Search Results - "ARESU, Luca"

Canine Lymphoma, More Than a Morphological Diagnosis: What We Have Learned about Diffuse Large B-Cell Lymphoma by Aresu, Luca

“…Diffuse large B-cell lymphoma (DLBCL) is the most common canine aggressive B-cell lymphoma worldwide, and new recent molecular approaches have shown that DLBCL…”
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Comprehensive Analysis of Microsatellite Instability in Canine Cancers: Implications for Comparative Oncology and Personalized Veterinary Medicine by Mazzone, Eugenio, Aresu, Luca

“…Microsatellite instability (MSI) is a crucial feature in cancer biology, yet its prevalence and significance in canine cancers remain largely unexplored. This…”
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The K9 lymphoma assay allows a genetic subgrouping of canine lymphomas with improved risk classification by Fanelli, Antonella, Licenziato, Luca, Mazzone, Eugenio, Divari, Sara, Rinaldi, Andrea, Marino, Michele, Maga, Ilaria, Bertoni, Francesco, Marconato, Laura, Aresu, Luca

“…We present here the K9 lymphoma assay, a novel 31-gene targeted next-generation sequencing panel designed for genomic profiling of canine lymphoid neoplasms…”
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Circulating nucleosomes as a potential cancer biomarker in dogs with splenic nodular lesions by Meazzi, Sara, Martini, Valeria, Marconato, Laura, Aralla, Marina, Licenziato, Luca, Olimpo, Matteo, Roccabianca, Paola, Sabattini, Silvia, Ubiali, Alessandra, Zaccone, Riccardo, Aresu, Luca

“…Splenic nodular lesions in dogs can be either benign or malignant. They might be discovered incidentally or, in case of rupture, they may lead to hemoabdomen…”
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DNA Copy Number Changes in Diffuse Large B Cell Lymphomas by Cascione, Luciano, Aresu, Luca, Baudis, Michael, Bertoni, Francesco

“…Copy number aberrations (CNV/CNA) represent a major contribution to the somatic mutation landscapes in cancers, and their identification can lead to the…”
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Mutational landscape of canine B-cell lymphoma profiled at single nucleotide resolution by RNA-seq by Giannuzzi, Diana, Marconato, Laura, Cascione, Luciano, Comazzi, Stefano, Elgendy, Ramy, Pegolo, Sara, Cecchinato, Alessio, Bertoni, Francesco, Aresu, Luca, Ferraresso, Serena

“…The genomic landscape in human B-cell lymphoma has revealed several somatic mutations and potentially relevant germline alterations affecting therapy and…”
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New molecular and therapeutic insights into canine diffuse large B-cell lymphoma elucidates the role of the dog as a model for human disease by Aresu, Luca, Ferraresso, Serena, Marconato, Laura, Cascione, Luciano, Napoli, Sara, Gaudio, Eugenio, Kwee, Ivo, Tarantelli, Chiara, Testa, Andrea, Maniaci, Chiara, Ciulli, Alessio, Hillmann, Petra, Bohnacker, Thomas, Wymann, Matthias P, Comazzi, Stefano, Milan, Massimo, Riondato, Fulvio, Rovere, Giulia Dalla, Giantin, Mery, Giannuzzi, Diana, Bertoni, Francesco

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The diagnostic relevance of mesenteric lymph node biopsy in small intestinal lymphoma in cats by Marconato, Laura, Martini, Valeria, Banco, Barbara, Benali, Silvia, Crocchianti, Veronica, Iussich, Selina, Marino, Michele, Massaro, Maria, Pagano, Teresa Bruna, Aresu, Luca

“…Background Regional lymph nodes are frequently sampled in cats with suspected intestinal lymphoma; however, their diagnostic value has not been explored…”
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Predictive value of TP53 RNAscope ® in situ hybridization and p53 immunohistochemistry for TP53 mutational status in canine diffuse large B-cell lymphoma by Foiani, Greta, Licenziato, Luca, Marconato, Laura, Fanelli, Antonella, Melchiotti, Erica, Zanardello, Claudia, Aresu, Luca, Vascellari, Marta

“…mutations are associated with short survival and poor treatment response in canine diffuse large B-cell lymphoma (cDLBCL). The expression of by RNAscope…”
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A First NGS Investigation Suggests No Association Between Viruses and Canine Cancers by Giannuzzi, Diana, Aresu, Luca

“…Approximately 10–15% of worldwide human cancers are attributable to viral infection. When operating as carcinogenic elements, viruses may act with various…”
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Randomized, Placebo-Controlled, Double-Blinded Chemoimmunotherapy Clinical Trial in a Pet Dog Model of Diffuse Large B-cell Lymphoma by MARCONATO, Laura, FRAYSSINET, Patrick, ROUQUET, Nicole, COMAZZI, Stefano, LEONE, Vito Ferdinando, LAGANGA, Paola, ROSSI, Federica, VIGNOLI, Massimo, PEZZOLI, Lorenzo, ARESU, Luca

“…Active immunotherapy is a promising antitumoral strategy; however its use in combination with chemotherapy in dogs with large B-cell lymphoma (DLBCL) remains…”
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Bridging clinic and wildlife care with AI-powered pan-species computational pathology by AbdulJabbar, Khalid, Castillo, Simon P., Hughes, Katherine, Davidson, Hannah, Boddy, Amy M., Abegglen, Lisa M., Minoli, Lucia, Iussich, Selina, Murchison, Elizabeth P., Graham, Trevor A., Spiro, Simon, Maley, Carlo C., Aresu, Luca, Palmieri, Chiara, Yuan, Yinyin

“…Cancers occur across species. Understanding what is consistent and varies across species can provide new insights into cancer initiation and evolution, with…”
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Performance of lymph node cytopathology in diagnosis and characterization of lymphoma in dogs by Martini, Valeria, Marano, Giuseppe, Aresu, Luca, Bonfanti, Ugo, Boracchi, Patrizia, Caniatti, Mario, Cian, Francesco, Gambini, Matteo, Marconato, Laura, Masserdotti, Carlo, Nicoletti, Arturo, Riondato, Fulvio, Roccabianca, Paola, Stefanello, Damiano, Teske, Erik, Comazzi, Stefano

“…Background Cytopathology is a minimally invasive and convenient diagnostic procedure, often used as a substitute for histopathology to diagnose and…”
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Hypermethylation-Mediated Silencing of CIDEA , MAL and PCDH17 Tumour Suppressor Genes in Canine DLBCL: From Multi-Omics Analyses to Mechanistic Studies by Zorzan, Eleonora, Elgendy, Ramy, Guerra, Giorgia, Da Ros, Silvia, Gelain, Maria Elena, Bonsembiante, Federico, Garaffo, Giulia, Vitale, Nicoletta, Piva, Roberto, Marconato, Laura, Aresu, Luca, Dacasto, Mauro, Giantin, Mery

“…Gene expression is controlled by epigenetic deregulation, a hallmark of cancer. The DNA methylome of canine diffuse large B-cell lymphoma (cDLBCL), the most…”
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Validation of epigenetic mechanisms regulating gene expression in canine B-cell lymphoma: An in vitro and in vivo approach by Da Ros, Silvia, Aresu, Luca, Ferraresso, Serena, Zorzan, Eleonora, Gaudio, Eugenio, Bertoni, Francesco, Dacasto, Mauro, Giantin, Mery

“…Despite canine B-cell Lymphoma (BCL) representing the most common haematological tumour, epigenetic events driving development and progression are scarcely…”
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DNA methylation profiling reveals common signatures of tumorigenesis and defines epigenetic prognostic subtypes of canine Diffuse Large B-cell Lymphoma by Ferraresso, Serena, Aricò, Arianna, Sanavia, Tiziana, Da Ros, Silvia, Milan, Massimo, Cascione, Luciano, Comazzi, Stefano, Martini, Valeria, Giantin, Mery, Di Camillo, Barbara, Mazzariol, Sandro, Giannuzzi, Diana, Marconato, Laura, Aresu, Luca

“…Epigenetic deregulation is a hallmark of cancer characterized by frequent acquisition of new DNA methylation in CpG islands. To gain insight into the…”
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Array-based comparative genomic hybridization analysis reveals chromosomal copy number aberrations associated with clinical outcome in canine diffuse large B-cell lymphoma by Aricò, Arianna, Ferraresso, Serena, Bresolin, Silvia, Marconato, Laura, Comazzi, Stefano, Te Kronnie, Geertruy, Aresu, Luca

“…Canine Diffuse Large B-cell Lymphoma (cDLBCL) is an aggressive cancer with variable clinical response. Despite recent attempts by gene expression profiling to…”
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A retrospective study on prophylactic regional lymphadenectomy versus nodal observation only in the management of dogs with stage I, completely resected, low-grade cutaneous mast cell tumors by Sabattini, Silvia, Kiupel, Matti, Finotello, Riccardo, Stefanello, Damiano, Faroni, Eugenio, Bertazzolo, Walter, Bonfanti, Ugo, Rigillo, Antonella, Del Magno, Sara, Foglia, Armando, Aresu, Luca, Gambini, Matteo, Caniatti, Mario, Marconato, Laura

“…Abstract Background While lymphadenectomy of metastatic lymph nodes (LNs) has been associated with improved outcome, the clinical utility of prophylactic…”
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Antitumor activity of the dual BET and CBP/EP300 inhibitor NEO2734 by Spriano, Filippo, Gaudio, Eugenio, Cascione, Luciano, Tarantelli, Chiara, Melle, Federica, Motta, Giovanna, Priebe, Valdemar, Rinaldi, Andrea, Golino, Gaetanina, Mensah, Afua Adjeiwaa, Aresu, Luca, Zucca, Emanuele, Pileri, Stefano, Witcher, Michael, Brown, Bill, Wahlestedt, Claes, Giles, Francis, Stathis, Anastasios, Bertoni, Francesco

“…Bromodomain and extra-terminal domain (BET) proteins, cyclic adenosine monophosphate response element-binding protein (CBP), and the E1A-binding protein of…”
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The Development of a Recombinant scFv Monoclonal Antibody Targeting Canine CD20 for Use in Comparative Medicine by Jain, Saurabh, Aresu, Luca, Comazzi, Stefano, Shi, Jianguo, Worrall, Erin, Clayton, John, Humphries, William, Hemmington, Sandra, Davis, Paul, Murray, Euan, Limeneh, Asmare A, Ball, Kathryn, Ruckova, Eva, Muller, Petr, Vojtesek, Borek, Fahraeus, Robin, Argyle, David, Hupp, Ted R

“…Monoclonal antibodies are leading agents for therapeutic treatment of human diseases, but are limited in use by the paucity of clinically relevant models for…”
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