Search Results - "ARZT, Eduardo"

Regulatory and Mechanistic Actions of Glucocorticoids on T and Inflammatory Cells by Liberman, Ana C, Budziñski, Maia L, Sokn, Clara, Gobbini, Romina Paula, Steininger, Anja, Arzt, Eduardo

“…Glucocorticoids (GCs) play an important role in regulating the inflammatory and immune response and have been used since decades to treat various inflammatory…”
Get full text

CRF signaling: molecular specificity for drug targeting in the CNS by Arzt, Eduardo, Holsboer, Florian

“…Corticotrophin-releasing factor (CRF) is the key mediator of the central nervous system response needed to adapt to stress. If adaptation fails, hypersecretion…”
Get full text

Genetically dissecting P2rx7 expression within the central nervous system using conditional humanized mice by Metzger, Michael W., Walser, Sandra M., Aprile-Garcia, Fernando, Dedic, Nina, Chen, Alon, Holsboer, Florian, Arzt, Eduardo, Wurst, Wolfgang, Deussing, Jan M.

“…The purinergic P2X7 receptor (P2X7R) has attracted considerable interest as a potential target for various central nervous system (CNS) pathologies including…”
Get full text

Cellular and molecular specificity of pituitary gland physiology by Perez-Castro, Carolina, Renner, Ulrich, Haedo, Mariana R, Stalla, Gunter K, Arzt, Eduardo

“…The anterior pituitary gland has the ability to respond to complex signals derived from central and peripheral systems. Perception of these signals and their…”
Get full text

The corticotropin-releasing hormone network and the hypothalamic-pituitary-adrenal axis: molecular and cellular mechanisms involved by Bonfiglio, Juan José, Inda, Carolina, Refojo, Damián, Holsboer, Florian, Arzt, Eduardo, Silberstein, Susana

“…Corticotropin-releasing hormone (CRH) plays a key role in adjusting the basal and stress-activated hypothalamic-pituitary-adrenal axis (HPA). CRH is also…”
Get more information

Editorial: Current Clinical and Pre-Clinical Progress in Cushing's Disease by Stalla, Günter Karl, Arzt, Eduardo, Losa, Marco, Renner, Ulrich

Get full text

RSUME Enhances Glucocorticoid Receptor SUMOylation and Transcriptional Activity by Druker, Jimena, Liberman, Ana C., Antunica-Noguerol, María, Gerez, Juan, Paez-Pereda, Marcelo, Rein, Theo, Iñiguez-Lluhí, Jorge A., Holsboer, Florian, Arzt, Eduardo

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
Get full text

gp130 cytokine signaling in the pituitary gland: a paradigm for cytokine-neuro-endocrine pathways by Arzt, E

Get full text

Impact of RSUME Actions on Biomolecular Modifications in Physio-Pathological Processes by Fuertes, Mariana, Elguero, Belén, Gonilski-Pacin, David, Herbstein, Florencia, Rosmino, Josefina, Ciancio Del Giudice, Nicolas, Fiz, Manuel, Falcucci, Lara, Arzt, Eduardo

“…The small RWD domain-containing protein called RSUME or RWDD3 was cloned from pituitary tumor cells with increasing tumorigenic and angiogenic proficiency…”
Get full text

Co-Expression of Wild-Type P2X7R with Gln460Arg Variant Alters Receptor Function by Aprile-Garcia, Fernando, Metzger, Michael W, Paez-Pereda, Marcelo, Stadler, Herbert, Acuña, Matías, Liberman, Ana C, Senin, Sergio A, Gerez, Juan, Hoijman, Esteban, Refojo, Damian, Mitkovski, Mišo, Panhuysen, Markus, Stühmer, Walter, Holsboer, Florian, Deussing, Jan M, Arzt, Eduardo

“…The P2X7 receptor is a member of the P2X family of ligand-gated ion channels. A single-nucleotide polymorphism leading to a glutamine (Gln) by arginine (Arg)…”
Get full text

serine/arginine-rich protein SF2/ASF regulates protein sumoylation by Pelisch, Federico, Gerez, Juan, Druker, Jimena, Schor, Ignacio E, Muñoz, Manuel J, Risso, Guillermo, Petrillo, Ezequiel, Westman, Belinda J, Lamond, Angus I, Arzt, Eduardo, Srebrow, Anabella

“…Protein modification by conjugation of small ubiquitin-related modifier (SUMO) is involved in diverse biological functions, such as transcription regulation,…”
Get full text

Compound A, a dissociated glucocorticoid receptor modulator, inhibits T-bet (Th1) and induces GATA-3 (Th2) activity in immune cells by Liberman, Ana C, Antunica-Noguerol, Maria, Ferraz-de-Paula, Viviane, Palermo-Neto, Joao, Castro, Carla N, Druker, Jimena, Holsboer, Florian, Perone, Marcelo J, Gerlo, Sarah, De Bosscher, Karolien, Haegeman, Guy, Arzt, Eduardo

“…Compound A (CpdA) is a dissociating non-steroidal glucocorticoid receptor (GR) ligand which has anti-inflammatory properties exerted by down-modulating…”
Get full text

New Insights in Cushing Disease Treatment With Focus on a Derivative of Vitamin A by Fuertes, Mariana, Tkatch, Julieta, Rosmino, Josefina, Nieto, Leandro, Guitelman, Mirtha Adriana, Arzt, Eduardo

“…Cushing's disease (CD) is an endocrine disorder originated by a corticotroph tumor. It is linked with high mortality and morbidity due to chronic…”
Get full text

Activation and Induction of NUR77/NURR1 in Corticotrophs by CRH/cAMP: Involvement of Calcium, Protein Kinase A, and MAPK Pathways by Kovalovsky, Damián, Refojo, Damián, Liberman, Ana Clara, Hochbaum, Daniel, Pereda, Marcelo Paez, Coso, Omar A, Stalla, Günter K, Holsboer, Florian, Arzt, Eduardo

“…Nur factors are critical for proopiomelanocortin (POMC) induction by CRH in corticotrophs, but the pathways linking CRH to Nur are unknown. In this study we…”
Get full text

Retinoic Acid as a Novel Medical Therapy for Cushing’s Disease in Dogs by Castillo, Victor, Giacomini, Damiana, Páez-Pereda, Marcelo, Stalla, Johanna, Labeur, Marta, Theodoropoulou, Marily, Holsboer, Florian, Grossman, Ashley B, Stalla, Günter K, Arzt, Eduardo

“…Cushing’s disease is almost always caused by an ACTH-secreting pituitary tumor, but effective medical therapy is currently limited. Because retinoic acid has…”
Get full text

In silico structural and functional characterization of the RSUME splice variants by Gerez, Juan, Fuertes, Mariana, Tedesco, Lucas, Silberstein, Susana, Sevlever, Gustavo, Paez-Pereda, Marcelo, Holsboer, Florian, Turjanski, Adrián G, Arzt, Eduardo

“…RSUME (RWD-containing SUMO Enhancer) is a small protein that increases SUMO conjugation to proteins. To date, four splice variants that codify three RSUME…”
Get full text

Involvement of Bone Morphogenetic Protein 4 (BMP-4) in Pituitary Prolactinoma Pathogenesis through a Smad/Estrogen Receptor Crosstalk by Páez-Pereda, Marcelo, Giacomini, Damiana, Refojo, Damian, Nagashima, Alberto Carbia, Hopfner, Ursula, Grübler, Yvonne, Chervin, Alberto, Goldberg, Victoria, Goya, Rodolfo, Hentges, Shane T., Low, Malcolm J., Holsboer, Florian, Stalla, Günter K., Arzt, Eduardo

“…Pituitary tumor development involves clonal expansion stimulated by hormones and growth factors/cytokines. Using mRNA differential display, we found that the…”
Get full text

Localization of vascular endothelial growth factor (VEGF) receptors in normal and adenomatous pituitaries: detection of a non-endothelial function of VEGF in pituitary tumours by Onofri, Chiara, Theodoropoulou, Marily, Losa, Marco, Uhl, Eberhard, Lange, Manfred, Arzt, Eduardo, Stalla, Günter K, Renner, Ulrich

“…As for any solid tumour, pituitary adenoma expansion is dependent on neovascularization through angiogenesis. In this process, vascular endothelial growth…”
Get full text

Corticotropin-Releasing Hormone Activates ERK1/2 MAPK in Specific Brain Areas by Refojo, Damián, Echenique, Carlos, Müller, Marianne B., Johannes M. H. M. Reul, Deussing, Jan M., Wurst, Wolfgang, Sillaber, Inge, Paez-Pereda, Marcelo, Holsboer, Florian, Arzt, Eduardo, McCann, S. M.

“…Corticotropin-releasing hormone (CRH) coordinates hormonal and behavioral responses to stress. The mitogen-activated protein kinase extracellular…”
Get full text

Bone Morphogenetic Protein-4 Inhibits Corticotroph Tumor Cells: Involvement in the Retinoic Acid Inhibitory Action by Giacomini, Damiana, Páez-Pereda, Marcelo, Theodoropoulou, Marily, Labeur, Marta, Refojo, Damian, Gerez, Juan, Chervin, Alberto, Berner, Silvia, Losa, Marco, Buchfelder, Michael, Renner, Ulrich, Stalla, Günter K, Arzt, Eduardo

“…The molecular mechanisms governing the pathogenesis of ACTH-secreting pituitary adenomas are still obscure. Furthermore, the pharmacological treatment of these…”
Get full text