Search Results - "ARASHIKI, Nobuto"

Reduction in flippase activity contributes to surface presentation of phosphatidylserine in human senescent erythrocytes by Seki, Momoko, Arashiki, Nobuto, Takakuwa, Yuichi, Nitta, Kosaku, Nakamura, Fumio

“…Mature human erythrocytes circulate in blood for approximately 120 days, and senescent erythrocytes are removed by splenic macrophages. During this process,…”
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ATP11C T418N, a gene mutation causing congenital hemolytic anemia, reduces flippase activity due to improper membrane trafficking by Arashiki, Nobuto, Niitsuma, Kusumi, Seki, Momoko, Takakuwa, Yuichi, Nakamura, Fumio

“…Distribution of phosphatidylserine (PS) in the erythrocyte membrane is essential for its activity. Flippase transports phospholipids from the outer to the…”
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Novel multivalent S100A8 inhibitory peptides attenuate tumor progression and metastasis by inhibiting the TLR4-dependent pathway by Deguchi, Atsuko, Watanabe-Takahashi, Miho, Mishima, Taishi, Omori, Tsutomu, Ohto, Umeharu, Arashiki, Nobuto, Nakamura, Fumio, Nishikawa, Kiyotaka, Maru, Yoshiro

“…The tumor-elicited inflammation is closely related to tumor microenvironment during tumor progression. S100A8 , an endogenous ligand of Toll-like receptor 4…”
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An Unrecognized Function of Cholesterol: Regulating the Mechanism Controlling Membrane Phospholipid Asymmetry by Arashiki, Nobuto, Saito, Masaki, Koshino, Ichiro, Kamata, Kotoe, Hale, John, Mohandas, Narla, Manno, Sumie, Takakuwa, Yuichi

“…An asymmetric distribution of phospholipids in the membrane bilayer is inseparable from physiological functions, including shape preservation and survival of…”
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ATP11C is a major flippase in human erythrocytes and its defect causes congenital hemolytic anemia by Arashiki, Nobuto, Takakuwa, Yuichi, Mohandas, Narla, Hale, John, Yoshida, Kenichi, Ogura, Hiromi, Utsugisawa, Taiju, Ohga, Shouichi, Miyano, Satoru, Ogawa, Seishi, Kojima, Seiji, Kanno, Hitoshi

“…Phosphatidylserine is localized exclusively to the inner leaflet of the membrane lipid bilayer of most cells, including erythrocytes. This asymmetric…”
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Monoallelic CRMP1 gene variants cause neurodevelopmental disorder by Ravindran, Ethiraj, Arashiki, Nobuto, Becker, Lena-Luise, Takizawa, Kohtaro, Lévy, Jonathan, Rambaud, Thomas, Makridis, Konstantin L, Goshima, Yoshio, Li, Na, Vreeburg, Maaike, Demeer, Bénédicte, Dickmanns, Achim, Stegmann, Alexander P A, Hu, Hao, Nakamura, Fumio, Kaindl, Angela M

“…Collapsin response mediator proteins (CRMPs) are key for brain development and function. Here, we link CRMP1 to a neurodevelopmental disorder. We report…”
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The covalent modification of spectrin in red cell membranes by the lipid peroxidation product 4-hydroxy-2-nonenal by Arashiki, Nobuto, Otsuka, Yayoi, Ito, Daisuke, Yang, Mira, Komatsu, Tomohiko, Sato, Kota, Inaba, Mutsumi

“…Spectrin strengthens the red cell membrane through its direct association with membrane lipids and through protein–protein interactions. Spectrin loss reduces…”
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Maintenance and regulation of asymmetric phospholipid distribution in human erythrocyte membranes: implications for erythrocyte functions by Arashiki, Nobuto, Takakuwa, Yuichi

“…PURPOSE OF REVIEWThe article summarizes new insights in the molecular mechanisms for the maintenance and regulation of the asymmetric distribution of…”
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Parallel Reductions in Stomatin and Na,K-ATPase through the Exosomal Pathway during Reticulocyte Maturation in Dogs: Stomatin as a Genotypic and Phenotypic Marker of High K+ and Low K+ Red Cells by KOMATSU, Tomohiko, SATO, Kota, OTSUKA, Yayoi, ARASHIKI, Nobuto, TANAKA, Kohei, TAMAHARA, Satoshi, ONO, Ken-ichiro, INABA, Mutsumi

“…Dogs can be divided into two genetic groups (a minor HK phenotype and a major LK phenotype) based on erythrocyte monovalent cation concentrations, which are…”
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Senescence mechanism of human erythrocytes by Takakuwa, Yuichi, Arashiki, Nobuto, Saito, Masaki

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Membrane Peroxidation and Methemoglobin Formation Are Both Necessary for Band 3 Clustering: Mechanistic Insights into Human Erythrocyte Senescence by Arashiki, Nobuto, Kimata, Naoki, Manno, Sumie, Mohandas, Narla, Takakuwa, Yuichi

“…Oxidative damage and clustering of band 3 in the membrane have been implicated in the removal of senescent human erythrocytes from the circulation at the end…”
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Structural implications of the EL(K/Q)(L/C)LD(A/G)DD sequence in the C-terminal cytoplasmic tail for proper targeting of anion exchanger 1 to the plasma membrane by Adachi, H., Hokkaido Univ., Sapporo (Japan), Ito, D, Kurooka, T, Otsuka, Y, Arashiki, N, Sato, K, Inaba, M

“…While the C-terminal cytoplasmic tail of anion exchanger 1 (AE1, band 3) has been reported to possess important physiological roles, including one for proper…”
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Storage-Related Changes in Autologous Whole Blood and Irradiated Allogeneic Red Blood Cells and Their Ex Vivo Effects on Deformability, Indices, and Density of Circulating Erythrocytes in Patients Undergoing Cardiac Surgery With Cardiopulmonary Bypass by Ichikawa, Junko, Koshino, Ichiro, Arashiki, Nobuto, Nakamura, Fumio, Komori, Makiko

“…Blood-processing techniques and preservation conditions cause storage lesions, possibly leading to adverse outcomes after transfusion. The authors investigated…”
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Extrusion of Na, K-ATPase and transferrin receptor with lipid raft-associated proteins in different populations of exosomes during reticulocyte maturation in dogs by Komatsu, T., Hokkaido Univ., Sapporo (Japan), Arashiki, N, Otsuka, Y, Sato, K, Inaba, M

“…The present study characterizes canine reticulocyte exosomes. Exosomes are small membrane vesicles involved in membrane remodeling that are released from…”
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3627 PHOSPHATIDYLSERINE EXPOSURE AND SHORTENED LIFE SPAN OF ERYTHROCYTES IN RENAL ANEMIA by Seki, Momoko, Arashiki, Nobuto, Hanafusa, Norio, Hoshino, Junichi, Tsuchiya, Ken, Nakamura, Fumio

“…Abstract Background and Aims The lifespan of erythrocytes in patients with renal anemia is shortened (∼70 days) compared to that of healthy erythrocytes (120…”
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Identification of genes for two major sialoglycoproteins, glycophorin A and glycophorin C in canine red cell membranes by Sato, K.(Hokkaido Univ., Sapporo (Japan)), Otsuka, Y, Arashiki, N, Komatsu, T, Wang, C.C, Tamahara, S, Inaba, M

“…Glycophorins are the major sialoglycoproteins in red blood cell membranes, possessing various physiological and pathological roles. We examined membrane…”
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Changes in Erythrocyte Morphology at Initiation of Cardiopulmonary Bypass Without Blood Transfusion Were Not Associated With Less Deformability During Cardiac Surgery by Ichikawa, Junko, Koshino, Ichiro, Arashiki, Nobuto, Nakamura, Fumio, Komori, Makiko

“…During cardiac surgery, circulating red blood cells (RBCs) are at risk of exposure to environmental factors during extracorporeal circulation and transfusion…”
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Membrane skeleton hyperstability due to a novel alternatively spliced 4.1R can account for ellipsoidal camelid red cells with decreased deformability by Chen, Yuqi, Miyazono, Kosuke, Otsuka, Yayoi, Kanamori, Mariko, Yamashita, Aozora, Arashiki, Nobuto, Matsumoto, Takehisa, Takada, Kensuke, Sato, Kota, Mohandas, Narla, Inaba, Mutsumi

“…The red blood cells (RBCs) of vertebrates have evolved into two basic shapes, with nucleated nonmammalian RBCs having a biconvex ellipsoidal shape and anuclear…”
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Expression of alpha-hemoglobin stabilizing protein and cellular prion protein in a subclone of murine erythroleukemia cell line MEL by Otsuka, Y.(Hokkaido Univ., Sapporo (Japan)), Ito, D, Katsuoka, K, Arashiki, N, Komatsu, T, Inaba, M

“…alpha-Hemoglobin stabilizing protein (AHSP) functions as the erythroid-specific molecular chaperon for alpha-globin. AHSP gene expression has been reported to…”
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Band 3 phosphorylation induces irreversible alterations of stored red blood cells by Azouzi, Slim, Romana, Marc, Arashiki, Nobuto, Takakuwa, Yuichi, El Nemer, Wassim, Peyrard, Thierry, Colin, Yves, Amireault, Pascal, Le Van Kim, Caroline

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