Search Results - "ARAVAGIRI, M"

Clinical Outcome Following Neuroleptic Discontinuation in Patients With Remitted Recent-Onset Schizophrenia by Gitlin, Michael, Nuechterlein, Keith, Subotnik, Kenneth L., Ventura, Joseph, Mintz, Jim, Fogelson, David L., Bartzokis, George, Aravagiri, Manickam

“…OBJECTIVE: The goal of this report was to examine the clinical course following neuroleptic discontinuation of patients with recent-onset schizophrenia who had…”
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Simultaneous determination of clozapine and its N-desmethyl and N-oxide metabolites in plasma by liquid chromatography/electrospray tandem mass spectrometry and its application to plasma level monitoring in schizophrenic patients by Aravagiri, M, Marder, S.R

“…A liquid chromatography tandem mass spectrometry (LC-MS-MS) assay method for the simultaneous determination of clozapine and its N-desmethyl (norclozapine) and…”
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Distribution after repeated oral administration of different dose levels of risperidone and 9-hydroxy-risperidone in the brain and other tissues of rat by ARAVAGIRI, M, YUWILER, A, MARDER, S. R

“…Rats were treated with daily oral doses of 1, 4, and 6 mg/kg risperidone (RSP) and its metabolite, 9-hydroxy-risperidone (9-OH-RSP), for 15 consecutive days…”
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Effects of chronic haloperidol and clozapine treatment on neurotensin and c-fos mRNA in rat neostriatal subregions by Merchant, K M, Dobie, D J, Filloux, F M, Totzke, M, Aravagiri, M, Dorsa, D M

“…Previous studies have shown elevation of neurotensin neuromedin N (NT/N) and c-fos mRNA in the dorsolateral region of the rat neostriatum (DLSt) by acute…”
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Plasma concentrations of risperidone and its 9-hydroxy metabolite and their relationship to dose in schizophrenic patients: simultaneous determination by a high performance liquid chromatography with electrochemical detection by Aravagiri, M, Marder, S R, Wirshing, D, Wirshing, W C

“…A simple, sensitive and accurate method for the simultaneous determination of risperidone (RSP) and its 9-hydroxy metabolite (9-OH-RSP) in human plasma is…”
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Fluphenazine plasma level monitoring for patients receiving fluphenazine decanoate by Marder, S.R., Aravagiri, M., Wirshing, W.C., Wirshing, D.A., Lebell, M., Mintz, J.

“…Background: Finding a dose of an antipsychotic for maintenance therapy that is both safe and effective can be difficult because clinicians are unable to…”
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Neuroleptic Plasma Levels by Van Putten, Theodore, Marder, Stephen R, Wirshing, William C, Aravagiri, Manickam, Chabert, Nicole

“…There is enormous variation in plasma levels of most neuroleptics in patients on the same dose. Much of the past research on the relation between plasma levels…”
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Distribution of Fluphenazine and Its Metabolites in Brain Regions and Other Tissues of the Rat by ARAVAGIRI, M, MARDER, S. R, YUWILER, A, MIDHA, K. K, KULA, N. S, BALDESSARINI, R. J

“…Rats were given 5, 10, or 20 mg/kg oral doses of fluphenazine (FLU) dihydrochloride daily for 15 days. FLU and its sulfoxide (FL-SO), 7-hydroxy (7-OH-FLU) and…”
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Fluphenazine levels during maintenance treatment of recent-onset schizophrenia : relation to side effects, psychosocial function and depression by GITLIN, M. J, NUECHTERLEIN, K. H, MINTZ, J, FOGELSON, D, BARTZOKIS, G, VENTURA, J, SUBOTNIK, K, ARAVAGIRI, M

“…The utility of fluphenazine levels during maintenance treatment of schizophrenia is still unclear. This study investigated the relationship between…”
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Chronic haloperidol-induced changes in regional dopamine release and metabolism and neurotensin content in rats by See, R.E., Lynch, A.M., Aravagiri, M., Nemeroff, C.B., Owens, M.J.

“…Chronic neuroleptic administration has previously been shown to alter in vivo measures of dopaminergic function and lead to regionally selective increases in…”
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Plasma levels of fluphenazine in patients receiving fluphenazine decanoate. Relationship to clinical response by Marder, S R, Midha, K K, Van Putten, T, Aravagiri, M, Hawes, E M, Hubbard, J W, McKay, G, Mintz, J

“…The levels of fluphenazine and fluphenazine sulphoxide in schizophrenic patients who were randomly assigned to receive either 5 mg or 25 mg of fluphenazine…”
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Metabolism of phenothiazine and butyrophenone antipsychotic drugs. A review of some recent research findings and clinical implications by Hubbard, J W, Midha, K K, Hawes, E M, McKay, G, Marder, S R, Aravagiri, M, Korchinski, E D

“…Whereas some metabolites of antipsychotic drugs are psychoactive and contribute to clinical improvement, recent studies have provided evidence that certain…”
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Synthesis of the N-oxides of phenothiazine antipsychotic agents by Jaworski, T J, Sardessai, M S, Aravagiri, M, Lin, G, Shi, Y Y, Hawes, E M, Hubbard, J W, McKay, G, Midha, K K

“…Chlorpromazine N-oxide, fluphenazine N4'-oxide, prochlorperazine N4'-oxide, sulforidazine N-oxide, and trifluoperazine N4'-oxide were synthesized by oxidation…”
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Pharmacokinetics and tissue distribution of olanzapine in rats by Aravagiri, Manickam, Teper, Yaroslav, Marder, Stephen R.

“…The single dose pharmacokinetics of olanzapine in rats, following an oral dose and its distribution in the brain and other tissues after repeated oral and…”
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Clinical perspectives of some neuroleptics through development and application of their assays by Midha, K K, Marder, S R, Jaworski, T J, McKay, G, Hubbard, J W, Hawes, E M, Van Putten, T, Wirshing, W C, Aravagiri, M

“…Attempts to investigate relationships between plasma levels of neuroleptics and therapeutic outcome in schizophrenic patients have been hampered due to such…”
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Brain, plasma and tissue pharmacokinetics of risperidone and 9-hydroxyrisperidone after separate oral administration to rats by ARAVAGIRI, Manickam, MARDER, Stephen R

“…Following an oral dose of risperidone (RSP), concentrations of its major metabolite 9-hydroxyrisperidone (9-OHRSP) were high in plasma and tissues but…”
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Simultaneous determination of risperidone and 9-hydroxyrisperidone in plasma by liquid chromatography/electrospray tandem mass spectrometry by Aravagiri, Manickam, Marder, Stephen R.

“…A simple and highly sensitive liquid chromatographic/electrospray tandem mass spectrometric (LC/MS/MS) assay was developed for the simultaneous determination…”
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Plasma level monitoring for maintenance neuroleptic therapy by Marder, S R, Van Putten, T, Aravagiri, M

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Therapeutic monitoring of steady-state plasma levels of the N4'-oxide metabolite of fluphenazine in chronically treated schizophrenic patients determined by a specific and sensitive radioimmunoassay by Aravagiri, M, Marder, S R, Van Putten, T, Hawes, E M, McKay, G, Hubbard, J W, Midha, K K

“…Highly specific and sensitive antisera for fluphenazine-N4'-oxide (FLUNO) were obtained from New Zealand white rabbits immunized with a bovine serum albumin…”
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Development and application of a specific radioimmunoassay for trifluoperazine N4'-oxide to a kinetic study in humans by Aravagiri, M, Hawes, E M, Midha, K K

“…A hapten derivative of prochlorperazine N4'-oxide, 7-(3-carboxy-propionyl)-prochlorperazine N4'-oxide, was synthesized and coupled to bovine serum albumin…”
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