Search Results - "ARIMURA, Takuro"

Cardiac Ankyrin Repeat Protein Gene ( ANKRD1 ) Mutations in Hypertrophic Cardiomyopathy by Arimura, Takuro, DVM, PhD, Bos, J. Martijn, MD, Sato, Akinori, MD, Kubo, Toru, MD, PhD, Okamoto, Hiroshi, MD, PhD, Nishi, Hirofumi, MD, PhD, Harada, Haruhito, MD, PhD, Koga, Yoshinori, MD, PhD, Moulik, Mousumi, MD, Doi, Yoshinori L., MD, PhD, Towbin, Jeffrey A., MD, Ackerman, Michael J., MD, PhD, Kimura, Akinori, MD, PhD

“…Objectives The purpose of this study was to explore a novel disease gene for hypertrophic cardiomyopathy (HCM) and to evaluate functional alterations caused by…”
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Novel SCN3B Mutation Associated With Brugada Syndrome Affects Intracellular Trafficking and Function of Nav1.5 by Ishikawa, Taisuke, Takahashi, Naohiko, Ohno, Seiko, Sakurada, Harumizu, Nakamura, Kazufumi, On, Young Keun, Park, Jeong Euy, Makiyama, Takeru, Horie, Minoru, Arimura, Takuro, Makita, Naomasa, Kimura, Akinori

“…Background: Brugada syndrome (BrS) is characterized by specific alterations on ECG in the right precordial leads and associated with ventricular arrhythmia…”
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Activation of MAPK pathways links LMNA mutations to cardiomyopathy in Emery-Dreifuss muscular dystrophy by Muchir, Antoine, Pavlidis, Paul, Decostre, Valérie, Herron, Alan J, Arimura, Takuro, Bonne, Gisèle, Worman, Howard J

“…Mutations in LMNA, which encodes nuclear Lamins A and C cause diseases affecting various organs, including the heart. We have determined the effects of an Lmna…”
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ANKRD1 , the Gene Encoding Cardiac Ankyrin Repeat Protein, Is a Novel Dilated Cardiomyopathy Gene by Moulik, Mousumi, MD, Vatta, Matteo, PhD, Witt, Stephanie H., PhD, Arola, Anita M., MD, PhD, Murphy, Ross T., MD, McKenna, William J., MD, Boriek, Aladin M., PhD, Oka, Kazuhiro, PhD, Labeit, Siegfried, MD, Bowles, Neil E., PhD, Arimura, Takuro, DVM, PhD, Kimura, Akinori, MD, PhD, Towbin, Jeffrey A., MD

“…Objectives We evaluated ankyrin repeat domain 1 ( ANKRD1) , the gene encoding cardiac ankyrin repeat protein (CARP), as a novel candidate gene for dilated…”
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Autophagic degradation of nuclear components in mammalian cells by Park, Young-Eun, Hayashi, Yukiko K., Bonne, Gisèle, Arimura, Takuro, Noguchi, Satoru, Nonaka, Ikuya, Nishino, Ichizo

“…Autophagy is an evolutionally conserved intracellular mechanism for the degradation of organelles and proteins. Here we demonstrate the presence of perinuclear…”
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Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes by Tanaka, Atsushi, Yuasa, Shinsuke, Mearini, Giulia, Egashira, Toru, Seki, Tomohisa, Kodaira, Masaki, Kusumoto, Dai, Kuroda, Yusuke, Okata, Shinichiro, Suzuki, Tomoyuki, Inohara, Taku, Arimura, Takuro, Makino, Shinji, Kimura, Kensuke, Kimura, Akinori, Furukawa, Tetsushi, Carrier, Lucie, Node, Koichi, Fukuda, Keiichi

“…Background Despite the accumulating genetic and molecular investigations into hypertrophic cardiomyopathy (HCM), it remains unclear how this condition develops…”
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Replication of the association between a chromosome 9p21 polymorphism and coronary artery disease in Japanese and Korean populations by Hinohara, Kunihiko, Nakajima, Toshiaki, Takahashi, Megumi, Hohda, Shigeru, Sasaoka, Taishi, Nakahara, Ken-Ichi, Chida, Kouji, Sawabe, Motoji, Arimura, Takuro, Sato, Akinori, Lee, Bok-Soo, Ban, Ji-Min, Yasunami, Michio, Park, Jeong-Euy, Izumi, Toru, Kimura, Akinori

“…Coronary artery disease (CAD) has become a major health problem in many countries. Recent genome-wide association studies have identified the association…”
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Prevalence and Distribution of Sarcomeric Gene Mutations in Japanese Patients With Familial Hypertrophic Cardiomyopathy by Otsuka, Haruna, Arimura, Takuro, Abe, Tadaaki, Kawai, Hiroya, Aizawa, Yoshiyasu, Kubo, Toru, Kitaoka, Hiroaki, Nakamura, Hiroshi, Nakamura, Kazufumi, Okamoto, Hiroshi, Ichida, Fukiko, Ayusawa, Mamoru, Nunoda, Shinichi, Isobe, Mitsuaki, Matsuzaki, Masunori, Doi, Yoshinori L., Fukuda, Keiichi, Sasaoka, Taishi, Izumi, Toru, Ashizawa, Naoto, Kimura, Akinori

“…Background: Hypertrophic cardiomyopathy (HCM), which is inherited as an autosomal dominant trait, is the most prevalent hereditary cardiac disease. Although…”
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Dilated Cardiomyopathy-Associated FHOD3 Variant Impairs the Ability to Induce Activation of Transcription Factor Serum Response Factor by Arimura, Takuro, Takeya, Ryu, Ishikawa, Taisuke, Yamano, Tetsuhiro, Matsuo, Akiko, Tatsumi, Tetsuya, Nomura, Tetsuya, Sumimoto, Hideki, Kimura, Akinori

“…Background: Dilated cardiomyopathy (DCM) is characterized by a dilated left ventricular cavity with systolic dysfunction manifested by heart failure. It has…”
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Overexpression of heart-specific small subunit of myosin light chain phosphatase results in heart failure and conduction disturbance by Arimura, Takuro, Muchir, Antoine, Kuwahara, Masayoshi, Morimoto, Sachio, Ishikawa, Taisuke, Du, Cheng-Kun, Zhan, Dong-Yun, Nakao, Shu, Machida, Noboru, Tanaka, Ryo, Yamane, Yoshihisa, Hayashi, Takeharu, Kimura, Akinori

“…Mutations in genes encoding components of the sarcomere cause cardiomyopathy, which is often associated with abnormal Ca sensitivity of muscle contraction. We…”
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Molecular basis for clinical heterogeneity in inherited cardiomyopathies due to myopalladin mutations by PUREVJAV, Enkhsaikhan, ARIMURA, Takuro, OMMEN, Steve R, SHIBATA, Hiroki, TAKAHASHI, Megumi, ITOH-SATOH, Manatsu, MCKENNA, William J, MURPHY, Ross T, LABEIT, Siegfried, YAMANAKA, Yoichi, MACHIDA, Noboru, PARK, Jeong-Euy, AUGUSTIN, Sibylle, ALEXANDER, Peta M. A, WEINTRAUB, Robert G, KITAURA, Yasushi, ACKERMAN, Michael J, KIMURA, Akinori, TOWBIN, Jeffrey A, HUBY, Anne-Cecile, TAKAGI, Ken, NUNODA, Shinichi, KEARNEY, Debra L, TAYLOR, Michael D, TERASAKI, Fumio, BOS, Johan M

“…Abnormalities in Z-disc proteins cause hypertrophic (HCM), dilated (DCM) and/or restrictive cardiomyopathy (RCM), but disease-causing mechanisms are not fully…”
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DelK32-lamin A/C has abnormal location and induces incomplete tissue maturation and severe metabolic defects leading to premature death by Bertrand, Anne T., Renou, Laure, Papadopoulos, Aurélie, Beuvin, Maud, Lacène, Emmanuelle, Massart, Catherine, Ottolenghi, Chris, Decostre, Valérie, Maron, Sophia, Schlossarek, Saskia, Cattin, Marie-Elodie, Carrier, Lucie, Malissen, Marie, Arimura, Takuro, Bonne, Gisèle

“…The LMNA gene encodes lamin A/C intermediate filaments that polymerize beneath the nuclear membrane, and are also found in the nucleoplasm in an…”
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Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients by Higashikuse, Yuta, Mittal, Nishant, Arimura, Takuro, Yoon, Sung Han, Oda, Mayumi, Enomoto, Hirokazu, Kaneda, Ruri, Hattori, Fumiyuki, Suzuki, Takeshi, Kawakami, Atsushi, Gasch, Alexander, Furukawa, Tetsushi, Labeit, Siegfried, Fukuda, Keiichi, Kimura, Akinori, Makino, Shinji

“…Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene mutations causing HCM have been…”
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Heart-specific Small Subunit of Myosin Light Chain Phosphatase Activates Rho-associated Kinase and Regulates Phosphorylation of Myosin Phosphatase Target Subunit 1 by Shichi, Daisuke, Arimura, Takuro, Ishikawa, Taisuke, Kimura, Akinori

“…Phosphorylation of myosin regulatory light chain (MLC) plays a regulatory role in muscle contraction, and the level of MLC phosphorylation is balanced by MLC…”
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Nebulette Mutations Are Associated With Dilated Cardiomyopathy and Endocardial Fibroelastosis by Purevjav, Enkhsaikhan, MD, PhD, Varela, Jaquelin, BS, Morgado, Micaela, MS, Kearney, Debra L., MD, Li, Hua, PhD, Taylor, Michael D., MD, PhD, Arimura, Takuro, DVM, PhD, Moncman, Carole L., PhD, McKenna, William, MD, Murphy, Ross T., MD, Labeit, Siegfried, MD, Vatta, Matteo, PhD, Bowles, Neil E., PhD, Kimura, Akinori, MD, PhD, Boriek, Aladin M., PhD, Towbin, Jeffrey A., MD

“…Objectives Four variants (K60N, Q128R, G202R, and A592E) in the nebulette gene were identified in patients with dilated cardiomyopathy (DCM) and endocardial…”
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Nuclear accumulation of androgen receptor in gender difference of dilated cardiomyopathy due to lamin A/C mutations by Arimura, Takuro, Onoue, Kenji, Takahashi-Tanaka, Yumiko, Ishikawa, Taisuke, Kuwahara, Masayoshi, Setou, Mitsutoshi, Shigenobu, Shuji, Yamaguchi, Katsushi, Bertrand, Anne T, Machida, Noboru, Takayama, Kazumi, Fukusato, Masayuki, Tanaka, Ryo, Somekawa, Satoshi, Nakano, Tomoya, Yamane, Yoshihisa, Kuba, Keiji, Imai, Yumiko, Saito, Yoshihiko, Bonne, Gisèle, Kimura, Akinori

“…Dilated cardiomyopathy (DCM) is characterized by ventricular dilation associated with systolic dysfunction, which could be caused by mutations in lamina/C gene…”
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Tcap gene mutations in hypertrophic cardiomyopathy and dilated cardiomyopathy by Hayashi, Takeharu, Arimura, Takuro, Itoh-Satoh, Manatsu, Ueda, Kazuo, Hohda, Shigeru, Inagaki, Natsuko, Takahashi, Megumi, Hori, Hisae, Yasunami, Michio, Nishi, Hirofumi, Koga, Yoshinori, Nakamura, Hiroshi, Matsuzaki, Masunori, Choi, Bo Yoon, Bae, Sung Won, You, Cheol Woon, Han, Kyung Hoon, Park, Jeong Euy, Knöll, Ralph, Hoshijima, Masahiko, Chien, Kenneth R., Kimura, Akinori

“…We sought to explore the relationship between a Tcap gene (TCAP)abnormality and cardiomyopathy. Hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy…”
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Functional Characterization of a Trafficking-defective HCN4 Mutation, D553N, Associated with Cardiac Arrhythmia by Ueda, Kazuo, Nakamura, Kazufumi, Hayashi, Takeharu, Inagaki, Natsuko, Takahashi, Megumi, Arimura, Takuro, Morita, Hiroshi, Higashiuesato, Yasushi, Hirano, Yuji, Yasunami, Michio, Takishita, Shuichi, Yamashina, Akira, Ohe, Tohru, Sunamori, Makoto, Hiraoka, Masayasu, Kimura, Akinori

“…Hyperpolarization-activated cyclic nucleotide-gated channel 4 gene HCN4 is a pacemaker channel that plays a key role in automaticity of sinus node in the…”
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Screening of sarcomere gene mutations in young athletes with abnormal findings in electrocardiography: identification of a MYH7 mutation and MYBPC3 mutations by Kadota, Chika, Arimura, Takuro, Hayashi, Takeharu, Naruse, Taeko K, Kawai, Sachio, Kimura, Akinori

“…There is an overlap between the physiological cardiac remodeling associated with training in athletes, the so-called athlete's heart, and mild forms of…”
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Structural analysis of obscurin gene in hypertrophic cardiomyopathy by Arimura, Takuro, Matsumoto, Yuji, Okazaki, Osamu, Hayashi, Takeharu, Takahashi, Megumi, Inagaki, Natsuko, Hinohara, Kunihiko, Ashizawa, Naoto, Yano, Keisuke, Kimura, Akinori

“…Hypertrophic cardiomyopathy (HCM) is a cardiac disease characterized by left ventricular hypertrophy with diastolic dysfunction. Molecular genetic studies have…”
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