Search Results - "ASAI, Akira"

Metabolic Syndrome and Sarcopenia by Nishikawa, Hiroki, Asai, Akira, Fukunishi, Shinya, Nishiguchi, Shuhei, Higuchi, Kazuhide

“…Skeletal muscle is a major organ of insulin-induced glucose metabolism. In addition, loss of muscle mass is closely linked to insulin resistance (IR) and…”
Get full text

Cancer Cachexia: Its Mechanism and Clinical Significance by Nishikawa, Hiroki, Goto, Masahiro, Fukunishi, Shinya, Asai, Akira, Nishiguchi, Shuhei, Higuchi, Kazuhide

“…The term "cachexia" is derived from the Greek words kakos (bad) and hexis (habit). Cachexia is a malnutrition associated with chronic diseases such as cancer,…”
Get full text

Pathophysiology and mechanisms of primary sarcopenia (Review) by Nishikawa, Hiroki, Fukunishi, Shinya, Asai, Akira, Yokohama, Keisuke, Nishiguchi, Shuhei, Higuchi, Kazuhide

“…Aging causes skeletal muscle atrophy, and myofiber loss can be a critical component of this process. In 1989, Rosenberg emphasized the importance of the loss…”
Get full text

Body Composition in Chronic Liver Disease by Nishikawa, Hiroki, Kim, Soo Ki, Asai, Akira

“…Body composition has recently been attracting people's attention, not only from a cosmetic standpoint but also from the perspective of health and longevity…”
Get full text

The Significance of Zinc in Patients with Chronic Liver Disease by Nishikawa, Hiroki, Asai, Akira, Fukunishi, Shinya

“…Zinc is an essential trace element for the maintenance of life because it acts as a center of activity or cofactor for hundreds of enzymes. Zinc deficiency…”
Get full text

Increased both PD–L1 and PD–L2 expressions on monocytes of patients with hepatocellular carcinoma was associated with a poor prognosis by Yasuoka, Hidetaka, Asai, Akira, Ohama, Hideko, Tsuchimoto, Yusuke, Fukunishi, Shinya, Higuchi, Kazuhide

“…Anti-programmed cell death-1 (PD-1) antibodies has been approved to treat HCC. Some PD-1 ligands (PD–L1 and PD–L2) negative tumors respond to treatment of…”
Get full text

Selectively bred rodent models for studying the etiology of type 2 diabetes: Goto-Kakizaki rats and Oikawa-Nagao mice by Nagao, Mototsugu, Asai, Akira, Eliasson, Lena, Oikawa, Shinichi

“…Type 2 diabetes (T2D) is a polygenic disease and studies to understand the etiology of the disease have required selectively bred animal models with polygenic…”
Get full text

Leptin production capacity determines food intake and susceptibility to obesity-induced diabetes in Oikawa–Nagao Diabetes-Prone and Diabetes-Resistant mice by Asai, Akira, Nagao, Mototsugu, Hayakawa, Koji, Miyazawa, Teruo, Sugihara, Hitoshi, Oikawa, Shinichi

“…Aims/hypothesis Obesity caused by overeating plays a pivotal role in the development of type 2 diabetes. However, it remains poorly understood how individual…”
Get full text

Sarcopenia, frailty and type 2 diabetes mellitus (Review) by Nishikawa, Hiroki, Fukunishi, Shinya, Asai, Akira, Yokohama, Keisuke, Ohama, Hideko, Nishiguchi, Shuhei, Higuchi, Kazuhide

“…Skeletal muscle is the largest and most energy‑consuming organ in the human body, which plays an important role in energy metabolism and glucose uptake. There…”
Get full text

The Impacts of Cholesterol, Oxysterols, and Cholesterol Lowering Dietary Compounds on the Immune System by Yanagisawa, Rintaro, He, Chaoqi, Asai, Akira, Hellwig, Michael, Henle, Thomas, Toda, Masako

“…Cholesterol and its oxidized forms, oxysterols, are ingested from foods and are synthesized de novo. Cholesterol and oxysterols influence molecular and…”
Get full text

Discovery of a New STAT3 Inhibitor Acting on the Linker Domain by Koseki, Tatsuya, Suehiro, Naoya, Masuda, Yoshiaki, Miyoshi, Nao, Muraoka, Daisuke, Ogo, Naohisa, Asai, Akira

“…Signal transducer and activator of transcription 3 (STAT3) is a latent transcription factor that contributes to tumor cell growth and survival and is often…”
Get full text

Ileal Bile Acid Transporter Inhibitor Improves Hepatic Steatosis by Ameliorating Gut Microbiota Dysbiosis in NAFLD Model Mice by Matsui, Masahiro, Fukunishi, Shinya, Nakano, Takashi, Ueno, Takaaki, Higuchi, Kazuhide, Asai, Akira

“…Nonalcoholic fatty liver disease (NAFLD), characterized by excessive fat deposition in the liver unrelated to alcohol consumption, is highly prevalent…”
Get full text

Identification of serum and glucocorticoid-regulated kinase 1 as a regulator of signal transducer and activator of transcription 3 signaling by Araki, Toshihiro, Watanabe, Yuuki, Okada, Yusuke, Murakami, Hisashi, Ogo, Naohisa, Asai, Akira

“…Signal transducer and activator of transcription 3 (STAT3) plays key roles in cancer cell proliferation, invasion, and immunosuppression. In many human cancer…”
Get full text

Efficacy of combination treatment using YHO-1701, an orally active STAT3 inhibitor, with molecular-targeted agents on cancer cell lines by Taniguchi, Keisuke, Konishi, Hiroaki, Yoshinaga, Akiko, Tsugane, Momomi, Takahashi, Hiroyuki, Nishisaka, Fukiko, Shishido, Yoshiyuki, Asai, Akira

“…Signal transducer and activator of transcription 3 (STAT3) plays a critical role in regulating cell growth, survival, and metastasis. STAT3 signaling is…”
Get full text

Various effects of two types of kinesin-5 inhibitors on mitosis and cell proliferation by Sawada, Jun-ichi, Matsuno, Kenji, Ogo, Naohisa, Asai, Akira

“…[Display omitted] Kinesin-5 has received considerable attention as a new target for mitosis. Various small-molecule compounds targeting kinesin-5 have been…”
Get full text

Antitumor activity of a novel oral signal transducer and activator of transcription 3 inhibitor YHO‐1701 by Nishisaka, Fukiko, Taniguchi, Keisuke, Tsugane, Momomi, Hirata, Genya, Takagi, Akimitsu, Asakawa, Naoyuki, Kurita, Akinobu, Takahashi, Hiroyuki, Ogo, Naohisa, Shishido, Yoshiyuki, Asai, Akira

“…The signal transducer and activator of transcription 3 (STAT3) signaling pathway is a key mediator of cancer cell proliferation, survival and invasion…”
Get full text

Survival of Mice with Gastrointestinal Acute Radiation Syndrome through Control of Bacterial Translocation by Suzuki, Fujio, Loucas, Bradford D, Ito, Ichiaki, Asai, Akira, Suzuki, Sumihiro, Kobayashi, Makiko

“…Macrophages (Mϕ) with the M2b phenotype (Pheno2b-Mϕ) in bacterial translocation sites have been described as cells responsible for the increased susceptibility…”
Get full text

Metformin Attenuates Early-Stage Atherosclerosis in Mildly Hyperglycemic Oikawa-Nagao Mice by Asai, Akira, Shuto, Yuki, Nagao, Mototsugu, Kawahara, Momoyo, Miyazawa, Teruo, Sugihara, Hitoshi, Oikawa, Shinichi

“…Aim: Although metformin treatment has been reported to reduce the risk of cardiovascular events in patients with type 2 diabetes, the underlying mechanisms…”
Get full text

Long-Term Outcomes after Switching to Tenofovir Alafenamide in Patients with Chronic Hepatitis B by Nishikawa, Tomohiro, Matsui, Masahiro, Onishi, Saori, Ushiro, Kosuke, Asai, Akira, Kim, Soo-Ki, Nishikawa, Hiroki

“…We sought to determine the long-term outcomes of chronic hepatitis B (CHB) cases switching to tenofovir alafenamide (TAF, = 104, median age = 63.5 years). Data…”
Get full text

Sarcopenia and Frailty in Liver Cirrhosis by Nishikawa, Hiroki, Fukunishi, Shinya, Asai, Akira, Nishiguchi, Shuhei, Higuchi, Kazuhide

“…Skeletal muscle is the largest organ in the body, and skeletal muscle atrophy results from a shift in the balance of protein synthesis and degradation toward…”
Get full text