Search Results - "ARAI, Midori A"

Target Protein-Oriented Isolations for Bioactive Natural Products by Arai, Midori A.

“…Natural products are very attractive for development of medicine. Their structure and bioactivities are often beyond human knowledge and imagination. We have…”
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Methodology for awakening the potential secondary metabolic capacity in actinomycetes by Saito, Shun, Arai, Midori A

“…Secondary metabolites produced by actinomycete strains undoubtedly have great potential for use in applied research areas such as drug discovery. However, it…”
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Noaoxazole, a new heat shock metabolite produced by thermotolerant Streptomyces sp. HR41 by Saito, Shun, Suzuki, Shiina, Arai, Midori A.

“…The thermotolerant strain Streptomyces sp. HR41 was found to produce compound 1 only in a 45 °C culture, and not at the standard temperature. We previously…”
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Aspergillus terreus IFM 65899-THP-1 cells interaction triggers production of the natural product butyrolactone Ia, an immune suppressive compound by Ujie, Yukiko, Saito, Shun, Fukaya, Keisuke, Urabe, Daisuke, Yaguchi, Takashi, Arai, Midori A.

“…We focused on the possibility that pathogenic microorganisms might produce immune suppressors to evade the action of immune cells. Based on this possibility,…”
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Evaluation of Naturally Occurring HIF‐1 Inhibitors for Pulmonary Arterial Hypertension by Arai, Midori A., Sakuraba, Kota, Makita, Yoshinori, Hara, Yasumasa, Ishibashi, Masami

“…Pulmonary arterial hypertension (PAH) is a rare and severe progressive disorder characterized by high pulmonary artery pressure. Chronic hypoxia causes a…”
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Bioactive Secondary Metabolites with Unique Aromatic and Heterocyclic Structures Obtained from Terrestrial Actinomycetes Species by Abdelfattah, Mohamed S., Arai, Midori A., Ishibashi, Masami

“…Natural products from actinomycetes are important and valuable sources for drug discovery and the development of biological tools. The present review describes…”
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Corrrection to “Two Bioactive Compounds, Uniformides A and B, Isolated from a Culture of Nocardia uniformis IFM0856T in the Presence of Animal Cells” by Hara, Yasumasa, Watanabe, Keiichiro, Takaya, Akiko, Ebihara, Itsuki, Manome, Teruhisa, Arai, Midori A., Yaguchi, Takashi, Ishibashi, Masami

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Identification of BMI1 promoter inhibitors from Streptomyces sp. IFM-11958 by Yokoyama, Yusuke, Arai, Midori A., Hara, Yasumasa, Ishibashi, Masami

“…[Display omitted] B-cell-specific Moloney murine leukemia virus region 1 (BMI1) is a central component of polycomb repressive complex 1 (PRC1), which maintains…”
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Isolation of nocobactin NAs as Notch signal inhibitors from Nocardia farcinica, a possibility of invasive evolution by Arai, Midori A., Ebihara, Itsuki, Makita, Yoshinori, Hara, Yasumasa, Yaguchi, Takashi, Ishibashi, Masami

“…Notch signaling inhibitors with the potential of immune suppressor production by pathogenic bacteria for easy host infection were searched from extracts of…”
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Total synthesis of agalloside, isolated from Aquilaria agallocha, by the 5-O-glycosylation of flavan by Arai, Midori A, Yamaguchi, Yumi, Ishibashi, Masami

“…Agalloside (1) is a neural stem cell differentiation activator isolated from Aquilaria agallocha by our group using Hes1 immobilized beads. We conducted the…”
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Practical Stereoselective Synthesis of C3‐Spirooxindole‐ and C2‐Spiropseudoindoxyl‐Pyrrolidines via Organocatalyzed Pictet‐Spengler Reaction/Oxidative Rearrangement Sequence by Kondo, Masaru, Matsuyama, Naoki, Aye, Tin Z., Mattan, Irshad, Sato, Tomoyuki, Makita, Yoshinori, Ishibashi, Masami, Arai, Midori A., Takizawa, Shinobu, Sasai, Hiroaki

“…A stereoselective synthetic route to chiral C3‐spirooxindole‐ and C2‐spiropseudoindoxyl‐pyrrolidines was accomplished by an enantioselective organocatalyzed…”
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Dihydromaniwamycin E, a Heat-Shock Metabolite from Thermotolerant Streptomyces sp. JA74, Exhibiting Antiviral Activity against Influenza and SARS-CoV‑2 Viruses by Saito, Shun, Funayama, Kayo, Kato, Wataru, Okuda, Mayu, Kawamoto, Meiko, Matsubara, Teruhiko, Sato, Toshinori, Sato, Akihiko, Otsuguro, Satoko, Sasaki, Michihito, Orba, Yasuko, Sawa, Hirofumi, Maenaka, Katsumi, Shindo, Kazutoshi, Imoto, Masaya, Arai, Midori A.

“…Dihydromaniwamycin E (1), a new maniwamycin derivative featuring an azoxy moiety, has been isolated from the culture extract of thermotolerant Streptomyces sp…”
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The Notch inhibitor cowanin accelerates nicastrin degradation by Arai, Midori A., Akamine, Ryuta, Tsuchiya, Anna, Yoneyama, Tatsuro, Koyano, Takashi, Kowithayakorn, Thaworn, Ishibashi, Masami

“…Aberrant activation of Notch signaling contributes to the pathogenesis of several different types of cancer, and Notch pathway inhibitors may have significant…”
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Isolation of Peptidolipin NA Derivatives from the Culture of Nocardia arthritidis IFM10035T in the Presence of Mouse Macrophage Cells by Hara, Yasumasa, Ishibashi, Masami, Tanimura, Daiki, Manome, Teruhisa, A. Arai, Midori, Yaguchi, Takashi

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The Notch Inhibitors Isolated from Nerium indicum by Arai, Midori A, Akamine, Ryuta, Hayashi, Narumi, Koyano, Takashi, Kowithayakorn, Thaworn, Ishibashi, Masami

“…Notch signaling plays a crucial role in differentiation and cell maintenance, but once aberrantly activated, it contributes to cancer progression. Notch…”
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Total synthesis of lindbladione, a Hes1 dimerization inhibitor and neural stem cell activator isolated from Lindbladia tubulina by Arai, Midori A., Makita, Yuna, Yamaguchi, Yumi, Kawano, Haruka, Suganami, Akiko, Tamura, Yutaka, Ishibashi, Masami

“…Lindbladione ( 1 ) is a neural stem cell differentiation activator isolated from Lindbladia tubulina by our group. Hes1 dimerization inhibitory activity of…”
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Naturally Occurring Small-Molecule Inhibitors of Hedgehog/GLI-Mediated Transcription by Hosoya, Takahiro, Arai, Midori A, Koyano, Takashi, Kowithayakorn, Thaworn, Ishibashi, Masami

“…The aberrant hedgehog (Hh)/GLI signaling pathway causes the formation and progression of a variety of tumors. To search for Hh/GLI inhibitors, we screened for…”
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Cadinane sesquiterpenoids isolated from Santalum album using a screening program for Wnt signal inhibitory activity by Sato, Tomoyuki, Arai, Midori A., Yixizhuoma, Hara, Yasumasa, Koyano, Takashi, Kowithayakorn, Thaworn, Ishibashi, Masami

“…Upon screening compounds having Wnt signal inhibitory activity through evaluating TCF/β-catenin transcriptional (TOP) activity, eight cadinane…”
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Cerasoidine, a Bis-aporphine Alkaloid Isolated from Polyalthia cerasoides during Screening for Wnt Signal Inhibitors by Shono, Takumi, Ishikawa, Naoki, Toume, Kazufumi, Arai, Midori A, Masu, Hyuma, Koyano, Takashi, Kowithayakorn, Thaworn, Ishibashi, Masami

“…A new bis-aporphine alkaloid, cerasoidine (1), was isolated from the root extract of Polyalthia cerasoides together with the known bis-aporphine bidebiline E…”
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Development of Chiral Spiro Ligands for Metal-Catalyzed Asymmetric Reactions by Bajracharya, Gan B, Arai, Midori A, Koranne, Priti S, Suzuki, Takeyuki, Takizawa, Shinobu, Sasai, Hiroaki

“…This account focuses our works on the development of chiral spiro ligands bearing N-heterocycles as metal-coordinating units and their applications in the…”
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