Search Results - "APARNA, Gudlur"
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Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm
Published in Cell reports (Cambridge) (02-01-2018)“…STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca2+ and, through a conformational change in the STIM…”
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Initial activation of STIM1, the regulator of store-operated calcium entry
Published in Nature structural & molecular biology (01-08-2013)“…In immune cells, CRAC channels in the plasma membrane regulate store-operated Ca 2+ entry in response to STIM1, a sensor protein located in the endoplasmic…”
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Calcium sensing by the STIM1 ER-luminal domain
Published in Nature communications (31-10-2018)“…Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca 2+ levels to maintain cellular Ca 2+ balance and to support Ca 2+ signalling. The prevailing view…”
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TMEM110 regulates the maintenance and remodeling of mammalian ER–plasma membrane junctions competent for STIM–ORAI signaling
Published in Proceedings of the National Academy of Sciences - PNAS (22-12-2015)“…The stromal interaction molecule (STIM)–ORAI calcium release-activated calcium modulator (ORAI) pathway controls store-dependent calcium entry, a major…”
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A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure
Published in eLife (06-12-2018)“…Ca2+ signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved…”
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Two New Complete Genome Sequences Offer Insight into Host and Tissue Specificity of Plant Pathogenic Xanthomonas spp
Published in Journal of Bacteriology (01-10-2011)“…Article Usage Stats Services JB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A
Published in BMC genomics (01-05-2008)“…Xanthomonas oryzae pv. oryzae causes bacterial blight of rice (Oryza sativa L.), a major disease that constrains production of this staple crop in many parts…”
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Cell Wall-Degrading Esterase of Xanthomonas oryzae Requires a Unique Substrate Recognition Module for Pathogenesis on Rice
Published in The Plant cell (01-06-2009)“…Xanthomonas oryzae pv oryzae (Xoo) causes bacterial blight, a serious disease of rice (Oryza sativa). LipA is a secretory virulence factor of Xoo, implicated…”
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STIM calcium sensing and conformational change
Published in The Journal of physiology (01-05-2020)“…The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is…”
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STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel
Published in Nature communications (09-10-2014)“…The ER-resident regulatory protein STIM1 triggers store-operated Ca 2+ entry by direct interaction with the plasma membrane Ca 2+ channel ORAI1. The mechanism…”
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The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel
Published in Advances in experimental medicine and biology (2017)“…This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai…”
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Genome sequence and rapid evolution of the rice pathogen Xanthomonas oryzae pv. oryzae PXO99A
Published in BMC genomics (11-11-2008)Get full text
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Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor
Published in Proceedings of the National Academy of Sciences - PNAS (14-05-2019)“…The transcription factor nuclear factor of activated T cells (NFAT) has a key role in both T cell activation and tolerance and has emerged as an important…”
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L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins
Published in Proceedings of the National Academy of Sciences - PNAS (21-07-2020)“…Voltage-gated L-type Ca2+ channel (Cav1.2) blockers (LCCBs) are major drugs for treating hypertension, the preeminent risk factor for heart failure. Vascular…”
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Characterization of the Calcium Release-Activated Calcium (CRAC) Channel From the Human Pathogen Schistosoma mansoni
Published in Biophysical journal (02-02-2018)Get full text
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Calcium Sensing and Conformational Rearrangements in STIM1, the ER Calcium Sensor
Published in Biophysical journal (01-02-2019)Get full text
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STIM–ORAI Interactions That Control the CRAC Channel
Published in Current Topics in Membranes (2013)“…The Ca2+ sensor STIM1 and the Ca2+ channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca2+ entry…”
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Book Chapter Journal Article -
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STIM1 Function Is Controlled by Multiple Ca2+ Binding Sites in its Luminal Domain
Published in Biophysical journal (02-02-2018)Get full text
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L-type Ca 2+ channel blockers promote vascular remodeling through activation of STIM proteins
Published in Proceedings of the National Academy of Sciences - PNAS (21-07-2020)“…Voltage-gated L-type Ca channel (Ca 1.2) blockers (LCCBs) are major drugs for treating hypertension, the preeminent risk factor for heart failure. Vascular…”
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Mechanism of Activation of Calcium Channel Orai1 by its Regulatory Partner Stim1
Published in Biophysical journal (28-01-2014)Get full text
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