Search Results - "ASFAHA, S."

Protease‐activated receptor‐4: a novel mechanism of inflammatory pain modulation by Asfaha, S, Cenac, N, Houle, S, Altier, C, Papez, M D, Nguyen, C, Steinhoff, M, Chapman, K, Zamponi, G W, Vergnolle, N

“…Background and purpose: Protease‐activated receptor‐4 (PAR4), the most recently discovered member of the PARs family, is activated by thrombin, trypsin and…”
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Exacerbation of inflammation-associated colonic injury in rat through inhibition of cyclooxygenase-2 by Reuter, B K, Asfaha, S, Buret, A, Sharkey, K A, Wallace, J L

“…Cyclooxygenase type 1 is constitutively expressed and accounts for synthesis of prostaglandins in the normal gastrointestinal tract. Cyclooxygenase-2 is…”
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Cyclooxygenase 1 contributes to inflammatory responses in rats and mice: Implications for gastrointestinal toxicity by Wallace, John L., Bak ‡, Adrian, McKnight, Webb, Asfaha, Samuel, Sharkey §, Keith A., MacNaughton §, Wallace K.

“…Background & Aims: Selective inhibitors of cyclooxygenase (COX)-2 are being developed as gastrointestinal-sparing anti-inflammatory drugs based on the premise…”
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Aspirin causes rapid up‐regulation of cyclo‐oxygenase‐2 expression in the stomach of rats by DAVIES, N. M., SHARKEY, K. A., ASFAHA, S., MACNAUGHTON, W. K., WALLACE, J. L.

“…Background: Cyclo‐oxygenase‐1 (COX‐1) is believed to produce prostaglandins vital to mucosal defence, whereas cyclo‐oxygenase‐2 (COX‐2) is induced at sites of…”
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Persistent epithelial dysfunction and bacterial translocation after resolution of intestinal inflammation by Asfaha, S, MacNaughton, W K, Appleyard, C B, Chadee, K, Wallace, J L

“…Epithelial secretion may play an important role in reducing bacterial colonization and translocation in intestine. If so, secretory dysfunction could result in…”
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Enhanced anti-inflammatory effects of a nitric oxide–releasing derivative of mesalamine in rats by Wallace, John L., Vergnolle, Nathalie, Muscará, Marcelo N., Asfaha, Samuel, Chapman, Kevin, McKnight, Webb, Soldato, Piero Del, Morelli, Antonio, Fiorucci, Stefano

“…Background & Aims: Nitric oxide (NO)-releasing derivatives of cyclooxygenase inhibitors exhibit enhanced anti-inflammatory activity and greatly reduced…”
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Induction of cyclooxygenase 1 and 2 in the rat stomach during endotoxemia: Role in resistance to damage by Ferraz, JG, Sharkey, KA, Reuter, BK, Asfaha, S, Tigley, AW, Brown, ML, McKnight, W, Wallace, JL

“…BACKGROUND & AIMS: Prostaglandins and nitric oxide are key mediators of gastric mucosal defense. Endotoxemia alters gastric resistance to damage, but little is…”
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A222 EFFECT OF CLINICAL FACTORS ON IBD TREATMENT RESPONSE: FINDINGS FROM A NOVEL SINGLE CENTER PATIENT REGISTRY by Lavalle, C, Khanna, R, Asfaha, S

“…Abstract Background Inflammatory bowel disease (IBD), comprising both Crohn’s disease as well as ulcerative colitis, has shown heterogenous response to…”
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A4 DNA HYPOMETHYLATION INHIBITS COLITIS-ASSOCIATED CANCER by Larsen, F, Good, H, Shin, A, Derouet, M, Zhang, L, Castellani, C, Asfaha, S

“…Abstract Background Colorectal cancer is the second leading cause of cancer death in Canada. A major risk factor for the development of colorectal cancer is…”
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A86 CANNABIS USE IN PATIENTS WITH INFLAMMATORY BOWEL DISEASE IS HIGHER FOLLOWING LEGALIZATION OF CANNABIS IN CANADA AND IS ASSOCIATED WITH LOWER QUALITY OF LIFE by Iablokov, V, Chande, N, Ponich, T, Jairath, V, Gregor, J, Khanna, R, Asfaha, S

“…Abstract Background Patients with inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), often experience fluctuating…”
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A27 DNA HYPOMETHYLATION INDUCED BY 5-AZA-CDR OR LOSS OF DNMT1 INHIBITS COLITIS-ASSOCIATED COLORECTAL CANCER by Larsen, F, Good, H, Shin, A, Derouet, M, Zhang, L, Asfaha, S

“…Abstract Background Colorectal cancer is the second leading cause of cancer death in Canada. A major risk factor for the development of colorectal cancer is…”
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A30 INHIBITION OF NF-KB SIGNALING IN DCLK1+ CELLS PROMOTES COLONIC INFLAMMATION AND COLITIS-ASSOCIATED CANCER by Good, H, Shin, A E, Zhang, L, Asfaha, S

“…Abstract Background Colorectal cancer (CRC) is the 2nd leading cause of cancer death in Canada. A major risk factor for this disease is chronic inflammation…”
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A166 CANNABIS USE IN CANADIAN INDIVIDUALS WITH INFLAMMATORY BOWEL DISEASE FOLLOWING LEGALIZATION OF CANNABIS by Iablokov, V, Gregor, J C, Chande, N, Jairath, V, Khanna, R, Asfaha, S

“…Abstract Background Inflammatory bowel disease (IBD), including Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by remitting and relapsing…”
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A35 DNA HYPOMETHYLATION INHIBITS TUFT CELL-DERIVED COLITIS-ASSOCIATED CANCER by Larsen, F, Good, H J, Shin, A E, Zhang, L, Asfaha, S

“…Abstract Background Colorectal cancer is the second leading cause of cancer death in Canada. A major risk factor for the development of colorectal cancer is…”
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A246 ROLE OF DOUBLECORTIN-LIKE KINASE 1 (DCLK1) POSITIVE TUFT CELLS IN COLITIS-ASSOCIATED COLORECTAL CANCER by Shin, A, Fazio, E, Zhang, L, Good, H, Asfaha, S

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A245 THE ROLE OF NON-STEROIDAL ANTI-INFLAMMATORY DRUGS IN COLITIS-ASSOCIATED CANCER by Good, H, Shin, A, Fazio, E, Zhang, L, Asfaha, S

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A29 HOPX LABELS A COLONIC STEM CELL THAT CONTRIBUTES TO COLONIC REGENERATION BUT NOT COLONIC TUMORS by Iablokov, V, Good, H J, Shin, A E, Fazio, E N, Loggie, J W, Zhang, L, Asfaha, S

“…Abstract Background Colorectal cancer is the 2nd leading cause of cancer death in Canada. In rapidly dividing tissues such as the intestine or colon, only…”
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A1 F4/80+LY6CHI MACROPHAGES ARE KEY TO CANCER INITIATION IN COLITIS by Shin, A E, Good, H J, Tesfagiorgis, Y, Zhang, L, Kerfoot, S, Sherman, P M, Wang, T C, Howlett, C J, Asfaha, S

“…Abstract Background Colorectal cancer (CRC) is the third leading cause of cancer death, with a major risk factor being chronic inflammation. Thus, patients…”
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A8 THE ROLE OF CYCLOOXYGENASE IN COLITIS-ASSOCIATED CANCER by Good, H, Shin, A E, Zhang, L, Fazio, E N, Meriwether, D, Reddy, S, Wang, T C, Asfaha, S

“…Abstract Background Colorectal cancer (CRC) is the 2nd leading cause of cancer death in Canada. Inflammatory bowel disease (IBD), a chronic state of colonic…”
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A19 ROLE OF LGR5 IN DCLK1 POSITIVE CELL-DERIVED COLITIS-ASSOCIATED COLON CANCER by Shin, A E, Good, H, Zhang, L, Fazio, E N, Sherman, P M, Wang, T C, Asfaha, S

“…Abstract Background Colorectal cancer (CRC) is the second leading cause of cancer death in Canada, with the major risk factor being chronic inflammation. As…”
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