Search Results - "ASHLEY, Euan"

Towards precision medicine by Ashley, Euan A.

“…Key Points Precision medicine describes the definition of disease at a higher resolution by genomic and other technologies to enable more precise targeting of…”
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The Precision Medicine Initiative: A New National Effort by Ashley, Euan A

“…Ashley talks about the precision medicine initiative. He also discusses the treatment of cystic fibrosis with ivacaftor, an example of precision medicine…”
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Cardiovascular disease: The rise of the genetic risk score by Knowles, Joshua W, Ashley, Euan A

“…In a Perspective, Joshua Knowles and Euan Ashley discuss the potential for use of genetic risk scores in clinical practice…”
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Artificial Intelligence in Molecular Medicine by Gomes, Bruna, Ashley, Euan A.

“…Machine-learning methods for analyzing genomic, transcriptomic, epigenomic, proteomic, and metabolomic data sets have yielded clinically directive information,…”
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Deep Learning Automates the Quantitative Analysis of Individual Cells in Live-Cell Imaging Experiments by Van Valen, David A, Kudo, Takamasa, Lane, Keara M, Macklin, Derek N, Quach, Nicolas T, DeFelice, Mialy M, Maayan, Inbal, Tanouchi, Yu, Ashley, Euan A, Covert, Markus W

“…Live-cell imaging has opened an exciting window into the role cellular heterogeneity plays in dynamic, living systems. A major critical challenge for this…”
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A guide for the diagnosis of rare and undiagnosed disease: beyond the exome by Marwaha, Shruti, Knowles, Joshua W, Ashley, Euan A

“…Rare diseases affect 30 million people in the USA and more than 300-400 million worldwide, often causing chronic illness, disability, and premature death…”
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Polygenic Risk Scores for Cardiovascular Disease: A Scientific Statement From the American Heart Association by O’Sullivan, Jack W., Raghavan, Sridharan, Marquez-Luna, Carla, Luzum, Jasmine A., Damrauer, Scott M., Ashley, Euan A., O’Donnell, Christopher J., Willer, Cristen J., Natarajan, Pradeep

“…Cardiovascular disease is the leading contributor to years lost due to disability or premature death among adults. Current efforts focus on risk prediction and…”
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Video-based AI for beat-to-beat assessment of cardiac function by Ouyang, David, He, Bryan, Ghorbani, Amirata, Yuan, Neal, Ebinger, Joseph, Langlotz, Curtis P., Heidenreich, Paul A., Harrington, Robert A., Liang, David H., Ashley, Euan A., Zou, James Y.

“…Accurate assessment of cardiac function is crucial for the diagnosis of cardiovascular disease 1 , screening for cardiotoxicity 2 and decisions regarding the…”
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Accuracy in Wrist-Worn, Sensor-Based Measurements of Heart Rate and Energy Expenditure in a Diverse Cohort by Shcherbina, Anna, Mattsson, C Mikael, Waggott, Daryl, Salisbury, Heidi, Christle, Jeffrey W, Hastie, Trevor, Wheeler, Matthew T, Ashley, Euan A

“…The ability to measure physical activity through wrist-worn devices provides an opportunity for cardiovascular medicine. However, the accuracy of commercial…”
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Towards precision medicine in heart failure by Weldy, Chad S., Ashley, Euan A.

“…The number of therapies for heart failure (HF) with reduced ejection fraction has nearly doubled in the past decade. In addition, new therapies for HF caused…”
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The genetics of human performance by Kim, Daniel Seung, Wheeler, Matthew T., Ashley, Euan A.

“…Human physiology is likely to have been selected for endurance physical activity. However, modern humans have become largely sedentary, with physical activity…”
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Informed Consent by Grady, Christine, Cummings, Steven R, Rowbotham, Michael C, McConnell, Michael V, Ashley, Euan A, Kang, Gagandeep

“…An investigator obtaining informed consent traditionally asks participants to sign a written consent document — an approach that is becoming outdated. This…”
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Multi-task deep learning for cardiac rhythm detection in wearable devices by Torres-Soto, Jessica, Ashley, Euan A.

“…Wearable devices enable theoretically continuous, longitudinal monitoring of physiological measurements such as step count, energy expenditure, and heart rate…”
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Abnormal Calcium Handling Properties Underlie Familial Hypertrophic Cardiomyopathy Pathology in Patient-Specific Induced Pluripotent Stem Cells by Lan, Feng, Lee, Andrew S., Liang, Ping, Sanchez-Freire, Veronica, Nguyen, Patricia K., Wang, Li, Han, Leng, Yen, Michelle, Wang, Yongming, Sun, Ning, Abilez, Oscar J., Hu, Shijun, Ebert, Antje D., Navarrete, Enrique G., Simmons, Chelsey S., Wheeler, Matthew, Pruitt, Beth, Lewis, Richard, Yamaguchi, Yoshinori, Ashley, Euan A., Bers, Donald M., Robbins, Robert C., Longaker, Michael T., Wu, Joseph C.

“…Familial hypertrophic cardiomyopathy (HCM) is a prevalent hereditary cardiac disorder linked to arrhythmia and sudden cardiac death. While the causes of HCM…”
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Deep learning interpretation of echocardiograms by Ghorbani, Amirata, Ouyang, David, Abid, Abubakar, He, Bryan, Chen, Jonathan H., Harrington, Robert A., Liang, David H., Ashley, Euan A., Zou, James Y.

“…Echocardiography uses ultrasound technology to capture high temporal and spatial resolution images of the heart and surrounding structures, and is the most…”
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Genotype and Lifetime Burden of Disease in Hypertrophic Cardiomyopathy: Insights From the Sarcomeric Human Cardiomyopathy Registry (SHaRe) by Ho, Carolyn Y, Day, Sharlene M, Ashley, Euan A, Michels, Michelle, Pereira, Alexandre C, Jacoby, Daniel, Cirino, Allison L, Fox, Jonathan C, Lakdawala, Neal K, Ware, James S, Caleshu, Colleen A, Helms, Adam S, Colan, Steven D, Girolami, Francesca, Cecchi, Franco, Seidman, Christine E, Sajeev, Gautam, Signorovitch, James, Green, Eric M, Olivotto, Iacopo

“…BACKGROUND:A better understanding of the factors that contribute to heterogeneous outcomes and lifetime disease burden in hypertrophic cardiomyopathy (HCM) is…”
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De Novo and Rare Variants at Multiple Loci Support the Oligogenic Origins of Atrioventricular Septal Heart Defects by Priest, James R, Osoegawa, Kazutoyo, Mohammed, Nebil, Nanda, Vivek, Kundu, Ramendra, Schultz, Kathleen, Lammer, Edward J, Girirajan, Santhosh, Scheetz, Todd, Waggott, Daryl, Haddad, Francois, Reddy, Sushma, Bernstein, Daniel, Burns, Trudy, Steimle, Jeffrey D, Yang, Xinan H, Moskowitz, Ivan P, Hurles, Matthew, Lifton, Richard P, Nickerson, Debbie, Bamshad, Michael, Eichler, Evan E, Mital, Seema, Sheffield, Val, Quertermous, Thomas, Gelb, Bruce D, Portman, Michael, Ashley, Euan A

“…Congenital heart disease (CHD) has a complex genetic etiology, and recent studies suggest that high penetrance de novo mutations may account for only a small…”
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Molecular Choreography of Acute Exercise by Contrepois, Kévin, Wu, Si, Moneghetti, Kegan J., Hornburg, Daniel, Ahadi, Sara, Tsai, Ming-Shian, Metwally, Ahmed A., Wei, Eric, Lee-McMullen, Brittany, Quijada, Jeniffer V., Chen, Songjie, Christle, Jeffrey W., Ellenberger, Mathew, Balliu, Brunilda, Taylor, Shalina, Durrant, Matthew G., Knowles, David A., Choudhry, Hani, Ashland, Melanie, Bahmani, Amir, Enslen, Brooke, Amsallem, Myriam, Kobayashi, Yukari, Avina, Monika, Perelman, Dalia, Schüssler-Fiorenza Rose, Sophia Miryam, Zhou, Wenyu, Ashley, Euan A., Montgomery, Stephen B., Chaib, Hassan, Haddad, Francois, Snyder, Michael P.

“…Acute physical activity leads to several changes in metabolic, cardiovascular, and immune pathways. Although studies have examined selected changes in these…”
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Biological Insights Into Muscular Strength: Genetic Findings in the UK Biobank by Tikkanen, Emmi, Gustafsson, Stefan, Amar, David, Shcherbina, Anna, Waggott, Daryl, Ashley, Euan A., Ingelsson, Erik

“…We performed a large genome-wide association study to discover genetic variation associated with muscular strength, and to evaluate shared genetic aetiology…”
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Hypertrophic Cardiomyopathy With Left Ventricular Systolic Dysfunction: Insights From the SHaRe Registry by Marstrand, Peter, Han, Larry, Day, Sharlene M., Olivotto, Iacopo, Ashley, Euan A., Michels, Michelle, Pereira, Alexandre C., Wittekind, Samuel G., Helms, Adam, Saberi, Sara, Jacoby, Daniel, Ware, James S., Colan, Steven D., Semsarian, Christopher, Ingles, Jodie, Lakdawala, Neal K., Ho, Carolyn Y.

“…The term "end stage" has been used to describe hypertrophic cardiomyopathy (HCM) with left ventricular systolic dysfunction (LVSD), defined as occurring when…”
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