Search Results - "ARENDASH, G. W"

Caffeine protects Alzheimer’s mice against cognitive impairment and reduces brain β-amyloid production by Arendash, G.W., Schleif, W., Rezai-Zadeh, K., Jackson, E.K., Zacharia, L.C., Cracchiolo, J.R., Shippy, D., Tan, J.

“…A recent epidemiological study suggested that higher caffeine intake over decades reduces the risk of Alzheimer’s disease (AD). The present study sought to…”
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Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice by Sanchez-Ramos, J, Song, S, Sava, V, Catlow, B, Lin, X, Mori, T, Cao, C, Arendash, G.W

“…Abstract Granulocyte colony stimulating factor (G-CSF) is a multi-modal hematopoietic growth factor, which also has profound effects on the diseased CNS. G-CSF…”
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Long-term electromagnetic field treatment enhances brain mitochondrial function of both Alzheimer's transgenic mice and normal mice: a mechanism for electromagnetic field-induced cognitive benefit? by Dragicevic, N, Bradshaw, P.C, Mamcarz, M, Lin, X, Wang, L, Cao, C, Arendash, G.W

“…Abstract We have recently reported that long-term exposure to high frequency electromagnetic field (EMF) treatment not only prevents or reverses cognitive…”
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Evidence That Oxidative Stress Is Associated with the Pathophysiology of Inherited Hydrocephalus in the H-Tx Rat Model by Socci, D.J., Bjugstad, K.B., Jones, H.C., Pattisapu, J.V., Arendash, G.W.

“…Oxidative stress can contribute to many neurological disease processes. Because many events known to involve oxidative stress (infection, hemorrhage, brain…”
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Lifelong immunization with human β-amyloid (1–42) protects Alzheimer's transgenic mice against cognitive impairment throughout aging by Jensen, M.T., Mottin, M.D., Cracchiolo, J.R., Leighty, R.E., Arendash, G.W.

“…Although both active and passive β-amyloid (Aβ) immunotherapy have been shown to protect against or lessen cognitive impairment in various Alzheimer's…”
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The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimerʼs transgenic mice by Garcia, M. F, Gordon, M. N, Hutton, M, Lewis, J, McGowan, E, Dickey, C. A, Morgan, D, Arendash, G. W

“…To determine the effects of the recessive retinal degeneration (rd) gene on behavioral performance, three Alzheimerʼs transgenic lines (APPsw, P30lL,…”
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Short-Term β-Amyloid Vaccinations Do Not Improve Cognitive Performance in Cognitively Impaired APP+PS1 Mice by Austin, L, Arendash, G. W, Gordon, M. N, Diamond, D. M, DiCarlo, G, Dickey, C, Ugen, K, Morgan, D

“…Prior work demonstrated that β-amyloid (Aβ) immunotherapy for 8 months prevented cognitive impairment in 16-month-old APP+PS1 transgenic mice. In the present…”
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Chronic antioxidant treatment improves the cognitive performance of aged rats by Socci, D.J., Crandall, B.M., Arendash, G.W.

“…Free radicals and oxidative damage have been implicated in brain aging and several neurodegenerative diseases. The purpose of the present study was to…”
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Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study by Oestreicher, E, Sengstock, G J, Riederer, P, Olanow, C W, Dunn, A J, Arendash, G W

“…Parkinson's-diseased (PD) brains have increased levels of iron in the zona compacta of the substantia nigra (SNc). To determine whether these elevated nigral…”
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Improved learning and memory in aged rats with chronic administration of the nicotinic receptor agonist GTS-21 by Arendash, Gary W., Sengstock, Gregory J., Sanberg, Paul R., Kem, William R.

“…The ability of two synthetic nicotine receptor ligands, GTS-21 and DMAB, to chronically enhance the cognitive function of aged rats was evaluated in three…”
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Sorafenib inhibits nuclear factor kappa B, decreases inducible nitric oxide synthase and cyclooxygenase-2 expression, and restores working memory in APPswe mice by Echeverria, V, Burgess, S, Gamble-George, J, Zeitlin, R, Lin, X, Cao, C, Arendash, G.W

“…Abstract Alzheimer's disease (AD) is characterized by memory loss and the upregulation of pro-neuroinflammatory factors such as cRaf-1, cyclooxygenase-2…”
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In vitro and in vivo studies investigating possible antioxidant actions of nicotine: relevance to Parkinson’s and Alzheimer’s diseases by Linert, W., Bridge, M.H., Huber, M., Bjugstad, K.B., Grossman, S., Arendash, G.W.

“…An inverse relationship appears to exist between cigarette smoking and the risk of Parkinson’s and Alzheimer’s diseases. Since both diseases are characterized…”
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A diet high in omega-3 fatty acids does not improve or protect cognitive performance in Alzheimer’s transgenic mice by Arendash, G.W, Jensen, M.T, Salem, N, Hussein, N, Cracchiolo, J, Dickson, A, Leighty, R, Potter, H

“…Abstract Although a number of epidemiologic studies reported that higher intake of omega-3 fatty acids (largely associated with fish consumption) is protective…”
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Metals and free radicals in neurodegeneration by Olanow, C W, Arendash, G W

“…Substantial evidence has accumulated implicating metals and free radicals in the pathogenesis of the major neurodegenerative disorders (Parkinson's disease,…”
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Time-dependent changes in iron levels and associated neuronal loss within the substantia nigra following lesions within the neostriatum/globus pallidus complex by Sastry, S., Arendash, G.W.

“…The substantia nigra and globus pallidus (two iron-rich brain areas) receive a substantial innervation from the neostriatum, a considerable amount of which is…”
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Infusion of iron into the rat substantia nigra: nigral pathology and dose-dependent loss of striatal dopaminergic markers by Sengstock, G J, Olanow, C W, Menzies, R A, Dunn, A J, Arendash, G W

“…Iron has recently been suggested to contribute to the pathogenesis of Parkinson's disease (PD) because of the finding of increased iron levels in the…”
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Nicotine enhances morris water maze performance of young and aged rats by Socci, Debra J., Sanberg, Paul R., Arendash, Gary W.

“…We have recently demonstrated that nicotine administration improves the acquisition and/or memory retention of aged rats in 17-arm radial maze, Lashley III…”
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Aβ peptide vaccination prevents memory loss in an animal model of Alzheimer's disease by Morgan, Dave, Diamond, David M, Gottschall, Paul E, Ugen, Kenneth E, Dickey, Chad, Hardy, John, Duff, Karen, Jantzen, Paul, DiCarlo, Giovanni, Wilcock, Donna, Connor, Karen, Hatcher, Jaime, Hope, Caroline, Gordon, Marcia, Arendash, Gary W

“…Vaccinations with amyloid-β peptide (AB) can dramatically reduce amyloid deposition in a transgenic mouse model of Alzheimer's disease. To determine if the…”
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Intravascular infusions of soluble β-amyloid compromise the blood–brain barrier, activate CNS glial cells and induce peripheral hemorrhage by Su, George C, Arendash, Gary W, Kalaria, Rajesh N, Bjugstad, Kimberly B, Mullan, Michael

“…Vascular wall levels of soluble β-amyloid 1–40 (Aβ 1–40) are elevated in Alzheimer's disease (AD). Moreover, plasma Aβ levels are increased in familial AD, as…”
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Nicotine enhances the learning and memory of aged rats by Aren, Gary W., Sanberg, Paul R., Sengstock, Gregory J.

“…The cognitive performance of young adult (2–3-month-old) and aged (22–24 month-old) rats was characterized in one of three different behavioral tasks, and the…”
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