Search Results - "AREND, Michael"

Nonclinical Characterization of the Hypoxia-Inducible Factor Prolyl Hydroxylase Inhibitor Roxadustat, a Novel Treatment of Anemia of Chronic Kidney Disease by Del Balzo, Ughetta, Signore, Pierre E, Walkinshaw, Gail, Seeley, Todd W, Brenner, Mitchell C, Wang, Qingjian, Guo, Guangjie, Arend, Michael P, Flippin, Lee A, Chow, F Aisha, Gervasi, David C, Kjaergaard, Christian H, Langsetmo, Ingrid, Guenzler, Volkmar, Liu, David Y, Klaus, Steve J, Lin, Al, Neff, Thomas B

“…Anemia of chronic kidney disease (CKD) is a multifactorial disorder caused by impaired erythropoietin (EPO) production and altered iron homeostasis associated…”
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Preconditional activation of hypoxia-inducible factors ameliorates ischemic acute renal failure by BERNHARDT, Wanja M, CAMPEAN, Valentina, WILLAM, Carsten, WIESENER, Michael S, ECKARDT, Kai-Uwe, KANY, Sarah, JÜRGENSEN, Jan-Steffen, WEIDEMANN, Alexander, WARNECKE, Christina, AREND, Michael, KLAUS, Stephen, GÜNZLER, Volkmar, AMANN, Kerstin

“…Activation of hypoxia-inducible transcription factor (HIF) has been identified as an important mechanism of cellular adaptation to low oxygen. Normoxic…”
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Transmembrane prolyl 4-hydroxylase is a fourth prolyl 4-hydroxylase regulating EPO production and erythropoiesis by Laitala, Anu, Aro, Ellinoora, Walkinshaw, Gail, Mäki, Joni M., Rossi, Maarit, Heikkilä, Minna, Savolainen, Eeva-Riitta, Arend, Michael, Kivirikko, Kari I., Koivunen, Peppi, Myllyharju, Johanna

“…An endoplasmic reticulum transmembrane prolyl 4-hydroxylase (P4H-TM) is able to hydroxylate the α subunit of the hypoxia-inducible factor (HIF) in vitro and in…”
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Asymmetric Catalytic Aminoalkylations: New Powerful Methods for the Enantioselective Synthesis of Amino Acid Derivatives, Mannich Bases, and Homoallylic Amines by Arend, Michael

“…Modern methodologies such as the design of chiral catalysts using combinatorial techniques play a key role in the development of asymmetric aminoalkylations…”
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Hypoxia-inducible factor-2α-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization by Paliege, Alexander, Rosenberger, Christian, Bondke, Anja, Sciesielski, Lina, Shina, Ahuva, Heyman, Samuel N., Flippin, Lee A., Arend, Michael, Klaus, Stephen J., Bachmann, Sebastian

“…The adaptation of erythropoietin production to oxygen supply is determined by the abundance of hypoxia-inducible factor (HIF), a regulation that is induced by…”
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The positive impacts of Real-World Data on the challenges facing the evolution of biopharma by Wise, John, Möller, Angeli, Christie, David, Kalra, Dipak, Brodsky, Elia, Georgieva, Evelina, Jones, Greg, Smith, Ian, Greiffenberg, Lars, McCarthy, Marie, Arend, Michael, Luttringer, Olivier, Kloss, Sebastian, Arlington, Steve

“…•Some current challenges facing the biopharmaceutical industry are outlined.•The importance of Real World Data and Real World Evidence is…”
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Modern Variants of the Mannich Reaction by Arend, Michael, Westermann, Bernhard, Risch, Nikolaus

“…Important building blocks for the synthesis of drugs or natural products are found in Mannich bases and their derivatives. Modern variants of the Mannich…”
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Complexity of emotion regulation strategies in changing contexts: A study of varsity athletes by Kucharski, Brittany, Strating, Michael Arend, Ahluwalia Cameron, Aman, Pascual-Leone, Antonio

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Non-hypoxic Stabilization of Hypoxia-Inducible Factor Alpha (HIF-α): Relevance in Neural Progenitor/Stem Cells by Milosevic, Javorina, Adler, Irena, Manaenko, Anatol, Schwarz, Sigrid C., Walkinshaw, Gail, Arend, Michael, Flippin, Lee A., Storch, Alexander, Schwarz, Johannes

“…Hypoxia-inducible factor-1 (HIF-1) plays an important role in neural progenitor cell (NPC) propagation and dopaminergic differentiation. In the presence of…”
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Activation of hypoxia-inducible factors ameliorates hypoxic distal tubular injury in the isolated perfused rat kidney by Rosenberger, Christian, Rosen, Seymour, Shina, Ahuva, Frei, Ulrich, Eckardt, Kai-Uwe, Flippin, Lee A., Arend, Michael, Klaus, Stephen J., Heyman, Samuel N.

“…Background. Preconditional activation of HIF with specific prolyl-hydroxylase inhibitors (PHD-I) attenuates proximal tubular injury, induced by warm ischaemia/…”
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Abstract 16852: Inhibition of Hypoxia-Inducible Factor Prolyl Hydroxylase Reduces Infarct Size and Improves Cardiac Function in a Rat Model of Myocardial Ischemia Reperfusion Injury by Signore, Pierre, Wei, Zhihua, Fung, Cyra, Russell, Loren, Arend, Michael, Flippin, Lee, Walkinshaw, Gail, del Balzo, Ughetta

“…Abstract only Hypoxia-inducible factor (HIF) has been shown to have cardioprotective effects when stabilized prior to a cardiac ischemic event. In the present…”
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Stimulation of HIF-1α, HIF-2α, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells by Asikainen, Tiina M., Ahmad, Aftab, Schneider, Barbara K., Ho, Wen-Bin, Arend, Michael, Brenner, Mitchell, Günzler, Volkmar, White, Carl W.

“…Diminished alveolar and vascular development is characteristic of bronchopulmonary dysplasia (BPD) affecting many preterm newborns. Hypoxia promotes angiogenic…”
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Short-term effects of pharmacologic HIF stabilization on vasoactive and cytotrophic factors in developing mouse brain by Schneider, Christina, Krischke, Gudrun, Keller, Stephan, Walkinshaw, Gail, Arend, Michael, Rascher, Wolfgang, Gassmann, Max, Trollmann, Regina

“…Abstract Hypoxia-inducible transcription factors (HIFs) are crucially involved in brain development and cellular adaptation to hypoxia and ischemia…”
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A Convenient and Highly Regioselective One-Pot Synthesis of Quinolines by Addition of a Vilsmeier-Type Reagent to N-Arylimines by Katritzky, Alan R, Arend, Michael

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Hypoxia-inducible factor-2[alpha]-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization by Paliege, Alexander, Rosenberger, Christian, Bondke, Anja, Sciesielski, Lina, Shina, Ahuva, Heyman, Samuel N, Flippin, Lee A, Arend, Michael, Klaus, Stephen J, Bachmann, Sebastian

“…The adaptation of erythropoietin production to oxygen supply is determined by the abundance of hypoxia-inducible factor (HIF), a regulation that is induced by…”
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Asymmetrische katalytische Aminoalkylierungen: neue leistungsstarke Methoden zur enantioselektiven Synthese von Aminosäurederivaten, Mannich‐Basen und Homoallylaminen by Arend, Michael

“…Moderne Methoden wie das Design chiraler Katalysatoren mit kombinatorischen Verfahren spielen eine Schlüsselrolle bei der Entwicklung asymmetrischer…”
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Stimulation of HIF-1alpha, HIF-2alpha, and VEGF by prolyl 4-hydroxylase inhibition in human lung endothelial and epithelial cells by Asikainen, Tiina M, Ahmad, Aftab, Schneider, Barbara K, Ho, Wen-Bin, Arend, Michael, Brenner, Mitchell, Günzler, Volkmar, White, Carl W

“…Diminished alveolar and vascular development is characteristic of bronchopulmonary dysplasia (BPD) affecting many preterm newborns. Hypoxia promotes angiogenic…”
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A Simple and Versatile Route to Novel Conjugated β-Enaminonitriles and Their Application for the Highly Regioselective Synthesis of Nicotinonitriles Using a Vilsmeier-Type Reagent by Katritzky, Alan R, Denisenko, Anna, Arend, Michael

“…A straightforward synthesis of conjugated β-enaminonitriles from ketones and β-aminocrotononitrile mediated by TiCl4 is described. The reaction of these novel…”
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A highly regioselective synthesis of α,α-bis-Mannich bases by aminomethylation of imines with iminium salts by Arend, Michael, Risch, Nikolaus

“…The aminomethylation of imines R(CH 3)CNPr (R = alkyl, aryl) with iminium salts provides for the first time a mild, broadly applicable and highly…”
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Hypoxia-inducible factor-2alpha-expressing interstitial fibroblasts are the only renal cells that express erythropoietin under hypoxia-inducible factor stabilization by Paliege, Alexander, Rosenberger, Christian, Bondke, Anja, Sciesielski, Lina, Shina, Ahuva, Heyman, Samuel N, Flippin, Lee A, Arend, Michael, Klaus, Stephen J, Bachmann, Sebastian

“…The adaptation of erythropoietin production to oxygen supply is determined by the abundance of hypoxia-inducible factor (HIF), a regulation that is induced by…”
Get full text