Search Results - "ASH, John D"

Stimulation of AMPK prevents degeneration of photoreceptors and the retinal pigment epithelium by Xu, Lei, Kong, Li, Wang, Jiangang, Ash, John D.

“…Retinal degenerative diseases are generally characterized by a permanent loss of light-sensitive retinal neurons known as photoreceptors, or their support…”
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Mitochondrial oxidative stress in the retinal pigment epithelium (RPE) led to metabolic dysfunction in both the RPE and retinal photoreceptors by Brown, Emily E, DeWeerd, Alexander J, Ildefonso, Cristhian J, Lewin, Alfred S, Ash, John D

“…Age-related macular degeneration (AMD) is the leading cause of vision loss in the western world. Recent evidence suggests that RPE and photoreceptors have an…”
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The Common Antidiabetic Drug Metformin Reduces Odds of Developing Age-Related Macular Degeneration by Brown, Emily E, Ball, Jacob D, Chen, Zhaoyi, Khurshid, Gibran S, Prosperi, Mattia, Ash, John D

“…AMD is the leading cause of irreversible blindness in older individuals in the Western world, and there are currently no therapies to halt disease progression…”
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The Role of AMPK Pathway in Neuroprotection by Xu, Lei, Ash, John D

“…Adenosine monophosphate-activated kinase (AMPK) is a highly conserved protein kinase found in all eukaryotic genomes. It exists as heterotrimeric protein…”
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Mitochondria: The Retina's Achilles' Heel in AMD by Ferrington, Deborah A, Kenney, M Cristina, Atilano, Shari R, Hurley, James B, Brown, Emily E, Ash, John D

“…Strong experimental evidence from studies in human donor retinas and animal models supports the idea that the retinal pathology associated with age-related…”
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Damage-associated molecular pattern recognition is required for induction of retinal neuroprotective pathways in a sex-dependent manner by Hooper, Marcus J., Wang, Jiangang, Browning, Robert, Ash, John D.

“…Retinal degeneration is a common cause of irreversible blindness and is caused by the death of retinal light-sensitive neurons called photoreceptors. At the…”
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Preconditioning-induced protection from oxidative injury is mediated by leukemia inhibitory factor receptor (LIFR) and its ligands in the retina by Chollangi, Srinivas, Wang, Jiangang, Martin, Aaron, Quinn, John, Ash, John D

“…Abstract Preconditioning with moderate oxidative stress (e.g., moderate bright light or mild hypoxia) can induce changes in retinal tissue that protect…”
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Retinal homeostasis and metformin-induced protection are not affected by retina-specific Pparδ knockout by Xu, Lei, Brown, Emily E., Santiago, Clayton P., Keuthan, Casey J., Lobanova, Ekaterina, Ash, John D.

“…Peroxisome proliferator-activated receptors (PPARs) are a family of three nuclear hormone receptors (PPARα, PPARδ, and PPARγ) that are known to regulate…”
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Loss of Caveolin-1 Impairs Retinal Function Due to Disturbance of Subretinal Microenvironment by Li, Xiaoman, McClellan, Mark E., Tanito, Masaki, Garteiser, Philippe, Towner, Rheal, Bissig, David, Berkowitz, Bruce A., Fliesler, Steven J., Woodruff, Michael L., Fain, Gordon L., Birch, David G., Khan, M. Suhaib, Ash, John D., Elliott, Michael H.

“…Caveolin-1 (Cav-1), an integral component of caveolar membrane domains, is expressed in several retinal cell types, including photoreceptors, retinal vascular…”
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Acyl-CoA synthetase 6 controls rod photoreceptor function and survival by shaping the phospholipid composition of retinal membranes by Wang, Yixiao, Becker, Silke, Finkelstein, Stella, Dyka, Frank M., Liu, Haitao, Eminhizer, Mark, Hao, Ying, Brush, Richard S., Spencer, William J., Arshavsky, Vadim Y., Ash, John D., Du, Jianhai, Agbaga, Martin-Paul, Vinberg, Frans, Ellis, Jessica M., Lobanova, Ekaterina S.

“…The retina is light-sensitive neuronal tissue in the back of the eye. The phospholipid composition of the retina is unique and highly enriched in…”
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Leukemia Inhibitory Factor Coordinates the Down-regulation of the Visual Cycle in the Retina and Retinal-pigmented Epithelium by Chucair-Elliott, Ana J., Elliott, Michael H., Wang, Jiangang, Moiseyev, Gennadiy P., Ma, Jian-Xing, Politi, Luis E., Rotstein, Nora P., Akira, Shizuo, Uematsu, Satoshi, Ash, John D.

“…Leukemia inhibitory factor (LIF), an interleukin-6 family neurocytokine, is up-regulated in response to different types of retinal stress and has…”
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Preconditioning-induced protection of photoreceptors requires activation of the signal-transducing receptor gp130 in photoreceptors by Ueki, Yumi, Le, Yun-Zheng, Chollangi, Srinivas, Muller, Werner, Ash, John D

“…Retinal degenerations are a class of neurodegenerative disorders that ultimately lead to blindness due to the death of retinal photoreceptors. In most cases,…”
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Inherited Retinal Degenerations: Current Landscape and Knowledge Gaps by Duncan, Jacque L, Pierce, Eric A, Laster, Amy M, Daiger, Stephen P, Birch, David G, Ash, John D, Iannaccone, Alessandro, Flannery, John G, Sahel, José A, Zack, Donald J, Zarbin, Marco A

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Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa by Wang, Yixiao, Punzo, Claudio, Ash, John D, Lobanova, Ekaterina S

“…SignificanceStudies in multiple experimental systems have demonstrated that an increase in proteolytic capacity of post-mitotic cells improves cellular…”
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Mitochondria: Potential Targets for Protection in Age-Related Macular Degeneration by Brown, Emily E, Lewin, Alfred S, Ash, John D

“…Age-related macular degeneration (AMD) is the leading cause of blindness in older adults in developed countries. The molecular mechanisms of disease…”
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CD4 T-Cell Suppression by Cells from Toxoplasma gondii-Infected Retinas Is Mediated by Surface Protein PD-L1 by Charles, Elizabeth, Joshi, Sunil, Ash, John D, Fox, Barbara A, Farris, A. Darise, Bzik, David J, Lang, Mark L, Blader, Ira J

“…In the inflamed retina, CD4⁺ T cells can cause retinal damage when they are not properly regulated. Since tissue expression of major histocompatibility complex…”
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Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction by Lobanova, Ekaterina S, Schuhmann, Kai, Finkelstein, Stella, Lewis, Tylor R, Cady, Martha A, Hao, Ying, Keuthan, Casey, Ash, John D, Burns, Marie E, Shevchenko, Andrej, Arshavsky, Vadim Y

“…Retinal photoreceptor cells contain the highest concentration of docosahexaenoic acid (DHA) in our bodies, and it has been long assumed that this is critical…”
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Sustained delivery of NT-3 from lens fiber cells in transgenic mice reveals specificity of neuroprotection in retinal degenerations by LaVail, Matthew M., Nishikawa, Shimpei, Duncan, Jacque L., Yang, Haidong, Matthes, Michael T., Yasumura, Douglas, Vollrath, Douglas, Overbeek, Paul A., Ash, John D., Robinson, Michael L.

“…Several neurotrophic factors (NTFs) are effective in protecting retinal photoreceptor cells from the damaging effects of constant light and slowing the rate of…”
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STAT3 activation in photoreceptors by leukemia inhibitory factor is associated with protection from light damage by Ueki, Yumi, Wang, Jiangang, Chollangi, Srinivas, Ash, John D

“…Members of the interleukin-6 cytokine family, including leukemia inhibitory factor (LIF), signal through gp130. The neuroprotective role of gp130 activation…”
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A Drug-Tunable Gene Therapy for Broad-Spectrum Protection against Retinal Degeneration by Santiago, Clayton P., Keuthan, Casey J., Boye, Sanford L., Boye, Shannon E., Imam, Aisha A., Ash, John D.

“…Retinal degenerations are a large cluster of diseases characterized by the irreversible loss of light-sensitive photoreceptors that impairs the vision of 9.1…”
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