Search Results - "AQUINO, Christopher"

Flavonoids Suppress Pseudomonas aeruginosa Virulence through Allosteric Inhibition of Quorum-sensing Receptors by Paczkowski, Jon E., Mukherjee, Sampriti, McCready, Amelia R., Cong, Jian-Ping, Aquino, Christopher J., Kim, Hahn, Henke, Brad R., Smith, Chari D., Bassler, Bonnie L.

“…Quorum sensing is a process of cell-cell communication that bacteria use to regulate collective behaviors. Quorum sensing depends on the production, detection,…”
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Discovery of a Highly Potent, Nonabsorbable Apical Sodium-Dependent Bile Acid Transporter Inhibitor (GSK2330672) for Treatment of Type 2 Diabetes by Wu, Yulin, Aquino, Christopher J, Cowan, David J, Anderson, Don L, Ambroso, Jeff L, Bishop, Michael J, Boros, Eric E, Chen, Lihong, Cunningham, Alan, Dobbins, Robert L, Feldman, Paul L, Harston, Lindsey T, Kaldor, Istvan W, Klein, Ryan, Liang, Xi, McIntyre, Maggie S, Merrill, Christine L, Patterson, Kristin M, Prescott, Judith S, Ray, John S, Roller, Shane G, Yao, Xiaozhou, Young, Andrew, Yuen, Josephine, Collins, Jon L

“…The apical sodium-dependent bile acid transporter (ASBT) transports bile salts from the lumen of the gastrointestinal (GI) tract to the liver via the portal…”
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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors by Haffner, Curt D, Charnley, Adam K, Aquino, Christopher J, Casillas, Linda, Convery, Máire A, Cox, Julie A, Elban, Mark A, Goodwin, Nicole C, Gough, Peter J, Haile, Pamela A, Hughes, Terry V, Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S, Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F, Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J, Zhou, Huiqiang, Bertin, John, Marquis, Robert W

“…Herein we report the discovery of pyrazolocarboxamides as novel, potent, and kinase selective inhibitors of receptor interacting protein 2 kinase (RIP2)…”
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Defects in keratinocyte activation during wound healing in the syndecan-1-deficient mouse by Stepp, Mary Ann, Gibson, Heather E, Gala, Purvi H, Iglesia, Drina D Sta, Pajoohesh-Ganji, Ahdeah, Pal-Ghosh, Sonali, Brown, Marcus, Aquino, Christopher, Schwartz, Arnold M, Goldberger, Olga, Hinkes, Michael T, Bernfield, Merton

“…Mice lacking syndecan-1 are viable, fertile and have morphologically normal skin, hair and ocular surface epithelia. While studying the response of these mice…”
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Synthesis and structure activity relationship of guanidines as NPY Y5 antagonists by Aquino, Christopher J, Ramanjulu, Joshi M, Heyer, Dennis, Daniels, Alejandro J, Palazzo, Fabio, Dezube, Milana

“…A series of bis-aryl substituted guanidines have been discovered as potent NPY Y5 antagonists. The SAR and in vitro metabolic stability of these compounds are…”
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The Resilience of a School Community during a Pandemic: A Phenomenological Study of the Trials and Tribulations of Bishop John Paul Academy by Aquino, Christopher

“…The COVID-19 pandemic dramatically impacted the world of education. Schools were forced to rapidly adapt to new modes of teaching, learning, and assessment to…”
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Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity. 1. Optimization of the Agonist “Trigger” by Aquino, Christopher J, Armour, Duncan R, Berman, Judd M, Birkemo, Larry S, Carr, Robin A. E, Croom, Dallas K, Dezube, Milana, Dougherty, Robert W, Ervin, Gregory N, Grizzle, Mary K, Head, Julie E, Hirst, Gavin C, James, Michael K, Johnson, Michael F, Miller, Laurence J, Queen, Kennedy L, Rimele, Thomas J, Smith, David N, Sugg, Elizabeth E

“…Directed screening of compounds selected from the Glaxo registry file for contractile activity on the isolated guinea pig gallbladder (GPGB) identified a…”
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A Four-Channel, 36 V, 780 kHz Piezo Driver Chip for Structural Health Monitoring by Yang Guo, Aquino, Christopher, Zhang, David, Murmann, Boris

“…This paper describes a four-channel piezo driver chip for use in active structural health monitoring. Each channel can drive a piezoelectric transducer with a…”
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Aggressive spinal haemangiomas: imaging correlates to clinical presentation with analysis of treatment algorithm and clinical outcomes by Cloran, Francis J, Pukenas, Bryan A, Loevner, Laurie A, Aquino, Christopher, Schuster, James, Mohan, Suyash

“…Aggressive spinal haemangiomas (those with significant osseous expansion/extraosseous extension) represent approximately 1% of spinal haemangiomas and are…”
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Exploration of phenylpropanoic acids as agonists of the free fatty acid receptor 4 (FFA4): Identification of an orally efficacious FFA4 agonist by Sparks, Steven M., Aquino, Christopher, Banker, Pierette, Collins, Jon L., Cowan, David, Diaz, Caroline, Dock, Steven T., Hertzog, Donald L., Liang, Xi, Swiger, Erin D., Yuen, Josephine, Chen, Grace, Jayawickreme, Channa, Moncol, David, Nystrom, Christopher, Rash, Vincent, Rimele, Thomas, Roller, Shane, Ross, Sean

“…[Display omitted] The long chain free fatty acid receptor 4 (FFA4/GPR120) has recently been recognized as lipid sensor playing important roles in nutrient…”
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Magnetic resonance imaging of traumatic brain injury: a pictorial review by Aquino, Christopher, Woolen, Sean, Steenburg, Scott D.

“…Traumatic brain injury (TBI) is a significant source of major morbidity and mortality in blunt trauma patients. Computed tomography (CT) is the primary imaging…”
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Discovery of Pyrazolocarboxamides as Potent and Selective Receptor Interacting Protein 2 (RIP2) Kinase Inhibitors by Ha, #64256, ner, Curt D., Charnley, Adam K., Aquino, Christopher J., Casillas, Linda, Convery, Ma, #769, ire, A., Cox, Julie A., Elban, Mark A., Goodwin, Nicole C., Gough, Peter J., Haile, Pamela A., Hughes, Terry V., Knapp-Reed, Beth, Kreatsoulas, Constantine, Lakdawala, Ami S., Li, Huijie, Lian, Yiqian, Lipshutz, David, Mehlmann, John F., Ouellette, Michael, Romano, Joseph, Shewchuk, Lisa, Shu, Arthur, Votta, Bartholomew J., Zhou, Huiqiang, Bertin, John, Marquis, Robert W.

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Novel 4,4-Disubstituted Piperidine-Based C–C Chemokine Receptor-5 Inhibitors with High Potency against Human Immunodeficiency Virus-1 and an Improved human Ether-a-go-go Related Gene (hERG) Profile by Kazmierski, Wieslaw M, Anderson, Don L, Aquino, Christopher, Chauder, Brian A, Duan, Maosheng, Ferris, Robert, Kenakin, Terrence, Koble, Cecilia S, Lang, Dan G, Mcintyre, Maggie S, Peckham, Jennifer, Watson, Christian, Wheelan, Pat, Spaltenstein, Andrew, Wire, Mary B, Svolto, Angilique, Youngman, Michael

“…We recently described ( J. Med. Chem. 2008, 51, 6538−6546 ) a novel class of CCR5 antagonists with strong anti-HIV potency. Herein, we detail SAR converting…”
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A four-channel, ±36 V, 780 kHz piezo driver chip for structural health monitoring by Yang Guo, Aquino, Christopher, Zhang, David, Murmann, Boris

“…This paper describes a four-channel piezo driver chip for use in active structural health monitoring. Each channel can drive a piezoelectric transducer with a…”
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Discovery of Bioavailable 4,4-Disubstituted Piperidines as Potent Ligands of the Chemokine Receptor 5 and Inhibitors of the Human Immunodeficiency Virus-1 by Kazmierski, Wieslaw M, Aquino, Christopher, Chauder, Brian A, Deanda, Felix, Ferris, Robert, Jones-Hertzog, Deborah K, Kenakin, Terrence, Koble, Cecilia S, Watson, Christian, Wheelan, Pat, Yang, Hanbiao, Youngman, Michael

“…We describe robust chemical approaches toward putative CCR5 scaffolds designed in our laboratories. Evaluation of analogues in the 125I-[MIP-1β] binding and…”
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[2-(4-Phenyl-4-piperidinyl)ethyl]amine based CCR5 antagonists : derivatizations at the N-terminal of the piperidine ring by MAOSHENG DUAN, AQUINO, Christopher, FERRIS, Robert, KAZMIERSKI, Wieslaw M, KENAKIN, Terry, KOBLE, Cecilia, WHEELAN, Pat, WATSON, Chris, YOUNGMAN, Michael

“…Several series of CCR5 antagonists have been discovered by derivatization at the N-terminal of the piperidine ring of the core template 2. Some derivatives…”
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4,4-Disubstituted cyclohexylamine based CCR5 chemokine receptor antagonists as anti-HIV-1 agents by Duan, Maosheng, Aquino, Christopher, Dorsey, George F., Ferris, Robert, Kazmierski, Wieslaw M.

“…A series of 4,4-disubstituted cyclohexylamine based CCR5 antagonists has been designed and synthesized. Their antiviral structure–activity relationship has…”
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4,4-Disubstituted Cyclohexylamine based CCR5 Chemokine Receptor Antagonists as Anti-HIV-1 agents by Duan, Maosheng, Kazmierski, Wieslaw, Aquino, Christopher, Ferris, Rob, Kenakin, Terry, Watson, Chris, Wheelan, Pat

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Discovery of 1,5-Benzodiazepines with Peripheral Cholecystokinin (CCK-A) Receptor Agonist Activity (II):  Optimization of the C3 Amino Substituent by Hirst, Gavin C., Aquino, Christopher, Birkemo, Lawrence, Croom, Dallas K., Dezube, Milana, Dougherty, Robert W., Ervin, Gregory N., Grizzle, Mary K., Henke, Brad, James, Michael K., Johnson, Michael F., Momtahen, Tanya, Queen, Kennedy L., Sherrill, Ronald G., Szewczyk, Jerzy, Willson, Timothy M., Sugg, Elizabeth E.

“…Analogs of the previously reported 1,5-benzodiazepine peripheral cholecystokinin (CCK-A) receptor agonist 1 were prepared which explore substitution and/or…”
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