Search Results - "ASEHNOUNE, Karim"
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Trauma-Induced Damage-Associated Molecular Patterns-Mediated Remote Organ Injury and Immunosuppression in the Acutely Ill Patient
Published in Frontiers in immunology (15-06-2018)“…Trauma is one of the leading causes of death and disability in the world. Multiple trauma or isolated traumatic brain injury are both indicative of human…”
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Respiratory Management in Patients with Severe Brain Injury
Published in Critical care (London, England) (20-03-2018)“…This article is one of ten reviews selected from the Annual Update in Intensive Care and Emergency Medicine 2018. Other selected articles can be found online…”
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Contribution of Dendritic Cell Responses to Sepsis-Induced Immunosuppression and to Susceptibility to Secondary Pneumonia
Published in Frontiers in immunology (13-11-2018)“…Dendritic cells (DCs) are bone marrow derived cells which continuously seed in peripheral tissue. During infection, DCs play an essential interface between…”
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4
Alveolar macrophages are epigenetically altered after inflammation, leading to long-term lung immunoparalysis
Published in Nature immunology (01-06-2020)“…Sepsis and trauma cause inflammation and elevated susceptibility to hospital-acquired pneumonia. As phagocytosis by macrophages plays a critical role in the…”
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5
Immune modulation after traumatic brain injury
Published in Frontiers in medicine (01-12-2022)“…Traumatic brain injury (TBI) induces instant activation of innate immunity in brain tissue, followed by a systematization of the inflammatory response. The…”
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Mechanical ventilation in patients with acute brain injury: recommendations of the European Society of Intensive Care Medicine consensus
Published in Intensive care medicine (01-12-2020)“…Purpose To provide clinical practice recommendations and generate a research agenda on mechanical ventilation and respiratory support in patients with acute…”
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Prevalence and impact of frailty on mortality in elderly ICU patients: a prospective, multicenter, observational study
Published in Anaesthesia and intensive care medicine (01-05-2014)“…Purpose Frailty is a recent concept used for evaluating elderly individuals. Our study determined the prevalence of frailty in intensive care unit (ICU)…”
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Risk factors and outcomes for airway failure versus non-airway failure in the intensive care unit: a multicenter observational study of 1514 extubation procedures
Published in Critical care (London, England) (23-09-2018)“…Patients liberated from invasive mechanical ventilation are at risk of extubation failure, including inability to breathe without a tracheal tube (airway…”
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Mechanical ventilation in patients with acute brain injury: a systematic review with meta-analysis
Published in Critical care (London, England) (06-06-2023)“…To describe the potential effects of ventilatory strategies on the outcome of acute brain-injured patients undergoing invasive mechanical ventilation…”
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CD4CD8αα lymphocytes, a novel human regulatory T cell subset induced by colonic bacteria and deficient in patients with inflammatory bowel disease
Published in PLoS biology (01-04-2014)“…How the microbiota affects health and disease is a crucial question. In mice, gut Clostridium bacteria are potent inducers of colonic interleukin…”
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Early use of barbiturates is associated with increased mortality in traumatic brain injury patients from a propensity score-based analysis of a prospective cohort
Published in PloS one (04-05-2022)“…Barbiturates are proposed as a second/third line treatment for intracranial hypertension in traumatic brain injury (TBI) patients, but the literature remains…”
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Perioperative hemodynamic optimization: from guidelines to implementation—an experts’ opinion paper
Published in Annals of intensive care (14-04-2021)“…Despite a large body of evidence, the implementation of guidelines on hemodynamic optimization and goal-directed therapy remains limited in daily routine…”
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Rapid genetic and phenotypic changes in Pseudomonas aeruginosa clinical strains during ventilator-associated pneumonia
Published in Scientific reports (18-03-2019)“…Treatment with antibiotics leads to the selection of isolates with increased resistance. We investigated if evolution towards resistance was associated with…”
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Impact of treating iron deficiency, diagnosed according to hepcidin quantification, on outcomes after a prolonged ICU stay compared to standard care: a multicenter, randomized, single-blinded trial
Published in Critical care (London, England) (15-02-2021)“…Anemia is a significant problem in patients on ICU. Its commonest cause, iron deficiency (ID), is difficult to diagnose in the context of inflammation…”
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Impact of continuous hypertonic (NaCl 20%) saline solution on renal outcomes after traumatic brain injury (TBI): a post hoc analysis of the COBI trial
Published in Critical care (London, England) (27-01-2023)“…To evaluate if the increase in chloride intake during a continuous infusion of 20% hypertonic saline solution (HSS) is associated with an increase in the…”
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Ventilator-associated pneumonia in neurocritically ill patients: insights from the ENIO international prospective observational study
Published in Respiratory research (31-05-2023)“…Acute brain injured (ABI) patients are at high risk of developing ventilator-associated pneumonia (VAP). However, incidence, risk factors and effects on…”
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Could Azithromycin Be Part of Pseudomonas aeruginosa Acute Pneumonia Treatment?
Published in Frontiers in microbiology (16-03-2021)“…Azithromycin (AZM) is a 15-membered-ring macrolide that presents a broad-spectrum antimicrobial activity against Gram-positive bacteria and atypical…”
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A longitudinal cohort of stress cardiomyopathy assessed with speckle-tracking echocardiography after moderate to severe traumatic brain injury
Published in Critical care (London, England) (12-05-2020)“…Keywords: Stress cardiomyopathy, Traumatic brain injury, Speckle-tracking echocardiography…”
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Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in Intensive Care Unit: an observational study
Published in Annals of intensive care (12-02-2013)“…Background This study was design to investigate the prognostic value for death at day-28 of lactate course and lactate clearance during the first 24 hours in…”
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Diuretics decrease fluid balance in patients on invasive mechanical ventilation: the randomized-controlled single blind, IRIHS study
Published in Critical care (London, England) (10-03-2021)“…Fluid overload has been associated with increased morbidity and mortality in critically ill patients. The goal of this study was to assess the efficacy and…”
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