation accompanying numerous disease states. The primary therapeutic…”
Get full text

Correction to: TRPM7 channel activity in Jurkat T lymphocytes during magnesium depletion and loading: implications for divalent metal entry and cytotoxicity by Mellott, Alayna, Rockwood, Jananie, Zhelay, Tetyana, Luu, Charles Tuan, Kaitsuka, Taku, Kozak, J. Ashot

“…The original article was published with an error. In Figure 9b there are 3 typographical errors: instead of the Greek mu letter it shows the unconverted data…”
Get full text

Detailed examination of Mg2+ and pH sensitivity of human TRPM7 channels by Chokshi, Rikki, Matsushita, Masayuki, Kozak, J Ashot

“…TRPM7 channel kinase is a protein highly expressed in cells of hematopoietic lineage, such as lymphocytes. Studies performed in native and heterologous…”
Get more information

STIM1, an essential and conserved component of store-operated Ca²⁺ channel function by Roos, Jack, DiGregorio, Paul J, Yeromin, Andriy V, Ohlsen, Kari, Lioudyno, Maria, Zhang, Shenyuan, Safrina, Olga, Kozak, J. Ashot, Wagner, Steven L, Cahalan, Michael D, Veliçelebi, Gönůl, Stauderman, Kenneth A

“…Store-operated Ca²⁺ (SOC) channels regulate many cellular processes, but the underlying molecular components are not well defined. Using an RNA interference…”
Get full text

Orai1 and STIM1 move to the immunological synapse and are up-regulated during T cell activation by Lioudyno, Maria I, Kozak, J. Ashot, Penna, Aubin, Safrina, Olga, Zhang, Shenyuan L, Sen, Debasish, Roos, Jack, Stauderman, Kenneth A, Cahalan, Michael D

“…For efficient development of an immune response, T lymphocytes require long-lasting calcium influx through calcium release-activated calcium (CRAC) channels…”
Get full text

2-Aminoethyl diphenyl borinate (2-APB) inhibits TRPM7 channels through an intracellular acidification mechanism by Chokshi, Rikki, Fruasaha, Petronilla, Kozak, J Ashot

“…2-APB is a widely used compound in ion channel research. It affects numerous channels including inositol 1,4,5-trisphosphate receptors, store-operated calcium…”
Get full text

Store-dependent and -independent Modes Regulating Ca2+ Release-activated Ca2+ Channel Activity of Human Orai1 and Orai3 by Zhang, Shenyuan L., Kozak, J. Ashot, Jiang, Weihua, Yeromin, Andriy V., Chen, Jing, Yu, Ying, Penna, Aubin, Shen, Wei, Chi, Victor, Cahalan, Michael D.

“…We evaluated currents induced by expression of human homologs of Orai together with STIM1 in human embryonic kidney cells. When co-expressed with STIM1, Orai1…”
Get full text

Soluble amyloid oligomers increase bilayer conductance by altering dielectric structure by Sokolov, Yuri, Kozak, J Ashot, Kayed, Rakez, Chanturiya, Alexandr, Glabe, Charles, Hall, James E

“…The amyloid hypothesis of Alzheimer's toxicity has undergone a resurgence with increasing evidence that it is not amyloid fibrils but a smaller oligomeric…”
Get full text

The neuronal K+Cl− co-transporter 2 (Slc12a5) modulates insulin secretion by Kursan, Shams, McMillen, Timothy S., Beesetty, Pavani, Dias-Junior, Eduardo, Almutairi, Mohammed M., Sajib, Abu A., Kozak, J. Ashot, Aguilar-Bryan, Lydia, Di Fulvio, Mauricio

“…Intracellular chloride concentration ([Cl − ] i ) in pancreatic β-cells is kept above electrochemical equilibrium due to the predominant functional presence of…”
Get full text

Channel Function Is Dissociated from the Intrinsic Kinase Activity and Autophosphorylation of TRPM7/ChaK1 by Matsushita, Masayuki, Kozak, J. Ashot, Shimizu, Yoshio, McLachlin, Derek T., Yamaguchi, Hiroto, Wei, Fan-Yan, Tomizawa, Kazuhito, Matsui, Hideki, Chait, Brian T., Cahalan, Michael D., Nairn, Angus C.

“…TRPM7/ChaK1 is a unique channel/kinase that contains a TRPM channel domain with 6 transmembrane segments fused to a novel serine-threonine kinase domain at its…”
Get full text

Distinct properties of CRAC and MIC channels in RBL cells by Kozak, J Ashot, Kerschbaum, Hubert H, Cahalan, Michael D

“…In rat basophilic leukemia (RBL) cells and Jurkat T cells, Ca(2+) release-activated Ca(2+) (CRAC) channels open in response to passive Ca(2+) store depletion…”
Get full text

MIC Channels Are Inhibited by Internal Divalent Cations but Not ATP by Kozak, J. Ashot, Cahalan, Michael D.

“…TRPM7 channels are nonselective cation channels that possess a functional α-kinase domain. It has been proposed that heterologously expressed TRPM7 channels…”
Get full text

Charge screening by internal pH and polyvalent cations as a mechanism for activation, inhibition, and rundown of TRPM7/MIC channels by Kozak, J Ashot, Matsushita, Masayuki, Nairn, Angus C, Cahalan, Michael D

“…The Mg2+-inhibited cation (MIC) current, believed to represent activity of TRPM7 channels, is found in lymphocytes and mast cells, cardiac and smooth muscle,…”
Get full text

Effect of synthetic aβ peptide oligomers and fluorinated solvents on Kv1.3 channel properties and membrane conductance by Lioudyno, Maria I, Broccio, Matteo, Sokolov, Yuri, Rasool, Suhail, Wu, Jessica, Alkire, Michael T, Liu, Virginia, Kozak, J Ashot, Dennison, Philip R, Glabe, Charles G, Lösche, Mathias, Hall, James E

“…The impact of synthetic amyloid β (1-42) (Aβ(1-42)) oligomers on biophysical properties of voltage-gated potassium channels Kv 1.3 and lipid bilayer membranes…”
Get full text

Polyvalent Cations as Permeant Probes of MIC and TRPM7 Pores by Kerschbaum, Hubert H., Kozak, J. Ashot, Cahalan, Michael D.

“…Recent studies in Jurkat T cells and in rat basophilic leukemia cells revealed an Mg 2+-inhibited cation (MIC) channel that has electrophysiological properties…”
Get full text

Suppression of Store-operated Calcium Entry Channels and Cytokine Release by Cannabinoids by Kozak, J Ashot

Get full text