Search Results - "ARNONE, Marc R"

Dabrafenib; preclinical characterization, increased efficacy when combined with trametinib, while BRAF/MEK tool combination reduced skin lesions by King, Alastair J, Arnone, Marc R, Bleam, Maureen R, Moss, Katherine G, Yang, Jingsong, Fedorowicz, Kelly E, Smitheman, Kimberly N, Erhardt, Joseph A, Hughes-Earle, Angela, Kane-Carson, Laurie S, Sinnamon, Robert H, Qi, Hongwei, Rheault, Tara R, Uehling, David E, Laquerre, Sylvie G

“…Mitogen-Activated Protein Kinase (MAPK) pathway activation has been implicated in many types of human cancer. BRAF mutations that constitutively activate MAPK…”
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Discovery of Dabrafenib: A Selective Inhibitor of Raf Kinases with Antitumor Activity against B‑Raf-Driven Tumors by Rheault, Tara R., Stellwagen, John C., Adjabeng, George M., Hornberger, Keith R., Petrov, Kimberly G., Waterson, Alex G., Dickerson, Scott H., Mook, Robert A., Laquerre, Sylvie G., King, Alastair J., Rossanese, Olivia W., Arnone, Marc R., Smitheman, Kimberly N., Kane-Carson, Laurie S., Han, Chao, Moorthy, Ganesh S., Moss, Katherine G., Uehling, David E.

“…Hyperactive signaling of the MAP kinase pathway resulting from the constitutively active B-RafV600E mutated enzyme has been observed in a number of human…”
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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases by Markwalder, Jay A, Arnone, Marc R, Benfield, Pamela A, Boisclair, Michael, Burton, Catherine R, Chang, Chong-Hwan, Cox, Sarah S, Czerniak, Philip M, Dean, Charity L, Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A, Kaltenbach, Robert F, Nugiel, David A, Rossi, Karen A, Sherk, Susan R, Sisk, Lisa M, Stouten, Pieter, Trainor, George L, Worland, Peter, Seitz, Steven P

“…Using a high-throughput screening strategy, a series of 1-aryl-4,5-dihydro-1H-pyrazolo[3,4-d]pyrimidin-4-ones was identified that inhibit the cyclin-dependent…”
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Development of potent B-RafV600E inhibitors containing an arylsulfonamide headgroup by STELLWAGEN, John C, ADJABENG, George M, ROMINGER, Cynthia M, ROSSANESE, Olivia W, SMITHEMAN, Kimberly N, WATERSON, Alex G, UEHLING, David E, ARNONE, Marc R, DICKERSON, Scott H, CHAO HAN, HORNBERGER, Keith R, KING, Alastair J, MOOK, Robert A, PETROV, Kimberly G, RHEAULT, Tara R

“…A potent series of inhibitors against the B-Raf(V600E) kinase have been developed that show excellent activity in cellular assays and good oral bioavailability…”
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Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay by Snyder, Ronald D, Arnone, Marc R

“…Clastogenicity is frequently observed following treatment of mammalian cells with new chemical entities. This clastogenicity, unless proven otherwise, is…”
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Development of potent B-Raf super(V600E inhibitors containing an arylsulfonamide headgroup) by Stellwagen, John C, Adjabeng, George M, Arnone, Marc R, Dickerson, Scott H, Han, Chao, Hornberger, Keith R, King, Alastair J, Mook, Robert A, Petrov, Kimberly G, Rheault, Tara R, Rominger, Cynthia M, Rossanese, Olivia W, Smitheman, Kimberly N, Waterson, Alex G, Uehling, David E

“…A potent series of inhibitors against the B-Raf super(V600E kinase have been developed that show excellent activity in cellular assays and good oral…”
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Development of potent B-Raf V600E inhibitors containing an arylsulfonamide headgroup by Stellwagen, John C., Adjabeng, George M., Arnone, Marc R., Dickerson, Scott H., Han, Chao, Hornberger, Keith R., King, Alastair J., Mook, Robert A., Petrov, Kimberly G., Rheault, Tara R., Rominger, Cynthia M., Rossanese, Olivia W., Smitheman, Kimberly N., Waterson, Alex G., Uehling, David E.

“…A potent series of inhibitors against the B-Raf V600E kinase have been developed that show excellent activity in cellular assays and good oral bioavailability…”
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Putative identification of functional interactions between DNA intercalating agents and topoisomerase II using the V79 in vitro micronucleus assay by SNYDER, Ronald D, ARNONE, Marc R

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Synthesis and Biological Evaluation of 1-Aryl-4,5-dihydro-1 H -pyrazolo[3,4- d ]pyrimidin-4-one Inhibitors of Cyclin-Dependent Kinases by Markwalder, Jay A., Arnone, Marc R., Benfield, Pamela A., Boisclair, Michael, Burton, Catherine R., Chang, Chong-Hwan, Cox, Sarah S., Czerniak, Philip M., Dean, Charity L., Doleniak, Deborah, Grafstrom, Robert, Harrison, Barbara A., Kaltenbach, Robert F., Nugiel, David A., Rossi, Karen A., Sherk, Susan R., Sisk, Lisa M., Stouten, Pieter, Trainor, George L., Worland, Peter, Seitz, Steven P.

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