Search Results - "ASHKENAZI, Avi"

Targeting the extrinsic apoptotic pathway in cancer: lessons learned and future directions by Ashkenazi, Avi

“…Apoptosis is a metazoan process of controlled cell elimination that plays critical roles in embryonic development and adult tissue homeostasis. Apoptosis…”
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Targeting the extrinsic apoptosis pathway in cancer by Ashkenazi, Avi

“…Abstract Mutational inactivation of the p53 tumor-suppressor gene, which regulates apoptosis mainly via the cell-intrinsic pathway, reduces the sensitivity of…”
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Regulated Cell Death: Signaling and Mechanisms by Ashkenazi, Avi, Salvesen, Guy

“…Cell turnover is a fundamental feature in metazoans. Cells can die passively, as a consequence of severe damage to their structural integrity, or actively,…”
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From basic apoptosis discoveries to advanced selective BCL-2 family inhibitors by Ashkenazi, Avi, Fairbrother, Wayne J., Leverson, Joel D., Souers, Andrew J.

“…Key Points Members of the B cell lymphoma 2 (BCL-2) gene family have a key role in regulating programmed cell death by controlling pro-apoptotic and…”
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Misfolded proteins bind and activate death receptor 5 to trigger apoptosis during unresolved endoplasmic reticulum stress by Lam, Mable, Marsters, Scot A, Ashkenazi, Avi, Walter, Peter

“…Disruption of protein folding in the endoplasmic reticulum (ER) activates the unfolded protein response (UPR)-a signaling network that ultimately determines…”
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Death receptor signal transducers: nodes of coordination in immune signaling networks by Ashkenazi, Avi, Dixit, Vishva, Wilson, Nicholas S

“…Death receptors (DRs) are members of the tumor necrosis factor receptor superfamily that possess a cytoplasmic death domain (DD). DRs regulate important…”
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To kill a tumor cell: the potential of proapoptotic receptor agonists by Ashkenazi, Avi, Herbst, Roy S

“…Disturbances in mechanisms that direct abnormal cells to undergo apoptosis frequently and critically contribute to tumorigenesis, yielding a logical target for…”
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Opposing unfolded-protein-response signals converge on death receptor 5 to control apoptosis by Lu, Min, Lawrence, David A., Marsters, Scot, Acosta-Alvear, Diego, Kimmig, Philipp, Mendez, Aaron S., Paton, Adrienne W., Paton, James C., Walter, Peter, Ashkenazi, Avi

“…Protein folding by the endoplasmic reticulum (ER) is physiologically critical; its disruption causes ER stress and augments disease. ER stress activates the…”
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Endoplasmic reticulum stress activates human IRE1α through reversible assembly of inactive dimers into small oligomers by Belyy, Vladislav, Zuazo-Gaztelu, Iratxe, Alamban, Andrew, Ashkenazi, Avi, Walter, Peter

“…Protein folding homeostasis in the endoplasmic reticulum (ER) is regulated by a signaling network, termed the unfolded protein response (UPR)…”
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TWEAK Induces Apoptosis through a Death-signaling Complex Comprising Receptor-interacting Protein 1 (RIP1), Fas-associated Death Domain (FADD), and Caspase-8 by Ikner, Aminah, Ashkenazi, Avi

“…The tumor necrosis factor (TNF) superfamily member TNF-like weak inducer of apoptosis (TNFSF12, CD255) (TWEAK) can stimulate apoptosis in certain cancer cells…”
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Ligand-Based Targeting of Apoptosis in Cancer: The Potential of Recombinant Human Apoptosis Ligand 2/Tumor Necrosis Factor–Related Apoptosis-Inducing Ligand (rhApo2L/TRAIL) by ASHKENAZI, Avi, HOLLAND, Pamela, GAIL ECKHARDT, S

“…Cancer is a leading cause of premature human death and commands considerable research attention. Apoptosis (type 1 programmed cell death) is critical in…”
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Apoptosis initiation through the cell-extrinsic pathway by Nair, Pradeep, Lu, Min, Petersen, Sean, Ashkenazi, Avi

“…Apoptosis is a tightly regulated cell suicide process used by metazoans to eliminate unwanted or damaged cells that pose a threat to the organism…”
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Decoding non-canonical mRNA decay by the endoplasmic-reticulum stress sensor IRE1α by Le Thomas, Adrien, Ferri, Elena, Marsters, Scot, Harnoss, Jonathan M., Lawrence, David A., Zuazo-Gaztelu, Iratxe, Modrusan, Zora, Chan, Sara, Solon, Margaret, Chalouni, Cécile, Li, Weihan, Koeppen, Hartmut, Rudolph, Joachim, Wang, Weiru, Wu, Thomas D., Walter, Peter, Ashkenazi, Avi

“…Inositol requiring enzyme 1 (IRE1) mitigates endoplasmic-reticulum (ER) stress by orchestrating the unfolded-protein response (UPR). IRE1 spans the ER…”
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Pharmacological brake-release of mRNA translation enhances cognitive memory by Sidrauski, Carmela, Acosta-Alvear, Diego, Khoutorsky, Arkady, Vedantham, Punitha, Hearn, Brian R, Li, Han, Gamache, Karine, Gallagher, Ciara M, Ang, Kenny K-H, Wilson, Chris, Okreglak, Voytek, Ashkenazi, Avi, Hann, Byron, Nader, Karim, Arkin, Michelle R, Renslo, Adam R, Sonenberg, Nahum, Walter, Peter

“…Phosphorylation of the α-subunit of initiation factor 2 (eIF2) controls protein synthesis by a conserved mechanism. In metazoa, distinct stress conditions…”
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Cullin3-Based Polyubiquitination and p62-Dependent Aggregation of Caspase-8 Mediate Extrinsic Apoptosis Signaling by Jin, Zhaoyu, Li, Yun, Pitti, Robert, Lawrence, David, Pham, Victoria C., Lill, Jennie R., Ashkenazi, Avi

“…Cell-surface death receptors such as DR4 and DR5 trigger apoptosis through a death-inducing signaling complex (DISC) that recruits the apical protease…”
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Pumilio protects Xbp1 mRNA from regulated Ire1-dependent decay by Cairrão, Fátima, Santos, Cristiana C., Le Thomas, Adrien, Marsters, Scot, Ashkenazi, Avi, Domingos, Pedro M.

“…The unfolded protein response (UPR) maintains homeostasis of the endoplasmic reticulum (ER). Residing in the ER membrane, the UPR mediator Ire1 deploys its…”
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E-Cadherin Couples Death Receptors to the Cytoskeleton to Regulate Apoptosis by Lu, Min, Marsters, Scot, Ye, Xiaofen, Luis, Elizabeth, Gonzalez, Lino, Ashkenazi, Avi

“…Epithelial-to-mesenchymal transition (EMT) is a cellular process essential to the development and maintenance of solid tissues. In cancer, EMT suppresses…”
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Proapoptotic DR4 and DR5 signaling in cancer cells: toward clinical translation by Yang, Annie, Wilson, Nicholas S, Ashkenazi, Avi

“…Proapoptotic receptor agonists (PARAs) targeting death receptors (DRs) 4 and 5 hold promise for cancer therapy based on their selective ability to kill…”
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Activation of the IRE1 RNase through remodeling of the kinase front pocket by ATP-competitive ligands by Ferri, Elena, Le Thomas, Adrien, Wallweber, Heidi Ackerly, Day, Eric S., Walters, Benjamin T., Kaufman, Susan E., Braun, Marie-Gabrielle, Clark, Kevin R., Beresini, Maureen H., Mortara, Kyle, Chen, Yung-Chia A., Canter, Breanna, Phung, Wilson, Liu, Peter S., Lammens, Alfred, Ashkenazi, Avi, Rudolph, Joachim, Wang, Weiru

“…Inositol-Requiring Enzyme 1 (IRE1) is an essential component of the Unfolded Protein Response. IRE1 spans the endoplasmic reticulum membrane, comprising a…”
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AXL inhibition sensitizes mesenchymal cancer cells to antimitotic drugs by Wilson, Catherine, Ye, Xiaofen, Pham, Thinh, Lin, Eva, Chan, Sara, McNamara, Erin, Neve, Richard M, Belmont, Lisa, Koeppen, Hartmut, Yauch, Robert L, Ashkenazi, Avi, Settleman, Jeff

“…Molecularly targeted drug therapies have revolutionized cancer treatment; however, resistance remains a major limitation to their overall efficacy…”
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