Search Results - "AROUT, Caroline"

A placebo‐controlled investigation of the analgesic effects, abuse liability, safety and tolerability of a range of oral cannabidiol doses in healthy humans by Arout, Caroline A., Haney, Margaret, Herrmann, Evan S., Bedi, Gillinder, Cooper, Ziva D.

“…Aims Preclinical studies demonstrate that cannabidiol (CBD) elicits an antinociceptive response in animal models of neuropathic pain; in humans, limited data…”
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Gender Differences in the Prevalence of Fibromyalgia and in Concomitant Medical and Psychiatric Disorders: A National Veterans Health Administration Study by Arout, Caroline A, Sofuoglu, Mehmet, Bastian, Lori A, Rosenheck, Robert A

“…Fibromyalgia is a poorly understood, chronically disabling pain syndrome. While research has focused on its clinical presentation and treatment, less is known…”
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Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations by Arout, Caroline A., Edens, Ellen, Petrakis, Ismene L., Sofuoglu, Mehmet

“…Opioid analgesics have become a cornerstone in the treatment of moderate to severe pain, resulting in a steady rise of opioid prescriptions. Subsequently,…”
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The influence of drug class on reward in substance use disorders by Jones, Jermaine D., Arout, Caroline A., Luba, Rachel, Murugesan, Dillon, Madera, Gabriela, Gorsuch, Liam, Schusterman, Rebecca, Martinez, Suky

“…In the United States, the societal costs associated with drug use surpass $500 billion annually. The rewarding and reinforcing properties that drive the use of…”
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Minocycline does not affect experimental pain or addiction-related outcomes in opioid maintained patients by Arout, Caroline A., Waters, Andrew J., MacLean, R. Ross, Compton, Peggy, Sofuoglu, Mehmet

“…Rationale Minocycline, a tetracycline antibiotic, inhibits activation of microglia. In preclinical studies, minocycline prevented development of opioid…”
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5HT‐2C agonist lorcaserin decreases cannabis self‐administration in daily cannabis smokers by Arout, Caroline A., Cooper, Ziva D., Reed, Stephanie Collins, Foltin, Richard W., Comer, Sandra D., Levin, Frances R., Haney, Margaret

“…There are no FDA‐approved treatments for cannabis use disorder (CUD). Preclinical research has shown that the 5HT‐2C agonist lorcaserin attenuates cue‐induced…”
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Rates and Correlates of Pain Specialty Clinic Use Nationally in the Veterans Health Administration by Arout, Caroline A, Sofuoglu, Mehmet, Rosenheck, Robert A

“…Chronic pain management is a growing focus of attention, in part because of concern over excessive use of opioids for treatment of chronic noncancer pain. In…”
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Signaling-specific inhibition of the CB1 receptor for cannabis use disorder: phase 1 and phase 2a randomized trials by Haney, Margaret, Vallée, Monique, Fabre, Sandy, Collins Reed, Stephanie, Zanese, Marion, Campistron, Ghislaine, Arout, Caroline A., Foltin, Richard W., Cooper, Ziva D., Kearney-Ramos, Tonisha, Metna, Mathilde, Justinova, Zuzana, Schindler, Charles, Hebert-Chatelain, Etienne, Bellocchio, Luigi, Cathala, Adeline, Bari, Andrea, Serrat, Roman, Finlay, David B., Caraci, Filippo, Redon, Bastien, Martín-García, Elena, Busquets-Garcia, Arnau, Matias, Isabelle, Levin, Frances R., Felpin, François-Xavier, Simon, Nicolas, Cota, Daniela, Spampinato, Umberto, Maldonado, Rafael, Shaham, Yavin, Glass, Michelle, Thomsen, Lars Lykke, Mengel, Helle, Marsicano, Giovanni, Monlezun, Stéphanie, Revest, Jean-Michel, Piazza, Pier Vincenzo

“…Cannabis use disorder (CUD) is widespread, and there is no pharmacotherapy to facilitate its treatment. AEF0117, the first of a new pharmacological class, is a…”
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Spinal and supraspinal N -methyl- d -aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia by Arout, Caroline A, Caldwell, Megan, Rossi, Grace, Kest, Benjamin

“…Abstract Morphine elicits a paradoxical state of increased pain sensitivity, known as morphine-induced hyperalgesia (MIH), which complicates its clinical…”
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Rates and correlates of specialized pain clinic use nationally in the veterans health administration by Arout, Caroline A, Sofuoglu, Mehmet, Rosenheck, Robert A

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C-Fos activation in the periaqueductal gray following acute morphine-3β- d -glucuronide or morphine administration by Arout, Caroline A, Caldwell, Megan, McCloskey, Daniel P, Kest, Benjamin

“…Abstract Morphine-3β- d -glucuronide (M3G), a primary morphine metabolite, evokes hyperalgesia in mice and rats and putatively mediates hyperalgesia associated…”
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Thiopental Does Not Produce Hyperalgesia: A Laboratory Study Using Two Human Experimental Pain Models by Arout, Caroline A, Petrakis, Ismene L, Ralevski, Elizabeth, Acampora, Gregory, Koretski, Julia, DeNegre, Diana, Newcomb, Jenelle, Perrino, Albert C

“…Abstract Objective Past investigations assessing the effects of thiopental on pain are conflicting. Although several studies demonstrate hyperalgesia as a…”
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Effect of Intravenous Ethanol on Capsaicin-Induced Hyperalgesia in Human Subjects by Arout, Caroline A., Perrino Jr, Albert C., Ralevski, Elizabeth, Acampora, Gregory, Koretski, Julia, Limoncelli, Diana, Newcomb, Jenelle, Petrakis, Ismene L.

“…Background The objective of this study was to assess ethanol's (EtOH's) effects on capsaicin‐induced hyperalgesia in healthy participants. Specifically, we…”
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Morphine-6β-glucuronide Rapidly Increases Pain Sensitivity Independently of Opioid Receptor Activity in Mice and Humans by VAN DORP, Eveline L. A, KEST, Benjamin, KOWALCZYK, William J, MORARIU, Aurora M, WAXMAN, Amanda R, AROUT, Caroline A, DAHAN, Albert, SARTON, Elise Y

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Targeting Opioid-Induced Hyperalgesia in Clinical Treatment: Neurobiological Considerations by Arout, Caroline A., Edens, Ellen, Petrakis, Ismene L., Sofuoglu, Mehmet

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Acute and chronic heroin dependence in mice: Contribution of opioid and excitatory amino acid receptors by Klein, Gad, Juni, Aaron, Arout, Caroline A., Waxman, Amanda R., Inturrisi, Charles E., Kest, Benjamin

“…Opioid and excitatory amino acid receptors contribute to morphine dependence, but there are no studies of their role in heroin dependence. Thus, mice injected…”
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A survey of acute and chronic heroin dependence in ten inbred mouse strains: Evidence of genetic correlation with morphine dependence by Klein, Gad, Juni, Aaron, Waxman, Amanda R., Arout, Caroline A., Inturrisi, Charles E., Kest, Benjamin

“…Heroin and morphine exposure can cause physical dependence, with symptoms manifesting during their withdrawal. Inter-individual differences in symptom…”
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CHANGES IN ANALGESIC AND ABUSE-RELATED EFFECTS OF CANNABIS WITH REPEATED ADMINISTRATION IN HUMANS by Arout, Caroline, Harris, Hannah, Reed, Stephanie, Kearney-Ramos, Tonisha, Foltin, Richard, Haney, Margaret

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Acute effects of cannabinoids on symptoms of obsessive‐compulsive disorder: A human laboratory study by Kayser, Reilly R., Haney, Margaret, Raskin, Marissa, Arout, Caroline, Simpson, Helen Blair

“…Background Preclinical data implicate the endocannabinoid system in the pathology underlying obsessive‐compulsive disorder (OCD), while survey data have linked…”
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The impact of preexisting psychiatric disorders and antidepressant use on COVID-19 related outcomes: a multicenter study by Schultebraucks, Katharina, Blekic, Wivine, Basaraba, Cale, Corbeil, Tom, Khan, Zain, Henry, Brandy F., Krawczyk, Noa, Rivera, Bianca D., Allen, Bennett, Arout, Caroline, Pincus, Harold Alan, Martinez, Diana M., Levin, Frances R.

“…Pre-existing mental disorders are linked to COVID-19-related outcomes. However, the findings are inconsistent and a thorough analysis of a broader spectrum of…”
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