Search Results - "ARTHUR HEWITT, L"

Randomized Withdrawal Study of Patients With Symptomatic Neurogenic Orthostatic Hypotension Responsive to Droxidopa by Biaggioni, Italo, Freeman, Roy, Mathias, Christopher J, Low, Phillip, Hewitt, L Arthur, Kaufmann, Horacio

“…ABSTRACT—We evaluated whether droxidopa, a prodrug converted to norepinephrine, is beneficial in the treatment of symptomatic neurogenic orthostatic…”
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Integrated analysis of droxidopa trials for neurogenic orthostatic hypotension by Biaggioni, Italo, Arthur Hewitt, L, Rowse, Gerald J, Kaufmann, Horacio

“…Droxidopa, a prodrug of norepinephrine, was approved for treatment of neurogenic orthostatic hypotension (nOH) due to primary autonomic disorders based on 3…”
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Droxidopa for the Short-Term Treatment of Symptomatic Neurogenic Orthostatic Hypotension in Parkinson's Disease (nOH306B) by Hauser, Robert A., Isaacson, Stuart, Lisk, Jerome P., Hewitt, L. Arthur, Rowse, Gerry

“…ABSTRACT Neurogenic orthostatic hypotension (nOH) results from failure of norepinephrine responses to postural change to maintain standing systolic blood…”
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Characterization of the symptoms of neurogenic orthostatic hypotension and their impact from a survey of patients and caregivers by Claassen, Daniel O, Adler, Charles H, Hewitt, L Arthur, Gibbons, Christopher

“…Neurogenic orthostatic hypotension (nOH) results from impaired vasoconstriction due to dysfunction of the autonomic nervous system and is commonly associated…”
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Droxidopa and Reduced Falls in a Trial of Parkinson Disease Patients With Neurogenic Orthostatic Hypotension by Hauser, Robert A, Heritier, Stephane, Rowse, Gerald J, Hewitt, L Arthur, Isaacson, Stuart H

“…Droxidopa is a prodrug of norepinephrine indicated for the treatment of orthostatic dizziness, lightheadedness, or the "feeling that you are about to black…”
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Cardiovascular Safety of Droxidopa in Patients With Symptomatic Neurogenic Orthostatic Hypotension by White, William B., MD, Hauser, Robert A., MD, MBA, Rowse, Gerald J., PhD, Ziemann, Adam, MD, PhD, Hewitt, L. Arthur, PhD

“…Abstract The norepinephrine prodrug droxidopa improves symptoms of neurogenic orthostatic hypotension, a condition that is associated with diseases of…”
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A Call to Action: The Role of Healthcare Providers in Reducing the Burden Associated with Neurogenic Orthostatic Hypotension by Gibson, Jessie S., Hunter, Christine B., Hewitt, L. Arthur

“…Neurogenic orthostatic hypotension (nOH) is a sustained fall in blood pressure upon standing that frequently affects patients with neurodegenerative diseases…”
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Psychometric validation of a patient-reported single-item assessment of 'Good Day Bad Day' in a neurogenic orthostatic hypotension population treated with droxidopa by François, Clément, Germain, Nicola, Majewska, Renata, Taieb, Vanessa, Hewitt, L. Arthur, Kymes, Steven

“…Symptoms of neurogenic orthostatic hypotension (nOH), including lightheadedness/dizziness, presyncope, syncope, and falls, can lead to impaired functional…”
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Characterization of the changes in supine blood pressure with long‐term use of droxidopa in patients with neurogenic orthostatic hypotension by Hewitt, L. Arthur, Lindsten, Annika, Gorny, Stephen, Karnik‐Henry, Meghana, Kymes, Steven, Favit, Antonella

“…Background and Aims Patients with neurogenic orthostatic hypotension (nOH) due to autonomic dysfunction may also experience supine hypertension (defined as…”
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Effects of the novel norepinephrine prodrug, droxidopa, on ambulatory blood pressure in patients with neurogenic orthostatic hypotension by Kaufmann, Horacio, Norcliffe-Kaufmann, Lucy, Hewitt, L Arthur, Rowse, Gerald J, White, William B

“…The prodrug droxidopa increases blood pressure (BP) in patients with neurogenic orthostatic hypotension. The BP profile of droxidopa in neurogenic orthostatic…”
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Droxidopa for neurogenic orthostatic hypotension: A randomized, placebo-controlled, phase 3 trial by Kaufmann, Horacio, Freeman, Roy, Biaggioni, Italo, Low, Phillip, Pedder, Simon, Hewitt, L Arthur, Mauney, Joe, Feirtag, Michael, Mathias, Christopher J

“…OBJECTIVE:To determine whether droxidopa, an oral norepinephrine precursor, improves symptomatic neurogenic orthostatic hypotension (nOH). METHODS:Patients…”
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Efficacy and Safety of CH-1504, a Metabolically Stable Antifolate, in Patients with Active Rheumatoid Arthritis: Results of a Phase II Multicenter Randomized Study by KEYSTONE, Edward C, SHIRINSKY, Valery S, SIMON, Lee S, PEDDER, Simon, ARTHUR HEWITT, L

“…To investigate the potential efficacy, safety, and tolerability of daily use of CH-1504 in patients with active rheumatoid arthritis (RA). US National…”
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Droxidopa in patients with neurogenic orthostatic hypotension associated with Parkinson's disease (NOH306A) by Hauser, Robert A, Hewitt, L Arthur, Isaacson, Stuart

“…Neurogenic orthostatic hypotension (nOH) is common in Parkinson's disease (PD), and represents a failure to generate norepinephrine responses appropriate for…”
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Comparison of the Pharmacokinetics of Droxidopa After Dosing in the Fed Versus Fasted State and with 3-Times-Daily Dosing in Healthy Elderly Subjects by Chen, Jack J., Hewitt, L. Arthur

“…Background Droxidopa is an oral prodrug of norepinephrine approved for the treatment of symptomatic neurogenic orthostatic hypotension. This two-part,…”
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Integrated Analysis of Droxidopa for the Treatment of Neurogenic Orthostatic Hypotension in Patients with Parkinson Disease by Hauser, Robert A., Biaggioni, Italo, Hewitt, L. Arthur, Vernino, Steven

“…ABSTRACT Introduction Neurogenic orthostatic hypotension (nOH) is associated with neurodegenerative conditions, may cause symptoms of end‐organ hypoperfusion,…”
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Durability of the Clinical Benefit of Droxidopa for Neurogenic Orthostatic Hypotension During 12 Weeks of Open-Label Treatment by Hauser, Robert A., Favit, Antonella, Hewitt, L. Arthur, Lindsten, Annika, Gorny, Stephen, Kymes, Steven, Isaacson, Stuart H.

“…Introduction Droxidopa is approved to treat neurogenic orthostatic hypotension (nOH) symptoms in patients with autonomic failure based on short-term clinical…”
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Impact of the Norepinephrine Prodrug Droxidopa on the QTc Interval in Healthy Individuals by White, William B., Hewitt, L. Arthur, Mehdirad, Ali A.

“…A double‐blind, 4‐period crossover study (NCT01327066) was conducted to assess the effect of the novel norepinephrine prodrug droxidopa on the QT interval in…”
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A randomized, placebo-controlled, phase 2 study of the efficacy and safety of droxidopa in patients with intradialytic hypotension by Vannorsdall, Mark D., Hariachar, Srinivas, Hewitt, L. Arthur

“…Introduction: Intradialytic hypotension (IDH) is the most common complication of hemodialysis (HD), and it plays a significant role in the morbidity and…”
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Analysis of number needed to treat for droxidopa in patients with symptomatic neurogenic orthostatic hypotension by François, Clément, Rowse, Gerald J, Hewitt, L Arthur, Vo, Pamela, Hauser, Robert A

“…Droxidopa is an orally active prodrug that significantly improved dizziness/lightheadedness measured using the Orthostatic Hypotension Symptom Assessment…”
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Cost-effectiveness of droxidopa in patients with neurogenic orthostatic hypotension: post-hoc economic analysis of Phase 3 clinical trial data by François, Clément, Hauser, Robert A, Aballéa, Samuel, Dorey, Julie, Kharitonova, Elizaveta, Hewitt, L Arthur

“…Falls are associated with neurogenic orthostatic hypotension (nOH) and are an economic burden on the US healthcare system. Droxidopa is approved by the US FDA…”
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