Search Results - "ANVERSA, PIERO"

Role of Cardiac Stem Cells in Cardiac Pathophysiology: A Paradigm Shift in Human Myocardial Biology by Leri, Annarosa, Kajstura, Jan, Anversa, Piero

“…For nearly a century, the human heart has been viewed as a terminally differentiated postmitotic organ in which the number of cardiomyocytes is established at…”
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Cardiac Stem Cells and Mechanisms of Myocardial Regeneration by Leri, Annarosa, Kajstura, Jan, Anversa, Piero

“…Cardiovascular Research Institute, Department of Medicine, New York Medical College, Valhalla, New York This review discusses current understanding of the role…”
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Origin of Cardiomyocytes in the Adult Heart by Leri, Annarosa, Rota, Marcello, Pasqualini, Francesco S, Goichberg, Polina, Anversa, Piero

“…This review article discusses the mechanisms of cardiomyogenesis in the adult heart. They include the re-entry of cardiomyocytes into the cell cycle;…”
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Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial by Bolli, Roberto, Prof, Chugh, Atul R, MD, D'Amario, Domenico, MD, Loughran, John H, MD, Stoddard, Marcus F, Prof, Ikram, Sohail, Prof, Beache, Garth M, MD, Wagner, Stephen G, MD, Leri, Annarosa, MD, Hosoda, Toru, MD, Sanada, Fumihiro, MD, Elmore, Julius B, MD, Goichberg, Polina, PhD, Cappetta, Donato, PhD, Solankhi, Naresh K, MD, Fahsah, Ibrahim, MD, Rokosh, D Gregg, PhD, Slaughter, Mark S, Prof, Kajstura, Jan, PhD, Anversa, Piero, Prof

“…Summary Background c-kit-positive, lineage-negative cardiac stem cells (CSCs) improve post-infarction left ventricular (LV) dysfunction when administered to…”
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Innate Regeneration in the Aging Heart: Healing From Within by Anversa, Piero, MD, Leri, Annarosa, MD

“…Abstract The concept of the heart as a terminally differentiated organ incapable of replacing damaged myocytes has been at the center of cardiovascular…”
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Human cardiac stem cells by Bearzi, Claudia, Rota, Marcello, Hosoda, Toru, Tillmanns, Jochen, Nascimbene, Angelo, De Angelis, Antonella, Yasuzawa-Amano, Saori, Trofimova, Irina, Siggins, Robert W, LeCapitaine, Nicole, Cascapera, Stefano, Beltrami, Antonio P, D'Alessandro, David A, Zias, Elias, Quaini, Federico, Urbanek, Konrad, Michler, Robert E, Bolli, Roberto, Kajstura, Jan, Leri, Annarosa, Anversa, Piero

“…The identification of cardiac progenitor cells in mammals raises the possibility that the human heart contains a population of stem cells capable of generating…”
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Cardiac stem cell niches by Leri, Annarosa, Rota, Marcello, Hosoda, Toru, Goichberg, Polina, Anversa, Piero

“…The critical role that stem cell niches have in cardiac homeostasis and myocardial repair following injury is the focus of this review. Cardiac niches…”
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Anthracycline Cardiomyopathy Is Mediated by Depletion of the Cardiac Stem Cell Pool and Is Rescued by Restoration of Progenitor Cell Function by DE ANGELIS, Antonella, PIEGARI, Elena, URBANEK, Konrad, KAJSTURA, Jan, LERI, Annarosa, ROSSI, Francesco, ANVERSA, Piero, CAPPETTA, Donato, MARINO, Laura, FILIPPELLI, Amelia, BERRINO, Liberato, FERREIRA-MARTINS, Joao, HANQIAO ZHENG, HOSODA, Toru, ROTA, Marcello

“…Anthracyclines are the most effective drugs available in the treatment of neoplastic diseases; however, they have profound consequences on the structure and…”
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Cardiomyogenesis in the Adult Human Heart by Kajstura, Jan, Urbanek, Konrad, Perl, Shira, Hosoda, Toru, Zheng, Hanqiao, Ogórek, Barbara, Ferreira-Martins, João, Goichberg, Polina, Rondon-Clavo, Carlos, Sanada, Fumihiro, DʼAmario, Domenico, Rota, Marcello, del Monte, Federica, Orlic, Donald, Tisdale, John, Leri, Annarosa, Anversa, Piero

“…RATIONALE:The ability of the human heart to regenerate large quantities of myocytes remains controversial, and the extent of myocyte renewal claimed by…”
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Local Myocardial Insulin-Like Growth Factor 1 (IGF-1) Delivery with Biotinylated Peptide Nanofibers Improves Cell Therapy for Myocardial Infarction by Davis, Michael E., Hsieh, Patrick C. H., Takahashi, Tomosaburo, Song, Qing, Zhang, Shuguang, Kamm, Roger D., Grodzinsky, Alan J., Anversa, Piero, Lee, Richard T.

“…Strategies for cardiac repair include injection of cells, but these approaches have been hampered by poor cell engraftment, survival, and differentiation. To…”
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Stem Cell Niches in the Adult Mouse Heart by Urbanek, Konrad, Cesselli, Daniela, Rota, Marcello, Nascimbene, Angelo, De Angelis, Antonella, Hosoda, Toru, Bearzi, Claudia, Boni, Alessandro, Bolli, Roberto, Kajstura, Jan, Anversa, Piero, Leri, Annarosa

“…Cardiac stem cells (CSCs) have been identified in the adult heart, but the microenvironment that protects the slow-cycling, undifferentiated, and self-renewing…”
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Myocyte Death, Growth, and Regeneration in Cardiac Hypertrophy and Failure by Nadal-Ginard, Bernardo, Kajstura, Jan, Leri, Annarosa, Anversa, Piero

“…ABSTRACT—The accepted paradigm considers the adult mammalian heart as a postmitotic organ, which possesses a relatively constant number of myocytes from…”
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Human Cardiac Stem Cell Differentiation Is Regulated by a Mircrine Mechanism by HOSODA, Toru, HANQIAO ZHENG, URBANEK, Konrad, D'ALESSANDRO, David A, MICHLER, Robert E, ANVERSA, Piero, ROTA, Marcello, KAJSTURA, Jan, LERI, Annarosa, CABRAL-DA-SILVA, Mauricio, SANADA, Fumihiro, IDE-IWATA, Noriko, OGOREK, Barbara, FERREIRA-MARTINS, Joao, ARRANTO, Christian, D'AMARIO, Domenico, DEL MONTE, Federica

“…Cardiac stem cells (CSCs) delivered to the infarcted heart generate a large number of small fetal-neonatal cardiomyocytes that fail to acquire the…”
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Myocyte Turnover in the Aging Human Heart by Kajstura, Jan, Gurusamy, Narasimman, Ogórek, Barbara, Goichberg, Polina, Clavo-Rondon, Carlos, Hosoda, Toru, DʼAmario, Domenico, Bardelli, Silvana, Beltrami, Antonio P, Cesselli, Daniela, Bussani, Rossana, del Monte, Federica, Quaini, Federico, Rota, Marcello, Beltrami, Carlo A, Buchholz, Bruce A, Leri, Annarosa, Anversa, Piero

“…RATIONALE:The turnover of cardiomyocytes in the aging female and male heart is currently unknown, emphasizing the need to define human myocardial biology…”
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Effects of Age and Heart Failure on Human Cardiac Stem Cell Function by Cesselli, Daniela, Beltrami, Antonio P, D'Aurizio, Federica, Marcon, Patrizia, Bergamin, Natascha, Toffoletto, Barbara, Pandolfi, Maura, Puppato, Elisa, Marino, Laura, Signore, Sergio, Livi, Ugolino, Verardo, Roberto, Piazza, Silvano, Marchionni, Luigi, Fiorini, Claudia, Schneider, Claudio, Hosoda, Toru, Rota, Marcello, Kajstura, Jan, Anversa, Piero, Beltrami, Carlo A, Leri, Annarosa

“…Currently, it is unknown whether defects in stem cell growth and differentiation contribute to myocardial aging and chronic heart failure (CHF), and whether a…”
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Cardiac Progenitor Cells and Biotinylated Insulin-Like Growth Factor-1 Nanofibers Improve Endogenous and Exogenous Myocardial Regeneration After Infarction by PADIN-IRUEGAS, M. Elena, MISAO, Yu, LERI, Annarosa, LEE, Richard T, KAJSTURA, Jan, DAVIS, Michael E, SEGERS, Vincent F. M, ESPOSITO, Grazia, TOKUNOU, Tomotake, URBANEK, Konrad, HOSODA, Toru, ROTA, Marcello, ANVERSA, Piero

“…Cardiac progenitor cells (CPCs) possess the insulin-like growth factor-1 (IGF-1)-IGF-1 receptor system, and IGF-1 can be tethered to self-assembling peptide…”
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Identification of a coronary vascular progenitor cell in the human heart by Bearzi, Claudia, Leri, Annarosa, Lo Monaco, Francesco, Rota, Marcello, Gonzalez, Arantxa, Hosoda, Toru, Pepe, Martino, Qanud, Khaled, Ojaimi, Caroline, Bardelli, Silvana, D'Amario, Domenico, D'Alessandro, David A, Michler, Robert E, Dimmeler, Stefanie, Zeiher, Andreas M, Urbanek, Konrad, Hintze, Thomas H, Kajstura, Jan, Anversa, Piero

“…Primitive cells capable of generating small resistance arterioles and capillary structures in the injured myocardium have been identified repeatedly. However,…”
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Myocardial Regeneration by Activation of Multipotent Cardiac Stem Cells in Ischemic Heart Failure by Urbanek, Konrad, Torella, Daniele, Sheikh, Farooq, De Angelis, Antonella, Nurzynska, Daria, Silvestri, Furio, Beltrami, C. Alberto, Bussani, Rossana, Beltrami, Antonio P., Quaini, Federico, Bolli, Roberto, Leri, Annarosa, Kajstura, Jan, Anversa, Piero, Ignarro, Louis J.

“…In this study, we tested whether the human heart possesses a cardiac stem cell (CSC) pool that promotes regeneration after infarction. For this purpose, CSC…”
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Local Activation or Implantation of Cardiac Progenitor Cells Rescues Scarred Infarcted Myocardium Improving Cardiac Function by Rota, Marcello, Padin-Iruegas, M Elena, Misao, Yu, De Angelis, Antonella, Maestroni, Silvia, Ferreira-Martins, João, Fiumana, Emanuela, Rastaldo, Raffaella, Arcarese, Michael L, Mitchell, Thomas S, Boni, Alessandro, Bolli, Roberto, Urbanek, Konrad, Hosoda, Toru, Anversa, Piero, Leri, Annarosa, Kajstura, Jan

“…Ischemic heart disease is characterized chronically by a healed infarct, foci of myocardial scarring, cavitary dilation, and impaired ventricular performance…”
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Bone marrow cells adopt the cardiomyogenic fate in vivo by Rota, Marcello, Kajstura, Jan, Hosoda, Toru, Bearzi, Claudia, Vitale, Serena, Esposito, Grazia, Iaffaldano, Grazia, Padin-Iruegas, M. Elena, Gonzalez, Arantxa, Rizzi, Roberto, Small, Narissa, Muraski, John, Alvarez, Roberto, Chen, Xiongwen, Urbanek, Konrad, Bolli, Roberto, Houser, Steven R, Leri, Annarosa, Sussman, Mark A, Anversa, Piero

“…The possibility that adult bone marrow cells (BMCs) retain a remarkable degree of developmental plasticity and acquire the cardiomyocyte lineage after…”
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