Search Results - "APGAR, John"

Gsk3 is a metabolic checkpoint regulator in B cells by Jellusova, Julia, Cato, Matthew H, Apgar, John R, Ramezani-Rad, Parham, Leung, Charlotte R, Chen, Cindi, Richardson, Adam D, Conner, Elaine M, Benschop, Robert J, Woodgett, James R, Rickert, Robert C

“…Mature B cells remain in a quiescent state until activated. Rickert and colleagues identify a prominent role for the kinase Gsk3 in resting naive B cells and…”
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Regnase-1 is essential for B cell homeostasis to prevent immunopathology by Bhat, Numana, Virgen-Slane, Richard, Ramezani-Rad, Parham, Leung, Charlotte R, Chen, Cindi, Balsells, Daniel, Shukla, Ashima, Kao, Elaine, Apgar, John R, Fu, Mingui, Ware, Carl F, Rickert, Robert C

“…Regnase-1 is an emerging regulator of immune responses with essential roles in the posttranscriptional control of immune cell activation. Regnase-1 is…”
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E3 Ubiquitin Ligase Fbw7 Regulates the Survival of Mature B Cells by Ramezani-Rad, Parham, Leung, Charlotte R, Apgar, John R, Rickert, Robert C

“…Mature naive B cells expressing BCRs of the IgM and IgD isotypes respond to Ag in secondary lymphoid organs. However, the vast majority of B cells do not…”
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New Methods To Analyze B Cell Immune Responses to Thymus-Dependent Antigen Sheep Red Blood Cells by McAllister, Ellen J, Apgar, John R, Leung, Charlotte R, Rickert, Robert C, Jellusova, Julia

“…B cells contribute critically to an effective immune response by producing Ag-specific Abs. During the immune response to so-called "thymus-dependent Ags,"…”
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Critical role of galectin-3 in phagocytosis by macrophages by Sano, Hideki, Hsu, Daniel K, Apgar, John R, Yu, Lan, Sharma, Bhavya B, Kuwabara, Ichiro, Izui, Shozo, Liu, Fu-Tong

“…Galectin-3 is a member of a large family of animal lectins. This protein is expressed abundantly by macrophages, but its function in this cell type is not well…”
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ZAP-70 directly enhances IgM signaling in chronic lymphocytic leukemia by Chen, Liguang, Apgar, John, Huynh, Lang, Dicker, Frank, Giago-McGahan, Teresa, Rassenti, Laura, Weiss, Arthur, Kipps, Thomas J.

“…Chronic lymphocytic leukemia (CLL) B cells that express unmutated immunoglobulin heavy-chain variable region genes (IgVH) generally express ZAP-70, in contrast…”
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The AKT isoforms 1 and 2 drive B cell fate decisions during the germinal center response by Zhu, Zilu, Shukla, Ashima, Ramezani-Rad, Parham, Apgar, John R, Rickert, Robert C

“…The PI3K pathway is integral for the germinal center (GC) response. However, the contribution of protein kinase B (AKT) as a PI3K effector in GC B cells…”
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Critical Role for Galectin-3 in Airway Inflammation and Bronchial Hyperresponsiveness in a Murine Model of Asthma by Zuberi, Riaz I., Hsu, Daniel K., Kalayci, Omer, Chen, Huan-Yuan, Sheldon, Holly K., Yu, Lan, Apgar, John R., Kawakami, Toshiaki, Lilly, Craig M., Liu, Fu-Tong

“…Galectin-3 is a member of a β-galactoside-binding animal lectin family. Previous in vitro studies have demonstrated that galectin-3 is involved in a number of…”
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Human Galectin-3 Is a Novel Chemoattractant for Monocytes and Macrophages by Sano, Hideki, Hsu, Daniel K, Yu, Lan, Apgar, John R, Kuwabara, Ichiro, Yamanaka, Tohru, Hirashima, Mitsuomi, Liu, Fu-Tong

“…Galectin-3 is a beta-galactoside-binding protein implicated in diverse biological processes. We found that galectin-3 induced human monocyte migration in vitro…”
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Self-reactive B cells in the GALT are actively curtailed to prevent gut inflammation by Shukla, Ashima, Chen, Cindi, Jellusova, Julia, Leung, Charlotte R, Kao, Elaine, Bhat, Numana, Lin, Wai W, Apgar, John R, Rickert, Robert C

“…Immune homeostasis in the gut associated lymphoid tissues (GALT) is critical to prevent the development of inadvertent pathologies. B cells as the producers of…”
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The Role of Actin Microfilaments in the Down-Regulation of the Degranulation Response in RBL-2H3 Mast Cells by Frigeri, Luciano, Apgar, John R

“…Cross-linking of FcepsilonRI on rat basophilic leukemia (RBL) cells initiates a signaling cascade leading to degranulation of the cells and the release of…”
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Role for IgE in Airway Secretions: IgE Immune Complexes Are More Potent Inducers Than Antigen Alone of Airway Inflammation in a Murine Model by Zuberi, Riaz I, Apgar, John R, Chen, Swey-Shen, Liu, Fu-Tong

“…IgE is present in airway secretions from human patients with allergic rhinitis and bronchial asthma. However, the contribution of IgE present locally to the…”
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Pleckstrin Homology Domains Interact with Filamentous Actin by Yao, L, Janmey, P, Frigeri, L G, Han, W, Fujita, J, Kawakami, Y, Apgar, J R, Kawakami, T

“…A fraction of Bruton’s tyrosine kinase (Btk) co-localizes with actin fibers upon stimulation of mast cells via the high affinity IgE receptor (FcεRI). In…”
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The E3 ubiquitin ligase Fbw7 controls survival pathways to prevent apoptosis in mature B cells by Ramezani-Rad, Parham, Leung, Charlotte R, Apgar, John R, Rickert, Robert C

“…Proteolytic processing of proteins is crucial for cellular homeostasis, but also regulates signaling pathways required for effector functions and cell fate…”
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E3 ubiquitin ligase Fbw7 regulates B cell survival and T cell-independent responses by Ramezani-Rad, Parham, Leung, Charlotte R, Apgar, John R, Rickert, Robert C

“…B cells continuously populate peripheral organs to maintain a large number of diverse mature B cell clones. These cells have controlled temporal boundaries and…”
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FBXW7 Is Critical for B1 Cell Maintenance and Function by Ramezani-Rad, Parham, Leung, Charlotte R, Apgar, John R, Rickert, Robert C

“…Background: The E3 ubiquitin ligase Fbxw7 is responsible for the proteasomal degradation of several oncogenes involved in cellular proliferation, growth and…”
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ZAP-70 enhances IgM signaling independent of its kinase activity in chronic lymphocytic leukemia by Chen, Liguang, Huynh, Lang, Apgar, John, Tang, Li, Rassenti, Laura, Weiss, Arthur, Kipps, Thomas J.

“…We transduced chronic lymphocytic leukemia (CLL) cells lacking ZAP-70 with vectors encoding ZAP-70 or various mutant forms of ZAP-70 and monitored the response…”
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Mast cells. Receptors, secretagogues, and signaling by Sharma, Bhavya B, Apgar, John R, Liu, Fu-Tong

“…Mast cells (MC) are a major cell type involved in a number of pathological processes, from local cutaneous reactions to systemic inflammatory responses, which…”
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Cytometric bead array: a multiplexed assay platform with applications in various areas of biology by Morgan, Edward, Varro, Rudi, Sepulveda, Homero, Ember, Julia A, Apgar, John, Wilson, Jerry, Lowe, Larry, Chen, Roy, Shivraj, Lalita, Agadir, Anissa, Campos, Roberto, Ernst, David, Gaur, Amitabh

“…The introduction of flow cytometric bead-based technology has added a new approach for investigators to simultaneously measure multiple analytes in biological…”
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Threshold Levels of ABL Tyrosine Kinase Inhibitors Retained in Chronic Myeloid Leukemia Cells Determine Their Commitment to Apoptosis by O'HARE, Thomas, EIDE, Christopher A, RIDDLE, Steven M, MARKS, Bryan D, VOGEI, Kurt W, KOOP, Dennis R, APGAR, John, TYNER, Jeffrey W, DEININGER, Michael W, DRUKER, Brian J, AGARWAL, Anupriya, ADRIAN, Lauren T, ZABRISKIE, Matthew S, MACKENZIE, Ryan J, LATOCHA, Dorian H, JOHNSON, Kara J, HUIHONG YOU, LUO, Jenny

“…The imatinib paradigm in chronic myelogenous leukemia (CML) established continuous BCR-ABL inhibition as a design principle for ABL tyrosine kinase inhibitors…”
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