Search Results - "ASAKURA, TADASHI"

Curcumin β‐D‐glucuronide exhibits anti–tumor effects on oxaliplatin‐resistant colon cancer with less toxicity in vivo by Ozawa‐Umeta, Hitomi, Kishimoto, Atsuhiro, Imaizumi, Atsushi, Hashimoto, Tadashi, Asakura, Tadashi, Kakeya, Hideaki, Kanai, Masashi

“…The NF‐kappa B (NF‐κB) pathway plays a pivotal role in tumor progression and chemoresistance, and its inhibition has been shown to suppress tumor growth in a…”
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Proteasome inhibitor-resistant cells cause EMT-induction via suppression of E-cadherin by miR-200 and ZEB1 by ASAKURA, TADASHI, YAMAGUCHI, NORIKO, OHKAWA, KIYOSHI, YOSHIDA, KIYOTSUGU

“…Downregulation of E-cadherin (gene: CDH1) plays an important role in epithelial-mesenchymal transition (EMT), which is critical for normal development and…”
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Measurements of radiocesium in animals, plants and fungi in Svalbard after the Fukushima Daiichi nuclear power plant disaster by Mezaki, Yoshihiro, Kato, Shigeaki, Nishikawa, Osamu, Takashima, Isao, Tsubokura, Masaharu, Minowa, Haruka, Asakura, Tadashi, Matsuura, Tomokazu, Senoo, Haruki

“…An earthquake struck the eastern part of Japan on March 11, 2011. The Fukushima Daiichi nuclear power plant was severely damaged by the earthquake and…”
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Survivin expression in early hepatocellular carcinoma and post-treatment with anti-cancer drug under hypoxic culture condition by Mamori, Satoshi, Asakura, Tadashi, Ohkawa, Kiyoshi, Tajiri, Hisao

“…To investigate the expression of survivin during the early stages of hepatocellular carcinoma (HCC). Immunohistochemical expression of survivin in liver tumor…”
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Chemotherapeutic agents that induce mitochondrial apoptosis by Asakura, Tadashi, Ohkawa, Kiyoshi

“…In cancer chemotherapy, it is necessary to design an agent that suppresses or inhibits the targets that influence cell growth and apoptosis. We focus on the…”
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Conformational change in the active center region of GST P1-1, due to binding of a synthetic conjugate of DXR with GSH, enhanced JNK-mediated apoptosis by Asakura, Tadashi, Sasagawa, Atsuko, Takeuchi, Hitoshi, Shibata, Shun-ichi, Marushima, Hideki, Mamori, Satoshi, Ohkawa, Kiyoshi

“…Treatment of cells with a synthetic conjugate of DXR with GSH via glutaraldehyde (GSH-DXR) caused cytochrome c to be released from the mitochondria to the…”
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Chemotherapeutic Effect of CD147 Antibody-labeled Micelles Encapsulating Doxorubicin Conjugate Targeting CD147-Expressing Carcinoma Cells by Asakura, Tadashi, Yokoyama, Masayuki, Shiraishi, Koichi, Aoki, Katsuhiko, Ohkawa, Kiyoshi

“…CD147 (basigin/emmprin) is expressed on the surface of carcinoma cells. For studying the efficacy of CD147-targeting medicine on CD147-expressing cells, we…”
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Abstract P6-03-14: Conditional reprogrammed cells enable us to examine the drug resistance for recurrent metastatic hormone receptor-positive, human epidermal receptor 2-negative breast cancer by Mimoto, Rei, Yogosawa, Satomi, Fushimi, Atsushi, Nogi, Hiroko, Asakura, Tadashi, Yoshida, Kiyotsugu, Takeyama, Hiroshi

“…Objectives: Various new drugs have been developed for treating recurrent hormone receptor-positive/human epidermal receptor 2-negative breast cancer. However,…”
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Clinical implications of drug-screening assay for recurrent metastatic hormone receptor-positive, human epidermal receptor 2-negative breast cancer using conditionally reprogrammed cells by Mimoto, Rei, Yogosawa, Satomi, Saijo, Hiroki, Fushimi, Atsushi, Nogi, Hiroko, Asakura, Tadashi, Yoshida, Kiyotsugu, Takeyama, Hiroshi

“…Various new drugs have been developed for treating recurrent hormone receptor-positive (HR+)/human epidermal receptor 2-negative (HER2−) breast cancer…”
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Antibody to human α-fetoprotein inhibits cell growth of human hepatocellular carcinoma cells by resuscitating the PTEN molecule: in vitro experiments by Ohkawa, Kiyoshi, Asakura, Tadashi, Tsukada, Yutaka, Matsuura, Tomokazu

“…It has been proposed that α-fetoprotein (AFP) is a new member of the intracellular signaling molecule family of the phosphoinositide 3-kinase (PI3K)/AKT…”
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Antibody to human [alpha]-fetoprotein inhibits cell growth of human hepatocellular carcinoma cells by resuscitating the PTEN molecule: in vitro experiments by Ohkawa, Kiyoshi, Asakura, Tadashi, Tsukada, Yutaka, Matsuura, Tomokazu

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Calpain inhibitor inhibits secretory granule maturation and secretion of GH by Ohkawa, Kiyoshi, Takada, Koji, Asakura, Tadashi, Hashizume, Yukio, Okawa, Yutaka, Tashiro, Ken-ichi, Ueda, Junko, Itoh, Yoshitaka, Hibi, Nozomu

“…Clathrin- and AP-1-coated buds are present on immature secretory granules of endocrine cells that mature into clathrin-uncoated granules. The mechanism of…”
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Pharmacologic characterization of TBP1901, a prodrug form of aglycone curcumin, and CRISPR-Cas9 screen for therapeutic targets of aglycone curcumin by Abe, Tomoyuki, Horisawa, Yoshihito, Kikuchi, Osamu, Ozawa-Umeta, Hitomi, Kishimoto, Atsuhiro, Katsuura, Yasuhiro, Imaizumi, Atsushi, Hashimoto, Tadashi, Shirakawa, Kotaro, Takaori-Kondo, Akifumi, Yusa, Kosuke, Asakura, Tadashi, Kakeya, Hideaki, Kanai, Masashi

“…Curcumin (aglycone curcumin) has antitumor properties in a variety of malignancies via the alteration of multiple cancer-related biological pathways; however,…”
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Hypoxia promotes glycogen synthesis and accumulation in human ovarian clear cell carcinoma by IIDA, Yasushi, AOKI, Katsuhiko, ASAKURA, Tadashi, UEDA, Kazu, YANAIHARA, Nozomu, TAKAKURA, Satoshi, YAMADA, Kyosuke, OKAMOTO, Aikou, TANAKA, Tadao, OHKAWA, Kiyoshi

“…Ovarian clear cell carcinoma (OCCC) has several significant characteristics based on molecular features that are distinct from those of ovarian high-grade…”
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Three-dimensional culture promotes reconstitution of the tumor-specific hypoxic microenvironment under TGFβ stimulation by MARUSHIMA, Hideki, SHIBATA, Shun-Ichi, OHKAWA, Kiyoshi, ASAKURA, Tadashi, MATSUURA, Tomokazu, MAEHASHI, Haruka, ISHII, Yuji, EDA, Homare, AOKI, Katsuhiko, IIDA, Yasushi, MORIKAWA, Toshiaki

“…In vitro tumor growth in a three-dimensional (3D) architecture has been demonstrated to play an important role in biology not only for developmental…”
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The association of deamidation of Bcl-xL and translocation of Bax to the mitochondria through activation of JNK in the induction of apoptosis by treatment with GSH-conjugated DXR by ASAKURA, Tadashi, MAEDA, Kazuhiro, OMI, Hiroko, MATSUDAIRA, Hiroshi, OHKAWA, Kiyoshi

“…We investigated the induction of apoptosis via deamidation of Bcl-xL and translocation of Bax to the mitochondria by treatment with GSH-DXR. GSH-DXR treatment…”
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Absorption and Metabolism of Pyridoxamine in Mice: II. Transformation of Pyridoxamine to Pyridoxal in Intestinal Tissues by SAKURAI, Tae, ASAKURA, Tadashi, MIZUNO, Aritake, MATSUDA, Makoto

“…The absorption of pyridoxamine from the intestine of the mouse was studied in whole animals. [3H] Pyridoxamine was orally administered and the distribution of…”
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Absorption and Metabolism of Pyridoxamine in Mice. I.Pyridoxal as the Only Form of Transport in Blood by SAKURAI, Tae, ASAKURA, Tadashi, MIZUNO, Aritake, MATSUDA, Makoto

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Target chemotherapy of anti-CD147 antibody-labeled liposome encapsulated GSH-DXR conjugate on CD147 highly expressed carcinoma cells by MATSUDAIRA, Hiroshi, ASAKURA, Tadashi, AOKI, Katsuhiko, SEARASHI, Yasuyuki, MATSUURA, Tomokazu, NAKAJIMA, Hisato, TAJIRI, Hisao, OHKAWA, Kiyoshi

“…It was confirmed that CD147 (Emmprin) was expressed on the cell surface of carcinoma cells. For the purpose of studying the efficacy of a CD147-targeting agent…”
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Three-dimensional culture using a radial flow bioreactor induces matrix metalloprotease 7-mediated EMT-like process in tumor cells via TGFbeta1/Smad pathway by Shibata, Shun-Ichi, Marushima, Hideki, Asakura, Tadashi, Matsuura, Tomokazu, Eda, Homare, Aoki, Katsuhiko, Matsudaira, Hiroshi, Ueda, Kazu, Ohkawa, Kiyoshi

“…To confirm the usefulness of the radial flow type bioreactor (RFB) for a three-dimensional (3D) culture system, which provides a tissue architecture and…”
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