Search Results - "ARZUMANYAN, Alla"

Pathogenic mechanisms in HBV- and HCV-associated hepatocellular carcinoma by Arzumanyan, Alla, Reis, Helena M. G. P. V., Feitelson, Mark A.

“…Key Points Hepatitis B virus (HBV) and hepatitis C virus (HCV) are major aetiological agents of chronic liver disease and hepatocellular carcinoma (HCC). HCC…”
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Short chain fatty acids delay the development of hepatocellular carcinoma in HBx transgenic mice by McBrearty, Noreen, Arzumanyan, Alla, Bichenkov, Eugene, Merali, Salim, Merali, Carmen, Feitelson, Mark

“…Chronic infection with hepatitis B virus (HBV) is a major risk factor for the development of hepatocellular carcinoma (HCC). The HBV encoded oncoprotein, HBx,…”
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Sustained proliferation in cancer: Mechanisms and novel therapeutic targets by Feitelson, Mark A, Arzumanyan, Alla, Kulathinal, Rob J, Blain, Stacy W, Holcombe, Randall F, Mahajna, Jamal, Marino, Maria, Martinez-Chantar, Maria L, Nawroth, Roman, Sanchez-Garcia, Isidro, Sharma, Dipali, Saxena, Neeraj K, Singh, Neetu, Vlachostergios, Panagiotis J, Guo, Shanchun, Honoki, Kanya, Fujii, Hiromasa, Georgakilas, Alexandros G, Bilsland, Alan, Amedei, Amedeo, Niccolai, Elena, Amin, Amr, Ashraf, S. Salman, Boosani, Chandra S, Guha, Gunjan, Ciriolo, Maria Rosa, Aquilano, Katia, Chen, Sophie, Mohammed, Sulma I, Azmi, Asfar S, Bhakta, Dipita, Halicka, Dorota, Keith, W. Nicol, Nowsheen, Somaira

“…Abstract Proliferation is an important part of cancer development and progression. This is manifest by altered expression and/or activity of cell cycle related…”
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Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinoma by Medhat, Arvin, Arzumanyan, Alla, Feitelson, Mark A.

“…Hepatitis B virus (HBV) is a human pathogen that has infected an estimated two billion people worldwide. Despite the availability of highly efficacious…”
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Editorial: Microbiome metabolites in health and disease by Canfora, Emanuel E., Feitelson, Mark A., Arzumanyan, Alla

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Preclinical Characterization of GLS4, an Inhibitor of Hepatitis B Virus Core Particle Assembly by Wu, Guoyi, Liu, Bo, Zhang, Yingjun, Li, Jing, Arzumanyan, Alla, Clayton, Marcia M, Schinazi, Raymond F, Wang, Zhaohe, Goldmann, Siegfried, Ren, Qingyun, Zhang, Faxhou, Feitelson, Mark A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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The roles of hepatitis B virus-encoded X protein in virus replication and the pathogenesis of chronic liver disease by Feitelson, Mark A, Bonamassa, Barbara, Arzumanyan, Alla

“…Hepatitis B virus (HBV) is a major cause of chronic liver disease (CLD) and hepatocellular carcinoma (HCC) worldwide. More than 350 million people are at risk…”
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Does the Hepatitis B Antigen HBx Promote the Appearance of Liver Cancer Stem Cells? by ARZUMANYAN, Alla, FRIEDMAN, Tiffany, NG, Irene O. L, CLAYTON, Marcia M, ZHAORUI LIAN, FEITELSON, Mark A

“…Hepatitis B virus (HBV) is a major etiologic agent of chronic liver disease and hepatocellular carcinoma (HCC). HBV-encoded X antigen, HBx, and pathways…”
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Hepatitis B x (HBx) as a Component of a Functional Cure for Chronic Hepatitis B by Feitelson, Mark A, Arzumanyan, Alla, Spector, Ira, Medhat, Arvin

“…Patients who are carriers of the hepatitis B virus (HBV) are at high risk of chronic liver disease (CLD) which proceeds from hepatitis, to fibrosis, cirrhosis…”
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Studies on the Efficacy, Potential Cardiotoxicity and Monkey Pharmacokinetics of GLP-26 as a Potent Hepatitis B Virus Capsid Assembly Modulator by Hurwitz, Selwyn J, McBrearty, Noreen, Arzumanyan, Alla, Bichenkov, Eugene, Tao, Sijia, Bassit, Leda, Chen, Zhe, Kohler, James J, Amblard, Franck, Feitelson, Mark A, Schinazi, Raymond F

“…While treatment options are available for hepatitis B virus (HBV), there is currently no cure. Anti-HBV nucleoside analogs and interferon-alpha 2b rarely clear…”
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A spiroligomer α-helix mimic that binds HDM2, penetrates human cells and stabilizes HDM2 in cell culture by Brown, Zachary Z, Akula, Kavitha, Arzumanyan, Alla, Alleva, Jennifer, Jackson, Marcus, Bichenkov, Eugeney, Sheffield, Joel B, Feitelson, Mark A, Schafmeister, Christian E

“…We demonstrate functionalized spiroligomers that mimic the HDM2-bound conformation of the p53 activation domain. Spiroligomers are stereochemically defined,…”
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Evaluation of Single and Combination Therapies with Tenofovir Disoproxil Fumarate and Emtricitabine In Vitro and in a Robust Mouse Model Supporting High Levels of Hepatitis B Virus Replication by SCHINAZI, Raymond F, BASSIT, Leda, CLAYTON, Marcia M, SUN, Bill, KOHLER, James J, OBIKHOD, Aleksandr, ARZUMANYAN, Alla, FEITELSON, Mark A

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Short-chain fatty acids in cancer pathogenesis by Feitelson, Mark A., Arzumanyan, Alla, Medhat, Arvin, Spector, Ira

“…Cancer is a multi-step process that can be viewed as a cellular and immunological shift away from homeostasis in response to selected infectious agents,…”
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Epigenetic repression of E-cadherin expression by hepatitis B virus x antigen in liver cancer by Arzumanyan, A, Friedman, T, Kotei, E, Ng, I O L, Lian, Z, Feitelson, M A

“…Loss of E-cadherin is associated with acquisition of metastatic capacity. Numerous studies suggest that histone deacetylation and/or hypermethylation of CpG…”
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Hedgehog Signaling Blockade Delays Hepatocarcinogenesis Induced by Hepatitis B Virus X Protein by ARZUMANYAN, Alla, SAMBANDAM, Vaishnavi, CLAYTON, Marcia M, CHOI, Steve S, GUANHUA XIE, DIEHL, Anna Mae, YU, Dae-Yeul, FEITELSON, Mark A

“…The hepatitis B virus (HBV) encoded X protein (HBx) contributes centrally to the pathogenesis of hepatocellular carcinoma (HCC). Aberrant activation of the…”
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Effects of Ethanol on Mouse Embryonic Stem Cells by Arzumanyan, Alla, Anni, Helen, Rubin, Raphael, Rubin, Emanuel

“…Background:  Fetal alcohol syndrome (FAS) reflects a constellation of congenital abnormalities caused by excess maternal consumption of alcohol. It is likely…”
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A prospective study of prognostic role of plasma circulating tumor DNA (ctDNA) in patients (pts) with early-stage malignancies by Fedyanin, Mikhail, Boyarskikh, Uljana, Polyanskaya, Elizaveta, Aliev, Vechaslav, Mamedli, Zaman, Kechin, Andrey, Oscorbin, Igor, Shamovskaya, Darya, Popova, Anna, Polyakov, Alexandr, Kudashkin, Nikolay, Arzumanyan, Alla L., Trigolosov, Arkadiy, Nikulin, Maxim P., Nered, Sergey N., Stilidi, Ivan, Moroz, Ekaterina, Chekini, Antonio, Filipenko, Maxim, Tjulandin, Sergei

“…Abstract only 3559 Background: Recently, conflicting evidence has emerged showing the association of ctDNA level and cancer progression. The aim of our study…”
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Efficacy of nivolumab (Nivo) as 2+ line treatment and quality of life (QoL) in advanced refractory non-small cell lung cancer (NSCLC) patients: Interim results of observational prospective study by Laktionov, Konstantin K., Arzumanyan, Alla L., Bolotina, Larisa, Breder, Valeriy Vladimirovich, Buevich, Natalia N., Danilova, Anastasia, Filippova, Elena A, Kornietskaya, Anna, Kramchaninov, Mikhail M, Kushniruk, Eugenia K, Latipova, Dilorom H., Moiseenko, Fedor Vladimirovich, Nikitina, Tatiana P., Orlov, Sergey V., Orlova, Rashida, Protsenko, Svetlana A., Sarantseva, Ksenia A., Stroyakovskiy, Daniil L., Zinkovskaya, Anna V., Ionova, Tatyana I.

“…Abstract only…”
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Observational study of the efficacy of nivolumab (Nivo) as 2+ line treatment and quality of life (QoL) in advanced refractory non-small cell lung cancer (NSCLC) patients: Interim analysis by Laktionov, Konstantin K, Arzumanyan, Alla L, Bolotina, Larisa V, Breder, Valeriy Vladimirovich, Buevich, Natalia N, Danilova, Anastasia, Filippova, Elena A, Kornietskaya, Anna, Kramchaninov, Mikhail M, Kushniruk, Eugenia K, Latipova, Dilorom Hamidovna, Lipatova, Daria A, Moiseenko, Fedor Vladimirovich, Nikitina, Tatiana P, Orlov, Sergey, Orlova, Rashida, Protsenko, Svetlana, Sarantseva, Ksenia A, Stroyakovskiy, Daniil, Ionova, Tatyana I

“…Abstract only e14593 Background: Therapy with immune checkpoint inhibitors (ICI) changed the paradigm of treatment in many solid tumors including NSCLC…”
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Insulin receptor substrate (IRS)-1 regulates murine embryonic stem (mES) cells self-renewal by Rubin, Raphael, Arzumanyan, Alla, Soliera, Angela Rachele, Ross, Brian, Peruzzi, Francesca, Prisco, Marco

“…Mouse embryonic stem (mES) cells are pluripotent cells that can be propagated in vitro with leukemia inhibitory factor (LIF) and serum. Intracellular signaling…”
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