Search Results - "APARNA, Gudlur"

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    Coiled-Coil Formation Conveys a STIM1 Signal from ER Lumen to Cytoplasm by Hirve, Nupura, Rajanikanth, Vangipurapu, Hogan, Patrick G., Gudlur, Aparna

    Published in Cell reports (Cambridge) (02-01-2018)
    “…STIM1 and STIM2 are endoplasmic reticulum (ER) membrane proteins that sense decreases in ER-luminal free Ca2+ and, through a conformational change in the STIM…”
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    Journal Article
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    Initial activation of STIM1, the regulator of store-operated calcium entry by Zhou, Yubin, Srinivasan, Prasanna, Razavi, Shiva, Seymour, Sam, Meraner, Paul, Gudlur, Aparna, Stathopulos, Peter B, Ikura, Mitsuhiko, Rao, Anjana, Hogan, Patrick G

    Published in Nature structural & molecular biology (01-08-2013)
    “…In immune cells, CRAC channels in the plasma membrane regulate store-operated Ca 2+ entry in response to STIM1, a sensor protein located in the endoplasmic…”
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    Journal Article
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    Calcium sensing by the STIM1 ER-luminal domain by Gudlur, Aparna, Zeraik, Ana Eliza, Hirve, Nupura, Rajanikanth, V., Bobkov, Andrey A., Ma, Guolin, Zheng, Sisi, Wang, Youjun, Zhou, Yubin, Komives, Elizabeth A., Hogan, Patrick G.

    Published in Nature communications (31-10-2018)
    “…Stromal interaction molecule 1 (STIM1) monitors ER-luminal Ca 2+ levels to maintain cellular Ca 2+ balance and to support Ca 2+ signalling. The prevailing view…”
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    Journal Article
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    TMEM110 regulates the maintenance and remodeling of mammalian ER–plasma membrane junctions competent for STIM–ORAI signaling by Quintana, Ariel, Rajanikanth, Vangipurapu, Farber-Katz, Suzette, Gudlur, Aparna, Zhang, Chen, Jing, Ji, Zhou, Yubin, Rao, Anjana, Hogan, Patrick G.

    “…The stromal interaction molecule (STIM)–ORAI calcium release-activated calcium modulator (ORAI) pathway controls store-dependent calcium entry, a major…”
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    Journal Article
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    A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure by Pollak, Adam J, Liu, Canzhao, Gudlur, Aparna, Mayfield, Joshua E, Dalton, Nancy D, Gu, Yusu, Chen, Ju, Heller Brown, Joan, Hogan, Patrick G, Wiley, Sandra E, Peterson, Kirk L, Dixon, Jack E

    Published in eLife (06-12-2018)
    “…Ca2+ signaling is important for many cellular and physiological processes, including cardiac function. Although sarcoplasmic reticulum (SR) proteins involved…”
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    Journal Article
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    Cell Wall-Degrading Esterase of Xanthomonas oryzae Requires a Unique Substrate Recognition Module for Pathogenesis on Rice by Aparna, Gudlur, Chatterjee, Avradip, Sonti, Ramesh V, Sankaranarayanan, Rajan

    Published in The Plant cell (01-06-2009)
    “…Xanthomonas oryzae pv oryzae (Xoo) causes bacterial blight, a serious disease of rice (Oryza sativa). LipA is a secretory virulence factor of Xoo, implicated…”
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    Journal Article
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    STIM calcium sensing and conformational change by Gudlur, Aparna, Zeraik, Ana Eliza, Hirve, Nupura, Hogan, Patrick G.

    Published in The Journal of physiology (01-05-2020)
    “…The control of calcium influx at the plasma membrane by endoplasmic reticulum (ER) calcium stores, a process common to invertebrates and vertebrates, is…”
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    Journal Article
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    STIM1 triggers a gating rearrangement at the extracellular mouth of the ORAI1 channel by Gudlur, Aparna, Quintana, Ariel, Zhou, Yubin, Hirve, Nupura, Mahapatra, Sahasransu, Hogan, Patrick G.

    Published in Nature communications (09-10-2014)
    “…The ER-resident regulatory protein STIM1 triggers store-operated Ca 2+ entry by direct interaction with the plasma membrane Ca 2+ channel ORAI1. The mechanism…”
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    Journal Article
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    The STIM-Orai Pathway: Orai, the Pore-Forming Subunit of the CRAC Channel by Gudlur, Aparna, Hogan, Patrick G

    “…This chapter focuses on the Orai proteins, Orai1-Orai3, with special emphasis on Orai1, in humans and other mammals, and on the definitive evidence that Orai…”
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    Journal Article
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    Targeting the NFAT:AP-1 transcriptional complex on DNA with a small-molecule inhibitor by Mognol, Giuliana P., González-Avalos, Edahí, Ghosh, Srimoyee, Spreafico, Roberto, Gudlur, Aparna, Rao, Anjana, Damoiseaux, Robert, Hogan, Patrick G.

    “…The transcription factor nuclear factor of activated T cells (NFAT) has a key role in both T cell activation and tolerance and has emerged as an important…”
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    Journal Article
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    L-type Ca2+ channel blockers promote vascular remodeling through activation of STIM proteins by Johnson, Martin T., Gudlur, Aparna, Zhang, Xuexin, Xin, Ping, Emrich, Scott M., Yoast, Ryan E., Courjaret, Raphael, Nwokonko, Robert M., Li, Wei, Hempel, Nadine, Machaca, Khaled, Gill, Donald L., Hogan, Patrick G.

    “…Voltage-gated L-type Ca2+ channel (Cav1.2) blockers (LCCBs) are major drugs for treating hypertension, the preeminent risk factor for heart failure. Vascular…”
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    Journal Article
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    STIM–ORAI Interactions That Control the CRAC Channel by Gudlur, Aparna, Zhou, Yubin, Hogan, Patrick G.

    Published in Current Topics in Membranes (2013)
    “…The Ca2+ sensor STIM1 and the Ca2+ channel ORAI1 are the fundamental working machinery of the CRAC channel, a classical pathway for store-operated Ca2+ entry…”
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    Book Chapter Journal Article
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